Luteolin and luteolin-7-O-glucoside strengthen antioxidative potential through the modulation of Nrf2/MAPK mediated HO-1 signaling cascade in RAW 264.7 cells

Food and Chemical Toxicology

Volumn 65, Issue , 2014, Pages 70-75

  Song, Young Sun ^a   Park, Chung Mu ^b  

^a Inje University   (South Korea)

^b Dong Eui University   (South Korea)

Author keywords

Heme oxygenase 1; Luteolin; Luteolin 7 O glucoside; Mitogen activated protein kinase; Nuclear factor erythroid 2 p45 related factor 2

Indexed keywords

HEME OXYGENASE 1; LUTEOLIN; LUTEOLIN 7 GLUCOSIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTOPORPHYRIN COBALT; PROTOPORPHYRIN TIN; STRESS ACTIVATED PROTEIN KINASE; TERT BUTYL HYDROPEROXIDE; TRANSCRIPTION FACTOR NRF2; SYNAPTOPHYSIN;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; MACROPHAGE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; CELL VIABILITY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; OXIDATIVE STRESS;

HEME OXYGENASE-1; LUTEOLIN; LUTEOLIN-7-O-GLUCOSIDE; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR FACTOR-ERYTHROID 2 P45-RELATED FACTOR 2;

ANIMALS; ANTIOXIDANTS; CELL LINE; GLUCOSIDES; HEME OXYGENASE-1; LUTEOLIN; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; NF-E2-RELATED FACTOR 2; SIGNAL TRANSDUCTION;

EID: 84892149299     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.12.017     Document Type: Article

References (34)

1. Andlauer W., Kolb J., Furst P. Isoflavones from tofu are absorbed and metabolized in the isolated rat small intestine. J. Nutr. 2000, 130:3021-3027.
2. Baranano D.E., Rao M., Ferris C.D., Snyder S.H. Biliverdin reductase: a major physiologic cytoprotectant. Proc. Natl. Acad. Sci. USA 2002, 99:16093-16098.
3. Boobis A.R., Fawthrop D.J., Davies D.S. Mechanisms of cell death. Trends Pharmacol. Sci. 1989, 10:275-280.
4. Bussolati B., Ahmed A., Pemberton H., Landis R.C., Di Carlo F., Haskard D.O., Mason J.C. Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration. Blood 2004, 103:761-766.
5. Chen C.Y., Peng W.H., Tsai K.D., Hsu S.L. Luteolin suppresses inflammation-associated gene expression by blocking NF-kappaB and AP-1 activation pathway in mouse alveolar macrophages. Life Sci. 2007, 81:1602-1614.
6. 2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochem. Pharmacol. 2005, 69:1839-1851.
7. Eisenstein R.S., Garcia-Mayol D., Pettingell W., Munro H.N. Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron. Proc. Natl. Acad. Sci. USA 1991, 88:688-692.
8. Farombi E.O., Surh Y.J. Heme oxygenase-1 as a potential therapeutic target for hepatoprotection. J. Biochem. Mol. Biol. 2006, 39:479-491.
9. Hwang J.T., Park O.J., Lee Y.K., Sung M.J., Hur H.J., Kim M.S., Ha J.H., Kwon D.Y. Anti-tumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-kappaB modulation in HepG2 hepatocarcinoma cells. Int. J. Mol. Med. 2011, 28:25-31.
10. Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., Oyake T., Hayashi N., Satoh K., Hatayama I., Yamamoto M., Nabeshima Y. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 1997, 236:313-322.
11. Izumi T., Piskula M.K., Osawa S., Obata A., Tobe K., Saito M., Kataoka S., Kubota Y., Kikuchi M. Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in humans. J. Nutr. 2000, 130:1695-1699.
12. Jang S., Kelley K.W., Johnson R.W. Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1. Proc. Natl. Acad. Sci. USA 2008, 105:7534-7539.
13. Johnson G.L., Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002, 298:1911-1912.
14. Kim J., Cha Y.N., Surh Y.J. A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat. Res. 2010, 690:12-23.
15. Lee J.S., Surh Y.J. Nrf2 as a novel molecular target for chemoprevention. Cancer Lett. 2005, 224:171-184.
16. Ma Q. Role of Nrf2 in oxidative stress and toxicity. Annu. Rev. Pharmacol. Toxicol. 2013, 53:401-426.
17. Martin D., Rojo A.I., Salinas M., Diaz R., Gallardo G., Alam J., De Galarreta C.M., Cuadrado A. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J. Biol. Chem. 2004, 279:8919-8929.
18. Murota K., Shimizu S., Miyamoto S., Izumi T., Obata A., Kikuchi M., Terao J. Unique uptake and transport of isoflavone aglycones by human intestinal caco-2 cells: comparison of isoflavonoids and flavonoids. J. Nutr. 2002, 132:1956-1961.
19. Park C.M., Jin K.S., Lee Y.W., Song Y.S. Luteolin and chicoric acid synergistically inhibited inflammatory responses via inactivation of PI3K-Akt pathway and impairment of NF-kappaB translocation in LPS stimulated RAW 264.7 cells. Eur. J. Pharmacol. 2011, 660:454-459.
20. Park C.M., Park J.Y., Noh K.H., Shin J.H., Song Y.S. Taraxacum officinale Weber extracts inhibit LPS-induced oxidative stress and nitric oxide production via the NF-kappaB modulation in RAW 264.7 cells. J. Ethnopharmacol. 2011, 133:834-842.
21. Piskula M.K. Factors affecting flavonoids absorption. BioFactors 2000, 12:175-180.
22. Pradhan P., Giri J., Rieken F., Koch C., Mykhaylyk O., Doblinger M., Banerjee R., Bahadur D., Plank C. Targeted temperature sensitive magnetic liposomes for thermo-chemotherapy. J. Control Release 2010, 142:108-121.
23. Richelle M., Pridmore-Merten S., Bodenstab S., Enslen M., Offord E.A. Hydrolysis of isoflavone glycosides to aglycones by beta-glycosidase does not alter plasma and urine isoflavone pharmacokinetics in postmenopausal women. J. Nutr. 2002, 132:2587-2592.
24. Rowland I., Faughnan M., Hoey L., Wahala K., Williamson G., Cassidy A. Bioavailability of phyto-oestrogens. Br. J. Nutr. 2003, 89(Suppl. 1). S45-58.
25. Schutz K., Kammerer D.R., Carle R., Schieber A. Characterization of phenolic acids and flavonoids in dandelion (Taraxacum officinale WEB. ex WIGG.) root and herb by high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid. Commun. Mass Spectrom. 2005, 19:179-186.
26. Seelinger G., Merfort I., Schempp C.M. Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin. Planta Med. 2008, 74:1667-1677.
27. Shi X., Zhou B. The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos. Toxicol. Sci. 2010, 115:391-400.
28. Stocker R., Yamamoto Y., McDonagh A.F., Glazer A.N., Ames B.N. Bilirubin is an antioxidant of possible physiological importance. Science 1987, 235:1043-1046.
29. Valko M., Leibfritz D., Moncol J., Cronin M.T., Mazur M., Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 2007, 39:44-84.
30. Vitaglione P., Morisco F., Caporaso N., Fogliano V. Dietary antioxidant compounds and liver health. Crit. Rev. Food Sci. Nutr. 2004, 44:575-586.
31. Vrba J., Orolinova E., Ulrichova J. Induction of heme oxygenase-1 by Macleaya cordata extract and its constituent sanguinarine in RAW264.7 cells. Fitoterapia 2012, 83:329-335.
32. Wang H., Joseph J.A. Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic. Biol. Med. 1999, 27:612-616.
33. Yu R., Chen C., Mo Y.Y., Hebbar V., Owuor E.D., Tan T.H., Kong A.N. Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism. J. Biol. Chem. 2000, 275:39907-39913.
34. Zubik L., Meydani M. Bioavailability of soybean isoflavones from aglycone and glucoside forms in American women. Am. J. Clin. Nutr. 2003, 77:1459-1465.