-
1
-
-
78049460615
-
-
Alzheimer's Disease International, Available from: (accessed 19 March 2012).
-
Anders Wimo MP. World Alzheimer Report 2010. Alzheimer's Disease International, 2010; 1-54. Available from: http://www.alz.co.uk/research/files/WorldAlzheimerReport2010ExecutiveSummary.pdf (accessed 19 March 2012).
-
(2010)
World Alzheimer Report 2010
, pp. 1-54
-
-
Anders Wimo, M.P.1
-
2
-
-
0031883716
-
A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group
-
Rogers SL, Farlow MR, Doody RS, Mohs R, Friedhoff LT. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group. Neurology 1998; 50: 136-45.
-
(1998)
Neurology
, vol.50
, pp. 136-145
-
-
Rogers, S.L.1
Farlow, M.R.2
Doody, R.S.3
Mohs, R.4
Friedhoff, L.T.5
-
3
-
-
0034720816
-
Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group
-
Raskind MA, Peskind ER, Wessel T, Yuan W. Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group. Neurology 2000; 54: 2261-8.
-
(2000)
Neurology
, vol.54
, pp. 2261-2268
-
-
Raskind, M.A.1
Peskind, E.R.2
Wessel, T.3
Yuan, W.4
-
4
-
-
78149299057
-
Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future
-
Lang AE. Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future. Nat. Med. 2010; 16: 1223-6.
-
(2010)
Nat. Med.
, vol.16
, pp. 1223-1226
-
-
Lang, A.E.1
-
5
-
-
72549105935
-
Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial
-
Green RC, Schneider LS, Amato DA et al. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial. JAMA 2009; 302: 2557-64.
-
(2009)
JAMA
, vol.302
, pp. 2557-2564
-
-
Green, R.C.1
Schneider, L.S.2
Amato, D.A.3
-
6
-
-
0028169925
-
Visualization of A β 42(43) and A β 40 in senile plaques with end-specific A β monoclonals: evidence that an initially deposited species is A β 42(43)
-
Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A β 42(43) and A β 40 in senile plaques with end-specific A β monoclonals: evidence that an initially deposited species is A β 42(43). Neuron 1994; 13: 45-53.
-
(1994)
Neuron
, vol.13
, pp. 45-53
-
-
Iwatsubo, T.1
Odaka, A.2
Suzuki, N.3
Mizusawa, H.4
Nukina, N.5
Ihara, Y.6
-
7
-
-
0037041426
-
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh DM, Klyubin I, Fadeeva JV et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002; 416: 535-9.
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
-
8
-
-
73549108133
-
High striatal amyloid β-peptide deposition across different autosomal Alzheimer disease mutation types
-
Villemagne VL, Ataka S, Mizuno T et al. High striatal amyloid β-peptide deposition across different autosomal Alzheimer disease mutation types. Arch. Neurol. 2009; 66: 1537-44.
-
(2009)
Arch. Neurol.
, vol.66
, pp. 1537-1544
-
-
Villemagne, V.L.1
Ataka, S.2
Mizuno, T.3
-
9
-
-
0028322017
-
An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (β APP717) mutants
-
Suzuki N, Cheung TT, Cai XD et al. An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (β APP717) mutants. Science 1994; 264: 1336-40.
-
(1994)
Science
, vol.264
, pp. 1336-1340
-
-
Suzuki, N.1
Cheung, T.T.2
Cai, X.D.3
-
10
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 1996; 2: 864-70.
-
(1996)
Nat. Med.
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
-
11
-
-
16944362157
-
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
-
Citron M, Westaway D, Xia W et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nat. Med. 1997; 3: 67-72.
-
(1997)
Nat. Med.
, vol.3
, pp. 67-72
-
-
Citron, M.1
Westaway, D.2
Xia, W.3
-
12
-
-
0033536163
-
Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D, Barbour R, Dunn W et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999; 400: 173-7.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
-
13
-
-
84984755327
-
A β peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
Morgan D, Diamond DM, Gottschall PE et al. A β peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 2000; 408: 982-5.
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
Diamond, D.M.2
Gottschall, P.E.3
-
14
-
-
10744230547
-
Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization
-
Orgogozo JM, Gilman S, Dartigues JF et al. Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization. Neurology 2003; 61: 46-54.
-
(2003)
Neurology
, vol.61
, pp. 46-54
-
-
Orgogozo, J.M.1
Gilman, S.2
Dartigues, J.F.3
-
15
-
-
47149112621
-
Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
-
Holmes C, Boche D, Wilkinson D et al. Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 2008; 372: 216-23.
-
(2008)
Lancet
, vol.372
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
-
16
-
-
84864471159
-
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
-
Jonsson T, Atwal JK, Steinberg S et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 2012; 488: 96-9.
-
(2012)
Nature
, vol.488
, pp. 96-99
-
-
Jonsson, T.1
Atwal, J.K.2
Steinberg, S.3
-
17
-
-
0021271971
-
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
-
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-44.
-
(1984)
Neurology
, vol.34
, pp. 939-944
-
-
McKhann, G.1
Drachman, D.2
Folstein, M.3
Katzman, R.4
Price, D.5
Stadlan, E.M.6
-
18
-
-
79956142378
-
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
-
McKhann GM, Knopman DS, Chertkow H et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 263-9.
-
(2011)
Alzheimers Dement
, vol.7
, pp. 263-269
-
-
McKhann, G.M.1
Knopman, D.S.2
Chertkow, H.3
-
19
-
-
79956076567
-
Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
-
Jack CR Jr, Albert MS, Knopman DS et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 257-62.
-
(2011)
Alzheimers Dement
, vol.7
, pp. 257-262
-
-
Jack Jr., C.R.1
Albert, M.S.2
Knopman, D.S.3
-
20
-
-
0025954066
-
Ageing and Parkinson's disease: substantia nigra regional selectivity
-
Fearnley JM, Lees AJ. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 1991; 114 (Pt 5): 2283-301.
-
(1991)
Brain
, vol.114
, Issue.PART 5
, pp. 2283-2301
-
-
Fearnley, J.M.1
Lees, A.J.2
-
21
-
-
0031695197
-
Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset
-
Brookmeyer R, Gray S, Kawas C. Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am. J. Public Health 1998; 88: 1337-42.
-
(1998)
Am. J. Public Health
, vol.88
, pp. 1337-1342
-
-
Brookmeyer, R.1
Gray, S.2
Kawas, C.3
-
22
-
-
65449161780
-
Alzheimer's disease facts and figures
-
Alzheimer's A. Alzheimer's disease facts and figures. Alzheimers Dement 2009; 5: 234-70.
-
(2009)
Alzheimers Dement
, vol.5
, pp. 234-270
-
-
Alzheimer's, A.1
-
23
-
-
79956098248
-
Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
-
Sperling RA, Aisen PS, Beckett LA et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 280-92.
-
(2011)
Alzheimers Dement
, vol.7
, pp. 280-292
-
-
Sperling, R.A.1
Aisen, P.S.2
Beckett, L.A.3
-
24
-
-
23944444806
-
Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
-
Buckner RL, Snyder AZ, Shannon BJ et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J. Neurosci. 2005; 25: 7709-17.
-
(2005)
J. Neurosci.
, vol.25
, pp. 7709-7717
-
-
Buckner, R.L.1
Snyder, A.Z.2
Shannon, B.J.3
-
25
-
-
0032988610
-
Mild cognitive impairment: clinical characterization and outcome
-
Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch. Neurol. 1999; 56: 303-8.
-
(1999)
Arch. Neurol.
, vol.56
, pp. 303-308
-
-
Petersen, R.C.1
Smith, G.E.2
Waring, S.C.3
Ivnik, R.J.4
Tangalos, E.G.5
Kokmen, E.6
-
26
-
-
20344381835
-
Vitamin E and donepezil for the treatment of mild cognitive impairment
-
Petersen RC, Thomas RG, Grundman M et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N. Engl. J. Med. 2005; 352: 2379-88.
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 2379-2388
-
-
Petersen, R.C.1
Thomas, R.G.2
Grundman, M.3
-
27
-
-
33646437238
-
Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia
-
Jicha GA, Parisi JE, Dickson DW et al. Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Arch. Neurol. 2006; 63: 674-81.
-
(2006)
Arch. Neurol.
, vol.63
, pp. 674-681
-
-
Jicha, G.A.1
Parisi, J.E.2
Dickson, D.W.3
-
28
-
-
35948993429
-
Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study
-
Sarazin M, Berr C, De Rotrou J et al. Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study. Neurology 2007; 69: 1859-67.
-
(2007)
Neurology
, vol.69
, pp. 1859-1867
-
-
Sarazin, M.1
Berr, C.2
De Rotrou, J.3
-
29
-
-
32544435900
-
Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
-
Hansson O, Zetterberg H, Buchhave P, Londos E, Blennow K, Minthon L. Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol. 2006; 5: 228-34.
-
(2006)
Lancet Neurol.
, vol.5
, pp. 228-234
-
-
Hansson, O.1
Zetterberg, H.2
Buchhave, P.3
Londos, E.4
Blennow, K.5
Minthon, L.6
-
30
-
-
47249114750
-
Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus
-
Colliot O, Chetelat G, Chupin M et al. Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus. Radiology 2008; 248: 194-201.
-
(2008)
Radiology
, vol.248
, pp. 194-201
-
-
Colliot, O.1
Chetelat, G.2
Chupin, M.3
-
31
-
-
79551495391
-
Longitudinal assessment of A β and cognition in aging and Alzheimer disease
-
Villemagne VL, Pike KE, Chetelat G et al. Longitudinal assessment of A β and cognition in aging and Alzheimer disease. Ann. Neurol. 2011; 69: 181-92.
-
(2011)
Ann. Neurol.
, vol.69
, pp. 181-192
-
-
Villemagne, V.L.1
Pike, K.E.2
Chetelat, G.3
-
32
-
-
19944406770
-
MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET
-
Mosconi L, Perani D, Sorbi S et al. MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET. Neurology 2004; 63: 2332-40.
-
(2004)
Neurology
, vol.63
, pp. 2332-2340
-
-
Mosconi, L.1
Perani, D.2
Sorbi, S.3
-
33
-
-
34247331828
-
CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment
-
Bouwman FH, Schoonenboom SN, van der Flier WM et al. CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment. Neurobiol. Aging 2007; 28: 1070-4.
-
(2007)
Neurobiol. Aging
, vol.28
, pp. 1070-1074
-
-
Bouwman, F.H.1
Schoonenboom, S.N.2
van der Flier, W.M.3
-
34
-
-
77955662063
-
Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial
-
Katsuno M, Banno H, Suzuki K et al. Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2010; 9: 875-84.
-
(2010)
Lancet Neurol.
, vol.9
, pp. 875-884
-
-
Katsuno, M.1
Banno, H.2
Suzuki, K.3
-
35
-
-
84902586007
-
Translational research on disease-modifying therapies for neurodegenerative diseases
-
Katsuno M, Watanabe H, Tanaka F, Sobue G. Translational research on disease-modifying therapies for neurodegenerative diseases. Neurol. Clin. Neurosci. 2013; 1: 3-10.
-
(2013)
Neurol. Clin. Neurosci.
, vol.1
, pp. 3-10
-
-
Katsuno, M.1
Watanabe, H.2
Tanaka, F.3
Sobue, G.4
-
36
-
-
0037514257
-
Decreased β-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease
-
Sunderland T, Linker G, Mirza N et al. Decreased β-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease. JAMA 2003; 289: 2094-103.
-
(2003)
JAMA
, vol.289
, pp. 2094-2103
-
-
Sunderland, T.1
Linker, G.2
Mirza, N.3
-
37
-
-
68249090572
-
MRI and CSF biomarkers in normal, MCI, and AD subjects: diagnostic discrimination and cognitive correlations
-
Vemuri P, Wiste HJ, Weigand SD et al. MRI and CSF biomarkers in normal, MCI, and AD subjects: diagnostic discrimination and cognitive correlations. Neurology 2009; 73: 287-93.
-
(2009)
Neurology
, vol.73
, pp. 287-293
-
-
Vemuri, P.1
Wiste, H.J.2
Weigand, S.D.3
-
38
-
-
84875867608
-
Cerebral atrophy in mild cognitive impairment and Alzheimer disease: Rates and acceleration
-
Leung KK, Bartlett JW, Barnes J et al. Cerebral atrophy in mild cognitive impairment and Alzheimer disease: Rates and acceleration. Neurology 2013; 80: 648-54.
-
(2013)
Neurology
, vol.80
, pp. 648-654
-
-
Leung, K.K.1
Bartlett, J.W.2
Barnes, J.3
-
39
-
-
34447322271
-
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria
-
Dubois B, Feldman HH, Jacova C et al. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007; 6: 734-46.
-
(2007)
Lancet Neurol.
, vol.6
, pp. 734-746
-
-
Dubois, B.1
Feldman, H.H.2
Jacova, C.3
-
40
-
-
0035195760
-
Current concepts in mild cognitive impairment
-
Petersen RC, Doody R, Kurz A et al. Current concepts in mild cognitive impairment. Arch. Neurol. 2001; 58: 1985-92.
-
(2001)
Arch. Neurol.
, vol.58
, pp. 1985-1992
-
-
Petersen, R.C.1
Doody, R.2
Kurz, A.3
-
41
-
-
72049130805
-
Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
-
doi:10.1016/S1474-4422(09)70299-6
-
Jack CR, Knopman DS, Jagust WJ et al. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 2010; 9: 119-128. doi:10.1016/S1474-4422(09)70299-6
-
(2010)
Lancet Neurol.
, vol.9
, pp. 119-128
-
-
Jack, C.R.1
Knopman, D.S.2
Jagust, W.J.3
|