Targeted intra-arterial transplantation of stem cells to the injured CNS is more effective than intravenous administration: Engraftment is dependent on cell type and adhesion molecule expression

Cell Transplantation

Volumn 21, Issue 1, 2012, Pages 333-343

  Lundberg, Johan ^a,b   Södersten, Erik ^a   Sundström, Erik ^a   le Blanc, Katarina ^a,b   Andersson, Tommy ^a,b   Hermanson, Ola ^a   Holmin, Staffan ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Endovascular; Human mesenchymal stem cells (hMSCs); Human neural progenitor cells (hNPCs); Rat neural progenitor cells (rNPCs); Transplantation; Vascular cell adhesion molecule 1 (VCAM 1)

Indexed keywords

ALPHA4 INTEGRIN; CD18 ANTIGEN; CELL ADHESION MOLECULE; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL HOMING; CELL MIGRATION; CELL TYPE; CONTROLLED STUDY; DIAPEDESIS; ENGRAFTMENT; FEMALE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MICROARRAY ANALYSIS; NEURAL STEM CELL; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRAUMATIC BRAIN INJURY;

ANIMALS; ANTIGENS, CD11A; ANTIGENS, CD18; ARTERIES; BRAIN; BRAIN INJURIES; CELLS, CULTURED; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GRAFT SURVIVAL; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; NEURAL STEM CELLS; NEURONS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; STEM CELLS; VASCULAR CELL ADHESION MOLECULE-1; VEINS;

RATTUS;

EID: 84858123362     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368911X576036     Document Type: Article

References (31)

1. Akesson, E.; Piao, J. H.; Samuelsson, E. B.; Holmberg, L.; Kjaeldgaard, A.; Falci, S.; Sundstrom, E.; Seiger, A. Long-term culture and neuronal survival after intraspinal transplantation of human spinal cord-derived neurospheres. Physiol. Behav. 92(1-2):60-66; 2007.
2. Amar, A. P.; Zlokovic, B. V.; Apuzzo, M. L. Endovascu- lar restorative neurosurgery: A novel concept for molecular and cellular therapy of the nervous system. Neurosurgery 52(2):402-4l2; 2003.
3. Andersson, T.; Sodersten, E.; Duckworth, J. K.; Cascante, A.; Fritz, N.; Sacchetti, P.; Cervenka, I.; Bryja, V.; Hermanson, O. CXXC5 is a novel BMP4-regulated modulator of Wnt signaling in neural stem cells. J. Biol. Chem. 284(6):3672-3681; 2009.
4. Bang, O. Y.; Lee, J. S.; Lee, P. H.; Lee, G. Autologous mesenchymal stem cell transplantation in stroke patients. Ann. Neurol. 57(6):874-882; 2005.
5. Bederson, J. B.; Pitts, L. H.; Tsuji, M.; Nishimura, M. C.; Davis, R. L.; Bartkowski, H. Rat middle cerebral artery occlusion: Evaluation of the model and development of a neurologic examination. Stroke 17(3):472-476; 1986.
6. Ben-Haim, S.; Asaad, W. F.; Gale, J. T.; Eskandar, E. N. Risk factors for hemorrhage during microelectrode-guided deep brain stimulation and the introduction of an improved microelectrode design. Neurosurgery 64(4): 754-762; 2009.
7. Bliss, T. M.; Andres, R. H.; Steinberg, G. K. Optimizing the success of cell transplantation therapy for stroke. Neurobiol. Dis. 37(2):275-283; 2010.
8. Borlongan, C. V.; Hadman, M.; Sanberg, C. D.; Sanberg, P. R. Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in stroke. Stroke 35(10):2385-2389; 2004.
9. Carpenter, M. K.; Cui, X.; Hu, Z. Y.; Jackson, J.; Sherman, S.; Seiger, A.; Wahlberg, L. U. In vitro expansion of a multipotent population of human neural progenitor cells. Exp. Neurol. 158(2):265-278; 1999.
10. Clausen, F.; Lorant, T.; Lewen, A.; Hillered, L. Tlymphocyte trafficking: A novel target for neuroprotection in traumatic brain injury. J. Neurotrauma 24(8):1295-1307; 2007.
11. Feeney, D. M.; Boyeson, M. G.; Linn, R. T.; Murray, H. M.; Dail, W. G. Responses to cortical injury: I. Methodology and local effects of contusions in the rat. Brain Res. 211(1):67-77; 1981.
12. Field, M.; Witham, T. F.; Flickinger, J. C.; Kondziolka, D.; Lunsford, L. D. Comprehensive assessment of hemorrhage risks and outcomes after stereotactic brain biopsy. J. Neurosurg. 94(4):545-551; 2001.
13. Freed, C. R.; Greene, P. E.; Breeze, R. E.; Tsai, W. Y.; DuMouchel, W.; Kao, R.; Dillon, S.; Winfield, H.; Culver, S.; Trojanowski, J. Q.; Eidelberg, D.; Fahn, S. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Engl. J. Med. 344(10):710-719; 2001.
14. Gordon, P. H.; Yu, Q.; Qualls, C.; Winfield, H.; Dillon, S.; Greene, P. E.; Fahn, S.; Breeze, R. E.; Freed, C. R.; Pullman, S. L. Reaction time and movement time after embryonic cell implantation in Parkinson's disease. Arch. Neurol. 61(6):858-861; 2004.
15. Grinnemo, K. H.; Mansson-Broberg, A.; Leblanc, K.; Corbascio, M.; Wardell, E.; Siddiqui, A. J.; Hao, X.; Sylven, C.; Dellgren, G. Human mesenchymal stem cells do not differentiate into cardiomyocytes in a cardiac ischemic xenomodel. Ann. Med. 38(2):144-153; 2006.
16. Guzman, R.; De Los Angeles, A.; Cheshier, S.; Choi, R.; Hoang, S.; Liauw, J.; Schaar, B.; Steinberg, G. Intracarotid injection of fluorescence activated cell-sorted CD49d- positive neural stem cells improves targeted cell delivery and behavior after stroke in a mouse stroke model. Stroke 39(4):1300-1306; 2008.
17. Heng, B. C.; Hsu, S. H.; Cowan, C. M.; Liu, A.; Tai, J.; Chan, Y.; Sherman, W.; Basu, S. Transcatheter injection- induced changes in human bone marrow-derived mesenchymal stem cells. Cell Transplant. 18(10):1111-1121; 2009.
18. Jackson, J. S.; Golding, J. P.; Chapon, C.; Jones, W. A.; Bhakoo, K. K. Homing of stem cells to sites of inflammatory brain injury after intracerebral and intravenous administration: A longitudinal imaging study. Stem Cell Res. Ther. 1(2):17; 2010.
19. Jin, K.; Sun, Y.; Xie, L.; Mao, X. O.; Childs, J.; Peel, A.; Logvinova, A.; Banwait, S.; Greenberg, D. A. Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat. Neurobiol. Dis. 18(2):366-374; 2005.
20. Kamiya, N.; Ueda, M.; Igarashi, H.; Nishiyama, Y.; Suda, S.; Inaba, T.; Katayama, Y. Intra-arterial transplantation of bone marrow mononuclear cells immediately after reperfusion decreases brain injury after focal ischemia in rats. Life Sci. 83(11-12):433-437; 2008.
21. Kondziolka, D.; Wechsler, L.; Goldstein, S.; Meltzer, C.; Thulborn, K. R.; Gebel, J.; Jannetta, P.; DeCesare, S.; Elder, E. M.; McGrogan, M.; Reitman, M. A.; Bynum, L. Transplantation of cultured human neuronal cells for patients with stroke. Neurology 55(4):565-569; 2000.
22. Lundberg, J.; Jonsson, S.; Holmin, S. New endovascular method for transvascular exit of arteries and veins: Developed in simulator, in rat and in rabbit with full clinical integration. PLoS One 5(5):e10449; 2010.
23. Lundberg, J.; Le Blanc, K.; Soderman, M.; Andersson, T.; Holmin, S. Endovascular transplantation of stem cells to the injured rat CNS. Neuroradiology 51(10):661-667; 2009.
24. Piao, J. H.; Odeberg, J.; Samuelsson, E. B.; Kjaeldgaard, A.; Falci, S.; Seiger, A.; Sundstrom, E.; Akesson, E. Cellular composition of long-term human spinal cord- and forebrain-derived neurosphere cultures. J. Neurosci. Res. 84(3):471-482; 2006.
25. Rychlik, W.; Spencer, W. J.; Rhoads, R. E. Optimization of the annealing temperature for DNA amplification in vitro. Nucleic Acids Res. 18(21):6409-6412; 1990.
26. Savitz, S. I.; Dinsmore, J.; Wu, J.; Henderson, G. V.; Stieg, P.; Caplan, L. R. Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: A preliminary safety and feasibility study. Cerebrovasc. Dis. 20(2): 101-107; 2005.
27. Spandidos, A.; Wang, X.; Wang, H.; Seed, B. PrimerBank: A resource of human and mouse PCR primer pairs for gene expression detection and quantification. Nucleic Acids Res 38(Database issue):D792-799; 2010.
28. Stuve, O.; Gold, R.; Chan, A.; Mix, E.; Zettl, U.; Kieseier, B. C. alpha4-Integrin antagonism with natalizumab: Effects and adverse effects. J. Neurol. 255(Suppl. 6):58-65; 2008.
29. Sykova, E.; Homola, A.; Mazanec, R.; Lachmann, H.; Konradova, S. L.; Kobylka, P.; Padr, R.; Neuwirth, J.; Komrska, V.; Vavra, V.; Stulik, J.; Bojar, M. Autologous bone marrow transplantation in patients with subacute and chronic spinal cord injury. Cell Transplant. 15(8-9):675-687; 2006.
30. Wennersten, A.; Meier, X.; Holmin, S.; Wahlberg, L.; Mathiesen, T. Proliferation, migration, and differentiation of human neural stem/progenitor cells after transplantation into a rat model of traumatic brain injury. J. Neurosurg. 100(1):88-96; 2004.
31. Yu, S. J.; Soncini, M.; Kaneko, Y.; Hess, D. C.; Parolini, O.; Borlongan, C. V. Amnion: A potent graft source for cell therapy in stroke. Cell Transplant. 18(2):111-118; 2009.