Managing pulmonary embolism from presentation to extended treatment

Thrombosis Research

Volumn 133, Issue 2, 2014, Pages 139-148

  Cohen, Alexander T ^a   Dobromirski, Mark ^a   Gurwith, Meredith M P ^a  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Acute; Anticoagulant; Long term; Pulmonary embolism; Treatment

Indexed keywords

ANTICOAGULANT AGENT; ANTIVITAMIN K; APIXABAN; DABIGATRAN; EDOXABAN; ENOXAPARIN; FIBRINOLYTIC AGENT; RIVAROXABAN;

ANTICOAGULANT THERAPY; BLEEDING; DEEP VEIN THROMBOSIS; FIBRINOLYTIC THERAPY; HIGH RISK PATIENT; HUMAN; LUNG EMBOLISM; PATIENT MONITORING; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SUDDEN DEATH; THROMBECTOMY; THROMBOSIS; VENOUS THROMBOEMBOLISM;

ACC; ACCP; ACETYLSALICYLIC ACID; ACUTE; AMERICAN COLLEGE OF CARDIOLOGY; AMERICAN COLLEGE OF CHEST PHYSICIANS; ANTICOAGULANT; ASA; BID; CHEST X-RAY; CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION; CI; COMPRESSION ULTRASONOGRAPHY; COMPUTED TOMOGRAPHY; COMPUTED TOMOGRAPHY PULMONARY ANGIOGRAPHY; CONFIDENCE INTERVAL; CRCL; CREATININE CLEARANCE; CT; CTPA; CTPH; CUS; CXR; DEEP VEIN THROMBOSIS; DVT; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESC; EUROPEAN SOCIETY OF CARDIOLOGY; HAZARD RATIO; HR; I.V; INFERIOR VENA CAVA; INR; INTERNATIONAL NORMALISED RATIO; INTRAVENOUS; IVC; LMWH; LONG-TERM; LOW MOLECULAR WEIGHT HEPARIN; OAC; OD; ONCE DAILY; ORAL ANTICOAGULANT; PE; PESI; PULMONARY EMBOLISM; PULMONARY EMBOLISM SEVERITY INDEX; RECOMBINANT TISSUE PLASMINOGEN ACTIVATOR; RELATIVE RISK; RIGHT VENTRICULAR; RR; RTPA; RV; S.C; SUBCUTANEOUS; TREATMENT; TWICE DAILY; UFH; UNFRACTIONATED HEPARIN; V/Q; VENOUS THROMBOEMBOLISM; VENTILATION-PERFUSION SCINTIGRAPHY; VITAMIN K ANTAGONIST; VKA; VTE;

ANIMALS; ANTICOAGULANTS; HUMANS; PULMONARY ARTERY; PULMONARY EMBOLISM; THROMBOLYTIC THERAPY;

EID: 84892366652     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2013.09.040     Document Type: Review

References (98)

1. A.T. Cohen, G. Agnelli, F.A. Anderson, J.I. Arcelus, D. Bergqvist, and J.G. Brecht et al. Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality Thromb Haemost 98 2007 756 764
2. C. Becattini, G. Agnelli, R. Pesavento, M. Silingardi, R. Poggio, and M.R. Taliani et al. Incidence of chronic thromboembolic pulmonary hypertension after a first episode of pulmonary embolism Chest 130 2006 172 175
3. M. Miniati, S. Monti, M. Bottai, E. Scoscia, C. Bauleo, and L. Tonelli et al. Survival and restoration of pulmonary perfusion in a long-term follow-up of patients after acute pulmonary embolism Medicine (Baltimore) 85 2006 253 262
4. D. Poli, and M. Miniati The incidence of recurrent venous thromboembolism and chronic thromboembolic pulmonary hypertension following a first episode of pulmonary embolism Curr Opin Pulm Med 17 2011 392 397
5. V. Pengo, A.W. Lensing, M.H. Prins, A. Marchiori, B.L. Davidson, and F. Tiozzo et al. Incidence of chronic thromboembolic pulmonary hypertension after pulmonary embolism N Engl J Med 350 2004 2257 2264
6. D.N. Mohr, M.D. Silverstein, J.A. Heit, T.M. Petterson, W.M. O'Fallon, and L.J. Melton The venous stasis syndrome after deep venous thrombosis or pulmonary embolism: a population-based study Mayo Clin Proc 75 2000 1249 1256
7. S.R. Kahn, and J.S. Ginsberg Relationship between deep venous thrombosis and the postthrombotic syndrome Arch Intern Med 164 2004 17 26
8. G.H. Guyatt, E.A. Akl, M. Crowther, D.D. Gutterman, H.J. Schünemann, and American College of Chest Physicians Antithrombotic Therapy and Prevention of Thrombosis Panel Executive summary: antithrombotic therapy and prevention, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines Chest 141 2012 7S 47S
9. J.A. Heit, M.D. Silverstein, D.N. Mohr, T.M. Petterson, C.M. Lohse, and W.M. O'Fallon et al. The epidemiology of venous thromboembolism in the community Thromb Haemost 86 2001 452 463
10. A. Torbicki, A. Perrier, S. Konstantinides, G. Agnelli, N. Galiè, and P. Pruszczyk et al. Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC) Eur Heart J 29 2008 2276 2315
11. D.A. Sandler, and J.F. Martin Autopsy proven pulmonary embolism in hospital patients: are we detecting enough deep vein thrombosis? J R Soc Med 82 1989 203 205
12. P.D. Stein, H.A. Saltzman, and J.G. Weg Clinical characteristics of patients with acute pulmonary embolism Am J Cardiol 68 1991 1723 1724
13. M. Miniati, R. Prediletto, B. Formichi, C. Marini, G. Di Ricco, and L. Tonelli et al. Accuracy of clinical assessment in the diagnosis of pulmonary embolism Am J Respir Crit Care Med 159 1999 864 871
14. M. Miniati, C. Cenci, S. Monti, and D. Poli Clinical presentation of acute pulmonary embolism: survey of 800 cases PLoS One 7 2012 e30891
15. P.D. Stein, A. Beemath, F. Matta, J.G. Weg, R.D. Yusen, and C.A. Hales et al. Clinical characteristics of patients with acute pulmonary embolism: data from PIOPED II Am J Med 120 2007 871 879
16. S.R. Desai Unsuspected pulmonary embolism on CT scanning: yet another headache for clinicians? Thorax 62 2007 470 472
17. S. Soler, C. Delgado, A. Ballaz, E. Cisneros, R. Maly, and D. Bablis et al. Unsuspected pulmonary embolism in patients with cancer Thromb Res 129 2012 S16 S19 [Suppl.]
18. C.G. Cronin, D.G. Lohan, M. Keane, C. Roche, and J.M. Murphy Prevalence and significance of asymptomatic venous thromboembolic disease found on oncologic staging CT AJR Am J Roentgenol 189 2007 162 170
19. R.A. Douma, M.G. Kok, L.M. Verberne, P.W. Kamphuisen, and H.R. Büller Incidental venous thromboembolism in cancer patients: prevalence and consequence Thromb Res 125 2010 e306 e309
20. M.V. Huisman, H.R. Büller, J.W. ten Cate, E.A. van Royen, J. Vreeken, and M.J. Kersten et al. Unexpected high prevalence of silent pulmonary embolism in patients with deep venous thrombosis Chest 95 1989 498 502
21. I. Tzoran, G. Saharov, B. Brenner, D. Delsart, P. Román, and A. Visoná et al. Silent pulmonary embolism in patients with proximal deep vein thrombosis in the lower limbs J Thromb Haemost 10 2012 564 571
22. K.E. Wood Major pulmonary embolism: review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolism Chest 121 2002 877 905
23. J.C. Matthews, and V. McLaughlin Acute right ventricular failure in the setting of acute pulmonary embolism or chronic pulmonary hypertension: a detailed review of the pathophysiology, diagnosis, and management Curr Cardiol Rev 4 2008 49 59
24. D. Aujesky, D.S. Obrosky, R.A. Stone, T.E. Auble, A. Perrier, and J. Cornuz et al. Derivation and validation of a prognostic model for pulmonary embolism Am J Respir Crit Care Med 172 2005 1041 1046
25. D. Aujesky, P.M. Roy, C.P. Le Manach, F. Verschuren, G. Meyer, and D.S. Obrosky et al. Validation of a model to predict adverse outcomes in patients with pulmonary embolism Eur Heart J 27 2006 476 481
26. D. Aujesky, A. Perrier, P.M. Roy, R.A. Stone, J. Cornuz, and G. Meyer et al. Validation of a clinical prognostic model to identify low-risk patients with pulmonary embolism J Intern Med 261 2007 597 604
27. D. Jiménez, D. Aujesky, L. Moores, V. Gómez, J.L. Lobo, and F. Uresandi et al. Simplification of the Pulmonary Embolism Severity Index for prognostication in patients with acute symptomatic pulmonary embolism Arch Intern Med 170 2010 1383 1389
28. D. Jiménez, D. Aujesky, G. Díaz, M. Monreal, R. Otero, and D. Martí et al. Prognostic significance of deep vein thrombosis in patients presenting with acute symptomatic pulmonary embolism Am J Respir Crit Care Med 181 2010 983 991
29. P.S. Wells, D.R. Anderson, M. Rodger, J.S. Ginsberg, C. Kearon, and M. Gent et al. Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer Thromb Haemost 83 2000 416 420
30. J. Wicki, T.V. Perneger, A.F. Junod, H. Bounameaux, and A. Perrier Assessing clinical probability of pulmonary embolism in the emergency ward: a simple score Arch Intern Med 161 2001 92 97
31. F.A. Klok, I.C. Mos, M. Nijkeuter, M. Righini, A. Perrier, and G. Le Gal et al. Simplification of the revised Geneva score for assessing clinical probability of pulmonary embolism Arch Intern Med 168 2008 2131 2136
32. M. Miniati, M. Bottai, S. Monti, M. Salvadori, L. Serasini, and M. Passera Simple and accurate prediction of the clinical probability of pulmonary embolism Am J Respir Crit Care Med 178 2008 290 294
33. J.A. Kline, A.M. Mitchell, C. Kabrhel, P.B. Richman, and D.M. Courtney Clinical criteria to prevent unnecessary diagnostic testing in emergency department patients with suspected pulmonary embolism J Thromb Haemost 2 2004 1247 1255
34. G. Le Gal, M. Righini, P.M. Roy, O. Sanchez, D. Aujesky, and H. Bounameaux et al. Prediction of pulmonary embolism in the emergency department: the revised Geneva score Ann Intern Med 144 2006 165 171
35. S.J. Wolf, T.R. McCubbin, K.M. Feldhaus, J.P. Faragher, and D.M. Adcock Prospective validation of Wells Criteria in the evaluation of patients with suspected pulmonary embolism Ann Emerg Med 44 2004 503 510
36. P.S. Wells, D.R. Anderson, M. Rodger, I. Stiell, J.F. Dreyer, and D. Barnes et al. Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and D-dimer Ann Intern Med 135 2001 98 107
37. K.S. Yap, V. Kalff, A. Turlakow, and M.J. Kelly A prospective reassessment of the utility of the Wells score in identifying pulmonary embolism Med J Aust 187 2007 333 336
38. R.A. Douma, I.C. Mos, P.M. Erkens, T.A. Nizet, M.F. Durian, and M.M. Hovens et al. Performance of 4 clinical decision rules in the diagnostic management of acute pulmonary embolism: a prospective cohort study Ann Intern Med 154 2011 709 718
39. A. Elias, A. Cazanave, M. Elias, V. Chabbert, H. Juchet, and H. Paradis et al. Diagnostic management of pulmonary embolism using clinical assessment, plasma D-dimer assay, complete lower limb venous ultrasound and helical computed tomography of pulmonary arteries. A multicentre clinical outcome study Thromb Haemost 93 2005 982 988
40. A. Perrier, P.M. Roy, O. Sanchez, G. Le Gal, G. Meyer, and A.L. Gourdier et al. Multidetector-row computed tomography in suspected pulmonary embolism N Engl J Med 352 2005 1760 1768
41. A. van Belle, H.R. Büller, M.V. Huisman, P.M. Huisman, K. Kaasjager, and P.W. Kamphuisen et al. Effectiveness of managing suspected pulmonary embolism using an algorithm combining clinical probability, D-dimer testing, and computed tomography JAMA 295 2006 172 179
42. W. Ghanima, V. Almaas, S. Aballi, C. Dörje, B.E. Nielssen, and L.O. Holmen et al. Management of suspected pulmonary embolism (PE) by D-dimer and multi-slice computed tomography in outpatients: an outcome study J Thromb Haemost 3 2005 1926 1932
43. A. Perrier, N. Howarth, D. Didier, P. Loubeyre, P.F. Unger, and P. de Moerloose et al. Performance of helical computed tomography in unselected outpatients with suspected pulmonary embolism Ann Intern Med 135 2001 88 97
44. M.J. Van Strijen, W. De Monye, G.J. Kieft, P.M. Pattynama, M.H. Prins, and M.V. Huisman Accuracy of single-detector spiral CT in the diagnosis of pulmonary embolism: a prospective multicenter cohort study of consecutive patients with abnormal perfusion scintigraphy J Thromb Haemost 3 2005 17 25
45. The PIOPED Investigators Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the Prospective Investigation of Pulmonary Embolism Ddiagnosis (PIOPED) JAMA 263 1990 2753 2759
46. P.S. Wells, J.S. Ginsberg, D.R. Anderson, C. Kearon, M. Gent, and A.G. Turpie et al. Use of a clinical model for safe management of patients with suspected pulmonary embolism Ann Intern Med 129 1998 997 1005
47. P.M. Roy, I. Colombet, P. Durieux, G. Chatellier, H. Sors, and G. Meyer Systematic review and meta-analysis of strategies for the diagnosis of suspected pulmonary embolism BMJ 331 2005 259
48. A. Perrier, S. Desmarais, M.J. Miron, P. de Moerloose, R. Lepage, and D. Slosman et al. Non-invasive diagnosis of venous thromboembolism in outpatients Lancet 353 1999 190 195
49. A. Elias, D. Colombier, G. Victor, M. Elias, C. Arnaud, and H. Juchet et al. Diagnostic performance of complete lower limb venous ultrasound in patients with clinically suspected acute pulmonary embolism Thromb Haemost 91 2004 187 195
50. C. Kearon, J.S. Ginsberg, and J. Hirsh The role of venous ultrasonography in the diagnosis of suspected deep venous thrombosis and pulmonary embolism Ann Intern Med 129 1998 1044 1049
51. A. Perrier, and H. Bounameaux Ultrasonography of leg veins in patients suspected of having pulmonary embolism Ann Intern Med 128 1998 243 245
52. G. Le Gal, M. Righini, O. Sanchez, P.M. Roy, M. Baba-Ahmed, and A. Perrier et al. A positive compression ultrasonography of the lower limb veins is highly predictive of pulmonary embolism on computed tomography in suspected patients Thromb Haemost 95 2006 963 966
53. P.D. Stein, C. Athanasoulis, A. Alavi, R.H. Greenspan, C.A. Hales, and H.A. Saltzman et al. Complications and validity of pulmonary angiography in acute pulmonary embolism Circulation 85 1992 462 468
54. E.J. van Beek, E.M. Brouwers, B. Song, A.H. Bongaerts, and M. Oudkerk Lung scintigraphy and helical computed tomography for the diagnosis of pulmonary embolism: a meta-analysis Clin Appl Thromb Hemost 7 2001 87 92
55. J.A. Kline, M.M. Hogg, D.M. Courtney, C.D. Miller, A.E. Jones, and H.A. Smithline D-dimer threshold increase with pretest probability unlikely for pulmonary embolism to decrease unnecessary computerized tomographic pulmonary angiography J Thromb Haemost 10 2012 572 581
56. C.G. Elliott, S.Z. Goldhaber, L. Visani, and M. DeRosa Chest radiographs in acute pulmonary embolism. Results from the International Cooperative Pulmonary Embolism Registry Chest 118 2000 33 38
57. P.D. Stein, S.Z. Goldhaber, J.W. Henry, and A.C. Miller Arterial blood gas analysis in the assessment of suspected acute pulmonary embolism Chest 109 1996 78 81
58. M.A. Rodger, M. Carrier, G.N. Jones, P. Rasuli, F. Raymond, and H. Djunaedi et al. Diagnostic value of arterial blood gas measurement in suspected pulmonary embolism Am J Respir Crit Care Med 162 2000 2105 2108
59. A. Geibel, M. Zehender, W. Kasper, M. Olschewski, C. Klima, and S.V. Konstantinides Prognostic value of the ECG on admission in patients with acute major pulmonary embolism Eur Respir J 25 2005 843 848
60. W. Kasper, S. Konstantinides, A. Geibel, N. Tiede, T. Krause, and H. Just Prognostic significance of right ventricular afterload stress detected by echocardiography in patients with clinically suspected pulmonary embolism Heart 77 1997 346 349
61. S. Grifoni, I. Olivotto, P. Cecchini, F. Pieralli, A. Camaiti, and G. Santoro et al. Short-term clinical outcome of patients with acute pulmonary embolism, normal blood pressure, and echocardiographic right ventricular dysfunction Circulation 101 2000 2817 2822
62. M. Miniati, S. Monti, L. Pratali, G. Di Ricco, C. Marini, and B. Formichi et al. Value of transthoracic echocardiography in the diagnosis of pulmonary embolism: results of a prospective study in unselected patients Am J Med 110 2001 528 535
63. A. Perrier, C. Tamm, P.F. Unger, R. Lerch, and J. Sztajzel Diagnostic accuracy of Doppler-echocardiography in unselected patients with suspected pulmonary embolism Int J Cardiol 65 1998 101 109
64. R.R. Rudoni, R.E. Jackson, G.W. Godfrey, A.X. Bonfiglio, M.E. Hussey, and A.M. Hauser Use of two-dimensional echocardiography for the diagnosis of pulmonary embolus J Emerg Med 16 1998 5 8
65. C. Kearon, E.A. Akl, A.J. Comerota, P. Prandoni, H. Bounameaux, and S.Z. Goldhaber et al. Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines Chest 141 2012 e419S e494S
66. S. Wan, D.J. Quinlan, G. Agnelli, and J.W. Eikelboom Thrombolysis compared with heparin for the initial treatment of pulmonary embolism: a meta-analysis of the randomized controlled trials Circulation 110 2004 744 749
67. N. Meneveau, M.F. Seronde, M.C. Blonde, P. Legalery, K. Didier-Petit, and F. Briand et al. Management of unsuccessful thrombolysis in acute massive pulmonary embolism Chest 129 2006 1043 1050
68. M. Sharifi, C. Bay, L. Skrocki, F. Rahimi, and M. Mehdipour Moderate pulmonary embolism treated with thrombolysis (from the "MOPETT" Trial) Am J Cardiol 111 2013 273 277
69. N. Kucher, P. Boekstegers, E. Blessing, C. Kupatt, J. Beyer-Westendorf, and T. Heitzer et al. The ULTIMA trial: a prospective, randomized, controlled study of ultrasound accelerated thrombolysis for the treatment of acute pulmonary embolism J Am Coll Cardiol 61 2013 Abstract 2667-8
70. World's first pulmonary embolism trial comparing endovascular therapy to standard of care Available at: http://www.tctmd.com/show.aspx?id= 118137&AspxAutoDetectCookieSupport=1 2013
71. J. Kline, J. Hernandez, C. Kabrhel, D.M. Courtney, A.E. Jones, and K. Nordenholtz et al. Randomized trial of tenecteplase or placebo with low molecular weight heparin for acute submassive pulmonary embolism: assessment of patient-oriented cardiopulmonary outcomes at three months J Am Coll Cardiol 61 2013 Abstract 932-8
72. The Steering Committee Single-bolus tenecteplase plus heparin compared with heparin alone for normotensive patients with acute pulmonary embolism who have evidence of right ventricular dysfunction and myocardial injury: rationale and design of the Pulmonary Embolism Thrombolysis (PEITHO) trial Am Heart J 163 2012 33 38
73. S. Konstantinides, G. Meyer, T. Danays, E. Vicaut, and The PEITHO Investigators Single-bolus tenecteplase plus heparin compared with heparin alone for normotensive patients with acute pulmonary embolism who have evidence of right ventricular dysfunction and myocardial injury: the Pulmonary Embolism Thrombolysis (PEITHO) study J Am Coll Cardiol 61 2013 Abstract 304-15
74. ® Summary of Product Characteristics Available at: http://www.ema.europa.eu/docs/en-GB/document- library/EPAR-Product-Information/human/000944/WC500057108.pdf 2013
75. ® Prescribing Information Available at: http://www.accessdata.fda.gov/drugsatfda-docs/label/ 2013/202439s008lbl.pdf 2013
76. The EINSTEIN-PE Investigators Oral rivaroxaban for the treatment of symptomatic pulmonary embolism N Engl J Med 366 2012 1287 1297
77. The EINSTEIN Investigators Oral rivaroxaban for symptomatic venous thromboembolism N Engl J Med 363 2010 2499 2510
78. G. Agnelli, H.R. Buller, A. Cohen, M. Curto, A.S. Gallus, and M. Johnson et al. Oral apixaban for the treatment of acute venous thromboembolism N Engl J Med 369 2013 799 808
79. S. Schulman, C. Kearon, A.K. Kakkar, P. Mismetti, S. Schellong, and H. Eriksson et al. Dabigatran versus warfarin in the treatment of acute venous thromboembolism N Engl J Med 361 2009 2342 2352
80. The Hokusai-VTE Investigators Edoxaban versus warfarin for the treatment of symptomatic venous thromboembolism N Engl J Med 369 2013 1406 1415
81. S. Eichinger, A. Weltermann, E. Minar, M. Stain, V. Schonauer, and B. Schneider et al. Symptomatic pulmonary embolism and the risk of recurrent venous thromboembolism Arch Intern Med 164 2004 92 96
82. J.D. Douketis, C. Kearon, S. Bates, E.K. Duku, and J.S. Ginsberg Risk of fatal pulmonary embolism in patients with treated venous thromboembolism JAMA 279 1998 458 462
83. T. Baglin, J. Douketis, A. Tosetto, M. Marcucci, M. Cushman, and P. Kyrle et al. Does the clinical presentation and extent of venous thrombosis predict likelihood and type of recurrence? A patient level meta-analysis J Thromb Haemost 8 2010 2436 2442
84. J.A. Heit Predicting the risk of venous thromboembolism recurrence Am J Hematol 87 Suppl. 1 2012 S63 S67
85. S. Schulman, H. Eriksson, S.Z. Goldhaber, A.K. Kakkar, C. Kearon, and M. Kvamme et al. Dabigatran or warfarin for extended maintenance therapy of venous thromboembolism J Thromb Haemost 9 Suppl. 2 2011 733 Abstract O-TH-033
86. S. Schulman, D. Baanstra, H. Eriksson, S.Z. Goldhaber, A.K. Kakkar, and C. Kearon et al. Dabigatran versus placebo for extended maintenance therapy of venous thromboembolism J Thromb Haemost 9 Suppl. 2 2011 22 Abstract O-MO-037
87. G. Agnelli, H.R. Buller, A. Cohen, M. Curto, A.S. Gallus, and M. Johnson et al. Apixaban for extended treatment of venous thromboembolism N Engl J Med 368 2013 699 708
88. C. Becattini, G. Agnelli, A. Schenone, S. Eichinger, E. Bucherini, and M. Silingardi et al. Aspirin for preventing the recurrence of venous thromboembolism N Engl J Med 366 2012 1959 1967
89. T.A. Brighton, J.W. Eikelboom, K. Mann, R. Mister, A. Gallus, and P. Ockelford et al. Low-dose aspirin for preventing recurrent venous thromboembolism N Engl J Med 367 2012 1979 1987
90. P. Monagle, A.K. Chan, N.A. Goldenberg, R.N. Ichord, J.M. Journeycake, and U. Nowak-Gottl et al. Antithrombotic therapy in neonates and children: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines Chest 141 2012 e737S e801S
91. V.J. Willey, M.F. Bullano, O. Hauch, M. Reynolds, G. Wygant, and L. Hoffman et al. Management patterns and outcomes of patients with venous thromboembolism in the usual community practice setting Clin Ther 26 2004 1149 1159
92. S.B. Deitelzweig, J. Lin, C. Kreilick, M. Hussein, and D. Battleman Warfarin therapy in patients with venous thromboembolism: patterns of use and predictors of clinical outcomes Adv Ther 27 2010 623 633
93. C. Heneghan, A. Ward, R. Perera, C. Bankhead, A. Fuller, and R. Stevens et al. Self-monitoring of oral anticoagulation: systematic review and meta-analysis of individual patient data Lancet 379 2012 322 334
94. L.R. Goodman Small pulmonary emboli: what do we know? Radiology 234 2005 654 658
95. P.D. Stein, L.R. Goodman, R.D. Hull, J.E. Dalen, and F. Matta Diagnosis and management of isolated subsegmental pulmonary embolism: review and assessment of the options Clin Appl Thromb Hemost 18 2012 20 26
96. B.I. Eriksson, D.J. Quinlan, and J.W. Eikelboom Novel oral Factor Xa and thrombin inhibitors in the management of thromboembolism Annu Rev Med 62 2011 41 57
97. D.M. Siegal, and M.A. Crowther Acute management of bleeding in patients on novel oral anticoagulants Eur Heart J 34 2013 489 498
98. J.H. Levy, D. Faraoni, J.L. Spring, J.D. Douketis, and C.M. Samama Managing new oral anticoagulants in the perioperative and intensive care unit setting Anesthesiology 118 2013 1466 1474