Genomic identification of a novel co-trimoxazole resistance genotype and its prevalence amongst Streptococcus pneumoniae in Malawi

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 2, 2014, Pages 368-374

  Cornick, Jennifer E ^a,b   Harris, Simon R ^c   Parry, Christopher M ^d,e   Moore, Michael J ^a,f   Jassi, Chikondi ^a   Kamng'ona, Arox ^a,b   Kulohoma, Benard ^a,b   Heyderman, Robert S ^a,f   Bentley, Stephen D ^c   Everett, Dean B ^a,b  

^a UNIVERSITY OF MALAWI   (Malawi)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d MAHIDOL OXFORD TROPICAL MEDICINE RESEARCH UNIT   (Thailand)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Pneumococcal disease; Prophylaxis; Sulfamethoxazole; Trimethoprim

Indexed keywords

COTRIMOXAZOLE; DIHYDROFOLATE REDUCTASE; MOLECULAR MARKER; SULFONAMIDE; TRIMETHOPRIM;

AMINO ACID SEQUENCE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIUM ISOLATE; BACTERIUM ISOLATION; COMPUTER MODEL; CONTROLLED STUDY; DIHYDROFOLATE REDUCTASE GENE; DRUG BINDING SITE; FOLA GENE; FOLP GENE; GENE IDENTIFICATION; GENE INSERTION; GENE MUTATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; IN VITRO STUDY; MALAWI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PREVALENCE; STREPTOCOCCUS PNEUMONIAE;

PNEUMOCOCCAL DISEASE; PROPHYLAXIS; SULFAMETHOXAZOLE; TRIMETHOPRIM;

AMINO ACID SEQUENCE; GENOTYPE; HUMANS; MALAWI; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PNEUMOCOCCAL INFECTIONS; PREVALENCE; STREPTOCOCCUS PNEUMONIAE; TRIMETHOPRIM-SULFAMETHOXAZOLE COMBINATION;

EID: 84892471444     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkt384     Document Type: Article

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