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Volumn 6, Issue 2, 2013, Pages 129-138

Dietary immunosuppressants do not enhance UV-induced skin carcinogenesis, and reveal discordance between p53-mutant early clones and carcinomas

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; CASPASE 3; CYCLOSPORIN; MERCAPTOPURINE; MYCOPHENOLIC ACID; PROTEIN P53; RAPAMYCIN; TACROLIMUS;

EID: 84874497821     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-12-0361     Document Type: Article
Times cited : (10)

References (48)
  • 4
    • 0037464506 scopus 로고    scopus 로고
    • Skin cancers after organ transplantation
    • Euvrard S, Kanitakis J, Claudy A. Skin cancers after organ transplantation. N Engl J Med 2003;348:1681-91.
    • (2003) N Engl J Med , vol.348 , pp. 1681-1691
    • Euvrard, S.1    Kanitakis, J.2    Claudy, A.3
  • 5
    • 0018256779 scopus 로고
    • Immunologic aspects of tumor induction by ultraviolet radiation
    • Kripke ML, Fisher MS. Immunologic aspects of tumor induction by ultraviolet radiation. Natl Cancer Inst Monogr 1978:179-83.
    • (1978) Natl Cancer Inst Monogr , pp. 179-183
    • Kripke, M.L.1    Fisher, M.S.2
  • 6
    • 32844468634 scopus 로고    scopus 로고
    • Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation
    • Yarosh DB, Pena AV, Nay SL, Canning MT, Brown DA. Calcineurin inhibitors decrease DNA repair and apoptosis in human keratinocytes following ultraviolet B irradiation. J Invest Dermatol 2005; 125:1020-5.
    • (2005) J Invest Dermatol , vol.125 , pp. 1020-1025
    • Yarosh, D.B.1    Pena, A.V.2    Nay, S.L.3    Canning, M.T.4    Brown, D.A.5
  • 7
    • 0023199859 scopus 로고
    • Effects of immunosuppressive therapy on the induction of skin tumors by ultraviolet irradiation in hairless mice
    • Kelly GE, Meikle W, Sheil AG. Effects of immunosuppressive therapy on the induction of skin tumors by ultraviolet irradiation in hairless mice. Transplantation 1987;44:429-34.
    • (1987) Transplantation , vol.44 , pp. 429-434
    • Kelly, G.E.1    Meikle, W.2    Sheil, A.G.3
  • 9
    • 0034098326 scopus 로고    scopus 로고
    • Immunosuppressive drugs: The first 50 years and a glance forward
    • Allison AC. Immunosuppressive drugs: the first 50 years and a glance forward. Immunopharmacology 2000;47:63-83
    • (2000) Immunopharmacology , vol.47 , pp. 63-83
    • Allison, A.C.1
  • 10
  • 11
    • 78650848337 scopus 로고    scopus 로고
    • MTORC1 controls fasting-induced ketogenesis and its modulation by ageing
    • Sengupta S, Peterson TR, Laplante M, Oh S, Sabatini DM. mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. Nature 2010;468:1100-4.
    • (2010) Nature , vol.468 , pp. 1100-1104
    • Sengupta, S.1    Peterson, T.R.2    Laplante, M.3    Oh, S.4    Sabatini, D.M.5
  • 13
    • 0023579265 scopus 로고
    • Scheduled and unscheduled DNA synthesis in epidermal cells of hairless mice treated with immunosuppressive drugs and UVB-UVA irradiation
    • Kelly GE, Meikle W, Sheil AG. Scheduled and unscheduled DNA synthesis in epidermal cells of hairless mice treated with immunosuppressive drugs and UVB-UVA irradiation. Br J Dermatol 1987;117:429-40.
    • (1987) Br J Dermatol , vol.117 , pp. 429-440
    • Kelly, G.E.1    Meikle, W.2    Sheil, A.G.3
  • 15
    • 0028181387 scopus 로고
    • Anti-tumor activity of mycophenolate mofetil against human and mouse tumors in vivo
    • Tressler RJ, Garvin LJ, Slate DL. Anti-tumor activity of mycophenolate mofetil against human and mouse tumors in vivo. Int J Cancer 1994;57:568-73.
    • (1994) Int J Cancer , vol.57 , pp. 568-573
    • Tressler, R.J.1    Garvin, L.J.2    Slate, D.L.3
  • 16
    • 13144285677 scopus 로고    scopus 로고
    • Mycophenolate mofetil modulates adhesion receptors of the beta1 integrin family on tumor cells: Impact on tumor recurrence and malignancy
    • Engl T, Makarevic J, Relja B, Natsheh I, Muller I, Beecken WD, et al. Mycophenolate mofetil modulates adhesion receptors of the beta1 integrin family on tumor cells: impact on tumor recurrence and malignancy. BMC Cancer 2005;5:4.
    • (2005) BMC Cancer , vol.5 , pp. 4
    • Engl, T.1    Makarevic, J.2    Relja, B.3    Natsheh, I.4    Muller, I.5    Beecken, W.D.6
  • 17
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002;8:128-35.
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    Von Breitenbuch, P.2    Steinbauer, M.3    Koehl, G.4    Flegel, S.5    Hornung, M.6
  • 18
    • 2442668989 scopus 로고    scopus 로고
    • Rapamycin protects allografts from rejection while simultaneously attacking tumors in immunosuppressed mice
    • Koehl GE, Andrassy J, Guba M, Richter S, Kroemer A, Scherer MN, et al. Rapamycin protects allografts from rejection while simultaneously attacking tumors in immunosuppressed mice. Transplantation 2004;77:1319-26.
    • (2004) Transplantation , vol.77 , pp. 1319-1326
    • Koehl, G.E.1    Andrassy, J.2    Guba, M.3    Richter, S.4    Kroemer, A.5    Scherer, M.N.6
  • 19
    • 33749127216 scopus 로고    scopus 로고
    • Development of de novo cancer in p53 knock-out mice is dependent on the type of long-term immunosuppression used.
    • Koehl GE, Gaumann A, Zuelke C, Hoehn A, Hofstaedter F, Schlitt HJ, et al. Development of de novo cancer in p53 knock-out mice is dependent on the type of long-term immunosuppression used. Transplantation 2006;82:741-8.
    • (2006) Transplantation , vol.82 , pp. 741-748
    • Koehl, G.E.1    Gaumann, A.2    Zuelke, C.3    Hoehn, A.4    Hofstaedter, F.5    Schlitt, H.J.6
  • 20
    • 40349096481 scopus 로고    scopus 로고
    • More epidermal p53 patches adjacent to skin carcinomas in renal transplant recipients than in immunocompetent patients: The role of azathioprine
    • de Graaf YG, Rebel H, Elghalbzouri A, Cramers P, Nellen RG, Willemze R, et al. More epidermal p53 patches adjacent to skin carcinomas in renal transplant recipients than in immunocompetent patients: the role of azathioprine. Exp Dermatol 2008;17:349-55.
    • (2008) Exp Dermatol , vol.17 , pp. 349-355
    • De Graaf, Y.G.1    Rebel, H.2    Elghalbzouri, A.3    Cramers, P.4    Nellen, R.G.5    Willemze, R.6
  • 21
    • 84864145380 scopus 로고    scopus 로고
    • Rapamycin impairs UV induction of mutant-p53 overexpressing cell clusters without affecting tumor onset
    • Voskamp P, Bodmann CA, Rebel HG, Koehl GE, Tensen CP, Bouwes Bavinck JN, et al. Rapamycin impairs UV induction of mutant-p53 overexpressing cell clusters without affecting tumor onset. Int J Cancer 2012;131:1267-76.
    • (2012) Int J Cancer , vol.131 , pp. 1267-1276
    • Voskamp, P.1    Bodmann, C.A.2    Rebel, H.G.3    Koehl, G.E.4    Tensen, C.P.5    Bouwes Bavinck, J.N.6
  • 22
    • 77952940222 scopus 로고    scopus 로고
    • Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: Reduced rate of (pre-)malignancies and nonmelanoma skin cancer in a prospective, randomized, assessorblinded, controlled clinical trial
    • Salgo R, Gossmann J, Schöfer H, Kachel HG, Kuck J, Geiger H, et al. Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: reduced rate of (pre-)malignancies and nonmelanoma skin cancer in a prospective, randomized, assessorblinded, controlled clinical trial. Am J Transplantation 2010;10:1385-93.
    • (2010) Am J Transplantation , vol.10 , pp. 1385-1393
    • Salgo, R.1    Gossmann, J.2    Schöfer, H.3    Kachel, H.G.4    Kuck, J.5    Geiger, H.6
  • 25
    • 33847647531 scopus 로고    scopus 로고
    • Mycophenolate acid inhibits endothelial NAD(P)H oxidase activity and superoxide formation by a Rac1-dependent mechanism
    • Krotz F, Keller M, Derflinger S, Schmid H, Gloe T, Bassermann F, et al. Mycophenolate acid inhibits endothelial NAD(P)H oxidase activity and superoxide formation by a Rac1-dependent mechanism. Hypertension 2007;49:201-8.
    • (2007) Hypertension , vol.49 , pp. 201-208
    • Krotz, F.1    Keller, M.2    Derflinger, S.3    Schmid, H.4    Gloe, T.5    Bassermann, F.6
  • 26
  • 27
    • 0034045586 scopus 로고    scopus 로고
    • Mycophenolate mofetil and its mechanisms of action
    • Allison AC, Eugui EM. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology 2000;47:85-118.
    • (2000) Immunopharmacology , vol.47 , pp. 85-118
    • Allison, A.C.1    Eugui, E.M.2
  • 28
    • 77954720424 scopus 로고    scopus 로고
    • Early and late effects of the immunosuppressants rapamycin and mycophenolate mofetil on UV carcinogenesis
    • de Gruijl FR, Koehl GE, Voskamp P, Strik A, Rebel HG, Gaumann A, et al. Early and late effects of the immunosuppressants rapamycin and mycophenolate mofetil on UV carcinogenesis. Int J Cancer 2010;127:796-804.
    • (2010) Int J Cancer , vol.127 , pp. 796-804
    • De Gruijl, F.R.1    Koehl, G.E.2    Voskamp, P.3    Strik, A.4    Rebel, H.G.5    Gaumann, A.6
  • 29
    • 27944509203 scopus 로고    scopus 로고
    • Relationship between UV-induced mutant p53 patches and skin tumours, analysed by mutation spectra and by induction kinetics in various DNA-repair-deficient mice
    • Rebel H, Kram N, Westerman A, Banus S, van Kranen HJ, de Gruijl FR. Relationship between UV-induced mutant p53 patches and skin tumours, analysed by mutation spectra and by induction kinetics in various DNA-repair-deficient mice. Carcinogenesis 2005;26:2123-30.
    • (2005) Carcinogenesis , vol.26 , pp. 2123-2130
    • Rebel, H.1    Kram, N.2    Westerman, A.3    Banus, S.4    Van Kranen, H.J.5    De Gruijl, F.R.6
  • 30
    • 84255176347 scopus 로고    scopus 로고
    • UVA photosensitization of thiopurines and skin cancer in organ transplant recipients
    • Attard NR, Karran P. UVA photosensitization of thiopurines and skin cancer in organ transplant recipients. Photochem Photobiol Sci 2012; 11:62-8.
    • (2012) Photochem Photobiol Sci , vol.11 , pp. 62-68
    • Attard, N.R.1    Karran, P.2
  • 31
    • 6344254298 scopus 로고    scopus 로고
    • Melanin acts as a potentUVBphotosensitizer to cause an atypical mode of cell death in murine skin
    • Takeuchi S, Zhang W, Wakamatsu K, Ito S, Hearing VJ, Kraemer KH, et al. Melanin acts as a potentUVBphotosensitizer to cause an atypical mode of cell death in murine skin. Proc Natl Acad Sci U S A 2004; 101:15076-81.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 15076-15081
    • Takeuchi, S.1    Zhang, W.2    Wakamatsu, K.3    Ito, S.4    Hearing, V.J.5    Kraemer, K.H.6
  • 32
    • 0036692932 scopus 로고    scopus 로고
    • Cyclosporin-A suppresses p53-dependent repair DNA synthesis and apoptosis following ultraviolet-B irradiation
    • Sugie N, Fujii N, Danno K. Cyclosporin-A suppresses p53-dependent repair DNA synthesis and apoptosis following ultraviolet-B irradiation. Photodermatol Photoimmunol Photomed 2002;18:163-8.
    • (2002) Photodermatol Photoimmunol Photomed , vol.18 , pp. 163-168
    • Sugie, N.1    Fujii, N.2    Danno, K.3
  • 33
    • 2542609091 scopus 로고    scopus 로고
    • Wound-healing complications after kidney transplantation: A prospective, randomized comparison of sirolimus and tacrolimus
    • Dean PG, Lund WJ, Larson TS, Prieto M, Nyberg SL, Ishitani MB, et al. Wound-healing complications after kidney transplantation: a prospective, randomized comparison of sirolimus and tacrolimus. Transplantation 2004;77:1555-61.
    • (2004) Transplantation , vol.77 , pp. 1555-1561
    • Dean, P.G.1    Lund, W.J.2    Larson, T.S.3    Prieto, M.4    Nyberg, S.L.5    Ishitani, M.B.6
  • 34
    • 57349155737 scopus 로고    scopus 로고
    • NFAT regulates induction of COX-2 and apoptosis of keratinocytes in response to ultraviolet radiation exposure
    • Flockhart RJ, Diffey BL, Farr PM, Lloyd J, Reynolds NJ. NFAT regulates induction of COX-2 and apoptosis of keratinocytes in response to ultraviolet radiation exposure. FASEB J 2008;22:4218-27.
    • (2008) FASEB J , vol.22 , pp. 4218-4227
    • Flockhart, R.J.1    Diffey, B.L.2    Farr, P.M.3    Lloyd, J.4    Reynolds, N.J.5
  • 35
    • 18144385454 scopus 로고    scopus 로고
    • Patches of mutant p53-immunoreactive epidermal cells induced by chronic UVB irradiation harbor the same p53 mutations as squamous cell carcinomas in the skin of hairless SKH-1 mice
    • Kramata P, Lu Y-P, Lou Y-R, Singh RN, Kwon SM, Conney AH. Patches of mutant p53-immunoreactive epidermal cells induced by chronic UVB irradiation harbor the same p53 mutations as squamous cell carcinomas in the skin of hairless SKH-1 mice. Cancer Res 2005;65:3577-85.
    • (2005) Cancer Res , vol.65 , pp. 3577-3585
    • Kramata, P.1    Lu, Y.-P.2    Lou, Y.-R.3    Singh, R.N.4    Kwon, S.M.5    Conney, A.H.6
  • 36
    • 78651405693 scopus 로고    scopus 로고
    • Sun-induced nonsynonymous p53 mutations are extensively accumulated and tolerated in normal appearing human skin
    • Stahl PL, Stranneheim H, Asplund A, Berglund L, Ponten F, Lundeberg J. Sun-induced nonsynonymous p53 mutations are extensively accumulated and tolerated in normal appearing human skin. J Invest Dermatol 2011;131:504-8.
    • (2011) J Invest Dermatol , vol.131 , pp. 504-508
    • Stahl, P.L.1    Stranneheim, H.2    Asplund, A.3    Berglund, L.4    Ponten, F.5    Lundeberg, J.6
  • 37
    • 0027297004 scopus 로고
    • P53 Expression in three separate tumours from a patient with Li-Fraumeni's syndrome
    • King P, Craft AW, Malcolm AJ. p53 Expression in three separate tumours from a patient with Li-Fraumeni's syndrome. J Clin Pathol 1993;46:676-7.
    • (1993) J Clin Pathol , vol.46 , pp. 676-677
    • King, P.1    Craft, A.W.2    Malcolm, A.J.3
  • 38
    • 51749107469 scopus 로고    scopus 로고
    • Sirolimus reduces the incidence and progression of UVB-induced skin cancer in SKH mice even with co-administration of cyclosporine A
    • Wulff BC, Kusewitt DF, VanBuskirk AM, Thomas-Ahner JM, Duncan FJ, Oberyszyn TM. Sirolimus reduces the incidence and progression of UVB-induced skin cancer in SKH mice even with co-administration of cyclosporine A. J Invest Dermatol 2008;128:2467-73.
    • (2008) J Invest Dermatol , vol.128 , pp. 2467-2473
    • Wulff, B.C.1    Kusewitt, D.F.2    Vanbuskirk, A.M.3    Thomas-Ahner, J.M.4    Duncan, F.J.5    Oberyszyn, T.M.6
  • 39
    • 35748985246 scopus 로고    scopus 로고
    • Clinically relevant immunosuppressants influence UVBinduced tumor size through effects on inflammation and angiogenesis
    • Duncan FJ, Wulff BC, Tober KL, Ferketich AK, Martin J, Thomas-Ahner JM, et al. Clinically relevant immunosuppressants influence UVBinduced tumor size through effects on inflammation and angiogenesis. Am J Transplantation 2007;7:2693-703.
    • (2007) Am J Transplantation , vol.7 , pp. 2693-2703
    • Duncan, F.J.1    Wulff, B.C.2    Tober, K.L.3    Ferketich, A.K.4    Martin, J.5    Thomas-Ahner, J.M.6
  • 40
    • 84874461366 scopus 로고    scopus 로고
    • Therapeutic Drug Monitoring of Tacrolimus.
    • Therapeutic Drug Monitoring of Tacrolimus. Dutch Society of Hospital Pharmacist; 2005. Available from: http://www.2nvza.nl/uploaddb/ downl-object.asp?atoom=5858&VolgNr=1
    • (2005) Dutch Society of Hospital Pharmacist
  • 41
    • 76049119424 scopus 로고    scopus 로고
    • Cyclosporine A suppresses keratinocyte cell death through MPTP inhibition in a model for skin cancer in organ transplant recipients
    • Norman KG, Canter JA, Shi M, Milne GL, Morrow JD, Sligh JE. Cyclosporine A suppresses keratinocyte cell death through MPTP inhibition in a model for skin cancer in organ transplant recipients. Mitochondrion 2010;10:94-101.
    • (2010) Mitochondrion , vol.10 , pp. 94-101
    • Norman, K.G.1    Canter, J.A.2    Shi, M.3    Milne, G.L.4    Morrow, J.D.5    Sligh, J.E.6
  • 42
    • 17144439199 scopus 로고    scopus 로고
    • Anticancer drugs for noncancer diseases
    • 180-4,190
    • Lash AA. Anticancer drugs for noncancer diseases. Medsurg Nurs 1996;5:177,180-4,190.
    • (1996) Medsurg Nurs , vol.5 , pp. 177
    • Lash, A.A.1
  • 43
    • 84866418985 scopus 로고    scopus 로고
    • Oxidation-mediated DNA cross-linking contributes to the toxicity of 6-thioguanine in human cells
    • Brem R, Karran P. Oxidation-mediated DNA cross-linking contributes to the toxicity of 6-thioguanine in human cells. Cancer Res 2012;72:4787-95.
    • (2012) Cancer Res , vol.72 , pp. 4787-4795
    • Brem, R.1    Karran, P.2
  • 44
    • 0035114197 scopus 로고    scopus 로고
    • Early p53-positive foci as indicators of tumor risk in ultraviolet-exposed hairless mice: Kinetics of induction, effects of DNA repair deficiency, and p53 heterozygosity
    • Rebel H, Mosnier LO, Berg RJW, Westerman-de Vries A, van Steeg H, van Kranen HJ, et al. Early p53-positive foci as indicators of tumor risk in ultraviolet-exposed hairless mice: kinetics of induction, effects of DNA repair deficiency, and p53 heterozygosity. Cancer Res 2001;61:977-83.
    • (2001) Cancer Res , vol.61 , pp. 977-983
    • Rebel, H.1    Mosnier, L.O.2    Berg, R.J.W.3    Westerman-De Vries, A.4    Van Steeg, H.5    Van Kranen, H.J.6
  • 46
    • 0030031401 scopus 로고    scopus 로고
    • Early p53 alterations in mouse skin carcinogenesis by UVB radiation: Immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells
    • Berg RJ, van Kranen HJ, Rebel HG, de Vries A, van Vloten WA, Van Kreijl CF, et al. Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells. Proc Natl Acad Sci 1996;93:274-8.
    • (1996) Proc Natl Acad Sci , vol.93 , pp. 274-278
    • Berg, R.J.1    Van Kranen, H.J.2    Rebel, H.G.3    De Vries, A.4    Van Vloten, W.A.5    Van Kreijl, C.F.6
  • 48
    • 27144510955 scopus 로고    scopus 로고
    • Non-melanoma skin cancer: What drives tumor development and progression?
    • Boukamp P. Non-melanoma skin cancer: what drives tumor development and progression? Carcinogenesis 2005;26:1657-67.
    • (2005) Carcinogenesis , vol.26 , pp. 1657-1667
    • Boukamp, P.1


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