Increased circulating level of the survival factor GP88 (Progranulin) in the serum of breast cancer patients when compared to healthy subjects

Breast Cancer: Basic and Clinical Research

Volumn 5, Issue 1, 2011, Pages 155-162

  Tkaczuk, Katherine Rak ^a   Yue, Binbin ^b   Zhan, Min ^c   Tait, Nancy ^a   Yarlagadda, Lavanya ^a   Dai, Huifang ^b   Serrero, Ginette ^a,b  

^a UNIVERSITY OF MARYLAND   (United States)

^b A&G Pharmaceutical   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Biomarker; Breast cancer; GP88; Progranulin

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; PROGRANULIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; BLOOD ANALYSIS; BLOOD SAMPLING; BREAST CANCER; CANCER DIAGNOSIS; CANCER GRADING; CANCER STAGING; CONTROLLED STUDY; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; FOLLOW UP; HUMAN; IMMUNOASSAY; PATIENT MONITORING; PROGNOSIS; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION;

EID: 79959933419     PISSN: 11782234     EISSN: None     Source Type: Journal    
DOI: 10.4137/BCBCR.S7224     Document Type: Article

References (30)

1. American Cancer Society: Cancer Facts and Figures 2010. Atlanta, American Cancer Society. 2010:1-62.
2. Hou MF, Tsai LY, Tsai SM, et al. Evaluation of serum CA27.29, CA15-3 and CEA in patients with breast cancer. Kaohsiung J Med Sci. 1999;15:520-8.
3. Einarsson R, Lindman H, Bergh J. Use of TPS and CA15-3 assays for monitoring chemotherapy in metastatic breast cancer patients. Anticancer Res. 2000;20:5089-93.
4. Hayes DF, Zurawski VR Jr, Kufe DW. Comparison of circulating CA15-3 and carcinoembryonic antigen levels in patients with breast cancer. J Clin Oncol. 1986;4:1542-50.
5. Wojtacki J, Kruszewski WJ, Sliwińska M, et al. Elevation of serum CA15-3 antigen: an early indicator of distant metastasis from breast cancer. Retrospective analysis of 733 cases. Przegl Lek. 2001;58:498-503.
6. Bensouda Y, André F, Boulet T, et al. Prevalence of elevated serum CA15-3 at time of metastatic relapse of breast cancer and correlation with hormone receptor status. Bull Cancer. 2009;96:923-8.
7. Safi F, Kohler I, Röttinger E, Suhr P, Beger HG. Comparison of CA15-3 and CEA in diagnosis and monitoring of breast cancer. Int J Biol Markers. 1989;4:207-14.
8. Uehara M, Kinoshita T, Hojo T, et al. Long-term prognostic study of carcinoembryonic antigen (CEA) and carbohydrate antigen 15-3 (CA15-3) in breast cancer. Int J Clin Oncol. 2008;13:447-51.
9. Duffy MJ, Evoy D, McDermott EW. CA15-3: Uses and limitation as a biomarker for breast cancer. Clin Chim Acta. 2010;411:1869-74.
10. Meijer-van Gelder ME, Look MP, Peters HA, et al. Urokinase-type plasminogen activator system in breast cancer: association with tamoxifen therapy in recurrent disease. Cancer Res. 2004;64:4563-8.
11. Esteva FJ, Cheli CD, Fritsche H, et al. Clinical utility of serum HER2/neu in monitoring and prediction of progression-free survival in metastatic breast cancer patients treated with trastuzumab-based therapies. Breast Cancer Res. 2005;7:R436-43.
12. Bhandari V, Palfree RG, Bateman A. Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. Proc Natl Acad Sci U S A. 1992;89:1715-9.
13. Plowman GD, Green JM, Neubauer MG, et al. The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth. J Biol Chem. 1992;267:13073-8.
14. Zhang H, Serrero G. Inhibition of tumorigenicity of the teratoma PC cell line by transfection with antisense cDNA for PC cell-derived growth factor (PCDGF). Proc Natl Acad Sci U S A. 1998;95:14202-7.
15. Lu R, Serrero G. Inhibition of PC cell-derived growth factor (PCDGF, epithelin/granulin precursor) expression by antisense PCDGF cDNA transfection inhibits tumorigenicity of the human breast carcinoma cell line MDA-MB-468. Proc Natl Acad Sci U S A. 2000;97:3993-8.
16. Xu SQ, Tang D, Chamberlain S, et al. The granulin/epithelin precursor abrogates the requirement for the insulin-like growth factor 1 receptor for growth in vitro. J Biol Chem. 1998;273:20078-83.
17. He Z, Bateman A. Progranulin gene expression regulates epithelial cell growth and promotes tumor growth in vivo. Cancer Res. 1999;59:3222-9.
18. Díaz-Cueto L, Stein P, Jacobs A, Schultz RM, Gerton GL. Modulation of mouse preimplantation embryo development by acrogranin (epithelin/granulin precursor. Dev Biol. 2000;217:406-18.
19. Tangkeangsirisin W, Serrero G. PC-cell derived growth factor (PCDGF/ GP88) stimulates migration, invasiveness and VEGF expression in breast cancer cells. Carcinogenesis. 2004;25:1587-9.
20. He Z, Bateman A. Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis. J Mol Med. 2003;81:600-12.
21. Serrero G. Autocrine growth factor revisited: PC-cell-derived growth factor (progranulin), a critical player in breast cancer tumorigenesis. Biochem Biophys Res Commun. 2003;308:409-13.
22. Zanocco-Marani T, Bateman A, Romano G, Valentinis B, He ZH, Baserga R. Biological activities and signaling pathways of the granulin/epithelin precursor. Cancer Res. 1999;59:5331-40.
23. Jones MB, Michener CM, Blanchette JO, et al. The granulin-epithelin precursor: a putative new growth factor for ovarian cancer. Gynecol Oncol. 2003;88:S136-9.
24. Pizarro GO, Zhou XC, Koch A, et al. Prosurvival function of the granulinepithelin precursor is important in tumor progression and chemoresponse. Int J Cancer. 2007;120:2339-43.
25. Liu Y, Xi L, Liao G, et al. Inhibition of PC cell-derived growth factor (PCDGF)/granulin-epithelin precursor (GEP) decreased cell proliferation and invasion through downregulation of cyclin D and CDK4 and inactivation of MMP-2. BMC Cancer. 2007;7:22.
26. Lu R, Serrero G. Mediation of estrogen mitogenic effect in human breast cancer MCF-7 cells by PC-cell-derived growth factor (PCDGF/granulin precursor). Proc Natl Acad Sci U S A. 2001;98:142-7.
27. Tangkeangsirisin W, Hayashi J, Serrero G. PC cell-derived growth factor mediates tamoxifen resistance and promotes tumor growth of human breast cancer cells. Cancer Res. 2004;64:1737-43.
28. Kim WE, Serrero G. PC-Cell Derived Growth Factor (PCDGF/GP88, progranulin) stimulates proliferation and confers Herceptin resistance to Her-2 overexpressing breast cancer cells. Clin Can Res. 2006;12:4192-9.
29. Kudoh K, Ramanna M, Ravatn R, et al. Monitoring the expression profiles of doxorubicin-induced and doxorubicin-resistant cancer cells by cDNA microarray. Cancer Res. 2000;60:4161-6.
30. Serrero G, Ioffe O. Expression of the novel autocrine growth factor PC-cell derived growth factor in human breast cancer tissue. Human Pathology. 2003;34:1148-54.