UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Choi, Haeri ^a   Schneider, Heather ^a   Klum, Shannon ^a   Chandler Brown, Devon ^a   Kaeberlein, Matt ^a   Shamieh, Lara ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b REGIS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ETHOSUXIMIDE; SUCCINIMIDE; TRIMETHADIONE;

ANTHELMINTIC ACTIVITY; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DIET RESTRICTION; DOSE RESPONSE; DRUG POTENCY; DRUG SPECIFICITY; DRUG STRUCTURE; LIFE EXTENSION; LIFESPAN; LONGEVITY; NONHUMAN; PHOTOCHEMISTRY; RADIATION EXPOSURE; TEMPERATURE SENSITIVITY; ULTRAVIOLET RADIATION;

ANIMALS; ANTICONVULSANTS; CAENORHABDITIS ELEGANS; ETHOSUXIMIDE; FOOD DEPRIVATION; LONGEVITY; ULTRAVIOLET RAYS;

EID: 84892402563     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082543     Document Type: Article

References (23)

1. Goren MZ, Onat F (2007) Ethosuximide: from bench to bedside. CNS Drug Rev 13: 224-239.
2. Huguenard JR (2002) Block of T -Type Ca(2+) Channels Is an Important Action of Succinimide Antiabsence Drugs. Epilepsy Curr 2: 49-52.
3. Mattson RH (1995) Efficacy and adverse effects of established and new antiepileptic drugs. Epilepsia 36 Suppl 2: S13-26.
4. Rogvi-Hansen B, Gram L (1995) Adverse effects of established and new antiepileptic drugs: an attempted comparison. Pharmacol Ther 68: 425-434.
5. Kornfeld K, Evason K (2006) Effects of anticonvulsant drugs on life span. Arch Neurol 63: 491-496.
6. Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science 307: 258-262.
7. Hughes SE, Evason K, Xiong C, Kornfeld K (2007) Genetic and pharmacological factors that influence reproductive aging in nematodes. PLoS Genet 3: e25.
8. Lakowski B, Hekimi S (1998) The genetics of caloric restriction in Caenorhabditis elegans. Proc Natl Acad Sci U S A 95: 13091-13096.
9. Lin K, Dorman JB, Rodan A, Kenyon C (1997) daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278: 1319-1322.
10. Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, et al. (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389: 994-999.
11. Henderson ST, Johnson TE (2001) daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr Biol 11: 1975-1980.
12. Collins JJ, Evason K, Pickett CL, Schneider DL, Kornfeld K (2008) The anticonvulsant ethosuximide disrupts sensory function to extend C. elegans lifespan. PLoS Genet 4: e1000230.
13. Kaeberlein TL, Smith ED, Tsuchiya M, Welton KL, Thomas JH, et al. (2006) Lifespan extension in Caenorhabditis elegans by complete removal of food. Aging Cell 5: 487-494.
14. Sutphin GL, Kaeberlein M (2008) Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes. Exp Gerontol 43: 130-135.
15. Lee GD, Wilson MA, Zhu M, Wolkow CA, de Cabo R, et al. (2006) Dietary deprivation extends lifespan in Caenorhabditis elegans. Aging Cell 5: 515-524.
16. Smith ED, Kaeberlein TL, Lydum BT, Sager J, Welton KL, et al. (2008) Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans. BMC Dev Biol 8: 49.
17. Sutphin GL, Kaeberlein M (2009) Measuring Caenorhabditis elegans life span on solid media. J Vis Exp 27
18. Garigan D, Hsu AL, Fraser AG, Kamath RS, Ahringer J, et al. (2002) Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation. Genetics 161: 1101-1112.
19. Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, et al. (2003) Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science 300: 1921.
20. Leiser SF, Begun A, Kaeberlein M (2011) HIF-1 modulates longevity and healthspan in a temperature-dependent manner. Aging cell 10: 318-326.
21. Sutphin GL, Bishop E, Yanos ME, Moller RM, Kaeberlein M (2012) Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans. Longevity & Healthspan 1: 9.
22. Xiao R, Zhang B, Dong Y, Gong J, Xu T, et al. (2013) A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Cell 152: 806-817.
23. Lee SJ, Kenyon C (2009) Regulation of the longevity response to temperature by thermosensroy neurons in Caenorhabdtis elegans. Curr Biol 19:715-722