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Volumn 8, Issue 6, 2013, Pages 624-634

Comprehensive methylome analysis of ovarian tumors reveals hedgehog signaling pathway regulators as prognostic DNA methylation biomarkers

Author keywords

DNA methylation; Hedgehog pathway; Ovarian cancer; ZIC1; ZIC4

Indexed keywords

ARTICLE; CANCER PROGNOSIS; CANCER SURVIVAL; CELL INVASION; CELL MIGRATION; CELL VIABILITY; DISEASE COURSE; DNA METHYLATION; GENE SILENCING; GENETIC ASSOCIATION; GENETIC TRANSFECTION; HISTOLOGY; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; OVARY TUMOR; PROGRESSION FREE SURVIVAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS;

EID: 84891959461     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.24816     Document Type: Article
Times cited : (53)

References (52)
  • 1
    • 34248581720 scopus 로고    scopus 로고
    • The management of recurrent ovarian cancer
    • PMID: 17512352; DOI: 10.1053/j.seminoncol.2007.03.012
    • Bukowski RM, Ozols RF, Markman M. The management of recurrent ovarian cancer. Semin Oncol 2007; 34:S1-15; PMID: 17512352; DOI: 10.1053/j.seminoncol.2007.03.012.
    • (2007) Semin Oncol , vol.34
    • Bukowski, R.M.1    Ozols, R.F.2    Markman, M.3
  • 2
    • 15444378146 scopus 로고    scopus 로고
    • Cancer of the ovary
    • author reply 1268-9; PMID: 15791705; DOI: 10.1056/NEJM200503243521222
    • Liu CM. Cancer of the ovary. N Engl J Med 2005; 352:1268-9, author reply 1268-9; PMID: 15791705; DOI: 10.1056/NEJM200503243521222.
    • (2005) N Engl J Med , vol.352 , pp. 1268-1269
    • Liu, C.M.1
  • 3
    • 0037037385 scopus 로고    scopus 로고
    • First-line treatment for advanced ovarian cancer: Paclitaxel, platinum and the evidence
    • PMID: 12373593; DOI: 10.1038/sj.bjc.6600567
    • Sandercock J, Parmar MK, Torri V, Qian W. First-line treatment for advanced ovarian cancer: paclitaxel, platinum and the evidence. Br J Cancer 2002; 87:815-24; PMID: 12373593; DOI: 10.1038/sj.bjc.6600567.
    • (2002) Br J Cancer , vol.87 , pp. 815-824
    • Sandercock, J.1    Parmar, M.K.2    Torri, V.3    Qian, W.4
  • 4
    • 67650401865 scopus 로고    scopus 로고
    • DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage
    • PMID: 18826610; DOI: 10.1186/1755-8794-1-47
    • Watts GS, Futscher BW, Holtan N, Degeest K, Domann FE, Rose SL. DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage. BMC Med Genomics 2008; 1:47; PMID: 18826610; DOI: 10.1186/1755-8794-1-47.
    • (2008) BMC Med Genomics , vol.1 , pp. 47
    • Watts, G.S.1    Futscher, B.W.2    Holtan, N.3    Degeest, K.4    Domann, F.E.5    Rose, S.L.6
  • 5
    • 0035992386 scopus 로고    scopus 로고
    • Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers
    • PMID: 12114427
    • Wei SH, Chen CM, Strathdee G, Harnsomburana J, Shyu CR, Rahmatpanah F, et al. Methylation microarray analysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers. Clin Cancer Res 2002; 8:2246-52; PMID: 12114427.
    • (2002) Clin Cancer Res , vol.8 , pp. 2246-2252
    • Wei, S.H.1    Chen, C.M.2    Strathdee, G.3    Harnsomburana, J.4    Shyu, C.R.5    Rahmatpanah, F.6
  • 6
    • 40949087119 scopus 로고    scopus 로고
    • DNA methylation changes in ovarian cancer: Implications for early diagnosis, prognosis and treatment
    • PMID: 18234305; DOI: 10.1016/j.ygyno.2007.12.017
    • Barton CA, Hacker NF, Clark SJ, O'Brien PM. DNA methylation changes in ovarian cancer: implications for early diagnosis, prognosis and treatment. Gynecol Oncol 2008; 109:129-39; PMID: 18234305; DOI: 10.1016/j.ygyno.2007.12.017.
    • (2008) Gynecol Oncol , vol.109 , pp. 129-139
    • Barton, C.A.1    Hacker, N.F.2    Clark, S.J.3    O'Brien, P.M.4
  • 7
    • 69249145317 scopus 로고    scopus 로고
    • Minireview: Epigenetic changes in ovarian cancer
    • PMID: 19574400; DOI: 10.1210/en.2009-0404
    • Balch C, Fang F, Matei DE, Huang TH, Nephew KP. Minireview: epigenetic changes in ovarian cancer. Endocrinology 2009; 150:4003-11; PMID: 19574400; DOI: 10.1210/en.2009-0404.
    • (2009) Endocrinology , vol.150 , pp. 4003-4011
    • Balch, C.1    Fang, F.2    Matei, D.E.3    Huang, T.H.4    Nephew, K.P.5
  • 8
    • 4644271551 scopus 로고    scopus 로고
    • Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients
    • PMID: 15374957; DOI: 10.1158/0008-5472.CAN-04-1529
    • Ibanez de Caceres I, Battagli C, Esteller M, Herman JG, Dulaimi E, Edelson MI, et al. Tumor cell-specific BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fluid from ovarian cancer patients. Cancer Res 2004; 64:6476-81; PMID: 15374957; DOI: 10.1158/0008-5472.CAN-04-1529.
    • (2004) Cancer Res , vol.64 , pp. 6476-6481
    • de Caceres, I.I.1    Battagli, C.2    Esteller, M.3    Herman, J.G.4    Dulaimi, E.5    Edelson, M.I.6
  • 9
    • 46049092192 scopus 로고    scopus 로고
    • HOXA11 DNA methylation--a novel prognostic biomarker in ovarian cancer
    • PMID: 18478570; DOI: 10.1002/ijc.23563
    • Fiegl H, Windbichler G, Mueller-Holzner E, Goebel G, Lechner M, Jacobs IJ, et al. HOXA11 DNA methylation--a novel prognostic biomarker in ovarian cancer. Int J Cancer 2008; 123:725-9; PMID: 18478570; DOI: 10.1002/ijc.23563.
    • (2008) Int J Cancer , vol.123 , pp. 725-729
    • Fiegl, H.1    Windbichler, G.2    Mueller-Holzner, E.3    Goebel, G.4    Lechner, M.5    Jacobs, I.J.6
  • 10
    • 0035872480 scopus 로고    scopus 로고
    • Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer
    • PMID: 11358853
    • Shridhar V, Bible KC, Staub J, Avula R, Lee YK, Kalli K, et al. Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer. Cancer Res 2001; 61:4258-65; PMID: 11358853.
    • (2001) Cancer Res , vol.61 , pp. 4258-4265
    • Shridhar, V.1    Bible, K.C.2    Staub, J.3    Avula, R.4    Lee, Y.K.5    Kalli, K.6
  • 11
    • 11144355535 scopus 로고    scopus 로고
    • Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: Its correlation with aberrant DNA methylation
    • PMID: 15102672; DOI: 10.1158/1078-0432.CCR-03-0510
    • Akahira J, Sugihashi Y, Suzuki T, Ito K, Niikura H, Moriya T, et al. Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation. Clin Cancer Res 2004; 10:2687-93; PMID: 15102672; DOI: 10.1158/1078-0432.CCR-03-0510.
    • (2004) Clin Cancer Res , vol.10 , pp. 2687-2693
    • Akahira, J.1    Sugihashi, Y.2    Suzuki, T.3    Ito, K.4    Niikura, H.5    Moriya, T.6
  • 12
    • 33646725688 scopus 로고    scopus 로고
    • Prognostic DNA methylation biomarkers in ovarian cancer
    • PMID: 16675572; DOI: 10.1158/1078-0432.CCR-05-1551
    • Wei SH, Balch C, Paik HH, Kim YS, Baldwin RL, Liyanarachchi S, et al. Prognostic DNA methylation biomarkers in ovarian cancer. Clin Cancer Res 2006; 12:2788-94; PMID: 16675572; DOI: 10.1158/1078-0432.CCR-05-1551.
    • (2006) Clin Cancer Res , vol.12 , pp. 2788-2794
    • Wei, S.H.1    Balch, C.2    Paik, H.H.3    Kim, Y.S.4    Baldwin, R.L.5    Liyanarachchi, S.6
  • 13
    • 27144499187 scopus 로고    scopus 로고
    • Hypermethylation of 18S and 28S ribosomal DNAs predicts progression-free survival in patients with ovarian cancer
    • PMID: 16243810; DOI: 10.1158/1078-0432.CCR-05-1100
    • Chan MW, Wei SH, Wen P, Wang Z, Matei DE, Liu JC, et al. Hypermethylation of 18S and 28S ribosomal DNAs predicts progression-free survival in patients with ovarian cancer. Clin Cancer Res 2005; 11:7376-83; PMID: 16243810; DOI: 10.1158/1078-0432.CCR-05-1100.
    • (2005) Clin Cancer Res , vol.11 , pp. 7376-7383
    • Chan, M.W.1    Wei, S.H.2    Wen, P.3    Wang, Z.4    Matei, D.E.5    Liu, J.C.6
  • 14
    • 25444485414 scopus 로고    scopus 로고
    • CpG island methylation of DNA damage response genes in advanced ovarian cancer
    • PMID: 16204069; DOI: 10.1158/0008-5472.CAN-05-1187
    • Teodoridis JM, Hall J, Marsh S, Kannall HD, Smyth C, Curto J, et al. CpG island methylation of DNA damage response genes in advanced ovarian cancer. Cancer Res 2005; 65:8961-7; PMID: 16204069; DOI: 10.1158/0008-5472.CAN-05-1187.
    • (2005) Cancer Res , vol.65 , pp. 8961-8967
    • Teodoridis, J.M.1    Hall, J.2    Marsh, S.3    Kannall, H.D.4    Smyth, C.5    Curto, J.6
  • 15
    • 23044466227 scopus 로고    scopus 로고
    • Promoter hypermethylation profile of ovarian epithelial neoplasms
    • PMID: 16061849; DOI: 10.1158/1078-0432.CCR-04-2455
    • Makarla PB, Saboorian MH, Ashfaq R, Toyooka KO, Toyooka S, Minna JD, et al. Promoter hypermethylation profile of ovarian epithelial neoplasms. Clin Cancer Res 2005; 11:5365-9; PMID: 16061849; DOI: 10.1158/1078-0432.CCR-04-2455.
    • (2005) Clin Cancer Res , vol.11 , pp. 5365-5369
    • Makarla, P.B.1    Saboorian, M.H.2    Ashfaq, R.3    Toyooka, K.O.4    Toyooka, S.5    Minna, J.D.6
  • 16
    • 84857138378 scopus 로고    scopus 로고
    • Integrative genome-wide expression and promoter DNA methylation profiling identifies a potential novel panel of ovarian cancer epigenetic biomarkers
    • PMID: 22155104; DOI: 10.1016/j.canlet.2011.12.003
    • Gloss BS, Patterson KI, Barton CA, Gonzalez M, Scurry JP, Hacker NF, et al. Integrative genome-wide expression and promoter DNA methylation profiling identifies a potential novel panel of ovarian cancer epigenetic biomarkers. Cancer Lett 2012; 318:76-85; PMID: 22155104; DOI: 10.1016/j.canlet.2011.12.003.
    • (2012) Cancer Lett , vol.318 , pp. 76-85
    • Gloss, B.S.1    Patterson, K.I.2    Barton, C.A.3    Gonzalez, M.4    Scurry, J.P.5    Hacker, N.F.6
  • 17
    • 84863796925 scopus 로고    scopus 로고
    • Smoothened antagonists reverse taxane resistance in ovarian cancer
    • PMID: 22553355; DOI: 10.1158/1535-7163.MCT-11-1058
    • Steg AD, Katre AA, Bevis KS, Ziebarth A, Dobbin ZC, Shah MM, et al. Smoothened antagonists reverse taxane resistance in ovarian cancer. Mol Cancer Ther 2012; 11:1587-97; PMID: 22553355; DOI: 10.1158/1535-7163.MCT-11-1058.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1587-1597
    • Steg, A.D.1    Katre, A.A.2    Bevis, K.S.3    Ziebarth, A.4    Dobbin, Z.C.5    Shah, M.M.6
  • 18
    • 59449104701 scopus 로고    scopus 로고
    • Role of hedgehog signaling in ovarian cancer
    • PMID: 19047091; DOI: 10.1158/1078-0432.CCR-08-1414
    • Bhattacharya R, Kwon J, Ali B, Wang E, Patra S, Shridhar V, et al. Role of hedgehog signaling in ovarian cancer. Clin Cancer Res 2008; 14:7659-66; PMID: 19047091; DOI: 10.1158/1078-0432.CCR-08-1414.
    • (2008) Clin Cancer Res , vol.14 , pp. 7659-7666
    • Bhattacharya, R.1    Kwon, J.2    Ali, B.3    Wang, E.4    Patra, S.5    Shridhar, V.6
  • 19
    • 0020559574 scopus 로고
    • A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer
    • PMID: 6310399; DOI: 10.1056/NEJM198310133091503
    • Bast RC, Klug TL, St John E, Jenison E, Niloff JM, Lazarus H, et al. A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med 1983; 309:883-7; PMID: 6310399; DOI: 10.1056/NEJM198310133091503.
    • (1983) N Engl J Med , vol.309 , pp. 883-887
    • Bast, R.C.1    Klug, T.L.2    St John, E.3    Jenison, E.4    Niloff, J.M.5    Lazarus, H.6
  • 20
    • 58949100355 scopus 로고    scopus 로고
    • Aberrant activation of hedgehog signaling pathway in ovarian cancers: Effect on prognosis, cell invasion and differentiation
    • PMID: 19028702; DOI: 10.1093/carcin/bgn230
    • Liao X, Siu MK, Au CW, Wong ES, Chan HY, Ip PP, et al. Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation. Carcinogenesis 2009; 30:131-40; PMID: 19028702; DOI: 10.1093/carcin/bgn230.
    • (2009) Carcinogenesis , vol.30 , pp. 131-140
    • Liao, X.1    Siu, M.K.2    Au, C.W.3    Wong, E.S.4    Chan, H.Y.5    Ip, P.P.6
  • 21
    • 79951922993 scopus 로고    scopus 로고
    • ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer
    • PMID: 21347233; DOI: 10.1371/journal.pone.0016916
    • Gan L, Chen S, Zhong J, Wang X, Lam EK, Liu X, et al. ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer. PLoS One 2011; 6:e16916; PMID: 21347233; DOI: 10.1371/journal.pone.0016916.
    • (2011) PLoS One , vol.6
    • Gan, L.1    Chen, S.2    Zhong, J.3    Wang, X.4    Lam, E.K.5    Liu, X.6
  • 22
    • 58949102772 scopus 로고    scopus 로고
    • ZIC1 is downregulated through promoter hypermethylation in gastric cancer
    • PMID: 19135984; DOI: 10.1016/j.bbrc.2008.12.180
    • Wang LJ, Jin HC, Wang X, Lam EK, Zhang JB, Liu X, et al. ZIC1 is downregulated through promoter hypermethylation in gastric cancer. Biochem Biophys Res Commun 2009; 379:959-63; PMID: 19135984; DOI: 10.1016/j.bbrc.2008.12.180.
    • (2009) Biochem Biophys Res Commun , vol.379 , pp. 959-963
    • Wang, L.J.1    Jin, H.C.2    Wang, X.3    Lam, E.K.4    Zhang, J.B.5    Liu, X.6
  • 23
    • 79959838081 scopus 로고    scopus 로고
    • Integrated genomic analyses of ovarian carcinoma
    • PMID: 21720365; DOI: 10.1038/nature10166
    • Network CGAR. Integrated genomic analyses of ovarian carcinoma. Nature 2011; 474:609-15; PMID: 21720365; DOI: 10.1038/nature10166.
    • (2011) Nature , vol.474 , pp. 609-615
    • Network, C.G.A.R.1
  • 24
    • 0035910569 scopus 로고    scopus 로고
    • Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins
    • PMID: 11053430; DOI: 10.1074/jbc.M004430200
    • Mizugishi K, Aruga J, Nakata K, Mikoshiba K. Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J Biol Chem 2001; 276:2180-8; PMID: 11053430; DOI: 10.1074/jbc.M004430200.
    • (2001) J Biol Chem , vol.276 , pp. 2180-2188
    • Mizugishi, K.1    Aruga, J.2    Nakata, K.3    Mikoshiba, K.4
  • 25
    • 79955892727 scopus 로고    scopus 로고
    • Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles
    • PMID: 21577013; DOI: 10.1159/000327746
    • Bauerschlag DO, Ammerpohl O, Bräutigam K, Schem C, Lin Q, Weigel MT, et al. Progression-free survival in ovarian cancer is reflected in epigenetic DNA methylation profiles. Oncology 2011; 80:12-20; PMID: 21577013; DOI: 10.1159/000327746.
    • (2011) Oncology , vol.80 , pp. 12-20
    • Bauerschlag, D.O.1    Ammerpohl, O.2    Bräutigam, K.3    Schem, C.4    Lin, Q.5    Weigel, M.T.6
  • 26
    • 79959218200 scopus 로고    scopus 로고
    • Systematic CpG islands methylation profiling of genes in the wnt pathway in epithelial ovarian cancer identifies biomarkers of progression-free survival
    • PMID: 21459799; DOI: 10.1158/1078-0432.CCR-10-3021
    • Dai W, Teodoridis JM, Zeller C, Graham J, Hersey J, Flanagan JM, et al. Systematic CpG islands methylation profiling of genes in the wnt pathway in epithelial ovarian cancer identifies biomarkers of progression-free survival. Clin Cancer Res 2011; 17:4052-62; PMID: 21459799; DOI: 10.1158/1078-0432.CCR-10-3021.
    • (2011) Clin Cancer Res , vol.17 , pp. 4052-4062
    • Dai, W.1    Teodoridis, J.M.2    Zeller, C.3    Graham, J.4    Hersey, J.5    Flanagan, J.M.6
  • 27
    • 77954093340 scopus 로고    scopus 로고
    • Emerging promise of epigenetics and DNA methylation for the diagnosis and management of women's cancers
    • PMID: 22122746; DOI: 10.2217/epi.09.47
    • Jones A, Lechner M, Fourkala EO, Kristeleit R, Widschwendter M. Emerging promise of epigenetics and DNA methylation for the diagnosis and management of women's cancers. Epigenomics 2010; 2:9-38; PMID: 22122746; DOI: 10.2217/epi.09.47.
    • (2010) Epigenomics , vol.2 , pp. 9-38
    • Jones, A.1    Lechner, M.2    Fourkala, E.O.3    Kristeleit, R.4    Widschwendter, M.5
  • 29
    • 0042025123 scopus 로고    scopus 로고
    • Methylation and prognosis: Of molecular clocks and hypermethylator phenotypes
    • PMID: 12912930
    • Issa JP. Methylation and prognosis: of molecular clocks and hypermethylator phenotypes. Clin Cancer Res 2003; 9:2879-81; PMID: 12912930.
    • (2003) Clin Cancer Res , vol.9 , pp. 2879-2881
    • Issa, J.P.1
  • 30
    • 0035099160 scopus 로고    scopus 로고
    • Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes
    • PMID: 11238060; DOI: 10.1016/S0002-9440(10)64059-X
    • Strathdee G, Appleton K, Illand M, Millan DW, Sargent J, Paul J, et al. Primary ovarian carcinomas display multiple methylator phenotypes involving known tumor suppressor genes. Am J Pathol 2001; 158:1121-7; PMID: 11238060; DOI: 10.1016/S0002-9440(10)64059-X.
    • (2001) Am J Pathol , vol.158 , pp. 1121-1127
    • Strathdee, G.1    Appleton, K.2    Illand, M.3    Millan, D.W.4    Sargent, J.5    Paul, J.6
  • 31
    • 0034075153 scopus 로고    scopus 로고
    • Hypermethylation of multiple genes in pancreatic adenocarcinoma
    • PMID: 10766168
    • Ueki T, Toyota M, Sohn T, Yeo CJ, Issa JP, Hruban RH, et al. Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res 2000; 60:1835-9; PMID: 10766168.
    • (2000) Cancer Res , vol.60 , pp. 1835-1839
    • Ueki, T.1    Toyota, M.2    Sohn, T.3    Yeo, C.J.4    Issa, J.P.5    Hruban, R.H.6
  • 32
    • 0033229890 scopus 로고    scopus 로고
    • Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
    • PMID: 10554013
    • Toyota M, Ahuja N, Suzuki H, Itoh F, Ohe-Toyota M, Imai K, et al. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype. Cancer Res 1999; 59:5438-42; PMID: 10554013.
    • (1999) Cancer Res , vol.59 , pp. 5438-5442
    • Toyota, M.1    Ahuja, N.2    Suzuki, H.3    Itoh, F.4    Ohe-Toyota, M.5    Imai, K.6
  • 33
    • 80155153035 scopus 로고    scopus 로고
    • Status and significance of CpG island methylator phenotype in endometrial cancer
    • PMID: 21968189; DOI: 10.1159/000324496
    • Zhang QY, Yi DQ, Zhou L, Zhang DH, Zhou TM. Status and significance of CpG island methylator phenotype in endometrial cancer. Gynecol Obstet Invest 2011; 72:183-91; PMID: 21968189; DOI: 10.1159/000324496.
    • (2011) Gynecol Obstet Invest , vol.72 , pp. 183-191
    • Zhang, Q.Y.1    Yi, D.Q.2    Zhou, L.3    Zhang, D.H.4    Zhou, T.M.5
  • 34
    • 84857738869 scopus 로고    scopus 로고
    • Differential analysis of ovarian and endometrial cancers identifies a methylator phenotype
    • PMID: 22403726; DOI: 10.1371/journal.pone.0032941
    • Kolbe DL, DeLoia JA, Porter-Gill P, Strange M, Petrykowska HM, Guirguis A, et al. Differential analysis of ovarian and endometrial cancers identifies a methylator phenotype. PLoS One 2012; 7:e32941; PMID: 22403726; DOI: 10.1371/journal.pone.0032941.
    • (2012) PLoS One , vol.7
    • Kolbe, D.L.1    Deloia, J.A.2    Porter-Gill, P.3    Strange, M.4    Petrykowska, H.M.5    Guirguis, A.6
  • 35
    • 0034898120 scopus 로고    scopus 로고
    • DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells
    • PMID: 11531283; DOI: 10.1006/gyno.2001.6284
    • Ahluwalia A, Hurteau JA, Bigsby RM, Nephew KP. DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells. Gynecol Oncol 2001; 82:299-304; PMID: 11531283; DOI: 10.1006/gyno.2001.6284.
    • (2001) Gynecol Oncol , vol.82 , pp. 299-304
    • Ahluwalia, A.1    Hurteau, J.A.2    Bigsby, R.M.3    Nephew, K.P.4
  • 36
    • 84863090745 scopus 로고    scopus 로고
    • Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer
    • PMID: 22768205; DOI: 10.1371/journal.pone.0040024
    • Bai X, Song Z, Fu Y, Yu Z, Zhao L, Zhao H, et al. Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer. PLoS One 2012; 7:e40024; PMID: 22768205; DOI: 10.1371/journal.pone.0040024.
    • (2012) PLoS One , vol.7
    • Bai, X.1    Song, Z.2    Fu, Y.3    Yu, Z.4    Zhao, L.5    Zhao, H.6
  • 37
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: Too much, but also too little
    • PMID: 12154403; DOI: 10.1038/sj.onc.1205651
    • Ehrlich M. DNA methylation in cancer: too much, but also too little. Oncogene 2002; 21:5400-13; PMID: 12154403; DOI: 10.1038/sj.onc.1205651.
    • (2002) Oncogene , vol.21 , pp. 5400-5413
    • Ehrlich, M.1
  • 38
    • 13444270332 scopus 로고    scopus 로고
    • CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas
    • PMID: 15705880
    • Abe M, Ohira M, Kaneda A, Yagi Y, Yamamoto S, Kitano Y, et al. CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas. Cancer Res 2005; 65:828-34; PMID: 15705880.
    • (2005) Cancer Res , vol.65 , pp. 828-834
    • Abe, M.1    Ohira, M.2    Kaneda, A.3    Yagi, Y.4    Yamamoto, S.5    Kitano, Y.6
  • 39
    • 35948981194 scopus 로고    scopus 로고
    • Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy
    • PMID: 17947473; DOI: 10.1158/1078-0432.CCR-07-1011
    • Shen L, Catalano PJ, Benson AB, O'Dwyer P, Hamilton SR, Issa JP. Association between DNA methylation and shortened survival in patients with advanced colorectal cancer treated with 5-fluorouracil based chemotherapy. Clin Cancer Res 2007; 13:6093-8; PMID: 17947473; DOI: 10.1158/1078-0432.CCR-07-1011.
    • (2007) Clin Cancer Res , vol.13 , pp. 6093-6098
    • Shen, L.1    Catalano, P.J.2    Benson, A.B.3    O'Dwyer, P.4    Hamilton, S.R.5    Issa, J.P.6
  • 40
    • 19944428803 scopus 로고    scopus 로고
    • Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma
    • PMID: 15701853
    • An C, Choi IS, Yao JC, Worah S, Xie K, Mansfield PF, et al. Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma. Clin Cancer Res 2005; 11:656-63; PMID: 15701853.
    • (2005) Clin Cancer Res , vol.11 , pp. 656-663
    • An, C.1    Choi, I.S.2    Yao, J.C.3    Worah, S.4    Xie, K.5    Mansfield, P.F.6
  • 41
    • 84858447225 scopus 로고    scopus 로고
    • CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer
    • PMID: 22001634; DOI: 10.1016/j.surg.2011.08.013
    • Jo P, Jung K, Grade M, Conradi LC, Wolff HA, Kitz J, et al. CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer. Surgery 2012; 151:564-70; PMID: 22001634; DOI: 10.1016/j.surg.2011.08.013.
    • (2012) Surgery , vol.151 , pp. 564-570
    • Jo, P.1    Jung, K.2    Grade, M.3    Conradi, L.C.4    Wolff, H.A.5    Kitz, J.6
  • 42
    • 79951958851 scopus 로고    scopus 로고
    • CpG island methylator phenotype of cell-cycle regulators associated with TNM stage and poor prognosis in patients with oesophageal squamous cell carcinoma
    • PMID: 21169275; DOI: 10.1136/jcp.2010.082875
    • Ling Y, Huang G, Fan L, Wei L, Zhu J, Liu Y, et al. CpG island methylator phenotype of cell-cycle regulators associated with TNM stage and poor prognosis in patients with oesophageal squamous cell carcinoma. J Clin Pathol 2011; 64:246-51; PMID: 21169275; DOI: 10.1136/jcp.2010.082875.
    • (2011) J Clin Pathol , vol.64 , pp. 246-251
    • Ling, Y.1    Huang, G.2    Fan, L.3    Wei, L.4    Zhu, J.5    Liu, Y.6
  • 43
    • 0035831529 scopus 로고    scopus 로고
    • Physical and functional interactions between Zic and Gli proteins
    • PMID: 11238441; DOI: 10.1074/jbc.C000773200
    • Koyabu Y, Nakata K, Mizugishi K, Aruga J, Mikoshiba K. Physical and functional interactions between Zic and Gli proteins. J Biol Chem 2001; 276:6889-92; PMID: 11238441; DOI: 10.1074/jbc.C000773200.
    • (2001) J Biol Chem , vol.276 , pp. 6889-6892
    • Koyabu, Y.1    Nakata, K.2    Mizugishi, K.3    Aruga, J.4    Mikoshiba, K.5
  • 44
    • 15844421228 scopus 로고    scopus 로고
    • The ZIC gene family in development and disease
    • PMID: 15733262; DOI: 10.1111/j.1399-0004.2005.00418.x
    • Grinberg I, Millen KJ. The ZIC gene family in development and disease. Clin Genet 2005; 67:290-6; PMID: 15733262; DOI: 10.1111/j.1399-0004.2005.00418.x.
    • (2005) Clin Genet , vol.67 , pp. 290-296
    • Grinberg, I.1    Millen, K.J.2
  • 45
    • 84865100609 scopus 로고    scopus 로고
    • The zinc finger gene ZIC2 has features of an oncogene and its overexpression correlates strongly with the clinical course of epithelial ovarian cancer
    • PMID: 22733541; DOI: 10.1158/1078-0432.CCR-12-0037
    • Marchini S, Poynor E, Barakat RR, Clivio L, Cinquini M, Fruscio R, et al. The zinc finger gene ZIC2 has features of an oncogene and its overexpression correlates strongly with the clinical course of epithelial ovarian cancer. Clin Cancer Res 2012; 18:4313-24; PMID: 22733541; DOI: 10.1158/1078-0432.CCR-12-0037.
    • (2012) Clin Cancer Res , vol.18 , pp. 4313-4324
    • Marchini, S.1    Poynor, E.2    Barakat, R.R.3    Clivio, L.4    Cinquini, M.5    Fruscio, R.6
  • 46
    • 33751549095 scopus 로고    scopus 로고
    • Targeting the Hedgehog pathway in cancer
    • PMID: 17139287; DOI: 10.1038/nrd2086
    • Rubin LL, de Sauvage FJ. Targeting the Hedgehog pathway in cancer. Nat Rev Drug Discov 2006; 5:1026-33; PMID: 17139287; DOI: 10.1038/nrd2086.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 1026-1033
    • Rubin, L.L.1    de Sauvage, F.J.2
  • 47
    • 34848901657 scopus 로고    scopus 로고
    • The Gli code: An information nexus regulating cell fate, stemness and cancer
    • PMID: 17845852; DOI: 10.1016/j.tcb.2007.06.007
    • Ruiz i Altaba A, Mas C, Stecca B. The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol 2007; 17:438-47; PMID: 17845852; DOI: 10.1016/j.tcb.2007.06.007.
    • (2007) Trends Cell Biol , vol.17 , pp. 438-447
    • Altaba, R.A.1    Mas, C.2    Stecca, B.3
  • 48
    • 84869091778 scopus 로고    scopus 로고
    • Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1, and inhibition of platinum-DNA adduct repair
    • PMID: 22266871; DOI: 10.1038/onc.2011.610
    • Kudo K, Gavin E, Das S, Amable L, Shevde LA, Reed E. Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1, and inhibition of platinum-DNA adduct repair. Oncogene 2012; 31:4718-24; PMID: 22266871; DOI: 10.1038/onc.2011.610.
    • (2012) Oncogene , vol.31 , pp. 4718-4724
    • Kudo, K.1    Gavin, E.2    Das, S.3    Amable, L.4    Shevde, L.A.5    Reed, E.6
  • 49
    • 77954445464 scopus 로고    scopus 로고
    • Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway
    • PMID: 19957335; DOI: 10.1002/ijc.25083
    • Su HY, Lai HC, Lin YW, Liu CY, Chen CK, Chou YC, et al. Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway. Int J Cancer 2010; 127:555-67; PMID: 19957335; DOI: 10.1002/ijc.25083.
    • (2010) Int J Cancer , vol.127 , pp. 555-567
    • Su, H.Y.1    Lai, H.C.2    Lin, Y.W.3    Liu, C.Y.4    Chen, C.K.5    Chou, Y.C.6
  • 50
    • 84879131885 scopus 로고    scopus 로고
    • Epigenetic deregulation of the anaplastic lymphoma kinase gene modulates mesenchymal characteristics of oral squamous cell carcinomas
    • PMID: 23568951; DOI: 10.1093/carcin/bgt112
    • Huang TT, Gonzales CB, Gu F, Hsu YT, Jadhav RR, Wang CM, et al. Epigenetic deregulation of the anaplastic lymphoma kinase gene modulates mesenchymal characteristics of oral squamous cell carcinomas. Carcinogenesis 2013; PMID: 23568951; DOI: 10.1093/carcin/bgt112.
    • (2013) Carcinogenesis
    • Huang, T.T.1    Gonzales, C.B.2    Gu, F.3    Hsu, Y.T.4    Jadhav, R.R.5    Wang, C.M.6
  • 51
    • 68249159896 scopus 로고    scopus 로고
    • Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer
    • PMID: 19505326; DOI: 10.1186/1755-8794-2-34
    • Li M, Balch C, Montgomery JS, Jeong M, Chung JH, Yan P, et al. Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer. BMC Med Genomics 2009; 2:34; PMID: 19505326; DOI: 10.1186/1755-8794-2-34.
    • (2009) BMC Med Genomics , vol.2 , pp. 34
    • Li, M.1    Balch, C.2    Montgomery, J.S.3    Jeong, M.4    Chung, J.H.5    Yan, P.6
  • 52
    • 27644582534 scopus 로고    scopus 로고
    • Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer
    • PMID: 16227399; DOI: 10.1158/1535-7163.MCT-05-0216
    • Balch C, Yan P, Craft T, Young S, Skalnik DG, Huang TH, et al. Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer. Mol Cancer Ther 2005; 4:1505-14; PMID: 16227399; DOI: 10.1158/1535-7163.MCT-05-0216.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1505-1514
    • Balch, C.1    Yan, P.2    Craft, T.3    Young, S.4    Skalnik, D.G.5    Huang, T.H.6


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