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Volumn 1, Issue 2, 2013, Pages 49-54

Disease-modifying therapy for Alzheimer's disease: Challenges and hopes

Author keywords

Alzheimer's disease, Alzheimer's disease neuroimaging initiative; Amyloid cascade hypothesis; Amyloid

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

EID: 84892466091     PISSN: None     EISSN: 20494173     Source Type: Journal    
DOI: 10.1002/ncn3.20     Document Type: Article
Times cited : (10)

References (41)
  • 1
    • 78049460615 scopus 로고    scopus 로고
    • Alzheimer's Disease International, Available from: (accessed 19 March 2012).
    • Anders Wimo MP. World Alzheimer Report 2010. Alzheimer's Disease International, 2010; 1-54. Available from: http://www.alz.co.uk/research/files/WorldAlzheimerReport2010ExecutiveSummary.pdf (accessed 19 March 2012).
    • (2010) World Alzheimer Report 2010 , pp. 1-54
    • Anders Wimo, M.P.1
  • 2
    • 0031883716 scopus 로고    scopus 로고
    • A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group
    • Rogers SL, Farlow MR, Doody RS, Mohs R, Friedhoff LT. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group. Neurology 1998; 50: 136-45.
    • (1998) Neurology , vol.50 , pp. 136-145
    • Rogers, S.L.1    Farlow, M.R.2    Doody, R.S.3    Mohs, R.4    Friedhoff, L.T.5
  • 3
    • 0034720816 scopus 로고    scopus 로고
    • Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group
    • Raskind MA, Peskind ER, Wessel T, Yuan W. Galantamine in AD: A 6-month randomized, placebo-controlled trial with a 6-month extension. The Galantamine USA-1 Study Group. Neurology 2000; 54: 2261-8.
    • (2000) Neurology , vol.54 , pp. 2261-2268
    • Raskind, M.A.1    Peskind, E.R.2    Wessel, T.3    Yuan, W.4
  • 4
    • 78149299057 scopus 로고    scopus 로고
    • Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future
    • Lang AE. Clinical trials of disease-modifying therapies for neurodegenerative diseases: the challenges and the future. Nat. Med. 2010; 16: 1223-6.
    • (2010) Nat. Med. , vol.16 , pp. 1223-1226
    • Lang, A.E.1
  • 5
    • 72549105935 scopus 로고    scopus 로고
    • Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial
    • Green RC, Schneider LS, Amato DA et al. Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial. JAMA 2009; 302: 2557-64.
    • (2009) JAMA , vol.302 , pp. 2557-2564
    • Green, R.C.1    Schneider, L.S.2    Amato, D.A.3
  • 6
    • 0028169925 scopus 로고
    • Visualization of A β 42(43) and A β 40 in senile plaques with end-specific A β monoclonals: evidence that an initially deposited species is A β 42(43)
    • Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y. Visualization of A β 42(43) and A β 40 in senile plaques with end-specific A β monoclonals: evidence that an initially deposited species is A β 42(43). Neuron 1994; 13: 45-53.
    • (1994) Neuron , vol.13 , pp. 45-53
    • Iwatsubo, T.1    Odaka, A.2    Suzuki, N.3    Mizusawa, H.4    Nukina, N.5    Ihara, Y.6
  • 7
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
    • Walsh DM, Klyubin I, Fadeeva JV et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002; 416: 535-9.
    • (2002) Nature , vol.416 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3
  • 8
    • 73549108133 scopus 로고    scopus 로고
    • High striatal amyloid β-peptide deposition across different autosomal Alzheimer disease mutation types
    • Villemagne VL, Ataka S, Mizuno T et al. High striatal amyloid β-peptide deposition across different autosomal Alzheimer disease mutation types. Arch. Neurol. 2009; 66: 1537-44.
    • (2009) Arch. Neurol. , vol.66 , pp. 1537-1544
    • Villemagne, V.L.1    Ataka, S.2    Mizuno, T.3
  • 9
    • 0028322017 scopus 로고
    • An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (β APP717) mutants
    • Suzuki N, Cheung TT, Cai XD et al. An increased percentage of long amyloid β protein secreted by familial amyloid β protein precursor (β APP717) mutants. Science 1994; 264: 1336-40.
    • (1994) Science , vol.264 , pp. 1336-1340
    • Suzuki, N.1    Cheung, T.T.2    Cai, X.D.3
  • 10
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner D, Eckman C, Jensen M et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat. Med. 1996; 2: 864-70.
    • (1996) Nat. Med. , vol.2 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3
  • 11
    • 16944362157 scopus 로고    scopus 로고
    • Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
    • Citron M, Westaway D, Xia W et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nat. Med. 1997; 3: 67-72.
    • (1997) Nat. Med. , vol.3 , pp. 67-72
    • Citron, M.1    Westaway, D.2    Xia, W.3
  • 12
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • Schenk D, Barbour R, Dunn W et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999; 400: 173-7.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3
  • 13
    • 84984755327 scopus 로고    scopus 로고
    • A β peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
    • Morgan D, Diamond DM, Gottschall PE et al. A β peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 2000; 408: 982-5.
    • (2000) Nature , vol.408 , pp. 982-985
    • Morgan, D.1    Diamond, D.M.2    Gottschall, P.E.3
  • 14
    • 10744230547 scopus 로고    scopus 로고
    • Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization
    • Orgogozo JM, Gilman S, Dartigues JF et al. Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization. Neurology 2003; 61: 46-54.
    • (2003) Neurology , vol.61 , pp. 46-54
    • Orgogozo, J.M.1    Gilman, S.2    Dartigues, J.F.3
  • 15
    • 47149112621 scopus 로고    scopus 로고
    • Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial
    • Holmes C, Boche D, Wilkinson D et al. Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 2008; 372: 216-23.
    • (2008) Lancet , vol.372 , pp. 216-223
    • Holmes, C.1    Boche, D.2    Wilkinson, D.3
  • 16
    • 84864471159 scopus 로고    scopus 로고
    • A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
    • Jonsson T, Atwal JK, Steinberg S et al. A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 2012; 488: 96-9.
    • (2012) Nature , vol.488 , pp. 96-99
    • Jonsson, T.1    Atwal, J.K.2    Steinberg, S.3
  • 17
    • 0021271971 scopus 로고
    • Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-44.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 18
    • 79956142378 scopus 로고    scopus 로고
    • The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • McKhann GM, Knopman DS, Chertkow H et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 263-9.
    • (2011) Alzheimers Dement , vol.7 , pp. 263-269
    • McKhann, G.M.1    Knopman, D.S.2    Chertkow, H.3
  • 19
    • 79956076567 scopus 로고    scopus 로고
    • Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • Jack CR Jr, Albert MS, Knopman DS et al. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 257-62.
    • (2011) Alzheimers Dement , vol.7 , pp. 257-262
    • Jack Jr., C.R.1    Albert, M.S.2    Knopman, D.S.3
  • 20
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: substantia nigra regional selectivity
    • Fearnley JM, Lees AJ. Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain 1991; 114 (Pt 5): 2283-301.
    • (1991) Brain , vol.114 , Issue.PART 5 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 21
    • 0031695197 scopus 로고    scopus 로고
    • Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset
    • Brookmeyer R, Gray S, Kawas C. Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am. J. Public Health 1998; 88: 1337-42.
    • (1998) Am. J. Public Health , vol.88 , pp. 1337-1342
    • Brookmeyer, R.1    Gray, S.2    Kawas, C.3
  • 22
    • 65449161780 scopus 로고    scopus 로고
    • Alzheimer's disease facts and figures
    • Alzheimer's A. Alzheimer's disease facts and figures. Alzheimers Dement 2009; 5: 234-70.
    • (2009) Alzheimers Dement , vol.5 , pp. 234-270
    • Alzheimer's, A.1
  • 23
    • 79956098248 scopus 로고    scopus 로고
    • Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • Sperling RA, Aisen PS, Beckett LA et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011; 7: 280-92.
    • (2011) Alzheimers Dement , vol.7 , pp. 280-292
    • Sperling, R.A.1    Aisen, P.S.2    Beckett, L.A.3
  • 24
    • 23944444806 scopus 로고    scopus 로고
    • Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
    • Buckner RL, Snyder AZ, Shannon BJ et al. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J. Neurosci. 2005; 25: 7709-17.
    • (2005) J. Neurosci. , vol.25 , pp. 7709-7717
    • Buckner, R.L.1    Snyder, A.Z.2    Shannon, B.J.3
  • 26
    • 20344381835 scopus 로고    scopus 로고
    • Vitamin E and donepezil for the treatment of mild cognitive impairment
    • Petersen RC, Thomas RG, Grundman M et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N. Engl. J. Med. 2005; 352: 2379-88.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 2379-2388
    • Petersen, R.C.1    Thomas, R.G.2    Grundman, M.3
  • 27
    • 33646437238 scopus 로고    scopus 로고
    • Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia
    • Jicha GA, Parisi JE, Dickson DW et al. Neuropathologic outcome of mild cognitive impairment following progression to clinical dementia. Arch. Neurol. 2006; 63: 674-81.
    • (2006) Arch. Neurol. , vol.63 , pp. 674-681
    • Jicha, G.A.1    Parisi, J.E.2    Dickson, D.W.3
  • 28
    • 35948993429 scopus 로고    scopus 로고
    • Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study
    • Sarazin M, Berr C, De Rotrou J et al. Amnestic syndrome of the medial temporal type identifies prodromal AD: a longitudinal study. Neurology 2007; 69: 1859-67.
    • (2007) Neurology , vol.69 , pp. 1859-1867
    • Sarazin, M.1    Berr, C.2    De Rotrou, J.3
  • 29
    • 32544435900 scopus 로고    scopus 로고
    • Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study
    • Hansson O, Zetterberg H, Buchhave P, Londos E, Blennow K, Minthon L. Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study. Lancet Neurol. 2006; 5: 228-34.
    • (2006) Lancet Neurol. , vol.5 , pp. 228-234
    • Hansson, O.1    Zetterberg, H.2    Buchhave, P.3    Londos, E.4    Blennow, K.5    Minthon, L.6
  • 30
    • 47249114750 scopus 로고    scopus 로고
    • Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus
    • Colliot O, Chetelat G, Chupin M et al. Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus. Radiology 2008; 248: 194-201.
    • (2008) Radiology , vol.248 , pp. 194-201
    • Colliot, O.1    Chetelat, G.2    Chupin, M.3
  • 31
    • 79551495391 scopus 로고    scopus 로고
    • Longitudinal assessment of A β and cognition in aging and Alzheimer disease
    • Villemagne VL, Pike KE, Chetelat G et al. Longitudinal assessment of A β and cognition in aging and Alzheimer disease. Ann. Neurol. 2011; 69: 181-92.
    • (2011) Ann. Neurol. , vol.69 , pp. 181-192
    • Villemagne, V.L.1    Pike, K.E.2    Chetelat, G.3
  • 32
    • 19944406770 scopus 로고    scopus 로고
    • MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET
    • Mosconi L, Perani D, Sorbi S et al. MCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET. Neurology 2004; 63: 2332-40.
    • (2004) Neurology , vol.63 , pp. 2332-2340
    • Mosconi, L.1    Perani, D.2    Sorbi, S.3
  • 33
    • 34247331828 scopus 로고    scopus 로고
    • CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment
    • Bouwman FH, Schoonenboom SN, van der Flier WM et al. CSF biomarkers and medial temporal lobe atrophy predict dementia in mild cognitive impairment. Neurobiol. Aging 2007; 28: 1070-4.
    • (2007) Neurobiol. Aging , vol.28 , pp. 1070-1074
    • Bouwman, F.H.1    Schoonenboom, S.N.2    van der Flier, W.M.3
  • 34
    • 77955662063 scopus 로고    scopus 로고
    • Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial
    • Katsuno M, Banno H, Suzuki K et al. Efficacy and safety of leuprorelin in patients with spinal and bulbar muscular atrophy (JASMITT study): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet Neurol. 2010; 9: 875-84.
    • (2010) Lancet Neurol. , vol.9 , pp. 875-884
    • Katsuno, M.1    Banno, H.2    Suzuki, K.3
  • 35
    • 84902586007 scopus 로고    scopus 로고
    • Translational research on disease-modifying therapies for neurodegenerative diseases
    • Katsuno M, Watanabe H, Tanaka F, Sobue G. Translational research on disease-modifying therapies for neurodegenerative diseases. Neurol. Clin. Neurosci. 2013; 1: 3-10.
    • (2013) Neurol. Clin. Neurosci. , vol.1 , pp. 3-10
    • Katsuno, M.1    Watanabe, H.2    Tanaka, F.3    Sobue, G.4
  • 36
    • 0037514257 scopus 로고    scopus 로고
    • Decreased β-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease
    • Sunderland T, Linker G, Mirza N et al. Decreased β-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease. JAMA 2003; 289: 2094-103.
    • (2003) JAMA , vol.289 , pp. 2094-2103
    • Sunderland, T.1    Linker, G.2    Mirza, N.3
  • 37
    • 68249090572 scopus 로고    scopus 로고
    • MRI and CSF biomarkers in normal, MCI, and AD subjects: diagnostic discrimination and cognitive correlations
    • Vemuri P, Wiste HJ, Weigand SD et al. MRI and CSF biomarkers in normal, MCI, and AD subjects: diagnostic discrimination and cognitive correlations. Neurology 2009; 73: 287-93.
    • (2009) Neurology , vol.73 , pp. 287-293
    • Vemuri, P.1    Wiste, H.J.2    Weigand, S.D.3
  • 38
    • 84875867608 scopus 로고    scopus 로고
    • Cerebral atrophy in mild cognitive impairment and Alzheimer disease: Rates and acceleration
    • Leung KK, Bartlett JW, Barnes J et al. Cerebral atrophy in mild cognitive impairment and Alzheimer disease: Rates and acceleration. Neurology 2013; 80: 648-54.
    • (2013) Neurology , vol.80 , pp. 648-654
    • Leung, K.K.1    Bartlett, J.W.2    Barnes, J.3
  • 39
    • 34447322271 scopus 로고    scopus 로고
    • Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria
    • Dubois B, Feldman HH, Jacova C et al. Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007; 6: 734-46.
    • (2007) Lancet Neurol. , vol.6 , pp. 734-746
    • Dubois, B.1    Feldman, H.H.2    Jacova, C.3
  • 40
    • 0035195760 scopus 로고    scopus 로고
    • Current concepts in mild cognitive impairment
    • Petersen RC, Doody R, Kurz A et al. Current concepts in mild cognitive impairment. Arch. Neurol. 2001; 58: 1985-92.
    • (2001) Arch. Neurol. , vol.58 , pp. 1985-1992
    • Petersen, R.C.1    Doody, R.2    Kurz, A.3
  • 41
    • 72049130805 scopus 로고    scopus 로고
    • Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
    • doi:10.1016/S1474-4422(09)70299-6
    • Jack CR, Knopman DS, Jagust WJ et al. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 2010; 9: 119-128. doi:10.1016/S1474-4422(09)70299-6
    • (2010) Lancet Neurol. , vol.9 , pp. 119-128
    • Jack, C.R.1    Knopman, D.S.2    Jagust, W.J.3


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