Adipose tissue 11βHSD1 gene expression, βcell function and ectopic fat in obese African Americans versus Hispanics

Obesity

Volumn 22, Issue 1, 2014, Pages 14-18

  Gyllenhammer, Lauren E ^a   Alderete, Tanya L ^a   Mahurka, Swapna ^a   Allayee, Hooman ^a   Goran, Michael I ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; INSULIN;

ADULT; AFRICAN AMERICAN; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ETHNIC DIFFERENCE; FEMALE; GENE EXPRESSION; HEPATIC FAT FRACTION; HEPATOBILIARY PARAMETERS; HISPANIC; HUMAN; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LIPID STORAGE; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; SUBCUTANEOUS FAT;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADOLESCENT; ADULT; AFRICAN AMERICANS; BODY MASS INDEX; CROSS-SECTIONAL STUDIES; FASTING; FEMALE; GENE EXPRESSION REGULATION; HISPANIC AMERICANS; HUMANS; INSULIN; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; LINEAR MODELS; MALE; OBESITY; SUBCUTANEOUS FAT; YOUNG ADULT;

EID: 84892369563     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1002/oby.20571     Document Type: Article

References (20)

1. Guerrero R, Vega GL, Grundy SM, Browning JD,. Ethnic differences in hepatic steatosis: an insulin resistance paradox? Hepatology 2009; 49: 791-801.
2. Alderete TL, Toledo-Corral CM, Desai P, Weigensberg MJ, Goran MI,. Liver fat has a stronger association with risk factors for type 2 diabetes in african-americans compared to Hispanics. (Under Review at JCEM).
3. Kotelevtsev Y, Holmes MC, Burchell A, et al. 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci U S A 1997; 94: 14924-14929.
4. Morton NM, Paterson JM, Masuzaki H, et al. Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice. Diabetes 2004; 53: 931-938.
5. Lindsay RS, Wake DJ, Nair S, et al. Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. J Clin Endocrinol Metab 2003; 88: 2738-2744.
6. Makkonen J, Westerbacka J, Kolak M, et al. Increased expression of the macrophage markers and of 11beta-HSD-1 in subcutaneous adipose tissue, but not in cultured monocyte-derived macrophages, is associated with liver fat in human obesity. Int J Obes (Lond) 2007; 31: 1617-1625.
7. Tomlinson JW, Finney J, Gay C, Hughes BA, Hughes SV, Stewart PM,. Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity. Diabetes 2008; 57: 2652-2660.
8. Veilleux A, Laberge PY, Morency J, Noel S, Luu-The V, Tchernof A,. Expression of genes related to glucocorticoid action in human subcutaneous and omental adipose tissue. J Steroid Biochem Mol Biol 2010; 122: 28-34.
9. Le KA, Mahurkar S, Alderete TL, et al. Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-kappaB stress pathway. Diabetes 2011; 60: 2802-2809.
10. Cutfield WS, Bergman RN, Menon RK, Sperling MA,. The modified minimal model: application to measurement of insulin sensitivity in children. J Clin Endocrinol Metab 1990; 70: 1644-1650.
11. Baron RM, Kenny DA,. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol 1986; 51: 1173-1182.
12. Donnelly KL, Smith CI, Schwarzenberg SJ, Jessurun J, Boldt MD, Parks EJ,. Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease. J Clin Invest 2005; 115: 1343-1351.
13. Nielsen S, Guo Z, Johnson CM, Hensrud DD, Jensen MD,. Splanchnic lipolysis in human obesity. J Clin Invest 2004; 113: 1582-1588.
14. Biddinger SB, Hernandez-Ono A, Rask-Madsen C, et al. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab 2008; 7: 125-134.
15. Morton NM,. Obesity and corticosteroids: 11beta-hydroxysteroid type 1 as a cause and therapeutic target in metabolic disease. Mol Cell Endocrinol 2010; 316: 154-164.
16. Candia R, Riquelme A, Baudrand R, et al. Overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in visceral adipose tissue and portal hypercortisolism in non-alcoholic fatty liver disease. Liver Int 2012; 32: 392-399.
17. Hazlehurst JM, Gathercole LL, Nasiri M, et al. Glucocorticoids fail to cause insulin resistance in human subcutaneous adipose tissue in vivo. J Clin Endocrinol Metab 2013.
18. Gathercole LL, Morgan SA, Bujalska IJ, Stewart PM, Tomlinson JW,. Short- and long-term glucocorticoid treatment enhances insulin signalling in human subcutaneous adipose tissue. Nutr Diabetes 2011; 1: e3.
19. Divertie GD, Jensen MD, Miles JM,. Stimulation of lipolysis in humans by physiological hypercortisolemia. Diabetes 1991; 40: 1228-1232.
20. Kim SP, Catalano KJ, Hsu IR, Chiu JD, Richey JM, Bergman RN,. Nocturnal free fatty acids are uniquely elevated in the longitudinal development of diet-induced insulin resistance and hyperinsulinemia. Am J Physiol Endocrinol Metab 2007; 292: E1590-E1598.