Determining the binding affinity of therapeutic monoclonal antibodies towards their native unpurified antigens in human serum

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Bee, Christine ^a   Abdiche, Yasmina N ^a   Pons, Jaume ^a   Rajpal, Arvind ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; FATTY ACID BINDING PROTEIN 4; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 19F7; MONOCLONAL ANTIBODY 21B8; MONOCLONAL ANTIBODY 2B2; MONOCLONAL ANTIBODY 33B12; MONOCLONAL ANTIBODY J16; MONOCLONAL ANTIBODY J17; PROGRANULIN; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; RECOMBINANT ANTIGEN; SERINE PROTEINASE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANALYTIC METHOD; ANTIGEN BINDING; ARTICLE; BIACORE CALIBRATION FREE CONCENTRATION ANALYSIS; BINDING AFFINITY; BINDING KINETICS; BLOOD PH; BLOOD SAMPLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; HUMAN; KINETIC EXCLUSION ASSAY;

ANTIBODIES, MONOCLONAL; ANTIGENS; CELL LINE; FATTY ACID-BINDING PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PROPROTEIN CONVERTASES; SERINE ENDOPEPTIDASES;

EID: 84892417483     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0080501     Document Type: Article

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