Hepatitis C virus NS5A protein modulates IRF-7-mediated interferon-α signaling

Journal of Interferon and Cytokine Research

Volumn 34, Issue 1, 2014, Pages 16-21

  Chowdhury, Joydip Bhanja ^a   Kim, Hangeun ^a   Ray, Ranjit ^a   Ray, Ratna B ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ALPHA INTERFERON 4; ARGININE; INTERFERON ALPHA14; INTERFERON ALPHA7; INTERFERON REGULATORY FACTOR 7; NONSTRUCTURAL PROTEIN 5A; UNCLASSIFIED DRUG; NS-5 PROTEIN, HEPATITIS C VIRUS; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENETIC ASSOCIATION; GENETIC TRANSFECTION; HEPATITIS C VIRUS SUBTYPE 1B; HEPATITIS C VIRUS SUBTYPE 2A; HUMAN; HUMAN CELL; LIVER CELL; LUCIFERASE ASSAY; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN STRUCTURE; REPLICON; REPORTER GENE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; ANTAGONISTS AND INHIBITORS; CELL CULTURE; GENETICS; METABOLISM;

CELLS, CULTURED; HUMANS; INTERFERON REGULATORY FACTOR-7; INTERFERON-ALPHA; SIGNAL TRANSDUCTION; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84892140629     PISSN: 10799907     EISSN: 15577465     Source Type: Journal    
DOI: 10.1089/jir.2013.0038     Document Type: Article

References (23)

1. Aly HH, Watashi K, Hijikata M, Kaneko H, Takada Y, Egawa H, Uemoto S, Shimotohno K. 2007. Serum-derived hepatitis C virus infectivity in interferon regulatory factor-7-suppressed human primary hepatocytes. J Hepatol 46:26-36
2. Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ. 2006. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med 144:705-714
3. Bigger CB, Guerra B, Brasky KM, Hubbard G, Beard MR, Luxon BA, Lemon SM, Lanford RE. 2004. Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees. J Virol 78:13779-13792
4. Eddy SR. 1995. Multiple alignment using hidden Markov models. Proc Int Conf Intell Syst Mol Biol 3:114-120
5. Honda K, Yanai H, Negishi H, Asagiri M, Sato M, Mizutani T, Shimada N, Ohba Y, Takaoka A, Yoshida N, Taniguchi T. 2005. IRF-7 is the master regulator of type-I interferondependent immune responses. Nature 434:772-777
6. Kanda T, Basu A, Steele R, Wakita T, Ryerse JS, Ray R, Ray RB. 2006. Generation of infectious hepatitis C virus in immortalized human hepatocytes. J Virol 80, 4633-4639
7. Kanda T, Steele R, Ray R, Ray RB. 2007. Hepatitis C virus infection induces the beta interferon signaling pathway in immortalized human hepatocytes. J Virol 81:12375-12381
8. Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. 2002. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 285:1-24
9. Kumar LV, Ramakrishna T, Rao CM. 1999. Structural and functional consequences of the mutation of a conserved arginine residue in alphaA and alphaB crystallins. J Biol Chem 274:24137-24141
10. Lei X, Sun Z, Liu X, Jin Q, He B, Wang J. 2011. Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3. J Virol 85:8811-8818
11. Lin R, Genin P, Mamane Y, Hiscott J. 2000. Selective DNA binding and association with the CREB binding protein coactivator contribute to differential activation of alpha/beta interferon genes by interferon regulatory factors 3 and 7. Mol Cell Biol 20:6342-6353
12. Liou DY, Hsu YH,Wung CH, Wang WH, Lin NS, Chang BY. 2000. Functional analyses and identification of two arginine residues essential to the ATP-utilizing activity of the triple gene block protein 1 of bamboo mosaic potexvirus. Virology 277:336-344
13. Lu R, Au WC, Yeow WS, Hageman N, Pitha PM. 2000. Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon and silencing by hypermethylation. J Biol Chem 275:31805-31812
14. Macdonald A, Mazaleyrat S, McCormick C, Street A, Burgoyne NJ, Jackson RM, Cazeaux V, Shelton H, Saksela K, Harris M. 2005. Further studies on hepatitis C virus NS5A-SH3 domain interactions: Identification of residues critical for binding and implications for viral RNA replication and modulation of cell signalling. J Gen Virol 86:1035-1044
15. MacQuillan GC, Mamotte C, Reed WD, Jeffrey GP, Allan JE. 2003. Upregulation of endogenous intrahepatic interferon stimulated genes during chronic hepatitis C virus infection. J Med Virol 70:219-227
16. Ramos HJ, Gale M Jr. 2011. RIG-I like receptors and their signaling crosstalk in the regulation of antiviral immunity. Curr Opin Virol 1:167-176
17. Ray RB, Meyer K, Ray R. 2000. Hepatitis C virus core protein promotes immortalization of primary human hepatocytes. Virology 271:193-204
18. Raychoudhuri A, Shrivastava S, Steele R, Dash S, Kanda T, Ray R, Ray RB. 2010. Hepatitis C virus infection impairs IRF-7 translocation and Alpha interferon synthesis in immortalized human hepatocytes. J Virol 84:10991-10998
19. Sarasin-Filipowicz M, Oakeley EJ, Duong FH, Christen V, Terracciano L, Filipowicz W, Heim MH. 2008. Interferon signaling and treatment outcome in chronic hepatitis C. Proc Natl Acad Sci U S A 105:7034-7039
20. Schröder M, Bowie AG. 2007. An arms race: Innate antiviral responses and counteracting viral strategies. Biochem Soc Trans 35:1512-1514
21. Sen GC. 2001. Viruses and interferons. Annu Rev Microbiol 55:255-281
22. Shah MA, Tayyab S, Ali R. 1996. Probing structure-Activity relationship in diamine oxidase -reactivities of lysine and arginine residues. Int J Biol Macromol 18:77-81
23. Thomas E, Feldm JJ, Li Q, Hu Z, Fried MW, Liang TJ. 2011. Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction in hepatitis C virus cell culture models. Hepatology 53:32-41