Arsenic metabolism efficiency has a causal role in arsenic toxicity: Mendelian randomization and gene-environment interaction

International Journal of Epidemiology

Volumn 42, Issue 6, 2013, Pages 1862-1872

  Pierce, Brandon L ^a   Tong, Lin ^a   Argos, Maria ^a   Gao, Jianjun ^a   Jasmine, Farzana ^a   Roy, Shantanu ^a   Paul Brutus, Rachelle ^a   Rahaman, Ronald ^a   Rakibuz Zaman, Muhammad ^b   Parvez, Faruque ^c   Ahmed, Alauddin ^b   Quasem, Iftekhar ^b   Hore, Samar K ^d   Alam, Shafiul ^b   Islam, Tariqul ^b   Harjes, Judith ^e   Sarwar, Golam ^b   Slavkovich, Vesna ^c   Gamble, Mary V ^c   Chen, Yu ^f   Yunus, Mohammad ^d   Rahman, Mahfuzar ^b   Baron, John A ^g   Graziano, Joseph H ^c   Ahsan, Habibul ^a   more..

^a UNIVERSITY OF CHICAGO   (United States)

^b U Chicago Research Bangladesh Ltd   (Bangladesh)

^c Columbia University ^*  (United States)

^d INTERNATIONAL CENTRE FOR DIARRHOEAL DISEASE RESEARCH   (Bangladesh)

^e DARTMOUTH MEDICAL SCHOOL   (United States)

^f NEW YORK UNIVERSITY   (United States)

^g UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Arsenic; Arsenic metabolism; AS3MT; Gene environment interaction; Mendelian randomization

Indexed keywords

ARSENIC; CACODYLIC ACID; METHANEARSONIC ACID;

ARSENIC; DISEASE INCIDENCE; DRINKING WATER; ECOTOXICOLOGY; GENOTYPE-ENVIRONMENT INTERACTION; HEALTH IMPACT; HEALTH SERVICES; INDIVIDUAL VARIATION; LESION; METABOLISM; POLLUTION EXPOSURE; RISK FACTOR; SKIN DISORDER;

ADULT; AGED; ARTICLE; BANGLADESH; CONTROLLED STUDY; FEMALE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MENDELIAN RANDOMIZATION ANALYSIS; METAL METABOLISM; MIDDLE AGED; PRIORITY JOURNAL; PRODUCTIVITY; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; SKIN DEFECT; YOUNG ADULT;

BANGLADESH;

ADOLESCENT; ADULT; AGED; ARSENIC POISONING; ARSENICALS; BANGLADESH; CACODYLIC ACID; CAUSALITY; COHORT STUDIES; ENVIRONMENTAL EXPOSURE; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MENDELIAN RANDOMIZATION ANALYSIS; METHYLTRANSFERASES; MIDDLE AGED; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; SKIN DISEASES; YOUNG ADULT;

EID: 84892468257     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyt182     Document Type: Article

References (48)

1. World Health Organization. United Nations Systhesis Report on Arsenic in Drinking Water. Geneva: WHO, 2001.
2. Celik I, Gallicchio L, Boyd K et al. Arsenic in drinking water and lung cancer: a systematic review. Environ Res 2008;108:48-55.
3. Mink PJ, Alexander DD, Barraj LM, Kelsh MA, Tsuji JS. Low-level arsenic exposure in drinking water and bladder cancer: a review and meta-analysis. Regul Toxicol Pharmacol 2008;52:299-310.
4. Liu J, Waalkes MP. Liver is a target of arsenic carcinogenesis. Toxicol Sci 2008;105:24-32.
5. Yu HS, Liao WT, Chai CY. Arsenic carcinogenesis in the skin. J Biomed Sci 2006;13:657-66.
6. Chen CJ, Chen CW, Wu MM, Kuo TL. Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water. Br J Cancer 1992;66:888-92.
7. Yuan Y, Marshall G, Ferreccio C et al. Kidney cancer mortality: fifty-year latency patterns related to arsenic exposure. Epidemiology 2010;21:103-08.
8. States JC, Srivastava S, Chen Y, Barchowsky A. Arsenic and cardiovascular disease. Toxicol Sci 2009;107:312-23.
9. Vahter M. Effects of arsenic on maternal and fetal health. Annu Rev Nutr 2009;29:381-99.
10. Vahidnia A, van der Voet GB, de Wolff FA. Arsenic neurotoxicity-a review. Hum Exp Toxicol 2007;26:823-32.
11. Brinkel J, Khan MH, Kraemer A. A systematic review of arsenic exposure and its social and mental health effects with special reference to Bangladesh. Int J Environ Res Public Health 2009;6:1609-19.
12. Argos M, Kalra T, Rathouz PJ et al. Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study. Lancet 2010;376:252-58.
13. Sohel N, Persson LA, Rahman M et al. Arsenic in drinking water and adult mortality: a population-based cohort study in rural Bangladesh. Epidemiology 2009;20:824-30.
14. Argos M, Kalra T, Pierce BL et al. A prospective study of arsenic exposure from drinking water and incidence of skin lesions in Bangladesh. Am J Epidemiol 2011;174:185-94.
15. Tseng CH. A review on environmental factors regulating arsenic methylation in humans. Toxicol Appl Pharmacol 2009;235:338-50.
16. Pierce BL, Kibriya MG, Tong L et al. Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh. PLoS Genet 2012;8:e1002522.
17. Kile ML, Hoffman E, Rodrigues EG et al. A pathwaybased analysis of urinary arsenic metabolites and skin lesions. Am J Epidemiol 2011;173:778-86.
18. Ahsan H, Chen Y, Kibriya MG et al. Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Cancer Epidemiol Biomarkers Prev 2007;16:1270-78.
19. Lindberg AL, Rahman M, Persson LA, Vahter M. The risk of arsenic induced skin lesions in Bangladeshi men and women is affected by arsenic metabolism and the age at first exposure. Toxicol Appl Pharmacol 2008;230:9-16.
20. Valenzuela OL, Borja-Aburto VH, Garcia-Vargas GG et al. Urinary trivalent methylated arsenic species in a population chronically exposed to inorganic arsenic. Environ Health Perspect 2005;113:250-54.
21. Gao J, Yu J, Yang L. Urinary arsenic metabolites of subjects exposed to elevated arsenic present in coal in Shaanxi Province, China. Int J Environ Res Public Health 2011;8:1991-2008.
22. Engstrom K, Vahter M, Mlakar SJ et al. Polymorphisms in arsenic (+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism. Environ Health Perspect 2011;119:182-88.
23. Agusa T, Fujihara J, Takeshita H, Iwata H. Individual variations in inorganic arsenic metabolism associated with AS3MT genetic polymorphisms. Int J Mol Sci 2011;12:2351-82.
24. Davey Smith G, Ebrahim S. 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1-22.
25. Lawlor DA, Harbord RM, Sterne JA, Timpson N, Davey Smith G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat Med 2008;27:1133-63.
26. Ahsan H, Chen Y, Parvez F et al. Health Effects of Arsenic Longitudinal Study (HEALS): description of a multidisciplinary epidemiologic investigation. J Expo Sci Environ Epidemiol 2006;16:191-205.
27. Verret WJ, Chen Y, Ahmed A et al. A randomized, doubleblind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh. J Occup Environ Med 2005;47:1026-35.
28. Purcell S, Neale B, Todd-Brown K et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007;81:559-75.
29. Nixon DE, Mussmann GV, Eckdahl SJ, Moyer TP. Total arsenic in urine: palladium-persulfate vs nickel as a matrix modifier for graphite furnace atomic absorption spectrophotometry. Clin Chem 1991;37:1575-79.
30. Ahsan H, Chen Y, Parvez F et al. Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study. Am J Epidemiol 2006;163:1138-48.
31. Zhou X, Stephens M. Genome-wide efficient mixedmodel analysis for association studies. Nat Genet 2012;44:821-24.
32. Pierce BL, Ahsan H, Vanderweele TJ. Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants. Int J Epidemiol 2010;39:1037-45.
33. Pierce BL, Vanderweele TJ. The effect of non-differential measurement error on bias, precision and power in Mendelian randomization studies. Int J Epidemiol 2012;41:1383-93.
34. Chen Y, van Geen A, Graziano JH et al. Reduction in urinary arsenic levels in response to arsenic mitigation efforts in Araihazar, Bangladesh. Environ Health Perspect 2007;115:917-23.
35. Hosmer DW, Lemeshow S. Confidence interval estimation of interaction. Epidemiology 1992;3:452-56.
36. Assmann SF, Hosmer DW, Lemeshow S, Mundt KA. Confidence intervals for measures of interaction. Epidemiology 1996;7:286-90.
37. Burgess S, Thompson SG. Bias in causal estimates from Mendelian randomization studies with weak instruments. Stat Med 2011;30:1312-23.
38. Lindberg AL, Kumar R, Goessler W et al. Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms. Environ Health Perspect 2007;115:1081-86.
39. Hall MN, Gamble MV. Nutritional manipulation of onecarbon metabolism: effects on arsenic methylation and toxicity. J Toxicol 2012;2012; article ID 595307.
40. Gamble MV, Liu X, Ahsan H et al. Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh. Am J Clin Nutr 2006;84:1093-101.
41. Gamble MV, Liu X, Slavkovich V et al. Folic acid supplementation lowers blood arsenic. Am J Clin Nutr 2007;86:1202-09.
42. Engstrom KS, Hossain MB, Lauss M et al. Efficient arsenic metabolism-the AS3MT haplotype is associated with DNA methylation and expression of multiple genes around AS3MT. PLoS One 2013;8:e53732.
43. Glymour MM, Tchetgen EJ, Robins JM. Credible Mendelian randomization studies: approaches for evaluating the instrumental variable assumptions. Am J Epidemiol 2012;175:332-39.
44. Zhong H, Prentice RL. Correcting 'winner's curse' in odds ratios from genomewide association findings for major complex human diseases. Genet Epidemiol 2010;34:78-91.
45. Navas-Acien A, Silbergeld EK, Streeter RA, Clark JM, Burke TA, Guallar E. Arsenic exposure and type 2 diabetes: a systematic review of the experimental and epidemiological evidence. Environ Health Perspect 2006;114:641-48.
46. Smith AH, Marshall G, Yuan Y, Liaw J, Ferreccio C, Steinmaus C. Evidence from Chile that arsenic in drinking water may increase mortality from pulmonary tuberculosis. Am J Epidemiol 2011;173:414-20.
47. Thornton T, McPeek MS. ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure. Am J Hum Genet 2010;86:172-84.
48. Skrondal A. Interaction as departure from additivity in case-control studies: a cautionary note. Am J Epidemiol 2003;158:251-58.