Neuronal nitric oxide synthase inhibition attenuates cardiopulmonary dysfunctions after combined burn and smoke inhalation injury in sheep

Critical Care Medicine

Volumn 36, Issue 4, 2008, Pages 1196-1204

  Westphal, Martin ^a,b   Enkhbaatar, Perenlei ^b   Schmalstieg, Frank C ^c   Kulp, Gabriela A ^c   Traber, Lillian D ^b,c   Morita, Naoki ^b   Cox, Robert A ^c   Hawkins, Hal K ^c   Westphal Varghese, Beena B ^a,b   Rudloff, Helen E ^c   Maybauer, Dirk M ^b,d   Maybauer, Marc O ^b,d   Burke, Ann S ^c   Murakami, Kazunori ^b   Saunders, Fiona ^b   Horvath, Eszter M ^b   Szabo, Csaba ^b   Traber, Daniel L ^b,c  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b University of Texas Medical Branch School of Medicine   (United States)

^c SHRINERS HOSPITALS FOR CHILDREN   (United States)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

Acute respiratory distress syndrome; Hypoxic pulmonary vasoconstriction; Nitric oxide synthase; Peroxynitrite; Sheep; Systemic inflammation

Indexed keywords

3 NITROTYROSINE; 7 NITROINDAZOLE; MESSENGER RNA; NEURONAL NITRIC OXIDE SYNTHASE; NITRATE; NITRITE;

ADULT RESPIRATORY DISTRESS SYNDROME; AIRWAY OBSTRUCTION; ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; BURN; CARDIOPULMONARY FUNCTION; CONTROLLED STUDY; DEATH; ENZYME INHIBITION; HISTOPATHOLOGY; HYPOXIA; INTENSIVE CARE UNIT; LUNG BLOOD FLOW; LUNG BURN; LUNG EDEMA; LUNG GAS EXCHANGE; LUNG PARENCHYMA; LUNG PRESSURE; LUNG VASOCONSTRICTION; MYOCARDIAL DISEASE; NONHUMAN; PRIORITY JOURNAL; RANDOMIZATION; SHEEP;

EID: 41649106417     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31816a1a0c     Document Type: Article

References (37)

1. von Euler U, Liljestrand G: Observations on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 1946; 12:301-320
2. Fischer SR, Deyo DJ, Bone HG, et al: Nitric oxide synthase inhibition restores hypoxic pulmonary vasoconstriction in sepsis. Am J Respir Crit Care Med 1997; 156:833-839
3. Light RB: Effect of sodium nitroprusside and diethylcarbamazine on hypoxic pulmonary vasoconstriction and regional distribution of pulmonary blood flow in experimental pneumonia. Am J Respir Crit Care Med 1996; 53:325-330
4. Steudel W, Kirmse M, Weimann J, et al: Exhaled nitric oxide production by nitric oxide synthase-deficient mice. Am J Respir Crit Care Med 2000; 162:1262-1267
5. Gocan NC, Scott JA, Tyml K: Nitric oxide produced via neuronal NOS may impair vasodilation in septic rat skeletal muscle. Am J Physiol Heart Circ Physiol 2000; 278:H1480-H1489
6. Ichinose F, Hataishi R, Wu JC, et al: A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice. Am J Physiol Heart Circ Physiol 2003; 285:H2524-H2530
7. Sprague RS, Thiemermann C, Vane JR: Endogenous endothelium-derived relaxing factor opposes hypoxic pulmonary vasoconstriction and supports blood flow to hypoxic alveoli in anesthetized rabbits. Proc Nat Acad Sci U S A 1992; 89:8711-8715
8. Enkhbaatar P, Murakami K, Shimoda K, et al: Inhibition of neuronal nitric oxide synthase by 7-nitroindazole attenuates acute lung injury in an ovine model. Am J Physiol Regul Integr Physiol 2003; 285:R366-R372
9. Enkhbaatar P, Murakami K, Shimoda K, et al: The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury. Am J Respir Crit Care Med 2003; 167:1021-1026
10. Nakae H, Inaba H: Exression of heme oxygenase-1 in the lung and liver tissues in a rat model of burns. Burns 2002; 28:305-309
11. Soejima K, Schmalstieg FC, Sakurai H, et al: Pathophysiological analysis of combined burn and smoke inhalation injuries in sheep. Am J Physiol Regul Integr Comp Physiol 2002; 280:L1233-L1141
12. Soejima K, Traber LD, Schmalstieg FC, et al: Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury. Am J Respir Crit Care Med 2001; 163:745-752
13. Westphal M, Cox RA, Traber LD, et al: Combined burn and smoke inhalation injury impairs ovine hypoxic pulmonary vasoconstriction. Crit Care Med 2006; 34:1428-1436
14. Westphal M, Noshima S, Isago T, et al: Selective thromboxane A2 synthase inhibition by OKY-046 prevents cardiopulmonary dysfunction after ovine smoke inhalation injury. Anesthesiology 2005; 102:954-961
15. Westphal M, Morita N, Enkhbaatar P, et al: Acute effects of combined burn and smoke inhalation injury on carboxyhemoglobin formation, tissue oxygenation, and cardiac performance. Biochem Biophys Res Commun 2004; 317:945-949
16. Morita N, Shimoda K, Traber MG, et al: Vitamin E attenuates acute lung injury in sheep with burn and smoke inhalation injury. Redox Rep 2006; 11:61-70
17. Murakami K, Bjertnaes LJ, Schmalstieg FC, et al: A novel animal model of sepsis after acute lung injury in sheep. Crit Care Med 2002; 30:2083-2090
18. Baxter CR, Shires T: Physiological response to crystalloid resuscitation of severe burns. Ann N Y Acad Sci 1968; 150:874-894
19. Westphal M, Sielenkamper AW, Van Aken H, et al: Dopexamine reverses the vasopressin-associated impairment in tissue oxygen supply but decreases systemic blood pressure in ovine endotoxemia. Anesth Analg 2004; 99:878-885
20. Pearce ML, Yamashita J, Beazell J: Measurement of pulmonary edema. Circ Res 1965; 16:482-488
21. Cox RA, Burke AS, Soejima K, et al: Airway obstruction in sheep with burn and smoke inhalation injuries. Am J Respir Cell Mol Biol 2003; 29:295-302
22. Rubenfeld GD, Caldwell E, Peabody E, et al: Incidence and outcomes of acute lung injury. N Engl J Med 2005; 353:1685-1693
23. Maybauer MO, Maybauer DM, Herndon DN: Incidence and outcomes of acute lung injury. N Engl J Med 2006; 354:416-417
24. do Rosario Caneira da Silva M, Mota Filipe H, Pinto RM, et al: Nitric oxide and human thermal injury short term outcome. Burns 1998; 24:207-212
25. Ullrich R, Bloch KD, Ichinose F, et al: Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice. J Clin Invest 1999; 104:1421-1429
26. Enkhbaatar P, Murakami K, Traber LD, et al: The inhibition of inducible nitric oxide synthase in ovine sepsis model. Shock 2006; 25:522-527
27. Aaronson PI, Robertson TP, Knock GA, et al: Hypoxic pulmonary vasoconstriction: Mechanisms and controversies. J Physiol 2006; 570:53-58
28. Zou MH, Shi C, Cohen RA: Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest 2002; 109:817-826
29. Szabo C: Poly(ADP-ribose) polymerase activation by reactive nitrogen species: Relevance for the pathogenesis of inflammation. Nitric Oxide 2006; 169-179
30. Lee JK, Choi SS, Won JS, et al: The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells: Involvement of AP-1 and NFkappaB. Life Sci 2003; 73:595-609
31. Shimoda K, Murakami K, Enkhbaatar P, et al: Effect of poly(ADP ribose) synthase inhibition on burn and smoke inhalation injury in sheep. Am J Physiol Lung Cell Mol Physiol 2003; 285:L240-L249
32. Traber DL, Hawkins HK, Enkhbaatar P, et al: The role of the bronchial circulation in the acute lung injury resulting from burn and smoke inhalation. Pulm Pharmacol Ther 2007; 20:163-166
33. Moore PK, Wallace P, Gaffen Z, et al: Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: Antinociceptive and cardiovascular effects. Br J Pharmacol 1993; 110:219-224
34. Bland-Ward PA, Moore PK: 7-Nitro indazole derivatives are potent inhibitors of brain, endothelium and inducible isoforms of nitric oxide synthase. Life Sci 1995; 57:PL131-PL135
35. Ryter SW, Choi AM: Heme oxygenase-1: Molecular mechanisms of gene expression in oxygen-related stress. Antioxid Redox Signal 2002; 4:625-632
36. Vicente AM, Guillen MI, Habib A, et al: Beneficial effects of heme oxygenase-1 upregulation in the development of experimental inflammation induced by zymosan. J Pharmacol Exp Ther 2003; 307:1030-1037
37. Chandra A, Enkhbaatar P, Nakono Y, et al: Sepsis: Emerging role of nitric oxide and selectins. Clinics 2006; 61:71-76