Dihydromyricetin reduced bcl-2 expression via p53 in human hepatoma HepG2 cells

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Wu, Shixing ^a   Liu, Bin ^a   Zhang, Qingyu ^a   Liu, Jie ^a   Zhou, Wei ^a   Wang, Chang ^b   Li, Mingyi ^a   Bao, Shiting ^a   Zhu, Runzhi ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMPELOPSIN; ANTINEOPLASTIC AGENT; FLAVONOID; PIFITHRIN ALPHA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL COUNT; CELL STRAIN HEPG2; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME INDUCTION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MTT ASSAY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL PROLIFERATION; DOWN-REGULATION; DRUG SCREENING ASSAYS, ANTITUMOR; FLAVONOLS; HEP G2 CELLS; HUMANS; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84892428852     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076886     Document Type: Article

References (34)

1. Woo HJ, Kang HK, Nguyen TT, Kim GE, Kim YM, et al. (2012) Synthesis and characterization of ampelopsin glucosides using dextransucrase from Leuconostoc mesenteroides B-1299CB4: glucosylation enhancing physicochemical properties. Enzyme Microb Technol 51: 311-318.
2. Ye J, Guan Y, Zeng S, Liu D (2008) Ampelopsin prevents apoptosis induced by H2O2 in MT-4 lymphocytes. Planta medica 74: 252.
3. Kundaković T, Stanojković T, Milenković M, Grubin J, Juranić Z, et al. (2008) Cytotoxic, antioxidant, and antimicrobial activities of Ampelopsis brevipedunculata and Parthenocissus tricuspidata (Vitaceae). Archives of Biological Sciences 60: 641-647.
4. Zhang B, Dong S, Cen X, Wang X, Liu X, et al. (2012) Ampelopsin sodium exhibits antitumor effects against bladder carcinoma in orthotopic xenograft models. Anticancer Drugs 23: 590-596.
5. Qi S, Xin Y, Guo Y, Diao Y, Kou X, et al. (2012) Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-kappaB signaling pathways. Int Immunopharmacol 12: 278-287.
6. Ni F, Gong Y, Li L, Abdolmaleky HM, Zhou JR (2012) Flavonoid ampelopsin inhibits the growth and metastasis of prostate cancer in vitro and in mice. PLoS One 7: e38802.
7. Jeon SH, Chun W, Choi YJ, Kwon YS (2008) Cytotoxic constituents from the bark of Salix hulteni. Archives of pharmacal research 31: 978-982.
8. Freed-Pastor WA, Mizuno H, Zhao X, Langerod A, Moon SH, et al. (2012) Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell 148: 244-258.
9. Vazquez A, Bond EE, Levine AJ, Bond GL (2008) The genetics of the p53 pathway, apoptosis and cancer therapy. Nature Reviews Drug Discovery 7: 979-987.
10. Kruse JP, Gu W (2009) Modes of p53 regulation. Cell 137: 609-622.
11. Brady CA, Jiang D, Mello SS, Johnson TM, Jarvis LA, et al. (2011) Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression. Cell 145: 571-583.
12. Chee JL, Saidin S, Lane DP, Leong SM, Noll JE, et al. (2013) Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9. Cell Cycle 12: 278-288.
13. Burmakin M, Shi Y, Hedström E, Kogner P, Selivanova G (2013) Dual targeting of wild type and mutant p53 by small molecule RITA results in the inhibition of N-Myc and key survival oncogenes and kills neuroblastoma cells in vivo and in vitro. Clinical Cancer Research.
14. Hussein MR (2009) Analysis of p53, BCL-2 and epidermal growth factor receptor protein expression in the partial and complete hydatidiform moles. Exp Mol Pathol 87: 63-69.
15. Sidi S, Sanda T, Kennedy RD, Hagen AT, Jette CA, et al. (2008) Chk1 suppresses a caspase-2 apoptotic response to DNA damage that bypasses p53, Bcl-2, and caspase-3. Cell 133: 864-877.
16. Gu H, Rao S, Zhao J, Wang J, Mu R, et al. (2009) Gambogic acid reduced bcl-2 expression via p53 in human breast MCF-7 cancer cells. J Cancer Res Clin Oncol 135: 1777-1782.
17. Lobner D (2000) Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis? Journal of neuroscience methods 96: 147-152.
18. Chang Y, Yang S-T, Liu J-H, Dong E, Wang Y, et al. (2011) In vitro toxicity evaluation of graphene oxide on A549 cells. Toxicology letters 200: 201-210.
19. Xiong H, Zhang Z-G, Tian X-Q, Sun D-F, Liang Q-C, et al. (2008) Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells. Neoplasia (New York, NY) 10: 287.
20. Agarwal S, Arya V, Zhang L (2013) Review of P - gp Inhibition Data in Recently Approved New Drug Applications: Utility of the Proposed [I1]/IC50 and [I2]/IC50 Criteria in the P-gp Decision Tree. The Journal of Clinical Pharmacology 53: 228-233.
21. Zhou WM, He RR, Ye JT, Zhang N, Liu DY (2010) Synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives. Molecules 15: 2114-2123.
22. Kou X, Shen K, An Y, Qi S, Dai WX, et al. (2012) Ampelopsin inhibits H(2)O(2)-induced apoptosis by ERK and Akt signaling pathways and upregulation of heme oxygenase-1. Phytother Res 26: 988-994.
23. Negrini S, Gorgoulis VG, Halazonetis TD (2010) Genomic instability - an evolving hallmark of cancer. Nat Rev Mol Cell Biol 11: 220-228.
24. Huang F, Yang Z, Yu D, Wang J, Li R, et al. (2012) Sepia ink oligopeptide induces apoptosis in prostate cancer cell lines via caspase-3 activation and elevation of Bax/Bcl-2 ratio. Mar Drugs 10: 2153-2165.
25. Tasyriq M, Najmuldeen IA, In LL, Mohamad K, Awang K, et al. (2012) 7alpha-Hydroxy-beta-Sitosterol from Chisocheton tomentosus Induces Apoptosis via Dysregulation of Cellular Bax/Bcl-2 Ratio and Cell Cycle Arrest by Downregulating ERK1/2 Activation. Evid Based Complement Alternat Med 2012: 765316.
26. Del Poeta G, Ammatuna E, Lavorgna S, Capelli G, Zaza S, et al. (2010) The genotype nucleophosmin mutated and FLT3-ITD negative is characterized by high bax/bcl-2 ratio and favourable outcome in acute myeloid leukaemia. Br J Haematol 149: 383-387.
27. Ahamed M, Akhtar MJ, Raja M, Ahmad I, Siddiqui MK, et al. (2011) ZnO nanorod-induced apoptosis in human alveolar adenocarcinoma cells via p53, survivin and bax/bcl-2 pathways: role of oxidative stress. Nanomedicine 7: 904-913.
28. Tian Z, Shen J, Moseman AP, Yang Q, Yang J, et al. (2008) Dulxanthone A induces cell cycle arrest and apoptosis via up-regulation of p53 through mitochondrial pathway in HepG2 cells. Int J Cancer 122: 31-38.
29. Huang XF, Luo SK, Xu J, Li J, Xu DR, et al. (2008) Aurora kinase inhibitory VX-680 increases Bax/Bcl-2 ratio and induces apoptosis in Aurora-A-high acute myeloid leukemia. Blood 111: 2854-2865.
30. Goeman F, Fontemaggi G, Blandino G (2013) ChIP-on-chip to identify mutant p53 targets. Methods Mol Biol 962: 211-226.
31. Zhu HB, Yang K, Xie YQ, Lin YW, Mao QQ, et al. (2013) Silencing of mutant p53 by siRNA induces cell cycle arrest and apoptosis in human bladder cancer cells. World J Surg Oncol 11: 22.
32. Yeudall WA, Wrighton KH, Deb S (2013) Mutant p53 in cell adhesion and motility. Methods Mol Biol 962: 135-146.
33. Voskamp P, Bodmann CA, Koehl GE, Rebel HG, Van Olderen MG, et al. (2013) Dietary immunosuppressants do not enhance UV-induced skin carcinogenesis, and reveal discordance between p53-mutant early clones and carcinomas. Cancer Prev Res (Phila) 6: 129-138.
34. Lee JH, Gaddameedhi S, Ozturk N, Ye R, Sancar A (2013) DNA damage-specific control of cell death by cryptochrome in p53-mutant ras-transformed cells. Cancer Res 73: 785-791.