CreERT2 expression from within the c-Kit gene locus allows efficient inducible gene targeting in and ablation of mast cells

European Journal of Immunology

Volumn 44, Issue 1, 2014, Pages 296-306

  Heger, Klaus ^a   Seidler, Barbara ^b   Vahl, J Christoph ^a   Schwartz, Christian ^c   Kober, Maike ^a   Klein, Sabine ^b   Voehringer, David ^c   Saur, Dieter ^b   Schmidt Supprian, Marc ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

C Kit locus; Inducible conditional gene targeting; Mast cells

Indexed keywords

CRE RECOMBINASE; DIPHTHERIA TOXIN; STEM CELL FACTOR; TAMOXIFEN; DIPHTHERIA TOXIN FRAGMENT A; INTEGRASE; PEPTIDE FRAGMENT; STEM CELL FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE INDUCTION; GENE LOCUS; GENE TARGETING; HEMATOPOIETIC CELL; IN VITRO STUDY; IN VIVO STUDY; MAST CELL; MOUSE; MOUSE STRAIN; NONHUMAN; PASSIVE SKIN ANAPHYLAXIS; PERITONEUM MAST CELL; PRIORITY JOURNAL; REPORTER GENE; ANIMAL; ANTIBODY SPECIFICITY; CELL DEATH; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; PATHOLOGY; PROCEDURES; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; CELL DEATH; DIPHTHERIA TOXIN; GENE EXPRESSION REGULATION; GENE KNOCK-IN TECHNIQUES; GENE TARGETING; GENETIC LOCI; INTEGRASES; MAST CELLS; MICE; MICE, TRANSGENIC; ORGAN SPECIFICITY; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-KIT; TAMOXIFEN; TRANSGENES;

EID: 84892457557     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201343731     Document Type: Article

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