Celecoxib potentially inhibits metastasis of lung cancer promoted by surgery in mice, via suppression of the PGE2-modulated β-catenin pathway

Toxicology Letters

Volumn 225, Issue 2, 2014, Pages 201-207

  Zhang, Shuai ^a   Da, Liangshan ^a   Yang, Xin ^a   Feng, Dongjie ^a   Yin, Rong ^a   Li, Ming ^a   Zhang, Zhi ^a   Jiang, Feng ^a,b   Xu, Lin ^a  

^a JIANGSU CANCER HOSPITAL   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Celecoxib; Lung cancer; Metastasis; PGE2; Surgery

Indexed keywords

BETA CATENIN; CELECOXIB; GELATINASE A; GELATINASE B; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; PROSTAGLANDIN E2; SMALL INTERFERING RNA; UVOMORULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CANCER INHIBITION; CANCER SURGERY; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GENE DELETION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG METASTASIS; LUNG RESECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN BLOOD LEVEL; PROTEIN EXPRESSION; TUMOR CELL LINE; TUMOR INVASION; UPREGULATION; WOUND HEALING;

CELECOXIB; LUNG CANCER; METASTASIS; PGE2; SURGERY;

ANIMALS; BETA CATENIN; CADHERINS; CELL LINE, TUMOR; CELL PROLIFERATION; DINOPROSTONE; DOWN-REGULATION; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED BALB C; NEOPLASM METASTASIS; PHOSPHORYLATION; PYRAZOLES; RNA, MESSENGER; RNA, SMALL INTERFERING; SULFONAMIDES; UP-REGULATION;

EID: 84892463277     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.12.014     Document Type: Article

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