The role of traditional chinese medicines in osteogenesis and angiogenesis

Phytotherapy Research

Volumn 28, Issue 1, 2014, Pages 1-8

  Yang, Yanqi ^a   Chin, Alice ^b   Zhang, Linkun ^a,c   Lu, Jiajing ^a,d   Wong, Ricky Wing Kit ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b Government Orthodontic Clinic Department of Health   (Hong Kong)

^c NANKAI UNIVERSITY   (China)

^d TAIZHOU POLYTECHNIC COLLEGE   (China)

Author keywords

angiogenesis; osteoblast; osteogenesis; traditional Chinese medicines (TCMs); vascular endothelial growth factor (VEGF)

Indexed keywords

ALKALINE PHOSPHATASE; ANGELICA SINENSIS EXTRACT; ANGIOGENIC FACTOR; ASTRAGALUS MEMBRANACEUS EXTRACT; BONE DENSITY CONSERVATION AGENT; LIGUSTICUM CHUANXIONG EXTRACT; MESSENGER RNA; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; PUERARIA EXTRACT; SALVIA MILTIORRHIZA EXTRACT; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ANGELICA SINENSIS; ANGIOGENESIS; ASTRAGALUS MEMBRANACEUS; BONE DENSITY; BONE DEVELOPMENT; BONE METABOLISM; BURN; CHINESE MEDICINE; COMBINATION CHEMOTHERAPY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; GENE EXPRESSION REGULATION; HUMAN; MOLECULAR DYNAMICS; MONOTHERAPY; NONHUMAN; OSSIFICATION; OSTEOPOROSIS; PHYTOCHEMISTRY; PLANT ROOT; RADIUS FRACTURE; REVIEW; SALVIA MILTIORRHIZA; TIBIA FRACTURE; TREATMENT RESPONSE;

ANGELICA SINENSIS; ASTRAGALUS MEMBRANACEUS; DANGGUI; SALVIA MILTIORRHIZA;

ANGIOGENESIS; OSTEOBLAST; OSTEOGENESIS; TRADITIONAL CHINESE MEDICINES (TCMS); VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF);

ANGELICA SINENSIS; ASTRAGALUS MEMBRANACEUS; ASTRAGALUS PLANT; BONE AND BONES; DRUGS, CHINESE HERBAL; HUMANS; MEDICINE, CHINESE TRADITIONAL; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOBLASTS; OSTEOGENESIS; PHENANTHROLINES; SALVIA MILTIORRHIZA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84892437483     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4959     Document Type: Review

References (69)

1. Augustin G, Antabak A, Davila S,. 2007. The periosteum. Part 1: anatomy, histology and molecular biology. Injury 38: 1115-1130.
2. Benatti BB, Silvério KG, Casati MZ, Sallum EA, Nociti FH Jr., 2007. Physiological features of periodontal regeneration and approaches for periodontal tissue engineering utilizing periodontal ligament cells. J Biosci Bioeng 103: 1-6.
3. Carlevaro MF, Cermelli S, Cancedda R, Descalzi Cancedda F,. 2000. Vascular endothelial growth factor in cartilage neovascularization and chondrocyte differentiation auto-paracrine role during endochondral bone formation. J Cell Sci 113: 59-69.
4. Chai XS, Wang ZX, Chen PP, Wang LY, Lü XR, Kang B,. 1985. Anti-arrhythmic action of puerarin. Acta Pharmacol Sin 6: 166-168.
5. Chin A, Yang Y, Chai L, Wong RW, Rabie AB,. 2011. Effects of medicinal herb Salvia miltiorrhiza on osteoblastic cells in vitro. J Orthop Res 29: 1059-1963.
6. Chu TW, Wang ZG, Zhu PF, Jiao WC, Wen JL, Gong SG,. 2002. Effect of vascular endothelial growth factor in fracture healing. [Chinese] Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 16: 75-78.
7. Cochran DL, Wozney JM,. 1999. Biological mediators for periodontal regeneration. Periodontol 2000 19: 40-58.
8. Dai J, Rabie ABM,. 2007. VEGF: an essential mediator of both angiogenesis and endochondral ossification. J Dent Res 86: 937-950.
9. Deckers MM, Karperien M, van der Bent C, Yamashita T, Papapoulos SE, Löwik CW,. 2000. Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation. Endocrinology 141: 1667-1674.
10. Ding Y, Soma S, Takano-Yamamoto T, Matsumoto S, Sakuda M,. 1995. Effects of Salvia miltiorrhiza Bunge (SMB) on MC3T3-E1 cells. J Osaka Univ Dent Sch 35: 21-27.
11. Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R,. 1995. Toward a molecular understanding of skeletal development. Cell 80: 371-378.
12. Fan LL, O'Keefe DD, Powell WWJ,. 1985. Pharmacologic studies on radix puerariae: effect of puerarin on reginal myocardial blood flow and cardiac hemodynamics in dogs with acute myocardial ischemia. Chin Med J 98: 821-832.
13. Ferrara N,. 1999. Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int 56: 794-814.
14. Fu S, Du N, Shi W,. 1999. Biomechanical experimental study on effective fraction of radix Salvia miltiorrhiza Bunge on healing of bone fracture. [Chinese] Zhongguo Zhong Xi Yi Jie He Za Zhi 19: 106-107.
15. Gao D, Song J, Hu J, et al,. 2005. Angiogenesis promoting effects of Chinese herbal medicine for activating blood circulation to remove stasis on chick embryo chorio-allantoic membrane. [Chinese] Zhongguo Zhong Xi Yi Jie He Za Zhi 25: 912-915.
16. Geiger F, Bertram H, Berger I, et al,. 2005. Vascular endothelial growth factor gene-activated matrix (VEGF165-GAM) enhances osteogenesis and angiogenesis in large segmental bone defects. J Bone Miner Res 20: 2028-2035.
17. Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N,. 1999. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat Med 5: 623-628.
18. Glowacki J,. 1998. Angiogenesis in fracture repair. Clin Orthop 255 (suppl): 82-89.
19. Guenther HL, Fleisch H,., Sorgente N,. 1986. Endothelial cells in culture synthesize a potent bone cell active mitogen. Endocrinology 119: 193-201.
20. Haigh JJ, Gerber HP, Ferrara N, Wagner EF,. 2000. Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state. Development 127: 1445-1453.
21. Hsieh MT, Lin YT, Lin YH, Wu CR,. 2000. Radix Angelica sinensis extracts ameliorate scopolamine and cycloheximide-induced amnesia, but not p-chloroamphetamine-induced amnesia in rats. Am J Chin Med 28: 263-272.
22. Hu J, Ren L,. 1998. Experimental study of the effect of Danshen on the viability of burned skin. Chin J Repar Reconstr Surg 12: 205-208.
23. Hu MZ,. 1993. Effect of Radix Salvia miltiorrhiza Bunge on the mitotic activity of osteoblast-like cells isolated from chicken embryo calvariae cultured in vitro. [Chinese] Zhonghua Wai Ke Za Zhi 31: 251-253.
24. Huh JE, Yang HR, Park DS, et al,. 2006. Puerariae radix promotes differentiation of mineralization in human osteoblast-like SaOS-2 cells. J Ethnopharmacol 104: 345-350.
25. Ji SG, Chai YF, Wu YT, et al,. 1999. Determination of ferulic acid in Angelica sinensis and Chuanxiong by capillary zone electrophoresis. Biomed Chromatogr 13: 333-334.
26. Kim C, Ha H, Lee JH, Kim JS, Song K, Park SW,. 2003. Herbal extract prevents bone loss in ovariectomized rats. Arch Pharm Res 26: 917-924.
27. Kim HK, Woo ER, Lee HW, et al,. 2008. The correlation of Salvia miltiorrhiza Bunge extract-induced regulation of osteoclastogenesis with the amount of components tanshinone I, tanshinone IIA, cryptotanshinone, and dihydrotanshinone. Immunopharmacol Immunotoxicol 30: 347-364.
28. Lay IS, Chiu JH, Shiao MS, Lui WY, Wu CW,. 2003a. Crude extract of Salvia miltiorrhiza Bunge and salvianolic acid B enhance in vitro angiogenesis in murine SVR endothelial cell line. Planta Med 69: 26-32.
29. Lay IS, Hsieh CC, Chiu JH, Shiao MS, Lui WY, Wu CW,. 2003b. Salvianolic acid B enhances in vitro angiogenesis and improves skin flap survival in Sprague-Dawley rats. J Surg Res 115: 279-285.
30. Lei Y, Wang JH, Chen KJ,. 2003a. Comparative study on angiogenesis effect of Astragalus membranaceus Bunge and Angelica sinensis in chick embryo chorioallantoic membrane. [Chinese] Zhongguo Zhong Yao Za Zhi 28: 876-878.
31. Lei Y, Gao Q, Li YS,. 2003b. Study on effects of Astragalus, Angelica and their combination on vascular endothelial cell proliferation in vitro. [Chinese] Zhongguo Zhong Xi Yi Jie He Za Zhi 23: 753-756.
32. Leung FY, Rabie AB, Hagg U,. 2004. Neovascularization and bone formation in the condyle during stepwise mandibular advancement. Eur J Orthod 26: 137-141.
33. Li AR, Zhou Y, Zhou XL,. 1998. Traditional Chinese medical treatment. In Guzhi Shusong Zheng (Osteoporosis), Li AR, Zhou Y, Zhou XL, (eds). [Chinese] Anhui Scientific Technology Press: Hefei; 1-2.
34. Li Y, Fan YC,. 2004. Effect of Gegen on proliferation of HUVEC304 cells. Traditional Chin. Med. Pharm. 11: 448-449.
35. Liu J, Burdette JE, Xu H, et al,. 2001. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 49: 2472-2479.
36. Mayr-Wohlfart U, Waltenberger J, Hausser H,. 2002. Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts. Bone 30: 472-477.
37. Meng H, Guo J, Sun JY, et al,. 2008. Angiogenic effects of the extracts from Chinese herbs: Angelica and Chuanxiong. Am J Chin Med 36: 541-554.
38. Meng H, Zhu MZ, Guo J, Sun JY, Pei JM, Huang C,. 2006. The study on angiogenesis activity of Danggui, Chuanxiong and Danshen. [Chinese] Zhong Yao Cai 29: 574-576.
39. Midy V, Plouet J,. 1994. Vasculotropin/vascular endothelial growth factor induces differentiation in cultured osteoblasts. Biochem Biophys Res Commun 199: 380-386.
40. Peng H, Wright V, Usas A, et al,. 2002. Synergistic enhancement of bone formation and healing by stem cell-expressed VEGF and bone morphogenetic protein-4. J Clin Invest 110: 751-759.
41. Qin JZ, Wang XC,. 1992. Effect of Radix Salvia miltiorrhiza Bunge on calcium, zinc, copper content in serum, callus, and bony tissue in early stage of healing process in rat closed tibial fracture. [Chinese] Zhongguo Zhong Xi Yi Jie He Za Zhi 12: 354-356, 325-326.
42. Rabie ABM,. 1997. Vascular endothelial growth pattern during demineralized bone matrix induced osteogenesis. Connect Tissue Res 26: 337-345.
43. Rabie ABM, Shum L, Chayanupatkul A,. 2002a. VEGF and bone formation in the glenoid fossa during forward mandibular positioning. Am J Orthod Dentofacial Ortho 122: 202-209.
44. Rabie AB, Leung FY, Chayanupatkul A, Hägg U,. 2002b. The correlation between neovascularization and bone formation in the condyle during forward mandibular positioning. Angle Orthod 72: 431-438.
45. Ryan AM, Eppler DB, Hagler KE, et al,. 1999. Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody. Toxicol Pathol 27: 78-86.
46. Schmid J, Wallkamm B, Hämmerle CH, Gogolewski S, Lang NP,. 1997. The significance of angiogenesis in guided bone regeneration. A case report of a rabbit experiment. Clin Oral Implant Res 8: 244-248.
47. Shi W, Fu S, Du N,. 2000. Effect of effective fraction of Radix Salvia miltiorrhiza Bunge on procollagen gene expression in fracture healing. [Chinese] Zhongguo Zhong Xi Yi Jie He Za Zhi 20: 269-271.
48. State Pharmacopoeia Committee. 2000. The State Pharmacopoeia Commission of The People's Republic of China, Pharmacopoeia of The People's Republic of China. Vol II. English Edition. Chemical Industry Press: Beijing; 145-150.
49. Street J, Bao M, deGuzman L, et al,. 2002. Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. Proc Natl Acad Sci 99: 9656-9661.
50. Street J, Winter D, Wang JH, Wakai A, McGuinness A, Redmond HP,. 2000. Is human fracture hematoma inherently angiogenic? Clin Orthop 378: 224-237.
51. Tan YY, Yang YQ, Chai L, Wong RW, Rabie AB,. 2010. Effects of vascular endothelial growth factor (VEGF) on MC3T3-E1. Orthod Craniofac Res 13: 223-228.
52. Triffitt JT, Joyner CJ, Oreffo RO, Virdi AS,. 1998. Osteogenesis: bone development from primitive progenitors. Biochem Soc Trans 26: 21-27.
53. Wang DS, Miura M, Demura H, Sato K,. 1997. Anabolic effects of 1, 25-dihydroxyvitamin D3 on osteoblasts are enhanced by vascular endothelial growth factor produced by osteoblasts and by growth factors produced by endothelial cells. Endocrinology 138: 2953-2962.
54. Wang RG, You ZL, Liu XL,. 2005. Effect of ingredients of Astragalus-Salvia compound on vascular endothelial cell in placenta and vascular endothelial growth factor mRNA expression in trophocyte in pregnant rats with inhibited nitric oxide synthesis. [Chinese] Zhongguo Zhong Xi Yi Jie He Za Zhi 25: 516-519.
55. Wang X, Wu J, Chiba H, Umegaki K, Yamada K, Ishimi Y,. 2003. Puerariae radix prevents bone loss in ovariectomized mice. J Bone Miner Meta 21: 268.
56. Wong RW, Rabie AB,. 2006. Traditional Chinese medicines and bone formation - a review. J Oral Maxillofac Surg 64: 828-837.
57. Wong RWK, Rabie ABM,. 2008. Effect of Salvia miltiorrhiza Bunge extract on bone formation. J Biomed Mater Res 85A: 506-512.
58. Xu CJ, Guo F, Gao QP, Wu YF, Jian XC, Peng JY,. 2006. Effects of astragalus polysaccharides-chitosan/polylactic acid scaffolds and bone marrow stem cells on repairing supra-alveolar periodontal defects in dogs. [Chinese] Zhong Nan Da Xue Xue Bao Yi Xue Ban 31: 512-517.
59. Xu CJ, Jian XC, Cheng HQ,. 2004. Influence of Astragalus membranaceus Bunge injection on the proliferation of rabbit bone marrow stromal cells and differentiation to osteoblast. [Chinese] Zhong Nan Da Xue Xue Bao Yi Xue Ban 29: 489-491.
60. Xu CJ, Jian XC, Guo F, Gao QP, Peng JY, Xu XP,. 2007. Effect of astragalus polysaccharides on the proliferation and ultrastructure of dog bone marrow stem cells induced into osteoblasts in vitro. [Chinese] Hua Xi Kou Qiang Yi Xue Za Zhi 25: 432-436.
61. Yang Q, Populo SM, Zhang J, Yang G, Kodama H,. 2002. Effect of Angelica sinensis on the proliferation of human bone cells. Clin Chim Acta 324: 89-97.
62. Yang YQ, Tan YY, Wong R, Wenden A, Zhang LK, Rabie AB,. 2012. The role of vascular endothelial growth factor in ossification. Int J Oral Sci 4: 64-68.
63. Ye YN, Liu ES, Li Y, et al,. 2001. Protective effect of polysaccharides-enriched fraction from Angelica sinensis on hepatic injury. Life Sci 69: 637-646.
64. Yim TK, Wu WK, Pak WF, Mak DH, Liang SM, Ko KM,. 2000. Myocardial protection against ischaemia-reperfusion injury by a Polygonum multiflorum extract supplemented "Dang-Gui decoction for enriching blood", a compound formulation, ex vivo. Phytother Res 14: 195-199.
65. Zelzer E, McLean W, Ng YS, et al,. 2002. Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis. Development 129: 1893-1904.
66. Zhang S, Chen S, Shen Y, et al,. 2006. Puerarin induces angiogenesis in myocardium of rat with myocardial infarction. Biol Pharm Bull 29: 945-950.
67. Zhao H, Alexeev A, Sharma V, Guzman LD, Bojanowski K,. 2008. Effect of SBD.4A - a defined multicomponent preparation of Angelica sinensis - in periodontal regeneration models. Phytother Res 22: 923-928.
68. Zhao H, Mortezaei R, Wang Y, Sheng X, Aria F, Bojanowski K,. 2006. Bojanowski K: SBD.4 stimulates regenerative processes in vitro, and wound healing in genetically diabetic mice and in human skin/severe-combined immunodeficiency mouse chimera. Wound Repair Regen 14: 593-601.
69. Zhu YP,. 1998. Guidelines for application of Chinese materia medica. In Chinese Materia Medica, Chemistry, Pharmacology and Applications, Zhu YP, (ed). Harwood Academic Publishers: Netherlands; 459-463.