Advantages and pitfalls of combining intravenous antithrombin with nebulized heparin and tissue plasminogen activator in acute respiratory distress syndrome

Journal of Trauma and Acute Care Surgery

Volumn 76, Issue 1, 2014, Pages 126-133

  Rehberg, Sebastian ^a,e   Yamamoto, Yusuke ^a   Sousse, Linda E ^a   Jonkam, Collette ^a   Cox, Robert A ^b,c   Prough, Donald S ^a   Enkhbaatar, Perenlei ^a,d  

^a Department of Anesthesiology   (United States)

^b Department of Pathology ^*  (United States)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^d UNIVERSITY OF MÜNSTER   (Germany)

^e UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

Acute lung injury; Anticoagulants; Burn and smoke inhalation; Vascular leakage

Indexed keywords

ALTEPLASE; ANTITHROMBIN; HEPARIN; PLASMA PROTEIN; RECOMBINANT PROTEIN; SODIUM CHLORIDE; TISSUE PLASMINOGEN ACTIVATOR;

ADULT RESPIRATORY DISTRESS SYNDROME; AIRWAY OBSTRUCTION; AIRWAY PRESSURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTERIAL OXYGEN SATURATION; ARTICLE; ARTIFICIAL VENTILATION; BLOOD CARBON DIOXIDE TENSION; BLOOD OXYGEN TENSION; BODY SURFACE; BREATHING RATE; CLINICAL PROTOCOL; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; FEMALE; FLUID RESUSCITATION; HEART INDEX; HEART RATE; HEART STROKE VOLUME; HISTOLOGY; LEUKOCYTE ACTIVATION; LUNG ARTERY PRESSURE; LUNG BURN; LUNG EDEMA; LUNG GAS EXCHANGE; LYMPH FLOW; MICTURITION; NEBULIZATION; NEUTROPHIL COUNT; NITROSATIVE STRESS; NONHUMAN; OVINE MODEL; OXYGENATION; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTHROMBIN TIME; PULMONARY ARTERY OCCLUSION PRESSURE; PULMONARY SHUNT;

EID: 84892182274     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e3182ab0785     Document Type: Article

References (31)

1. Hofstra JJ, Haitsma JJ, Juffermans NP, Levi M, Schultz MJ. The role of bronchoalveolar hemostasis in the pathogenesis of acute lung injury. Semin Thromb Hemost. 2008;34(5):475-484.
2. Hofstra JJ, Vlaar AP, Knape P, Mackie DP, Determann RM, Choi G, van der Poll T, Levi M, Schultz MJ. Pulmonary activation of coagulation and inhibition of fibrinolysis after burn injuries and inhalation trauma. J Trauma. 2011;70(6):1389-1397.
3. Schultz MJ, Haitsma JJ, Zhang H, Slutsky AS. Pulmonary coagulopathy as a new target in therapeutic studies of acute lung injury or pneumoniaVa review. Crit Care Med. 2006;34(3):871-877.
4. Rehberg S, Traber DL, Enkhbaatar P. Update on antithrombin for the treatment of burn and smoke inhalation injury. In: Vincent JL, ed. Yearbook of Intensive Care and Emergency Medicine. Berlin, Heidelberg, New York: Springer; 2010:285-296.
5. MacLaren R, Stringer KA. Emerging role of anticoagulants and fibrinolytics in the treatment of acute respiratory distress syndrome. Pharmacotherapy. 2007;27(6):860-873.
6. Tuinman PR, Dixon B, Levi M, Juffermans NP, Schultz MJ. Nebulized anticoagulants for acute lung injuryVa systematic review of preclinical and clinical investigations. Crit Care. 2012;16(2):R70.
7. Rehberg S, Enkhbaatar P, Traber DL. Anticoagulant therapy in acute lung injury: a useful tool without proper operating instruction? Crit Care. 2008; 12(5):179.
8. Enkhbaatar P, Esechie A,Wang J, Cox RA, Nakano Y, Hamahata A, Lange M, Traber LD, Prough DS, Herndon DN, et al. Combined anticoagulants ameliorate acute lung injury in sheep after burn and smoke inhalation. Clin Sci (Lond). 2008;114(4):321-329.
9. Rehberg S, Maybauer MO, Enkhbaatar P, Maybauer DM, Yamamoto Y, Traber DL. Pathophysiology, management, and treatment of smoke inhalation injury. Expert Rev Resp Med. 2009;3(3):283-297.
10. Rehberg S, Yamamoto Y, Sousse LE, Jonkam C, Zhu Y, Traber LD, Cox RA, Prough DS, Traber DL, Enkhbaatar P. Antithrombin attenuates vascular leackage via inhibiting neutrophil activation in acute lung injury. Crit Care Med. 2013. [Epub ahead of print].
11. Dixon B, Schultz MJ, Smith R, Fink JB, Santamaria JD, Campbell DJ. Nebulized heparin is associated with fewer days of mechanical ventilation in critically ill patients: a randomized controlled trial. Crit Care. 2010; 14(5):R180.
12. Dixon B, Santamaria JD, Campbell DJ. A phase 1 trial of nebulised heparin in acute lung injury. Crit Care. 2008;12(3):R64.
13. Enkhbaatar P, Murakami K, Cox R, Westphal M, Morita N, Brantley K, Burke A, Hawkins H, Schmalstieg F, Traber L, et al. Aerosolized tissue plasminogen inhibitor improves pulmonary function in sheep with burn and smoke inhalation. Shock. 2004;22(1):70-75.
14. Hofstra JJ, Cornet AD, Declerck PJ, Dixon B, Aslami H, Vlaar AP, Roelofs JJ, van der Poll T, Levi M, Schultz MJ. Nebulized fibrinolytic agents improve pulmonary fibrinolysis but not inflammation in rat models of direct and indirect acute lung injury. PLoS One. 2013;8(2):e55262.
15. Enkhbaatar P, Connelly R, Wang J, Nakano Y, Lange M, Hamahata A, Horvath E, Szabo C, Jaroch S, Holscher P, et al. Inhibition of neuronal nitric oxide synthase in ovine model of acute lung injury. Crit Care Med. 2009;37(1):208-214.
16. Westphal M, Enkhbaatar P, Schmalstieg FC, Kulp GA, Traber LD, Morita N, Cox RA, Hawkins HK, Westphal-Varghese BB, Rudloff HE, et al. Neuronal nitric oxide synthase inhibition attenuates cardiopulmonary dysfunctions after combined burn and smoke inhalation injury in sheep. Crit Care Med. 2008;36(4):1196-1204.
17. Baxter CR, Shires T. Physiological response to crystalloid resuscitation of severe burns. Ann N Y Acad Sci. 1968;150(3):874-894.
18. Ferguson ND, Fan E, Camporota L, Antonelli M, Anzueto A, Beale R, Brochard L, Brower R, Esteban A, Gattinoni L, et al. The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med. 2012;38(10):1573-1582.
19. Cox RA, Burke AS, Soejima K, Murakami K, Katahira J, Traber LD, Herndon DN, Schmalstieg FC, Traber DL, Hawkins HK. Airway obstruction in sheep with burn and smoke inhalation injuries. Am J Respir Cell Mol Biol. 2003;29(3 Pt 1):295-302.
20. PearceML, Yamashita J, Beazell J.Measurement of pulmonary edema. Circ Res. 1965;16:482-488.
21. Enkhbaatar P, Cox RA, Traber LD, Westphal M, Aimalohi E, Morita N, Prough DS, Herndon DN, Traber DL. Aerosolized anticoagulants ameliorate acute lung injury in sheep after exposure to burn and smoke inhalation. Crit Care Med. 2007;35(12):2805-2810.
22. Lavrentieva A, Kontakiotis T, Bitzani M, Papaioannou-Gaki G, Parlapani A, Thomareis O, Tsotsolis N, Giala MA. Early coagulation disorders after severe burn injury: impact on mortality. Intensive Care Med. 2008; 34(4):700-706.
23. Hofstra JJ, Vlaar AP, Cornet AD, Dixon B, Roelofs JJ, Choi G, van der Poll T, Levi M, Schultz MJ. Nebulized anticoagulants limit pulmonary coagulopathy, but not inflammation, in a model of experimental lung injury. J Aerosol Med Pulm Drug Deliv. 2010;23(2):105-111.
24. Murakami K, McGuire R, Cox RA, Jodoin JM, Bjertnaes LJ, Katahira J, Traber LD, Schmalstieg FC, Hawkins HK, Herndon DN, et al. Heparin nebulization attenuates acute lung injury in sepsis following smoke inhalation in sheep. Shock. 2002;18(3):236-241.
25. Miller AC, Rivero A, Ziad S, Smith DJ, Elamin EM. Influence of nebulized unfractionated heparin and N-acetylcysteine in acute lung injury after smoke inhalation injury. J Burn Care Res. 2009;30(2):249-256.
26. Murakami K, Enkhbaatar P, Shimoda K, Mizutani A, Cox RA, Schmalstieg FC, Jodoin JM, Hawkins HK, Traber LD, Traber DL. High-dose heparin fails to improve acute lung injury following smoke inhalation in sheep. Clin Sci (Lond). 2003;104(4):349-356.
27. Olson ST, Bjork I, Sheffer R, Craig PA, Shore JD, Choay J. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement. J Biol Chem. 1992;267(18):12528-12538.
28. Justus AC, Roussev R, Norcross JL, Faulk WP. Antithrombin binding by human umbilical vein endothelial cells: effects of exogenous heparin. Thromb Res. 1995;79(2):175-186.
29. Woods A. Syndecans: transmembrane modulators of adhesion and matrix assembly. J Clin Invest. 2001;107(8):935-941.
30. Lin CC, Shih CH, Yang YL, Bien MY, Lin CH, Yu MC, Sureshbabu M, Chen BC. Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-kappaB signaling pathways in alveolar macrophages. Eur J Pharmacol. 2011;672(1-3):180-187.
31. Thors B, Halldorsson H, Thorgeirsson G. eNOS activation mediated by AMPK after stimulation of endothelial cells with histamine or thrombin is dependent on LKB1. Biochim Biophys Acta. 2011;1813(2):322-331.