Intravenous autologous bone marrow mononuclear cells for ischemic stroke

Annals of Neurology

Volumn 70, Issue 1, 2011, Pages 59-69

  Savitz, Sean I ^a   Misra, Vivek ^a   Kasam, Mallik ^a   Juneja, Harrinder ^a   Cox Jr , Charles S ^a   Alderman, Susan ^a   Aisiku, Imo ^a   Kar, Siddhartha ^a   Gee, Adrian ^b   Grotta, James C ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b CENTER FOR CELL AND GENE THERAPY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE MARROW BIOPSY; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRANIECTOMY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; ILIAC CREST; LUNG EMBOLISM; MALE; MIDDLE CEREBRAL ARTERY; OPEN STUDY; PATIENT SAFETY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BONE MARROW TRANSPLANTATION; BRAIN ISCHEMIA; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFUSIONS, INTRAVENOUS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; STROKE; TRANSPLANTATION, AUTOLOGOUS; YOUNG ADULT;

EID: 79960826161     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.22458     Document Type: Article

References (23)

1. Bliss TM, Andres RH, Steinberg GK,. Optimizing the success of cell transplantation therapy for stroke. Neurobiol Dis 2010; 37: 275-283.
2. Baker AH, Sica V, Work LM, et al. Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia. Proc Natl Acad Sci U S A 2007; 104: 3597-3602. (Pubitemid 46364204)
3. Iihoshi S, Honmou O, Houkin K, et al. A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats. Brain Res 2004; 1007: 1-9. (Pubitemid 38520167)
4. Brenneman M, Sharma S, Harting M, et al. Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats. J Cereb Blood Flow Metab 2010; 30: 140-149.
5. Giraldi-Guimaraes A, Rezende-Lima M, Bruno FP, Mendez-Otero R,. Treatment with bone marrow mononuclear cells induces functional recovery and decreases neurodegeneration after sensorimotor cortical ischemia in rats. Brain Res 2009 Feb 9 [Epub ahead of print].
6. Abdel-Latif A, Bolli R, Tleyjeh IM, et al. Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med 2007; 167: 989-997. (Pubitemid 46835786)
7. Cox CS Jr, Baumgartner JE, Harting MT, et al. Autologous bone marrow mononuclear cell therapy for severe traumatic brain injury in children. Neurosurgery 2011; 68: 588-600.
8. Yang B, Strong R, Sharma S, et al. Therapeutic time window and dose response of autologous bone marrow mononuclear cells for ischemic stroke. J Neurosci Res 2011; 89: 833-839.
9. Gee AP, Richman S, Durett A, et al. Multicenter cell processing for cardiovascular regenerative medicine applications: the Cardiovascular Cell Therapy Research Network (CCTRN) experience. Cytotherapy 2010; 12: 684-691.
10. Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke. Stroke 2009; 40: 510-515.
11. Phan TG, Donnan GA, Davis SM, Byrnes G,. Proof-of-principle phase II MRI studies in stroke: sample size estimates from dichotomous and continuous data. Stroke 2006; 37: 2521-2525. (Pubitemid 44454672)
12. Merino JG, Latour LL, Todd JW, et al. Lesion volume change after treatment with tissue plasminogen activator can discriminate clinical responders from nonresponders. Stroke 2007; 38: 2919-2923. (Pubitemid 350035684)
13. Fischer UM, Harting MT, Jimenez F, et al. Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect. Stem Cells Dev 2009; 18: 683-692.
14. Bang OY, Lee JS, Lee PH, Lee G,. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 2005; 57: 874-882. (Pubitemid 40798626)
15. Li Y, Chopp M,. Marrow stromal cell transplantation in stroke and traumatic brain injury. Neurosci Lett 2009; 456: 120-123.
16. Kondziolka D, Wechsler L, Goldstein S, et al. Transplantation of cultured human neuronal cells for patients with stroke. Neurology 2000; 55: 565-569. (Pubitemid 30647258)
17. Kondziolka D, Steinberg GK, Wechsler L, et al. Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial. J Neurosurg 2005; 103: 38-45. (Pubitemid 43193932)
18. Savitz SI, Dinsmore J, Wu J, et al. Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study. Cerebrovasc Dis 2005; 20: 101-107. (Pubitemid 41160209)
19. Sharma S, Yang B, Strong R, et al. Bone marrow mononuclear cells protect neurons and modulate microglia in cell culture models of ischemic stroke. J Neurosci Res 2010; 88: 2869-2876.
20. Janowski M, Walczak P, Date I,. Intravenous route of cell delivery for treatment of neurological disorders: a meta-analysis of preclinical results. Stem Cells Dev 2010; 19: 5-16.
21. Nakano-Doi A, Nakagomi T, Fujikawa M, et al. Bone marrow mononuclear cells promote proliferation of endogenous neural stem cells through vascular niches after cerebral infarction. Stem Cells 2010; 28: 1292-1302.
22. Baird AE, Benfield A, Schlaug G, et al. Enlargement of human cerebral ischemic lesion volumes measured by diffusion-weighted magnetic resonance imaging. Ann Neurol 1997; 41: 581-589. (Pubitemid 27212651)
23. Lansberg MG, O'Brien MW, Tong DC, et al. Evolution of cerebral infarct volume assessed by diffusion-weighted magnetic resonance imaging. Arch Neurol 2001; 58: 613-617. (Pubitemid 32295713)