메뉴 건너뛰기




Volumn 30, Issue 6, 2013, Pages 2820-2828

Resveratrol suppresses the STAT3 signaling pathway and inhibits proliferation of high glucose-exposed HepG2 cells partly through SIRT1

Author keywords

Hepatocellular carcinoma; Hyperglycemia; Proliferation; Resveratrol; SIRT1; STAT3

Indexed keywords

CYCLIN B1; CYCLIN D1; GELATINASE B; GLUCOSE; PROTEIN KINASE B; RESVERATROL; SIRTUIN 1; STAT3 PROTEIN; TETRAZOLIUM; VASCULOTROPIN;

EID: 84892374743     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2748     Document Type: Article
Times cited : (39)

References (27)
  • 1
    • 33644759114 scopus 로고    scopus 로고
    • The association between diabetes and hepatocellular carcinoma: A systematic review of epidemiologic evidence
    • El-Serag HB, Hampel H and Javadi F: The association between diabetes and hepatocellular carcinoma: a systematic review of epidemiologic evidence. Clin Gastroenterol Hepatol 4: 369-380, 2006.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 369-380
    • El-Serag, H.B.1    Hampel, H.2    Javadi, F.3
  • 2
    • 84868547837 scopus 로고    scopus 로고
    • Side-effects of resveratrol in HepG2 cells: Reduced pten and increased bcl-xl mRNA expression
    • Zheng M, Chen R, Zhong H, et al: Side-effects of resveratrol in HepG2 cells: reduced pten and increased bcl-xl mRNA expression. Mol Med Rep 6: 1367-1370, 2012.
    • (2012) Mol Med Rep , vol.6 , pp. 1367-1370
    • Zheng, M.1    Chen, R.2    Zhong, H.3
  • 3
    • 33947197883 scopus 로고    scopus 로고
    • Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-κB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells
    • Bhardwaj A, Sethi G, Vadhan-Raj S, et al: Resveratrol inhibits proliferation, induces apoptosis, and overcomes chemoresistance through down-regulation of STAT3 and nuclear factor-κB-regulated antiapoptotic and cell survival gene products in human multiple myeloma cells. Blood 109: 2293-2302, 2007.
    • (2007) Blood , vol.109 , pp. 2293-2302
    • Bhardwaj, A.1    Sethi, G.2    Vadhan-Raj, S.3
  • 4
    • 84867096089 scopus 로고    scopus 로고
    • Identification of potent small-molecule inhibitors of STAT3 with anti-inflammatory properties in RAW 264.7 macrophages
    • Capiralla H, Vingtdeux V, Venkatesh J, et al: Identification of potent small-molecule inhibitors of STAT3 with anti-inflammatory properties in RAW 264.7 macrophages. FEBS J 279: 3791-3799, 2012.
    • (2012) FEBS J , vol.279 , pp. 3791-3799
    • Capiralla, H.1    Vingtdeux, V.2    Venkatesh, J.3
  • 6
    • 80052699312 scopus 로고    scopus 로고
    • Inhibition of NF-κB signaling commits resveratrol-treated medulloblastoma cells to apoptosis without neuronal differentiation
    • Wen S, Li H, Wu ML, et al: Inhibition of NF-κB signaling commits resveratrol-treated medulloblastoma cells to apoptosis without neuronal differentiation. J Neurooncol 104: 169-177, 2011.
    • (2011) J Neurooncol , vol.104 , pp. 169-177
    • Wen, S.1    Li, H.2    Wu, M.L.3
  • 7
    • 84862852344 scopus 로고    scopus 로고
    • SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of â-catenin
    • Cho IR, Koh SS, Malilas W, et al: SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of â-catenin. Biochem Biophys Res Commun 423: 270-275, 2012.
    • (2012) Biochem Biophys Res Commun , vol.423 , pp. 270-275
    • Cho, I.R.1    Koh, S.S.2    Malilas, W.3
  • 8
    • 84862854402 scopus 로고    scopus 로고
    • miR-486-5p induces replicative senescence of human adipose tissue-derived mesenchymal stem cells and its expression is controlled by high glucose
    • Kim YJ, Hwang SH, Lee SY, et al: miR-486-5p induces replicative senescence of human adipose tissue-derived mesenchymal stem cells and its expression is controlled by high glucose. Stem Cells Dev 21: 1749-1760, 2012.
    • (2012) Stem Cells Dev , vol.21 , pp. 1749-1760
    • Kim, Y.J.1    Hwang, S.H.2    Lee, S.Y.3
  • 9
    • 64049109876 scopus 로고    scopus 로고
    • STAT3 inhibition of gluconeogenesis is downregulated by SirT1
    • Nie Y, Erion DM, Yuan Z, et al: STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nat Cell Biol 11: 492-500, 2009.
    • (2009) Nat Cell Biol , vol.11 , pp. 492-500
    • Nie, Y.1    Erion, D.M.2    Yuan, Z.3
  • 10
    • 73149109931 scopus 로고    scopus 로고
    • Evaluation of antileukemia effect of resveratrol by modulating STAT3 signaling
    • Li T, Wang W, Chen H, Li T and Ye L: Evaluation of antileukemia effect of resveratrol by modulating STAT3 signaling. Int Immunopharmacol 10: 18-25, 2010.
    • (2010) Int Immunopharmacol , vol.10 , pp. 18-25
    • Li, T.1    Wang, W.2    Chen, H.3    Li, T.4    Ye, L.5
  • 11
    • 84897990837 scopus 로고    scopus 로고
    • STAT3 and HIF1alpha cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells
    • Apr 22, Epub ahead of print
    • Pawlus MR, Wang L and Hu CJ: STAT3 and HIF1alpha cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene: Apr 22, 2013 (Epub ahead of print).
    • (2013) Oncogene
    • Pawlus, M.R.1    Wang, L.2    Hu, C.J.3
  • 12
    • 84878171024 scopus 로고    scopus 로고
    • STAT3 acetylation-induced promoter methylation is associated with downregulation of the ARHI tumor-suppressor gene in ovarian cancer
    • Li J, Cui G, Sun L, et al: STAT3 acetylation-induced promoter methylation is associated with downregulation of the ARHI tumor-suppressor gene in ovarian cancer. Oncol Rep 30: 165-170, 2013.
    • (2013) Oncol Rep , vol.30 , pp. 165-170
    • Li, J.1    Cui, G.2    Sun, L.3
  • 13
    • 38349049466 scopus 로고    scopus 로고
    • VIP inhibits human HepG2 cell proliferation in vitro
    • Absood A, Hu B, Bassily N and Colletti L: VIP inhibits human HepG2 cell proliferation in vitro. Regul Pept 146: 285-292, 2008.
    • (2008) Regul Pept , vol.146 , pp. 285-292
    • Absood, A.1    Hu, B.2    Bassily, N.3    Colletti, L.4
  • 14
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur JA and Sinclair DA: Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 5: 493-506, 2006.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 15
    • 34547882115 scopus 로고    scopus 로고
    • Resveratrol: A review of preclinical studies for human cancer prevention
    • Athar M, Back JH, Tang X, et al: Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol 224: 274-283, 2007.
    • (2007) Toxicol Appl Pharmacol , vol.224 , pp. 274-283
    • Athar, M.1    Back, J.H.2    Tang, X.3
  • 16
    • 33645464650 scopus 로고    scopus 로고
    • Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
    • Kotha A, Sekharam M, Cilenti L, et al: Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Mol Cancer Ther 5: 621-629, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 621-629
    • Kotha, A.1    Sekharam, M.2    Cilenti, L.3
  • 17
    • 45849113190 scopus 로고    scopus 로고
    • Inhibition of STAT3 expression and signaling in resveratrol- differentiated medulloblastoma cells
    • Yu LJ, Wu ML, Li H, et al: Inhibition of STAT3 expression and signaling in resveratrol-differentiated medulloblastoma cells. Neoplasia 10: 736-744, 2008.
    • (2008) Neoplasia , vol.10 , pp. 736-744
    • Yu, L.J.1    Wu, M.L.2    Li, H.3
  • 19
    • 84861399789 scopus 로고    scopus 로고
    • S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites
    • Deng J, Liu Y, Lee H, et al: S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell 21: 642-654, 2012.
    • (2012) Cancer Cell , vol.21 , pp. 642-654
    • Deng, J.1    Liu, Y.2    Lee, H.3
  • 20
    • 84864134596 scopus 로고    scopus 로고
    • Targeting Stat3 induces senescence in tumor cells and elicits prophylactic and therapeutic immune responses against breast cancer growth mediated by NK cells and CD4+ T cells
    • Tkach M, Coria L, Rosemblit C, et al: Targeting Stat3 induces senescence in tumor cells and elicits prophylactic and therapeutic immune responses against breast cancer growth mediated by NK cells and CD4+ T cells. J Immunol 189: 1162-1172, 2012.
    • (2012) J Immunol , vol.189 , pp. 1162-1172
    • Tkach, M.1    Coria, L.2    Rosemblit, C.3
  • 21
    • 84866431328 scopus 로고    scopus 로고
    • Targeting Stat3 abrogates EGFR inhibitor resistance in cancer
    • Sen M, Joyce S, Panahandeh M, et al: Targeting Stat3 abrogates EGFR inhibitor resistance in cancer. Clin Cancer Res 18: 4986-4996, 2012.
    • (2012) Clin Cancer Res , vol.18 , pp. 4986-4996
    • Sen, M.1    Joyce, S.2    Panahandeh, M.3
  • 22
    • 84861476075 scopus 로고    scopus 로고
    • Curcumin blocks small cell lung cancer cell migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway
    • Yang CL, Liu YY, Ma YG, et al: Curcumin blocks small cell lung cancer cell migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway. PLoS One 7: e37960, 2012.
    • (2012) PLoS One , vol.7
    • Yang, C.L.1    Liu, Y.Y.2    Ma, Y.G.3
  • 23
    • 0033887456 scopus 로고    scopus 로고
    • Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
    • Frye RA: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 273: 793-798, 2000.
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 793-798
    • Frye, R.A.1
  • 24
    • 0036599352 scopus 로고    scopus 로고
    • Regulation of lifespan by histone deacetylase
    • Chang KT and Min KT: Regulation of lifespan by histone deacetylase. Ageing Res Rev 1: 313-326, 2002.
    • (2002) Ageing Res Rev , vol.1 , pp. 313-326
    • Chang, K.T.1    Min, K.T.2
  • 25
    • 79954569231 scopus 로고    scopus 로고
    • STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation
    • Sestito R, Madonna S, Scarponi C, et al: STAT3-dependent effects of IL-22 in human keratinocytes are counterregulated by sirtuin 1 through a direct inhibition of STAT3 acetylation. FASEB J 25: 916-927, 2011.
    • (2011) FASEB J , vol.25 , pp. 916-927
    • Sestito, R.1    Madonna, S.2    Scarponi, C.3
  • 26
    • 79957582559 scopus 로고    scopus 로고
    • Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein
    • Bernier M, Paul RK, Martin-Montalvo A, et al: Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein. J Biol Chem 286: 19270-19279, 2011.
    • (2011) J Biol Chem , vol.286 , pp. 19270-19279
    • Bernier, M.1    Paul, R.K.2    Martin-Montalvo, A.3
  • 27
    • 84861193475 scopus 로고    scopus 로고
    • Comprehensive two-dimensional HepG2/cell membrane chromatography/ monolithic column/time-of-flight mass spectrometry system for screening anti-tumor components from herbal medicines
    • Chen X, Cao Y, Lv D, Zhu Z, Zhang J and Chai Y: Comprehensive two-dimensional HepG2/cell membrane chromatography/ monolithic column/time-of-flight mass spectrometry system for screening anti-tumor components from herbal medicines. J Chromatogr A 1242: 67-74, 2012.
    • (2012) J Chromatogr a , vol.1242 , pp. 67-74
    • Chen, X.1    Cao, Y.2    Lv, D.3    Zhu, Z.4    Zhang, J.5    Chai, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.