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Volumn 2, Issue 1, 2010, Pages 9-38

Emerging promise of epigenetics and DNA methylation for the diagnosis and management of womens cancers

Author keywords

breast cancer; cervical cancer; DNA methylation; DNA methylation marker; DNMT inhibitor; endometrial cancer; epigenetics; gynecological cancer; HDAC inhibitor; ovarian cancer; therapeutic target

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AZACITIDINE; BELINOSTAT; BISULFITE; CAPECITABINE; CARBOPLATIN; DEPSIPEPTIDE; DNA METHYLTRANSFERASE 1; ESTROGEN RECEPTOR; EXEMESTANE; GEMCITABINE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; N (2 AMINOPHENYL) 4 [4 (3 PYRIDINYL) 2 PYRIMIDINYLAMINOMETHYL]BENZAMIDE; N PHTHALOYLTRYPTOPHAN; PACLITAXEL; PANOBINOSTAT; ROMIDEPSIN; TAMOXIFEN; TRASTUZUMAB; VORINOSTAT;

EID: 77954093340     PISSN: 17501911     EISSN: 1750192X     Source Type: Journal    
DOI: 10.2217/epi.09.47     Document Type: Review
Times cited : (23)

References (252)
  • 1
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg AP, Tycko B: The history of cancer epigenetics. Nat. Rev. Cancer 4(2), 143-153 (2004).
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.2 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 2
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB: The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3(6), 415-428 (2002).
    • (2002) Nat. Rev. Genet. , vol.3 , Issue.6 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 3
    • 58149144567 scopus 로고    scopus 로고
    • Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3́ exons of TACSTD1
    • Ligtenberg MJ, Kuiper R P, Chan TL et al.: Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3́ exons of TACSTD1. Nat. Genet. 41(1), 112-117 (2009).
    • (2009) Nat. Genet. , vol.41 , Issue.1 , pp. 112-117
    • Ligtenberg, M.J.1    Kuiper, R.P.2    Chan, T.L.3
  • 4
    • 31044433795 scopus 로고    scopus 로고
    • The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells
    • Weinberg MS, Villeneuve LM, Ehsani A et al.: The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. RNA 12(2), 256-262 (2006).
    • (2006) RNA , vol.12 , Issue.2 , pp. 256-262
    • Weinberg, M.S.1    Villeneuve, L.M.2    Ehsani, A.3
  • 5
    • 23044507007 scopus 로고    scopus 로고
    • Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation
    • Ting AH, Schuebel KE, Herman JG, Baylin SB: Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation. Nat. Genet. 37(8), 906-910 (2005).
    • (2005) Nat. Genet. , vol.37 , Issue.8 , pp. 906-910
    • Ting, A.H.1    Schuebel, K.E.2    Herman, J.G.3    Baylin, S.B.4
  • 6
    • 36048951040 scopus 로고    scopus 로고
    • Antisense RNA stabilization induces transcriptional gene silencing via histone deacetylation in S. cerevisiae
    • Camblong J, Iglesias N, Fickentscher C, Dieppois G, Stutz F: Antisense RNA stabilization induces transcriptional gene silencing via histone deacetylation in S. cerevisiae. Cell 131(4), 706-717 (2007).
    • (2007) Cell , vol.131 , Issue.4 , pp. 706-717
    • Camblong, J.1    Iglesias, N.2    Fickentscher, C.3    Dieppois, G.4    Stutz, F.5
  • 8
    • 34147207047 scopus 로고    scopus 로고
    • Allele-specifc binding of CTCF to the multipartite imprinting control region KvDMR1
    • Fitzpatrick GV, Pugacheva EM, Shin JY et al.: Allele-specifc binding of CTCF to the multipartite imprinting control region KvDMR1. Mol. Cell. Biol. 27(7), 2636-2647 (2007).
    • (2007) Mol. Cell. Biol. , vol.27 , Issue.7 , pp. 2636-2647
    • Fitzpatrick, G.V.1    Pugacheva, E.M.2    Shin, J.Y.3
  • 9
    • 55349100420 scopus 로고    scopus 로고
    • Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos
    • Terranova R, Yokobayashi S, Stadler MB et al.: Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev. Cell 15(5), 668-679 (2008).
    • (2008) Dev. Cell , vol.15 , Issue.5 , pp. 668-679
    • Terranova, R.1    Yokobayashi, S.2    Stadler, M.B.3
  • 10
    • 10644237968 scopus 로고    scopus 로고
    • RNAi-mediated pathways in the nucleus
    • Matzke MA, Birchler JA: RNAi-mediated pathways in the nucleus. Nat. Rev. Genet. 6(1), 24-35 (2005).
    • (2005) Nat. Rev. Genet. , vol.6 , Issue.1 , pp. 24-35
    • Ma, M.1    Birchler, J.A.2
  • 11
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg A P, Tycko B: The history of cancer epigenetics. Nat. Rev. Cancer 4(2), 143-153 (2004).
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.2 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 13
    • 0036144048 scopus 로고    scopus 로고
    • DNA methylation patterns and epigenetic memory
    • Bird A: DNA methylation patterns and epigenetic memory. Genes Dev. 16(1), 6-21 (2002).
    • (2002) Genes Dev. , vol.16 , Issue.1 , pp. 6-21
    • Bird, A.1
  • 14
    • 0033601073 scopus 로고    scopus 로고
    • Methylation-induced repression-belts, braces, and chromatin
    • Bird AP, Wolffe AP: Methylation-induced repression-belts, braces, and chromatin. Cell 99(5), 451-454 (1999).
    • (1999) Cell , vol.99 , Issue.5 , pp. 451-454
    • Bird, A.P.1    Wolffe, A.P.2
  • 15
    • 0034055278 scopus 로고    scopus 로고
    • Mammalian methyltransferases and methyl-CpG-binding domains: Proteins involved in DNA methylation
    • Hendrich B, Bird A: Mammalian methyltransferases and methyl-CpG-binding domains: proteins involved in DNA methylation. Curr. Top. Microbiol. Immunol. 249, 55-74 (2000).
    • (2000) Curr. Top. Microbiol. Immunol. , vol.249 , pp. 55-74
    • Hendrich, B.1    Bird, A.2
  • 16
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB: The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3(6), 415-428 (2002).
    • (2002) Nat. Rev. Genet. , vol.3 , Issue.6 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 17
    • 0022540321 scopus 로고
    • CpG-rich islands and the function of DNA methylation
    • Bird AP: CpG-rich islands and the function of DNA methylation. Nature 321(6067), 209-213 (1986).
    • (1986) Nature , vol.321 , Issue.6067 , pp. 209-213
    • Bird, A.P.1
  • 18
    • 0035839057 scopus 로고    scopus 로고
    • The role of DNA methylation in mammalian epigenetics
    • Jones PA, Takai D: The role of DNA methylation in mammalian epigenetics. Science 293(5532), 1068-1070 (2001).
    • (2001) Science , vol.293 , Issue.5532 , pp. 1068-1070
    • Jones, P.A.1    Takai, D.2
  • 19
    • 34249279527 scopus 로고    scopus 로고
    • Stability and fexibility of epigenetic gene regulation in mammalian development
    • Reik W: Stability and fexibility of epigenetic gene regulation in mammalian development. Nature 447(7143), 425-432 (2007).
    • (2007) Nature , vol.447 , Issue.7143 , pp. 425-432
    • Reik, W.1
  • 20
    • 34249683635 scopus 로고    scopus 로고
    • Cross-talk between aging and cancer: The epigenetic language
    • Fraga MF, Agrelo R, Esteller M: Cross-talk between aging and cancer: the epigenetic language. Ann. NY Acad. Sci. 1100, 60-74 (2007).
    • (2007) Ann. NY Acad. Sci. , vol.1100 , pp. 60-74
    • Fraga, M.F.1    Agrelo, R.2    Esteller, M.3
  • 21
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB: The epigenomics of cancer. Cell 128(4), 683-692 (2007).
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 22
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird A: Perceptions of epigenetics. Nature 447(7143), 396-398 (2007).
    • (2007) Nature , vol.447 , Issue.7143 , pp. 396-398
    • Bird, A.1
  • 23
    • 77954106482 scopus 로고    scopus 로고
    • The potential prognostic, predictive, and therapeutic values of DNA methylation in cancer
    • Widschwendter M, Jones PA: The potential prognostic, predictive, and therapeutic values of DNA methylation in cancer. Commentaryre
    • Commentaryre
    • Widschwendter, M.1    Jones, P.A.2
  • 24
    • 0036152306 scopus 로고    scopus 로고
    • Promoter hypermethylation of multiple genes in nasopharyngeal carcinoma
    • J. Kwong et al., promoter hypermethylation of multiple genes in nasopharyngeal carcinoma. Clin. Cancer Res. 8, 131-137, 2002
    • (2002) Clin. Cancer Res. , vol.8 , pp. 131-137
    • Kwong Et Al., J.1
  • 25
    • 0036152815 scopus 로고    scopus 로고
    • Detection of aberrant p16 methylation in the serum of colorectal cancer patients
    • H-Z. Zou et al., detection of aberrant p16 methylation in the serum of colorectal cancer patients. Clin. Cancer Res. 8: 188-191, 2002.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 188-191
    • Zou Et Al., H.-Z.1
  • 26
    • 0003189638 scopus 로고    scopus 로고
    • Clin. Cancer Res. 8(1), 17-21 (2002)
    • (2002) Clin. Cancer Res. , vol.8 , Issue.1 , pp. 17-21
  • 27
    • 40949087119 scopus 로고    scopus 로고
    • DNA methylation changes in ovarian cancer: Implications for early diagnosis, prognosis and treatment
    • Barton CA, Hacker NF, Clark SJ, O'Brien PM: DNA methylation changes in ovarian cancer: implications for early diagnosis, prognosis and treatment. Gynecol. Oncol. 109(1), 129-139 (2008).
    • (2008) Gynecol. Oncol. , vol.109 , Issue.1 , pp. 129-139
    • Barton, C.A.1    Hacker, N.F.2    Clark, S.J.3    O'Brien, P.M.4
  • 28
    • 34648843717 scopus 로고    scopus 로고
    • Epigenetic considerations for endometrial cancer prevention, diagnosis and treatment
    • Zhou XC, Dowdy SC, Podratz KC, Jiang SW: Epigenetic considerations for endometrial cancer prevention, diagnosis and treatment. Gynecol. Oncol. 107(1), 143-153 (2007).
    • (2007) Gynecol. Oncol. , vol.107 , Issue.1 , pp. 143-153
    • Zhou, X.C.1    Dowdy, S.C.2    Podratz, K.C.3    Jiang, S.W.4
  • 30
    • 0020699979 scopus 로고
    • Hypomethylation distinguishes genes of some human cancers from their normal counterparts
    • Feinberg AP, Vogelstein B: Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature 301(5895), 89-92 (1983).
    • (1983) Nature , vol.301 , Issue.5895 , pp. 89-92
    • Feinberg, A.P.1    Vogelstein, B.2
  • 31
    • 0035102316 scopus 로고    scopus 로고
    • Review of anthropometric factors and breast cancer risk
    • Friedenreich CM: Review of anthropometric factors and breast cancer risk. Eur. J. Cancer Prev. 10(1), 15-32 (2001).
    • (2001) Eur. J. Cancer Prev. , vol.10 , Issue.1 , pp. 15-32
    • Friedenreich, C.M.1
  • 32
    • 3242663659 scopus 로고    scopus 로고
    • An integrated epigenetic and genetic approach to common human disease
    • Bjornsson HT, Fallin MD, Feinberg AP: An integrated epigenetic and genetic approach to common human disease. Trends Genet. 20(8), 350-358 (2004).
    • (2004) Trends Genet. , vol.20 , Issue.8 , pp. 350-358
    • Bjornsson, H.T.1    Fallin, M.D.2    Feinberg, A.P.3
  • 33
    • 84977752409 scopus 로고    scopus 로고
    • Alfred Knudson and his two-hit hypothesis. (interview by Ezzie Hutchinson)
    • Knudson A: Alfred Knudson and his two-hit hypothesis. (interview by Ezzie Hutchinson). Lancet Oncol. 2(10), 642-645 (2001).
    • (2001) Lancet Oncol. , vol.2 , Issue.10 , pp. 642-645
    • Knudson, A.1
  • 34
    • 33847000890 scopus 로고    scopus 로고
    • Genetics and epigenetics-nature's pen-and-pencil set
    • Gosden RG, Feinberg AP: Genetics and epigenetics-nature's pen-and-pencil set. N. Engl. J. Med 356(7), 731-733 (2007).
    • (2007) N. Engl. J. Med , vol.356 , Issue.7 , pp. 731-733
    • Gosden, R.G.1    Feinberg, A.P.2
  • 35
    • 33846576622 scopus 로고    scopus 로고
    • Epigenetic stem cell signature in cancer
    • Widschwendter M, Fiegl H, Egle D et al.: Epigenetic stem cell signature in cancer. Nat. Genet. 39(2), 157-158 (2007).
    • (2007) Nat. Genet. , vol.39 , Issue.2 , pp. 157-158
    • Widschwendter, M.1    Fiegl, H.2    Egle, D.3
  • 36
    • 34548757364 scopus 로고    scopus 로고
    • Epigenetic reprogramming and imprinting in origins of disease
    • Tang WY, Ho SM: Epigenetic reprogramming and imprinting in origins of disease. Rev. Endocr. Metab. Disord. 8(2), 173-182 (2007).
    • (2007) Rev. Endocr. Metab. Disord. , vol.8 , Issue.2 , pp. 173-182
    • Tang, W.Y.1    Ho, S.M.2
  • 37
    • 33745621608 scopus 로고    scopus 로고
    • Neonatal exposure to diethylstilbestrol alters the expression of DNA methyltransferases and methylation of genomic DNA in the epididymis of mice
    • Sato K, Fukata H, Kogo Y, Ohgane J, Shiota K, Mori C: Neonatal exposure to diethylstilbestrol alters the expression of DNA methyltransferases and methylation of genomic DNA in the epididymis of mice. Endocr. J. 53(3), 331-337 (2006).
    • (2006) Endocr. J. , vol.53 , Issue.3 , pp. 331-337
    • Sato, K.1    Fukata, H.2    Kogo, Y.3    Ohgane, J.4    Shiota, K.5    Mori, C.6
  • 38
    • 2542629617 scopus 로고    scopus 로고
    • Association of breast cancer DNA methylation profles with hormone receptor status and response to tamoxifen
    • Widschwendter M, Siegmund KD, Muller HM et al.: Association of breast cancer DNA methylation profles with hormone receptor status and response to tamoxifen. Cancer Res. 64(11), 3807-3813 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.11 , pp. 3807-3813
    • Widschwendter, M.1    Siegmund, K.D.2    Muller, H.M.3
  • 39
    • 50549100645 scopus 로고    scopus 로고
    • Epigenotyping in peripheral blood cell DNA and breast cancer risk: A proof of principle study
    • Widschwendter M, Apostolidou S, Raum E et al.: Epigenotyping in peripheral blood cell DNA and breast cancer risk: a proof of principle study. PLoS ONE 3(7), E2656 (2008).
    • (2008) PLoS ONE , vol.3 , Issue.7
    • Widschwendter, M.1    Apostolidou, S.2    Raum, E.3
  • 40
    • 0021761269 scopus 로고
    • Methylation of either cytosine in the recognition sequence CGCG inhibits ThaI cleavage of DNA
    • Strobl JS, Thompson EB: Methylation of either cytosine in the recognition sequence CGCG inhibits ThaI cleavage of DNA. Nucleic Acids Res. 12(21), 8073-8083 (1984).
    • (1984) Nucleic Acids Res. , vol.12 , Issue.21 , pp. 8073-8083
    • Strobl, J.S.1    Thompson, E.B.2
  • 41
    • 0019322522 scopus 로고
    • The 5́-cytosine in CCGG1 is methylated in two eukaryotic DNAs and Msp i is sensitive to methylation at this site
    • Sneider TW: The 5́-cytosine in CCGG1 is methylated in two eukaryotic DNAs and Msp I is sensitive to methylation at this site. Nucleic Acids Res. 8(17), 3829-3840 (1980).
    • (1980) Nucleic Acids Res. , vol.8 , Issue.17 , pp. 3829-3840
    • Sneider, T.W.1
  • 42
    • 0019769519 scopus 로고
    • The effect of sequence specifc DNA methylation on restriction endonuclease cleavage
    • McClelland M: The effect of sequence specifc DNA methylation on restriction endonuclease cleavage. Nucleic Acids Res. 9(22), 5859-5866 (1981).
    • (1981) Nucleic Acids Res. , vol.9 , Issue.22 , pp. 5859-5866
    • McClelland, M.1
  • 43
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modifcation maps
    • Esteller M: Cancer epigenomics: DNA methylomes and histone-modifcation maps. Nat. Rev. Genet. 8(4), 286-298 (2007).
    • (2007) Nat. Rev. Genet. , vol.8 , Issue.4 , pp. 286-298
    • Esteller, M.1
  • 45
    • 0017841507 scopus 로고
    • Use of restriction enzymes to study eukaryotic DNA methylation: I. the methylation pattern in ribosomal DNA from Xenopus laevis
    • Bird AP, Southern EM: Use of restriction enzymes to study eukaryotic DNA methylation: I. The methylation pattern in ribosomal DNA from Xenopus laevis. J. Mol. Biol. 118(1), 27-47 (1978).
    • (1978) J. Mol. Biol. , vol.118 , Issue.1 , pp. 27-47
    • Bird, A.P.1    Southern, E.M.2
  • 46
    • 0025200793 scopus 로고
    • A method to analyze allele-specifc methylation
    • Bedford MT, van Helden PD: A method to analyze allele-specifc methylation. Biotechniques 9(6), 744-748 (1990).
    • (1990) Biotechniques , vol.9 , Issue.6 , pp. 744-748
    • Bedford, M.T.1    Van Helden, P.D.2
  • 47
    • 0025633560 scopus 로고
    • Fingerprinting genomes using PCR with arbitrary primers
    • Welsh J, McClelland M: Fingerprinting genomes using PCR with arbitrary primers. Nucleic Acids Res. 18(24), 7213-7218 (1990).
    • (1990) Nucleic Acids Res. , vol.18 , Issue.24 , pp. 7213-7218
    • Welsh, J.1    McClelland, M.2
  • 48
    • 0031050736 scopus 로고    scopus 로고
    • Identifcation and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR
    • Gonzalgo ML, Liang G, Spruck CH 3rd, Zingg JM, Rideout WM 3rd, Jones PA: Identifcation and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR. Cancer Res. 57(4), 594-599 (1997).
    • (1997) Cancer Res. , vol.57 , Issue.4 , pp. 594-599
    • Gonzalgo, M.L.1    Liang, G.2    Iii Ch, S.3    Zingg, J.M.4    Rideout Iii, W.M.5    Jones, P.A.6
  • 49
    • 33644782715 scopus 로고    scopus 로고
    • Satr-1 hypomethylation is a common and early event in breast cancer
    • Costa FF, Paixao VA, Cavalher FP et al.: Satr-1 hypomethylation is a common and early event in breast cancer. Cancer Genet. Cytogenet. 165(2), 135-143 (2006).
    • (2006) Cancer Genet. Cytogenet. , vol.165 , Issue.2 , pp. 135-143
    • Costa, F.F.1    Paixao, V.A.2    Cavalher, F.P.3
  • 51
    • 42049110756 scopus 로고    scopus 로고
    • Identifcation of novel methylation markers in cervical cancer using restriction landmark genomic scanning
    • Wang SS, Smiraglia DJ, Wu YZ et al.: Identifcation of novel methylation markers in cervical cancer using restriction landmark genomic scanning. Cancer Res. 68(7), 2489-2497 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.7 , pp. 2489-2497
    • Wang, S.S.1    Smiraglia, D.J.2    Wu, Y.Z.3
  • 52
    • 0033047813 scopus 로고    scopus 로고
    • Methylation profling of CpG islands in human breast cancer cells
    • Huang TH, Perry MR, Laux DE: Methylation profling of CpG islands in human breast cancer cells. Hum. Mol. Genet. 8(3), 459-470 (1999).
    • (1999) Hum. Mol. Genet. , vol.8 , Issue.3 , pp. 459-470
    • Huang, T.H.1    Perry, M.R.2    De, L.3
  • 54
    • 0034904625 scopus 로고    scopus 로고
    • DNA methylation and ovarian cancer. I. Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization
    • Ahluwalia A, Yan P, Hurteau JA et al.: DNA methylation and ovarian cancer. I. Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization. Gynecol. Oncol. 82(2), 261-268 (2001).
    • (2001) Gynecol. Oncol. , vol.82 , Issue.2 , pp. 261-268
    • Ahluwalia, A.1    Yan, P.2    Hurteau, J.A.3
  • 55
    • 0036322489 scopus 로고    scopus 로고
    • Applications of CpG island microarrays for high-throughput ana lysis of DNA methylation
    • Yan PS, Chen CM, Shi H, Rahmatpanah F, Wei SH, Huang TH: Applications of CpG island microarrays for high-throughput ana lysis of DNA methylation. J. Nutr. 132(8 Suppl.), S2430-S2434 (2002).
    • (2002) J. Nutr. , vol.132 , Issue.SUPPL.
    • Yan, P.S.1    Chen, C.M.2    Shi, H.3    Rahmatpanah, F.4    Wei, S.H.5    Huang, T.H.6
  • 56
    • 34249782843 scopus 로고    scopus 로고
    • Differential methylation hybridization array of endometrial cancers reveals two novel cancer-specifc methylation markers
    • Zighelboim I, Goodfellow PJ, Schmidt AP et al.: Differential methylation hybridization array of endometrial cancers reveals two novel cancer-specifc methylation markers. Clin. Cancer Res. 13(10), 2882-2889 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.10 , pp. 2882-2889
    • Zighelboim, I.1    Goodfellow, P.J.2    Schmidt, A.P.3
  • 57
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • Frommer M, Mcdonald LE, Millar DS et al.: A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc. Natl Acad. Sci. USA 89(5), 1827-1831 (1992).
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , Issue.5 , pp. 1827-1831
    • Frommer, M.1    McDonald, L.E.2    Millar, D.S.3
  • 59
    • 0034654669 scopus 로고    scopus 로고
    • Methylight: A high-throughput assay to measure DNA methylation
    • Eads CA, Danenberg KD, Kawakami K et al.: Methylight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res. 28(8), E32 (2000).
    • (2000) Nucleic Acids Res. , vol.28 , Issue.8
    • Eads, C.A.1    Danenberg, K.D.2    Kawakami, K.3
  • 60
    • 42449142344 scopus 로고    scopus 로고
    • Sensitive melting ana lysis after real time-methylation specifc PCR (SMART-MSP): High-throughput and probe-free quantitative DNA methylation detection
    • Kristensen LS, Mikeska T, Krypuy M, Dobrovic A: Sensitive melting ana lysis after real time-methylation specifc PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection. Nucleic Acids Res. 36(7), E42 (2008).
    • (2008) Nucleic Acids Res. , vol.36 , Issue.7
    • Kristensen, L.S.1    Mikeska, T.2    Krypuy, M.3    Dobrovic, A.4
  • 61
    • 0033607147 scopus 로고    scopus 로고
    • In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis
    • Nuovo GJ, Plaia TW, Belinsky SA, Baylin SB, Herman JG: In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis. Proc. Natl Acad. Sci. USA 96(22), 12754-12759 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , Issue.22 , pp. 12754-12759
    • Nuovo, G.J.1    Plaia, T.W.2    Belinsky, S.A.3    Baylin, S.B.4    Herman, J.G.5
  • 62
    • 0030825309 scopus 로고    scopus 로고
    • COBRA: A sensitive and quantitative DNA methylation assay
    • Xiong Z, Laird PW: COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res. 25(12), 2532-2534 (1997).
    • (1997) Nucleic Acids Res. , vol.25 , Issue.12 , pp. 2532-2534
    • Xiong, Z.1    Laird, P.W.2
  • 63
    • 27744443057 scopus 로고    scopus 로고
    • Methylated-CpG island recovery assay: A new technique for the rapid detection of methylated-CpG islands in cancer
    • Rauch T, Pfeifer GP: Methylated-CpG island recovery assay: a new technique for the rapid detection of methylated-CpG islands in cancer. Lab. Invest. 85(9), 1172-1180 (2005).
    • (2005) Lab. Invest. , vol.85 , Issue.9 , pp. 1172-1180
    • Rauch, T.1    Pfeifer, G.P.2
  • 64
    • 33748055105 scopus 로고    scopus 로고
    • Mira-assisted microarray ana lysis, a new technology for the determination of DNA methylation patterns, identifes frequent methylation of homeodomain-containing genes in lung cancer cells
    • Rauch T, Li H, Wu X, Pfeifer GP: Mira-assisted microarray ana lysis, a new technology for the determination of DNA methylation patterns, identifes frequent methylation of homeodomain-containing genes in lung cancer cells. Cancer Res. 66(16), 7939-7947 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.16 , pp. 7939-7947
    • Rauch, T.1    Li, H.2    Wu, X.3    Pfeifer, G.P.4
  • 65
    • 67549095233 scopus 로고    scopus 로고
    • Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer
    • Tommasi S, Karm DL, Wu X, Yen Y, Pfeifer GP: Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer. Breast Cancer Res. 11(1), R14 (2009).
    • (2009) Breast Cancer Res. , vol.11 , Issue.1
    • Tommasi, S.1    Karm, D.L.2    Wu, X.3    Yen, Y.4    Pfeifer, G.P.5
  • 66
    • 23044514626 scopus 로고    scopus 로고
    • Chromosome-wide and promoter-specifc analyses identify sites of differential DNA methylation in normal and transformed human cells
    • Weber M, Davies JJ, Wittig D et al.: Chromosome-wide and promoter-specifc analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat. Genet. 37(8), 853-862 (2005).
    • (2005) Nat. Genet. , vol.37 , Issue.8 , pp. 853-862
    • Weber, M.1    Davies, J.J.2    Wittig, D.3
  • 67
    • 0021101229 scopus 로고
    • The 5-methylcytosine content of DNA from human tumors
    • Gama-Sosa MA, Slagel VA, Trewyn RW et al.: The 5-methylcytosine content of DNA from human tumors. Nucleic Acids Res. 11(19), 6883-6894 (1983).
    • (1983) Nucleic Acids Res. , vol.11 , Issue.19 , pp. 6883-6894
    • Ma, G.1    Slagel, V.A.2    Trewyn, R.W.3
  • 68
    • 49249091385 scopus 로고    scopus 로고
    • DNA methylation ana lysis by digital bisulfte genomic sequencing and digital methylight
    • Weisenberger DJ, Trinh BN, Campan M et al.: DNA methylation ana lysis by digital bisulfte genomic sequencing and digital methylight. Nucleic Acids Res. 36(14), 4689-4698 (2008).
    • (2008) Nucleic Acids Res. , vol.36 , Issue.14 , pp. 4689-4698
    • Weisenberger, D.J.1    Trinh, B.N.2    Campan, M.3
  • 70
    • 33644649616 scopus 로고    scopus 로고
    • High-throughput DNA methylation profling using universal bead arrays
    • Bibikova M, Lin Z, Zhou L et al.: High-throughput DNA methylation profling using universal bead arrays. Genome Res. 16(3), 383-393 (2006).
    • (2006) Genome Res. , vol.16 , Issue.3 , pp. 383-393
    • Bibikova, M.1    Lin, Z.2    Zhou, L.3
  • 71
    • 0030738231 scopus 로고    scopus 로고
    • Rapid quantitation of methylation differences at specifc sites using methylation-sensitive single nucleotide primer extension (MS-SNUPE)
    • Gonzalgo ML, Jones PA: Rapid quantitation of methylation differences at specifc sites using methylation-sensitive single nucleotide primer extension (MS-SNUPE). Nucleic Acids Res. 25(12), 2529-2531 (1997).
    • (1997) Nucleic Acids Res. , vol.25 , Issue.12 , pp. 2529-2531
    • Gonzalgo, M.L.1    Jones, P.A.2
  • 72
    • 63149135457 scopus 로고    scopus 로고
    • Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients
    • Flanagan JM, Munoz-Alegre M, Henderson S et al.: Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients. Hum. Mol. Genet. 18(7), 1332-1342 (2009).
    • (2009) Hum. Mol. Genet. , vol.18 , Issue.7 , pp. 1332-1342
    • Flanagan, J.M.1    Munoz-Alegre, M.2    Henderson, S.3
  • 73
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specifc CpG island shores
    • Irizarry RA, Ladd-Acosta C, Wen B et al.: The human colon cancer methylome shows similar hypo-and hypermethylation at conserved tissue-specifc CpG island shores. Nat. Genet. 41(2), 178-186 (2009).
    • (2009) Nat. Genet. , vol.41 , Issue.2 , pp. 178-186
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Wen, B.3
  • 74
    • 43749098985 scopus 로고    scopus 로고
    • DNA methylation landscapes: Provocative insights from epigenomics
    • Suzuki MM, Bird A: DNA methylation landscapes: provocative insights from epigenomics. Nat. Rev. Genet. 9(6), 465-476 (2008).
    • (2008) Nat. Rev. Genet. , vol.9 , Issue.6 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.2
  • 75
    • 38049073696 scopus 로고    scopus 로고
    • Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer-associated cytosine-methylation patterns obtained from tissue and serum DNA
    • Korshunova Y, Maloney RK, Lakey N et al.: Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer-associated cytosine-methylation patterns obtained from tissue and serum DNA. Genome Res. 18(1), 19-29 (2008).
    • (2008) Genome Res. , vol.18 , Issue.1 , pp. 19-29
    • Korshunova, Y.1    Maloney, R.K.2    Lakey, N.3
  • 76
  • 77
    • 56749103412 scopus 로고    scopus 로고
    • The cell of origin of ovarian epithelial tumours
    • Dubeau L: The cell of origin of ovarian epithelial tumours. Lancet Oncol. 9(12), 1191-1197 (2008).
    • (2008) Lancet Oncol. , vol.9 , Issue.12 , pp. 1191-1197
    • Dubeau, L.1
  • 78
    • 4644271551 scopus 로고    scopus 로고
    • Tumor cell-specifc BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fuid from ovarian cancer patients
    • Ibanez De Caceres I, Battagli C, Esteller M et al.: Tumor cell-specifc BRCA1 and RASSF1A hypermethylation in serum, plasma, and peritoneal fuid from ovarian cancer patients. Cancer Res. 64(18), 6476-6481 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.18 , pp. 6476-6481
    • Ibanez De Caceres, I.1    Battagli, C.2    Esteller, M.3
  • 79
    • 0344241483 scopus 로고    scopus 로고
    • Promoter hypermethylation as an epigenetic component in type i and type II endometrial cancers
    • Risinger JI, Maxwell GL, Berchuck A, Barrett JC: Promoter hypermethylation as an epigenetic component in type I and type II endometrial cancers. Ann. NY Acad. Sci. 983, 208-212 (2003).
    • (2003) Ann. NY Acad. Sci. , vol.983 , pp. 208-212
    • Risinger, J.I.1    Maxwell, G.L.2    Berchuck, A.3    Barrett, J.C.4
  • 80
    • 13844255666 scopus 로고    scopus 로고
    • Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers
    • Xiong Y, Dowdy SC, Xue A et al.: Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers. Gynecol. Oncol. 96(3), 601-609 (2005).
    • (2005) Gynecol. Oncol. , vol.96 , Issue.3 , pp. 601-609
    • Xiong, Y.1    Dowdy, S.C.2    Xue, A.3
  • 81
    • 2542423215 scopus 로고    scopus 로고
    • Methylated DNA collected by tampons-a new tool to detect endometrial cancer
    • Fiegl H, Gattringer C, Widschwendter A et al.: Methylated DNA collected by tampons-a new tool to detect endometrial cancer. Cancer Epidemiol. Biomarkers Prev. 13(5), 882-888 (2004).
    • (2004) Cancer Epidemiol. Biomarkers Prev. , vol.13 , Issue.5 , pp. 882-888
    • Fiegl, H.1    Gattringer, C.2    Widschwendter, A.3
  • 82
    • 33748506081 scopus 로고    scopus 로고
    • Assessment of gene promoter hypermethylation for detection of cervical neoplasia
    • Wisman GB, Nijhuis ER, Hoque MO et al.: Assessment of gene promoter hypermethylation for detection of cervical neoplasia. Int. J. Cancer 119(8), 1908-1914 (2006).
    • (2006) Int. J. Cancer , vol.119 , Issue.8 , pp. 1908-1914
    • Wisman, G.B.1    Nijhuis, E.R.2    Hoque, M.O.3
  • 84
    • 33646725688 scopus 로고    scopus 로고
    • Prognostic DNA methylation biomarkers in ovarian cancer
    • Wei SH, Balch C, Paik HH et al.: Prognostic DNA methylation biomarkers in ovarian cancer. Clin. Cancer Res. 12(9), 2788-2794 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.9 , pp. 2788-2794
    • Wei, S.H.1    Balch, C.2    Paik, H.H.3
  • 85
    • 3042774430 scopus 로고    scopus 로고
    • The acquisition of HMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients
    • Gifford G, Paul J, Vasey PA, Kaye SB, Brown R: The acquisition of HMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients. Clin. Cancer Res. 10(13), 4420-4426 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , Issue.13 , pp. 4420-4426
    • Gifford, G.1    Paul, J.2    Vasey, P.A.3    Kaye, S.B.4    Brown, R.5
  • 86
    • 50349102805 scopus 로고    scopus 로고
    • Aneuploidy predicts outcome in patients with endometrial carcinoma and is related to lack of CDH13 hypermethylation
    • Suehiro Y, Okada T, Okada T et al.: Aneuploidy predicts outcome in patients with endometrial carcinoma and is related to lack of CDH13 hypermethylation. Clin. Cancer Res. 14(11), 3354-3361 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.11 , pp. 3354-3361
    • Suehiro, Y.1    Okada, T.2    Okada, T.3
  • 87
    • 0036604045 scopus 로고    scopus 로고
    • Ribosomal DNA methylation in patients with endometrial carcinoma: An independent prognostic marker
    • Powell MA, Mutch DG, Rader JS, Herzog TJ, Huang TH, Goodfellow PJ: Ribosomal DNA methylation in patients with endometrial carcinoma: an independent prognostic marker. Cancer 94(11), 2941-2952 (2002).
    • (2002) Cancer , vol.94 , Issue.11 , pp. 2941-2952
    • Ma, P.1    Mutch, D.G.2    Rader, J.S.3    Herzog, T.J.4    Huang, T.H.5    Goodfellow, P.J.6
  • 89
    • 10744226762 scopus 로고    scopus 로고
    • CDH1 and CDH13 methylation in serum is an independent prognostic marker in cervical cancer patients
    • Widschwendter A, Ivarsson L, Blassnig A et al.: CDH1 and CDH13 methylation in serum is an independent prognostic marker in cervical cancer patients. Int. J. Cancer 109(2), 163-166 (2004).
    • (2004) Int. J. Cancer , vol.109 , Issue.2 , pp. 163-166
    • Widschwendter, A.1    Ivarsson, L.2    Blassnig, A.3
  • 90
    • 25444485414 scopus 로고    scopus 로고
    • CpG island methylation of DNA damage response genes in advanced ovarian cancer
    • Teodoridis JM, Hall J, Marsh S et al.: CpG island methylation of DNA damage response genes in advanced ovarian cancer. Cancer Res. 65(19), 8961-8967 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.19 , pp. 8961-8967
    • Teodoridis, J.M.1    Hall, J.2    Marsh, S.3
  • 91
    • 55649100076 scopus 로고    scopus 로고
    • Her-2/neu overexpression and p53 mutations in ovarian carcinoma
    • Feng Q, Deftereos G, Hawes SE et al.: DNA hypermethylation, Her-2/neu overexpression and p53 mutations in ovarian carcinoma. Gynecol. Oncol. 111(2), 320-329 (2008).
    • (2008) Gynecol. Oncol. , vol.111 , Issue.2 , pp. 320-329
    • Feng, Q.1    Deftereos, G.2    Hawes, S.E.3
  • 92
    • 20444461499 scopus 로고    scopus 로고
    • Demethylation of the MCJ gene in stage III/IV epithelial ovarian cancer and response to chemotherapy
    • Strathdee G, Vass JK, Oien KA, Siddiqui N, Curto-Garcia J, Brown R: Demethylation of the MCJ gene in stage III/IV epithelial ovarian cancer and response to chemotherapy. Gynecol. Oncol. 97(3), 898-903 (2005).
    • (2005) Gynecol. Oncol. , vol.97 , Issue.3 , pp. 898-903
    • Strathdee, G.1    Vass, J.K.2    Oien, K.A.3    Siddiqui, N.4    Curto-Garcia, J.5    Brown, R.6
  • 93
    • 13944250245 scopus 로고    scopus 로고
    • Circulating tumor-specifc DNA: A marker for monitoring effcacy of adjuvant therapy in cancer patients
    • Fiegl H, Millinger S, Mueller-Holzner E et al.: Circulating tumor-specifc DNA: a marker for monitoring effcacy of adjuvant therapy in cancer patients. Cancer Res. 65(4), 1141-1145 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.4 , pp. 1141-1145
    • Fiegl, H.1    Millinger, S.2    Mueller-Holzner, E.3
  • 94
    • 50349097689 scopus 로고    scopus 로고
    • Methylated NEUROD1 promoter is a marker for chemosensitivity in breast cancer
    • Fiegl H, Jones A, Hauser-Kronberger C et al.: Methylated NEUROD1 promoter is a marker for chemosensitivity in breast cancer. Clin. Cancer Res. 14(11), 3494-3502 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.11 , pp. 3494-3502
    • Fiegl, H.1    Jones, A.2    Hauser-Kronberger, C.3
  • 95
    • 20144365156 scopus 로고    scopus 로고
    • Association of DNA methylation of phosphoserine aminotransferase with response to endocrine therapy in patients with recurrent breast cancer
    • Martens JW, Nimmrich I, Koenig T et al.: Association of DNA methylation of phosphoserine aminotransferase with response to endocrine therapy in patients with recurrent breast cancer. Cancer Res. 65(10), 4101-4117 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.10 , pp. 4101-4117
    • Martens, J.W.1    Nimmrich, I.2    Koenig, T.3
  • 97
    • 53549097349 scopus 로고    scopus 로고
    • MicroRNAs: Key players in the immune system, differentiation, tumorigenesis and cell death
    • Schickel R, Boyerinas B, Park SM, Peter ME: MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death. Oncogene 27(45), 5959-5974 (2008).
    • (2008) Oncogene , vol.27 , Issue.45 , pp. 5959-5974
    • Schickel, R.1    Boyerinas, B.2    Park, S.M.3    Peter, M.E.4
  • 98
    • 46949098033 scopus 로고    scopus 로고
    • Current status of epigenetic treatment in myelodysplastic syndromes
    • Kuendgen A, Lubbert M: Current status of epigenetic treatment in myelodysplastic syndromes. Ann. Hematol. 87(8), 601-611 (2008).
    • (2008) Ann. Hematol. , vol.87 , Issue.8 , pp. 601-611
    • Kuendgen, A.1    Lubbert, M.2
  • 99
    • 34547683194 scopus 로고    scopus 로고
    • Phase IIB multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma
    • Olsen EA, Kim YH, Kuzel TM et al.: Phase IIB multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma. J. Clin. Oncol. 25(21), 3109-3115 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.21 , pp. 3109-3115
    • Olsen, E.A.1    Kim, Y.H.2    Kuzel, T.M.3
  • 100
    • 68149126345 scopus 로고    scopus 로고
    • Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells
    • Saito Y, Suzuki H, Tsugawa H et al.: Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells. Oncogene 28(30), 2738-2744 (2009).
    • (2009) Oncogene , vol.28 , Issue.30 , pp. 2738-2744
    • Saito, Y.1    Suzuki, H.2    Tsugawa, H.3
  • 101
    • 66249127951 scopus 로고    scopus 로고
    • A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation
    • Datta J, Ghoshal K, Denny WA et al.: A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Cancer Res. 69(10), 4277-4285 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.10 , pp. 4277-4285
    • Datta, J.1    Ghoshal, K.2    Denny, W.A.3
  • 102
    • 38449106861 scopus 로고    scopus 로고
    • Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: Basic concepts and clinical applications
    • Mund C, Brueckner B, Lyko F: Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: basic concepts and clinical applications. Epigenetics 1(1), 7-13 (2006).
    • (2006) Epigenetics , vol.1 , Issue.1 , pp. 7-13
    • Mund, C.1    Brueckner, B.2    Lyko, F.3
  • 103
    • 38949146399 scopus 로고    scopus 로고
    • A Phase i pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors
    • Steele NL, Plumb JA, Vidal L et al.: A Phase I pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advanced solid tumors. Clin. Cancer Res. 14(3), 804-810 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.3 , pp. 804-810
    • Steele, N.L.1    Plumb, J.A.2    Vidal, L.3
  • 104
    • 33645086120 scopus 로고    scopus 로고
    • Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines
    • Stresemann C, Brueckner B, Musch T, Stopper H, Lyko F: Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 66(5), 2794-2800 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.5 , pp. 2794-2800
    • Stresemann, C.1    Brueckner, B.2    Musch, T.3    Stopper, H.4    Lyko, F.5
  • 105
    • 43949136445 scopus 로고    scopus 로고
    • Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine
    • Stresemann C, Lyko F: Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine. Int. J. Cancer 123(1), 8-13 (2008).
    • (2008) Int. J. Cancer , vol.123 , Issue.1 , pp. 8-13
    • Stresemann, C.1    Lyko, F.2
  • 106
    • 33749598345 scopus 로고    scopus 로고
    • Epigenetic activation of tumor suppressor microRNAs in human cancer cells
    • Saito Y, Jones PA: Epigenetic activation of tumor suppressor microRNAs in human cancer cells. Cell Cycle 5(19), 2220-2222 (2006).
    • (2006) Cell Cycle , vol.5 , Issue.19 , pp. 2220-2222
    • Saito, Y.1    Jones, P.A.2
  • 107
    • 3042822370 scopus 로고    scopus 로고
    • DNA hypomethylation and ovarian cancer biology
    • Widschwendter M, Jiang G, Woods C et al.: DNA hypomethylation and ovarian cancer biology. Cancer Res. 64(13), 4472-4480 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.13 , pp. 4472-4480
    • Widschwendter, M.1    Jiang, G.2    Woods, C.3
  • 108
    • 0242584449 scopus 로고    scopus 로고
    • Induction of tumors in mice by genomic hypomethylation
    • Gaudet F, Hodgson JG, Eden A et al.: Induction of tumors in mice by genomic hypomethylation. Science 300(5618), 489-492 (2003).
    • (2003) Science , vol.300 , Issue.5618 , pp. 489-492
    • Gaudet, F.1    Hodgson, J.G.2    Eden, A.3
  • 109
    • 28844468518 scopus 로고    scopus 로고
    • Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells
    • Chekhun VF, Kulik GI, Yurchenko OV et al.: Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells. Cancer Lett. 231(1), 87-93 (2006).
    • (2006) Cancer Lett. , vol.231 , Issue.1 , pp. 87-93
    • Chekhun, V.F.1    Kulik, G.I.2    Yurchenko, O.V.3
  • 110
    • 5444227862 scopus 로고    scopus 로고
    • Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach
    • Gius D, Cui H, Bradbury CM et al.: Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell 6(4), 361-371 (2004).
    • (2004) Cancer Cell , vol.6 , Issue.4 , pp. 361-371
    • Gius, D.1    Cui, H.2    Bradbury, C.M.3
  • 112
    • 67449147110 scopus 로고    scopus 로고
    • Targeting DNA methylation
    • Issa JP, Kantarjian HM: Targeting DNA methylation. Clin. Cancer Res. 15(12), 3938-3946 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.12 , pp. 3938-3946
    • Issa, J.P.1    Kantarjian, H.M.2
  • 113
    • 27144535374 scopus 로고    scopus 로고
    • Trapped in action: Direct visualization of DNA methyltransferase activity in living cells
    • Schermelleh L, Spada F, Easwaran HP et al.: Trapped in action: direct visualization of DNA methyltransferase activity in living cells. Nat. Methods 2(10), 751-756 (2005).
    • (2005) Nat. Methods , vol.2 , Issue.10 , pp. 751-756
    • Schermelleh, L.1    Spada, F.2    Easwaran, H.P.3
  • 114
    • 18944383889 scopus 로고    scopus 로고
    • 5-aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the ken box, bromo-adjacent homology domain, and nuclear localization signal
    • Ghoshal K, Datta J, Majumder S et al.: 5-aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the ken box, bromo-adjacent homology domain, and nuclear localization signal. Mol. Cell. Biol. 25(11), 4727-4741 (2005).
    • (2005) Mol. Cell. Biol. , vol.25 , Issue.11 , pp. 4727-4741
    • Ghoshal, K.1    Datta, J.2    Majumder, S.3
  • 115
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones PA, Taylor SM: Cellular differentiation, cytidine analogs and DNA methylation. Cell 20(1), 85-93 (1980).
    • (1980) Cell , vol.20 , Issue.1 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 116
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: Past, present and future
    • Yoo CB, Jones PA: Epigenetic therapy of cancer: past, present and future. Nat. Rev. Drug Discov. 5(1), 37-50 (2006).
    • (2006) Nat. Rev. Drug Discov. , vol.5 , Issue.1 , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2
  • 117
    • 34447123203 scopus 로고    scopus 로고
    • Delivery of 5-aza-2́-deoxycytidine to cells using oligodeoxynucleotides
    • Yoo CB, Jeong S, Egger G et al.: Delivery of 5-aza-2́-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res. 67(13), 6400-6408 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.13 , pp. 6400-6408
    • Yoo, C.B.1    Jeong, S.2    Egger, G.3
  • 118
    • 33846260563 scopus 로고    scopus 로고
    • Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fuoro-2́-deoxycytidine in mice
    • Beumer JH, Eiseman JL, Parise RA et al.: Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fuoro-2́-deoxycytidine in mice. Clin. Cancer Res. 12(24), 7483-7491 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.24 , pp. 7483-7491
    • Beumer, J.H.1    Eiseman, J.L.2    Parise, R.A.3
  • 119
    • 43749124047 scopus 로고    scopus 로고
    • Concentrations of the DNA methyltransferase inhibitor 5-fuoro-2́-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU)
    • Beumer JH, Parise RA, Newman EM et al.: Concentrations of the DNA methyltransferase inhibitor 5-fuoro-2́-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU). Cancer Chemother. Pharmacol. 62(2), 363-368 (2008).
    • (2008) Cancer Chemother. Pharmacol. , vol.62 , Issue.2 , pp. 363-368
    • Beumer, J.H.1    Parise, R.A.2    Newman, E.M.3
  • 120
    • 0037132383 scopus 로고    scopus 로고
    • Alcohol, tobacco and breast cancer-collaborative reana lysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease
    • Hamajima N, Hirose K, Tajima K et al.: Alcohol, tobacco and breast cancer-collaborative reana lysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br. J. Cancer 87(11), 1234-1245 (2002).
    • (2002) Br. J. Cancer , vol.87 , Issue.11 , pp. 1234-1245
    • Hamajima, N.1    Hirose, K.2    Tajima, K.3
  • 121
    • 34548414620 scopus 로고    scopus 로고
    • Phase i and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors
    • Appleton K, Mackay HJ, Judson I et al.: Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors. J. Clin. Oncol. 25(29), 4603-4609 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.29 , pp. 4603-4609
    • Appleton, K.1    MacKay, H.J.2    Judson, I.3
  • 122
    • 67449138841 scopus 로고    scopus 로고
    • Epigenetic modifers: Basic understanding and clinical development
    • Piekarz RL, Bates SE: Epigenetic modifers: basic understanding and clinical development. Clin. Cancer Res. 15(12), 3918-3926 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.12 , pp. 3918-3926
    • Piekarz, R.L.1    Bates, S.E.2
  • 123
    • 65649152375 scopus 로고    scopus 로고
    • Phase i study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors
    • Plummer R, Vidal L, Griffn M et al.: Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors. Clin. Cancer Res. 15(9), 3177-3183 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.9 , pp. 3177-3183
    • Plummer, R.1    Vidal, L.2    Griffn, M.3
  • 124
    • 42249104213 scopus 로고    scopus 로고
    • A Phase i biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia
    • Klisovic RB, Stock W, Cataland S et al.: A Phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia. Clin. Cancer Res. 14(8), 2444-2449 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.8 , pp. 2444-2449
    • Klisovic, R.B.1    Stock, W.2    Cataland, S.3
  • 125
    • 33645462696 scopus 로고    scopus 로고
    • Synthesis and in vitro evaluation of biotinylated RG108: A high affnity compound for studying binding interactions with human DNA methyltransferases
    • Schirrmacher E, Beck C, Brueckner B et al.: Synthesis and in vitro evaluation of biotinylated RG108: a high affnity compound for studying binding interactions with human DNA methyltransferases. Bioconjug. Chem. 17(2), 261-266 (2006).
    • (2006) Bioconjug. Chem. , vol.17 , Issue.2 , pp. 261-266
    • Schirrmacher, E.1    Beck, C.2    Brueckner, B.3
  • 126
    • 77954091256 scopus 로고    scopus 로고
    • Randomized Phase II study of decitabine in combination with carboplatin compared with carboplatin alone in patients with recurrent advanced ovarian cancer
    • Abstract 5562
    • Glasspool RM, Gore M, Rustin G et al.: Randomized Phase II study of decitabine in combination with carboplatin compared with carboplatin alone in patients with recurrent advanced ovarian cancer. J. Clin. Oncol. 27(Suppl. 15) (2009) (Abstract 5562).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL. 15
    • Glasspool, R.M.1    Gore, M.2    Rustin, G.3
  • 127
    • 0036794950 scopus 로고    scopus 로고
    • Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix
    • Pohlmann P, Dileone LP, Cancella AI et al.: Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix. Am. J. Clin. Oncol. 25(5), 496-501 (2002).
    • (2002) Am. J. Clin. Oncol. , vol.25 , Issue.5 , pp. 496-501
    • Pohlmann, P.1    Dileone, L.P.2    Cancella, A.I.3
  • 128
    • 58149174109 scopus 로고    scopus 로고
    • Phase i study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers
    • Braiteh F, Soriano AO, Garcia-Manero G et al.: Phase I study of epigenetic modulation with 5-azacytidine and valproic acid in patients with advanced cancers. Clin. Cancer Res. 14(19), 6296-6301 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.19 , pp. 6296-6301
    • Braiteh, F.1    Soriano, A.O.2    Garcia-Manero, G.3
  • 129
    • 33750914483 scopus 로고    scopus 로고
    • Observation of muon neutrino disappearance with the minos detectors in the numi neutrino beam
    • Michael DG, Adamson P, Alexopoulos T et al.: Observation of muon neutrino disappearance with the minos detectors in the numi neutrino beam. Phys. Rev. Lett. 97(19), 191801 (2006).
    • (2006) Phys. Rev. Lett. , vol.97 , Issue.19 , pp. 191801
    • Michael, D.G.1    Adamson, P.2    Alexopoulos, T.3
  • 131
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifcations and their function
    • Kouzarides T: Chromatin modifcations and their function. Cell 128(4), 693-705 (2007).
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 132
    • 43049163953 scopus 로고    scopus 로고
    • Acetylation is indispensable for p53 activation
    • Tang Y, Zhao W, Chen Y, Zhao Y, Gu W: Acetylation is indispensable for p53 activation. Cell 133(4), 612-626 (2008).
    • (2008) Cell , vol.133 , Issue.4 , pp. 612-626
    • Tang, Y.1    Zhao, W.2    Chen, Y.3    Zhao, Y.4    Gu, W.5
  • 133
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • Bolden JE, Peart MJ, Johnstone RW: Anticancer activities of histone deacetylase inhibitors. Nat. Rev. Drug Discov. 5(9), 769-784 (2006).
    • (2006) Nat. Rev. Drug Discov. , vol.5 , Issue.9 , pp. 769-784
    • Bolden, J.E.1    Peart, M.J.2    Johnstone, R.W.3
  • 134
    • 10444282190 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors for the treatment of cancer
    • Lindemann RK, Gabrielli B, Johnstone RW: Histone-deacetylase inhibitors for the treatment of cancer. Cell Cycle 3(6), 779-788 (2004).
    • (2004) Cell Cycle , vol.3 , Issue.6 , pp. 779-788
    • Lindemann, R.K.1    Gabrielli, B.2    Johnstone, R.W.3
  • 135
    • 33846014703 scopus 로고    scopus 로고
    • An acetylation site in the middle domain of Hsp90 regulates chaperone function
    • Scroggins BT, Robzyk K, Wang D et al.: An acetylation site in the middle domain of Hsp90 regulates chaperone function. Mol. Cell 25(1), 151-159 (2007).
    • (2007) Mol. Cell , vol.25 , Issue.1 , pp. 151-159
    • Scroggins, B.T.1    Robzyk, K.2    Wang, D.3
  • 136
    • 0033826515 scopus 로고    scopus 로고
    • Role of histone N-terminal tails and their acetylation in nucleosome dynamics
    • Morales V, Richard-Foy H: Role of histone N-terminal tails and their acetylation in nucleosome dynamics. Mol. Cell. Biol. 20(19), 7230-7237 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , Issue.19 , pp. 7230-7237
    • Morales, V.1    Richard-Foy, H.2
  • 138
    • 0036527775 scopus 로고    scopus 로고
    • Histone-deacetylase inhibitors: Novel drugs for the treatment of cancer
    • Johnstone RW: Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat. Rev. Drug Discov. 1(4), 287-299 (2002).
    • (2002) Nat. Rev. Drug Discov. , vol.1 , Issue.4 , pp. 287-299
    • Johnstone, R.W.1
  • 139
    • 0034730127 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation
    • Richon VM, Sandhoff TW, Rifkind RA, Marks PA: Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc. Natl Acad. Sci. USA 97(18), 10014-10019 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , Issue.18 , pp. 10014-10019
    • Richon, V.M.1    Sandhoff, T.W.2    Rifkind, R.A.3    Marks, P.A.4
  • 140
    • 9144225360 scopus 로고    scopus 로고
    • Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor NVP-LAQ824
    • Atadja P, Gao L, Kwon P et al.: Selective growth inhibition of tumor cells by a novel histone deacetylase inhibitor, NVP-LAQ824. Cancer Res. 64(2), 689-695 (2004).
    • (2004) Cancer Res. , vol.64 , Issue.2 , pp. 689-695
    • Atadja, P.1    Gao, L.2    Kwon, P.3
  • 141
    • 0036176617 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer treatment
    • Vigushin DM, Coombes RC: Histone deacetylase inhibitors in cancer treatment. Anticancer Drugs 13(1), 1-13 (2002).
    • (2002) Anticancer Drugs , vol.13 , Issue.1 , pp. 1-13
    • Vigushin, D.M.1    Coombes, R.C.2
  • 142
    • 1642453460 scopus 로고    scopus 로고
    • Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101
    • Plumb JA, Finn PW, Williams RJ et al.: Pharmacodynamic response and inhibition of growth of human tumor xenografts by the novel histone deacetylase inhibitor PXD101. Mol. Cancer Ther. 2(8), 721-728 (2003).
    • (2003) Mol. Cancer Ther. , vol.2 , Issue.8 , pp. 721-728
    • Plumb, J.A.1    Finn, P.W.2    Williams, R.J.3
  • 143
    • 0033825901 scopus 로고    scopus 로고
    • Chromatin-immune connections: Regulation of MHC and other genes
    • Magner WJ, Tomasi TB: Chromatin-immune connections: regulation of MHC and other genes. J. Reprod. Immunol. 48(1), 1-15 (2000).
    • (2000) J. Reprod. Immunol. , vol.48 , Issue.1 , pp. 1-15
    • Magner, W.J.1    Tomasi, T.B.2
  • 144
    • 0035048449 scopus 로고    scopus 로고
    • Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
    • Kim MS, Kwon HJ, Lee YM et al.: Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat. Med. 7(4), 437-443 (2001).
    • (2001) Nat. Med. , vol.7 , Issue.4 , pp. 437-443
    • Kim, M.S.1    Kwon, H.J.2    Lee, Y.M.3
  • 145
    • 85047699941 scopus 로고    scopus 로고
    • Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling
    • Deroanne CF, Bonjean K, Servotte S et al.: Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene 21(3), 427-436 (2002).
    • (2002) Oncogene , vol.21 , Issue.3 , pp. 427-436
    • Deroanne, C.F.1    Bonjean, K.2    Servotte, S.3
  • 146
    • 0037137896 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis
    • Kwon HJ, Kim MS, Kim MJ, Nakajima H, Kim KW: Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis. Int. J. Cancer 97(3), 290-296 (2002).
    • (2002) Int. J. Cancer , vol.97 , Issue.3 , pp. 290-296
    • Kwon, H.J.1    Kim, M.S.2    Kim, M.J.3    Nakajima, H.4    Kim, K.W.5
  • 147
    • 0038408486 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion
    • Liu LT, Chang HC, Chiang LC, Hung WC: Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion. Cancer Res. 63(12), 3069-3072 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.12 , pp. 3069-3072
    • Liu, L.T.1    Chang, H.C.2    Chiang, L.C.3    Hung, W.C.4
  • 148
    • 24744434639 scopus 로고    scopus 로고
    • Induction of polyploidy by histone deacetylase inhibitor: A pathway for antitumor effects
    • Xu WS, Perez G, Ngo L, Gui CY, Marks PA: Induction of polyploidy by histone deacetylase inhibitor: a pathway for antitumor effects. Cancer Res. 65(17), 7832-7839 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.17 , pp. 7832-7839
    • Xu, W.S.1    Perez, G.2    Ngo, L.3    Gui, C.Y.4    Marks, P.A.5
  • 149
    • 21144444486 scopus 로고    scopus 로고
    • HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
    • Kovacs JJ, Murphy PJ, Gaillard S et al.: HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol. Cell 18(5), 601-607 (2005).
    • (2005) Mol. Cell , vol.18 , Issue.5 , pp. 601-607
    • Kovacs, J.J.1    Murphy, P.J.2    Gaillard, S.3
  • 150
    • 46749139575 scopus 로고    scopus 로고
    • The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph-acute lymphoblastic leukemia cells
    • Scuto A, Kirschbaum M, Kowolik C et al.: The novel histone deacetylase inhibitor, LBH589, induces expression of DNA damage response genes and apoptosis in Ph-acute lymphoblastic leukemia cells. Blood 111(10), 5093-5100 (2008).
    • (2008) Blood , vol.111 , Issue.10 , pp. 5093-5100
    • Scuto, A.1    Kirschbaum, M.2    Kowolik, C.3
  • 151
  • 152
    • 34548564426 scopus 로고    scopus 로고
    • Attenuated DNA damage repair by trichostatin a through BRCA1 suppression
    • Zhang Y, Carr T, Dimtchev A, Zaer N, Dritschilo A, Jung M: Attenuated DNA damage repair by trichostatin a through BRCA1 suppression. Radiat. Res. 168(1), 115-124 (2007).
    • (2007) Radiat. Res. , vol.168 , Issue.1 , pp. 115-124
    • Zhang, Y.1    Carr, T.2    Dimtchev, A.3    Zaer, N.4    Dritschilo, A.5    Jung, M.6
  • 153
    • 36549026274 scopus 로고    scopus 로고
    • Intrauterine factors and risk of breast cancer: A systematic review and meta-ana lysis of current evidence
    • Xue F, Michels KB: Intrauterine factors and risk of breast cancer: a systematic review and meta-ana lysis of current evidence. Lancet Oncol. 8(12), 1088-1100 (2007).
    • (2007) Lancet Oncol. , vol.8 , Issue.12 , pp. 1088-1100
    • Xue, F.1    Michels, K.B.2
  • 154
    • 0037012344 scopus 로고    scopus 로고
    • Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228
    • Yu X, Guo ZS, Marcu MG et al.: Modulation of p53, ErbB1, ErbB2, and Raf-1 expression in lung cancer cells by depsipeptide FR901228. J. Natl Cancer Inst. 94(7), 504-513 (2002).
    • (2002) J. Natl Cancer Inst. , vol.94 , Issue.7 , pp. 504-513
    • Yu, X.1    Guo, Z.S.2    Marcu, M.G.3
  • 155
    • 1642490813 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B
    • Fuino L, Bali P, Wittmann S et al.: Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B. Mol. Cancer Ther. 2(10), 971-984 (2003).
    • (2003) Mol. Cancer Ther. , vol.2 , Issue.10 , pp. 971-984
    • Fuino, L.1    Bali, P.2    Wittmann, S.3
  • 156
    • 1942540759 scopus 로고    scopus 로고
    • Drastic decrease of progesterone receptor form B but not A mRNA refects poor patient prognosis in endometrial cancers
    • Sakaguchi H, Fujimoto J, Hong BL, Nakagawa Y, Tamaya T: Drastic decrease of progesterone receptor form B but not A mRNA refects poor patient prognosis in endometrial cancers. Gynecol. Oncol. 93(2), 394-399 (2004).
    • (2004) Gynecol. Oncol. , vol.93 , Issue.2 , pp. 394-399
    • Sakaguchi, H.1    Fujimoto, J.2    Hong, B.L.3    Nakagawa, Y.4    Tamaya, T.5
  • 157
    • 38449089087 scopus 로고    scopus 로고
    • Clinical potential of histone deacetylase inhibitors as stand alone therapeutics and in combination with other chemotherapeutics or radiotherapy for cancer
    • Karagiannis TC, El-Osta A: Clinical potential of histone deacetylase inhibitors as stand alone therapeutics and in combination with other chemotherapeutics or radiotherapy for cancer. Epigenetics 1(3), 121-126 (2006).
    • (2006) Epigenetics , vol.1 , Issue.3 , pp. 121-126
    • Karagiannis, T.C.1    El-Osta, A.2
  • 158
    • 34547122494 scopus 로고    scopus 로고
    • HDAC inhibitors: Clinical update and mechanism-based potential
    • Glaser KB: HDAC inhibitors: clinical update and mechanism-based potential. Biochem. Pharmacol. 74(5), 659-671 (2007).
    • (2007) Biochem. Pharmacol. , vol.74 , Issue.5 , pp. 659-671
    • Glaser, K.B.1
  • 159
    • 36048958965 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Overview and perspectives
    • DOI 10.1158/1541-7786.MCR-07-0324
    • Dokmanovic M, Clarke C, Marks PA: Histone deacetylase inhibitors: overview and perspectives. Mol. Cancer Res. 5(10), 981-989 (2007). (Pubitemid 350080267)
    • (2007) Molecular Cancer Research , vol.5 , Issue.10 , pp. 981-989
    • Dokmanovic, M.1    Clarke, C.2    Marks, P.A.3
  • 160
    • 0034671304 scopus 로고    scopus 로고
    • Transcriptional activation of estrogen receptor a in human breast cancer cells by histone deacetylase inhibition
    • Yang X, Ferguson AT, Nass SJ et al.: Transcriptional activation of estrogen receptor a in human breast cancer cells by histone deacetylase inhibition. Cancer Res. 60(24), 6890-6894 (2000).
    • (2000) Cancer Res. , vol.60 , Issue.24 , pp. 6890-6894
    • Yang, X.1    Ferguson, A.T.2    Nass, S.J.3
  • 161
    • 33745683507 scopus 로고    scopus 로고
    • Cardiac studies in patients treated with depsipeptide, FK228, in a Phase II trial for T-cell lymphoma
    • Piekarz RL, Frye AR, Wright JJ et al.: Cardiac studies in patients treated with depsipeptide, FK228, in a Phase II trial for T-cell lymphoma. Clin. Cancer Res. 12(12), 3762-3773 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.12 , pp. 3762-3773
    • Piekarz, R.L.1    Frye, A.R.2    Wright, J.J.3
  • 162
    • 38949096781 scopus 로고    scopus 로고
    • Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes
    • Garcia-Manero G, Yang H, Bueso-Ramos C et al.: Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes. Blood 111(3), 1060-1066 (2008).
    • (2008) Blood , vol.111 , Issue.3 , pp. 1060-1066
    • Garcia-Manero, G.1    Yang, H.2    Bueso-Ramos, C.3
  • 163
    • 33748063974 scopus 로고    scopus 로고
    • A Phase i study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies
    • Giles F, Fischer T, Cortes J et al.: A Phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies. Clin. Cancer Res. 12(15), 4628-4635 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.15 , pp. 4628-4635
    • Giles, F.1    Fischer, T.2    Cortes, J.3
  • 164
    • 54349120002 scopus 로고    scopus 로고
    • Phase i pharmacokinetic (PK) and pharmacodynamic (PD) study of lbh589, a novel deacetylase (DAC) inhibitor given intravenously on a new once weekly schedule
    • Sharma S, Vogelzang NJ, Beck J et al.: Phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of lbh589, a novel deacetylase (DAC) inhibitor given intravenously on a new once weekly schedule. J. Clin. Oncol. 25(18S), 14019 (2007).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 , pp. 14019
    • Sharma, S.1    Vogelzang, N.J.2    Beck, J.3
  • 165
    • 38349187877 scopus 로고    scopus 로고
    • Clinically relevant qtc prolongation is not associated with current dose schedules of LBH589 (panobinostat)
    • discussion 333-334
    • Zhang L, Lebwohl D, Masson E, Laird G, Cooper MR, Prince HM: Clinically relevant qtc prolongation is not associated with current dose schedules of LBH589 (panobinostat). J. Clin. Oncol. 26(2), 332-333; discussion 333-334 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.2 , pp. 332-333
    • Zhang, L.1    Lebwohl, D.2    Masson, E.3    Laird, G.4    Cooper, M.R.5    Prince, H.M.6
  • 166
    • 79953160130 scopus 로고    scopus 로고
    • A frst-in-human Phase i study of 4SC-201, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumors
    • Abstract 3530
    • Brunetto AT, Ang JE, Lal R: A frst-in-human Phase I study of 4SC-201, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumors. J. Clin. Oncol. 27(Suppl. 15) (2009) (Abstract 3530).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL. 15
    • Brunetto, A.T.1    Ang, J.E.2    Lal, R.3
  • 167
    • 77954105581 scopus 로고    scopus 로고
    • Preliminary results of an open-label Phase i harmacokinetic/ pharmacodynamic study of JNJ26481585: Early evidence of antitumor activity
    • Abstract
    • Postel-Vinay S, Kristeleit R, Fong P et al.: Preliminary results of an open-label Phase I harmacokinetic/pharmacodynamic study of JNJ26481585: early evidence of antitumor activity. J. Clin. Oncol. 27(Suppl.) (2009) (Abstract E13504).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.SUPPL.
    • Postel-Vinay, S.1    Kristeleit, R.2    Fong, P.3
  • 168
    • 26844499872 scopus 로고    scopus 로고
    • A Phase i study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes
    • Zambrano P, Segura-Pacheco B, Perez-Cardenas E et al.: A Phase I study of hydralazine to demethylate and reactivate the expression of tumor suppressor genes. BMC Cancer 5, 44 (2005).
    • (2005) BMC Cancer , vol.5 , pp. 44
    • Zambrano, P.1    Segura-Pacheco, B.2    Perez-Cardenas, E.3
  • 169
    • 18644379905 scopus 로고    scopus 로고
    • A Phase i trial of depsipeptide (FR901228) in patients with advanced cancer
    • Marshall JL, Rizvi N, Kauh J et al.: A Phase I trial of depsipeptide (FR901228) in patients with advanced cancer. J. Exp. Ther. Oncol. 2(6), 325-332 (2002).
    • (2002) J. Exp. Ther. Oncol. , vol.2 , Issue.6 , pp. 325-332
    • Marshall, J.L.1    Rizvi, N.2    Kauh, J.3
  • 170
    • 0036735385 scopus 로고    scopus 로고
    • FK228 (depsipeptide) as a natural prodrug that inhibits class i histone deacetylases
    • Furumai R, Matsuyama A, Kobashi N et al.: FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res. 62(17), 4916-4921 (2002).
    • (2002) Cancer Res. , vol.62 , Issue.17 , pp. 4916-4921
    • Furumai, R.1    Matsuyama, A.2    Kobashi, N.3
  • 171
    • 33645069138 scopus 로고    scopus 로고
    • Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176)
    • Robey RW, Zhan Z, Piekarz RL, Kayastha GL, Fojo T, Bates SE: Increased MDR1 expression in normal and malignant peripheral blood mononuclear cells obtained from patients receiving depsipeptide (FR901228, FK228, NSC630176). Clin. Cancer Res. 12(5), 1547-1555 (2006).
    • (2006) Clin. Cancer Res. , vol.12 , Issue.5 , pp. 1547-1555
    • Robey, R.W.1    Zhan, Z.2    Piekarz, R.L.3    Kayastha, G.L.4    Fojo, T.5    Bates, S.E.6
  • 172
    • 0033551152 scopus 로고    scopus 로고
    • A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors
    • Saito A, Yamashita T, Mariko Y et al.: A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. Proc. Natl Acad. Sci. USA 96(8), 4592-4597 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , Issue.8 , pp. 4592-4597
    • Saito, A.1    Yamashita, T.2    Mariko, Y.3
  • 173
    • 42949154252 scopus 로고    scopus 로고
    • Phase i study of MGCD0103 given as a three-times-per-week oral dose in patients with advanced solid tumors
    • Siu LL, Pili R, Duran I et al.: Phase I study of MGCD0103 given as a three-times-per-week oral dose in patients with advanced solid tumors. J. Clin. Oncol. 26(12), 1940-1947 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.12 , pp. 1940-1947
    • Siu, L.L.1    Pili, R.2    Duran, I.3
  • 174
    • 56449104265 scopus 로고    scopus 로고
    • Mutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors
    • Anglesio MS, Arnold JM, George J et al.: Mutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors. Mol. Cancer Res. 6(11), 1678-1690 (2008).
    • (2008) Mol. Cancer Res. , vol.6 , Issue.11 , pp. 1678-1690
    • Anglesio, M.S.1    Arnold, J.M.2    George, J.3
  • 175
    • 34547399478 scopus 로고    scopus 로고
    • Epigenetic silencing of HSULF-1 in ovarian cancer: Implications in chemoresistance
    • Staub J, Chien J, Pan Y et al.: Epigenetic silencing of HSULF-1 in ovarian cancer: implications in chemoresistance. Oncogene 26(34), 4969-4978 (2007).
    • (2007) Oncogene , vol.26 , Issue.34 , pp. 4969-4978
    • Staub, J.1    Chien, J.2    Pan, Y.3
  • 176
    • 53949094562 scopus 로고    scopus 로고
    • Apicidin down-regulates human papillomavirus type 16 E6 and E7 transcripts and proteins in SiHa cervical cancer cells
    • Luczak MW, Jagodzinski PP: Apicidin down-regulates human papillomavirus type 16 E6 and E7 transcripts and proteins in SiHa cervical cancer cells. Cancer Lett. 272(1), 53-60 (2008).
    • (2008) Cancer Lett. , vol.272 , Issue.1 , pp. 53-60
    • Luczak, M.W.1    Jagodzinski, P.P.2
  • 177
    • 43049091153 scopus 로고    scopus 로고
    • A Phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: A gynecologic oncology group study
    • Modesitt SC, Sill M, Hoffman JS, Bender DP: A Phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a gynecologic oncology group study. Gynecol. Oncol. 109(2), 182-186 (2008).
    • (2008) Gynecol. Oncol. , vol.109 , Issue.2 , pp. 182-186
    • Modesitt, S.C.1    Sill, M.2    Hoffman, J.S.3    Bender, D.P.4
  • 178
    • 50249095068 scopus 로고    scopus 로고
    • Early Phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer
    • Vansteenkiste J, van Cutsem E, Dumez H et al.: Early Phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer. Invest. New Drugs 26(5), 483-488 (2008).
    • (2008) Invest. New Drugs , vol.26 , Issue.5 , pp. 483-488
    • Vansteenkiste, J.1    Van Cutsem, E.2    Dumez, H.3
  • 179
    • 58149242889 scopus 로고    scopus 로고
    • A Phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: A california cancer consortium study
    • Luu TH, Morgan RJ, Leong L et al.: A Phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a california cancer consortium study. Clin. Cancer Res. 14(21), 7138-7142 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.21 , pp. 7138-7142
    • Luu, T.H.1    Morgan, R.J.2    Leong, L.3
  • 180
    • 67349278924 scopus 로고    scopus 로고
    • Phase II multicenter trial of the histone deactylase inhibitor (HDACi) belinostat, carboplatin and paclitaxel (BelCaP) in patients (pts) with relapsed epithelial ovarian cancer (EOC)
    • Abstract
    • Finkler NJ, Dizon DS, Braly P et al.: Phase II multicenter trial of the histone deactylase inhibitor (HDACi) belinostat, carboplatin and paclitaxel (BelCaP) in patients (pts) with relapsed epithelial ovarian cancer (EOC). J. Clin. Oncol. 26(Suppl.) (2008) (Abstract 5519).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.SUPPL. , pp. 5519
    • Finkler, N.J.1    Dizon, D.S.2    Braly, P.3
  • 181
    • 67649371461 scopus 로고    scopus 로고
    • Dznep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation
    • Miranda TB, Cortez CC, Yoo CB et al.: Dznep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol. Cancer Ther. 8(6), 1579-1588 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , Issue.6 , pp. 1579-1588
    • Miranda, T.B.1    Cortez, C.C.2    Yoo, C.B.3
  • 182
    • 70350494322 scopus 로고    scopus 로고
    • Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells
    • Fiskus W, Wang Y, Sreekumar A et al.: Combined epigenetic therapy with the histone methyltransferase EZH2 inhibitor 3-deazaneplanocin A and the histone deacetylase inhibitor panobinostat against human AML cells. Blood 114(13), 2733-2743 (2009).
    • (2009) Blood , vol.114 , Issue.13 , pp. 2733-2743
    • Fiskus, W.1    Wang, Y.2    Sreekumar, A.3
  • 183
    • 67650588646 scopus 로고    scopus 로고
    • MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3a and 3b and indirectly DNMT1
    • Garzon R, Liu S, Fabbri M et al.: MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3a and 3b and indirectly DNMT1. Blood 113(25), 6411-6418 (2009).
    • (2009) Blood , vol.113 , Issue.25 , pp. 6411-6418
    • Garzon, R.1    Liu, S.2    Fabbri, M.3
  • 184
    • 66349113515 scopus 로고    scopus 로고
    • A Phase II trial of the histone deacetylase inhibitor belinostat (PXD101) in patients with platinum resistant epithelial ovarian tumors and micropapillary/borderline (LMP) ovarian tumors. A PMH Phase II consortium trial
    • Abstract
    • Mackay H, Hirte H W, Covens A: A Phase II trial of the histone
    • (2008) J. Clin. Oncol. , vol.26 , Issue.SUPPL. , pp. 5518
    • MacKay, H.1    Hirte, H.W.2    Covens, A.3
  • 185
    • 76649109445 scopus 로고    scopus 로고
    • Phase i trial of panobinostat (LBH589) in combination with trastuzumab in pretreated HER2-positive metastatic breast cancer (mBC): Preliminary safety and tolerability results
    • Abstract
    • Conte P, Campone M, Pronzato P et al.: Phase I trial of panobinostat (LBH589) in combination with trastuzumab in pretreated HER2-positive metastatic breast cancer (mBC): preliminary safety and tolerability results. J. Clin. Oncol. 27(Suppl. 15) (2009) (Abstract 1081).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.15 SUPPL. , pp. 1081
    • Conte, P.1    Campone, M.2    Pronzato, P.3
  • 186
    • 68949114599 scopus 로고    scopus 로고
    • Signifcantly longer progression-free survival with nab-paclitaxel compared with docetaxel as frst-line therapy for metastatic breast cancer
    • Gradishar WJ, Krasnojon D, Cheporov S et al.: Signifcantly longer progression-free survival with nab-paclitaxel compared with docetaxel as frst-line therapy for metastatic breast cancer. J. Clin. Oncol. 27(22), 3611-3619 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.22 , pp. 3611-3619
    • Gradishar, W.J.1    Krasnojon, D.2    Cheporov, S.3
  • 187
    • 70249116811 scopus 로고    scopus 로고
    • HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer
    • Widschwendter M, Apostolidou S, Jones A et al.: HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer. Int. J. Cancer 125(9), 2214-2218 (2009).
    • (2009) Int. J. Cancer , vol.125 , Issue.9 , pp. 2214-2218
    • Widschwendter, M.1    Apostolidou, S.2    Jones, A.3
  • 188
    • 72449207714 scopus 로고    scopus 로고
    • DNA methylation ana lysis in liquid based cytology for cervical cancer screening
    • Apostolidou S, Hadwin R, Burnell M et al.: DNA methylation ana lysis in liquid based cytology for cervical cancer screening. Int. J. Cancer 125(12), 2995-3002 (2009).
    • (2009) Int. J. Cancer , vol.125 , Issue.12 , pp. 2995-3002
    • Apostolidou, S.1    Hadwin, R.2    Burnell, M.3
  • 189
    • 58249087346 scopus 로고    scopus 로고
    • An epigenetic marker panel for screening and prognostic prediction of ovarian cancer
    • Su HY, Lai HC, Lin YW, Chou YC, Liu CY, Yu MH: An epigenetic marker panel for screening and prognostic prediction of ovarian cancer. Int. J. Cancer 124(2), 387-393 (2009).
    • (2009) Int. J. Cancer , vol.124 , Issue.2 , pp. 387-393
    • Su, H.Y.1    Lai, H.C.2    Lin, Y.W.3    Chou, Y.C.4    Liu, C.Y.5    Yu, M.H.6
  • 190
    • 58849140824 scopus 로고    scopus 로고
    • Differential methylation profle of ovarian cancer in tissues and plasma
    • Melnikov A, Scholtens D, Godwin A, Levenson V: Differential methylation profle of ovarian cancer in tissues and plasma. J. Mol. Diagn. 11(1), 60-65 (2009).
    • (2009) J. Mol. Diagn. , vol.11 , Issue.1 , pp. 60-65
    • Melnikov, A.1    Scholtens, D.2    Godwin, A.3    Levenson, V.4
  • 191
    • 0034772724 scopus 로고    scopus 로고
    • Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix
    • Dong SM, Kim HS, Rha SH, Sidransky D: Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix. Clin. Cancer Res. 7(7), 1982-1986 (2001).
    • (2001) Clin. Cancer Res. , vol.7 , Issue.7 , pp. 1982-1986
    • Dong, S.M.1    Kim, H.S.2    Rha, S.H.3    Sidransky, D.4
  • 192
    • 36348989016 scopus 로고    scopus 로고
    • Evaluation of candidate methylation markers to detect cervical neoplasia
    • Shivapurkar N, Sherman ME, Stastny V et al.: Evaluation of candidate methylation markers to detect cervical neoplasia. Gynecol. Oncol. 107(3), 549-553 (2007).
    • (2007) Gynecol. Oncol. , vol.107 , Issue.3 , pp. 549-553
    • Shivapurkar, N.1    Sherman, M.E.2    Stastny, V.3
  • 194
    • 43949142803 scopus 로고    scopus 로고
    • Identifcation of novel DNA methylation markers in cervical cancer
    • Lai HC, Lin Y W, Huang TH et al.: Identifcation of novel DNA methylation markers in cervical cancer. Int. J. Cancer 123(1), 161-167 (2008).
    • (2008) Int. J. Cancer , vol.123 , Issue.1 , pp. 161-167
    • Lai, H.C.1    Lin, Y.W.2    Huang, T.H.3
  • 195
    • 53349143679 scopus 로고    scopus 로고
    • Effect of aberrant promoter methylation of FHIT and RASSF1A genes on susceptibility to cervical cancer in a North Indian population
    • Neyaz MK, Kumar RS, Hussain S et al.: Effect of aberrant promoter methylation of FHIT and RASSF1A genes on susceptibility to cervical cancer in a North Indian population. Biomarkers 13(6), 597-606 (2008).
    • (2008) Biomarkers , vol.13 , Issue.6 , pp. 597-606
    • Neyaz, M.K.1    Kumar, R.S.2    Hussain, S.3
  • 196
    • 39749114948 scopus 로고    scopus 로고
    • Quantitative methylation-specifc PCR for the detection of aberrant DNA methylation in liquid-based pap tests
    • Kahn SL, Ronnett BM, Gravitt PE, Gustafson KS: Quantitative methylation-specifc PCR for the detection of aberrant DNA methylation in liquid-based pap tests. Cancer 114(1), 57-64 (2008).
    • (2008) Cancer , vol.114 , Issue.1 , pp. 57-64
    • Kahn, S.L.1    Ronnett, B.M.2    Gravitt, P.E.3    Gustafson, K.S.4
  • 197
    • 33645461015 scopus 로고    scopus 로고
    • Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray ana lysis
    • Sova P, Feng Q, Geiss G et al.: Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray ana lysis. Cancer Epidemiol. Biomarkers Prev. 15(1), 114-123 (2006).
    • (2006) Cancer Epidemiol. Biomarkers Prev. , vol.15 , Issue.1 , pp. 114-123
    • Sova, P.1    Feng, Q.2    Geiss, G.3
  • 198
    • 34250855800 scopus 로고    scopus 로고
    • Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia
    • Feng Q, Hawes SE, Stern JE et al.: Promoter hypermethylation of tumor suppressor genes in urine from patients with cervical neoplasia. Cancer Epidemiol. Biomarkers Prev. 16(6), 1178-1184 (2007).
    • (2007) Cancer Epidemiol. Biomarkers Prev. , vol.16 , Issue.6 , pp. 1178-1184
    • Feng, Q.1    Hawes, S.E.2    Stern, J.E.3
  • 199
    • 20044383919 scopus 로고    scopus 로고
    • Detection of hypermethylated genes in women with and without cervical neoplasia
    • Feng Q, Balasubramanian A, Hawes SE et al.: Detection of hypermethylated genes in women with and without cervical neoplasia. J. Natl Cancer Inst. 97(4), 273-282 (2005).
    • (2005) J. Natl Cancer Inst. , vol.97 , Issue.4 , pp. 273-282
    • Feng, Q.1    Balasubramanian, A.2    Hawes, S.E.3
  • 200
    • 68149158305 scopus 로고    scopus 로고
    • Prediction of human papillomavirus 16 E6 gene expression and cervical intraepithelial neoplasia progression by methylation status
    • Hublarova P, Hrstka R, Rotterova P et al.: Prediction of human papillomavirus 16 E6 gene expression and cervical intraepithelial neoplasia progression by methylation status. Int. J. Gynecol. Cancer 19(3), 321-325 (2009).
    • (2009) Int. J. Gynecol. Cancer , vol.19 , Issue.3 , pp. 321-325
    • Hublarova, P.1    Hrstka, R.2    Rotterova, P.3
  • 201
    • 34147158249 scopus 로고    scopus 로고
    • Detection of RASSF1A and RARb hypermethylation in serum DNA from breast cancer patients
    • Shukla S, Mirza S, Sharma G, Parshad R, Gupta SD, Ralhan R: Detection of RASSF1A and RARb hypermethylation in serum DNA from breast cancer patients. Epigenetics 1(2), 88-93 (2006).
    • (2006) Epigenetics , vol.1 , Issue.2 , pp. 88-93
    • Shukla, S.1    Mirza, S.2    Sharma, G.3    Parshad, R.4    Gupta, S.D.5    Ralhan, R.6
  • 202
    • 34447100205 scopus 로고    scopus 로고
    • Promoter hypermethylation of TMS1, BRCA1, ERa and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients
    • Mirza S, Sharma G, Prasad CP et al.: Promoter hypermethylation of TMS1, BRCA1, ERa and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients. Life Sci. 81(4), 280-287 (2007).
    • (2007) Life Sci. , vol.81 , Issue.4 , pp. 280-287
    • Mirza, S.1    Sharma, G.2    Prasad, C.P.3
  • 203
    • 34147134560 scopus 로고    scopus 로고
    • ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients
    • DOI 10.1016/j.lfs.2007.02.026, PII S0024320507001828
    • ARF, CyclinD2 and Slit2 in serum and tumor DNA from breast cancer patients. Life Sci. 80(20), 1873-1881 (2007). (Pubitemid 46562520)
    • (2007) Life Sciences , vol.80 , Issue.20 , pp. 1873-1881
    • Sharma, G.1    Mirza, S.2    Prasad, C.P.3    Srivastava, A.4    Gupta, S.D.5    Ralhan, R.6
  • 204
    • 33749571963 scopus 로고    scopus 로고
    • Epigenetic ana lysis of body fuids and tumor tissues: Application of a comprehensive molecular assessment for early-stage breast cancer patients
    • Taback B, Giuliano AE, Lai R et al.: Epigenetic ana lysis of body fuids and tumor tissues: application of a comprehensive molecular assessment for early-stage breast cancer patients. Ann. NY Acad. Sci. 1075, 211-221 (2006).
    • (2006) Ann. NY Acad. Sci. , vol.1075 , pp. 211-221
    • Taback, B.1    Giuliano, A.E.2    Lai, R.3
  • 205
    • 4644297522 scopus 로고    scopus 로고
    • Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients
    • DOI 10.1158/1078-0432.CCR-04-0597
    • Dulaimi E, Hillinck J, Ibanez De Caceres I, Al-Saleem T, Cairns P: Tumor suppressor gene promoter hypermethylation in serum of breast cancer patients. Clin. Cancer Res. 10(18 Pt 1), 6189-6193 (2004). (Pubitemid 39287525)
    • (2004) Clinical Cancer Research , vol.10 , Issue.18 , pp. 6189-6193
    • Dulaimi, E.1    Hillinck, J.2    De Caceres, I.I.3    Al-Saleem, T.4    Cairns, P.5
  • 206
    • 1642576173 scopus 로고    scopus 로고
    • Detection of breast cancer in nipple aspirate fuid by CpG island hypermethylation
    • Krassenstein R, Sauter E, Dulaimi E et al.: Detection of breast cancer in nipple aspirate fuid by CpG island hypermethylation. Clin. Cancer Res. 10(1 Pt 1), 28-32 (2004).
    • (2004) Clin. Cancer Res. , vol.10 , Issue.1 PART 1 , pp. 28-32
    • Krassenstein, R.1    Sauter, E.2    Dulaimi, E.3
  • 207
    • 66649087110 scopus 로고    scopus 로고
    • Hypermethylated genes as biomarkers of cancer in women with pathologic nipple discharge
    • Fackler MJ, Rivers A, Teo WW et al.: Hypermethylated genes as biomarkers of cancer in women with pathologic nipple discharge. Clin. Cancer Res. 15(11), 3802-3811 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.11 , pp. 3802-3811
    • Fackler, M.J.1    Rivers, A.2    Teo, W.W.3
  • 208
    • 58149154845 scopus 로고    scopus 로고
    • Quantitative promoter hypermethylation profles of ductal carcinoma in situ in North American and Korean women: Potential applications for diagnosis
    • Lee JS, Fackler MJ, Teo WW et al.: Quantitative promoter hypermethylation profles of ductal carcinoma in situ in North American and Korean women: potential applications for diagnosis. Cancer Biol. Ther. 7(9), 1398-1406 (2008).
    • (2008) Cancer Biol. Ther. , vol.7 , Issue.9 , pp. 1398-1406
    • Lee, J.S.1    Fackler, M.J.2    Teo, W.W.3
  • 209
    • 42149087728 scopus 로고    scopus 로고
    • Quantitative hypermethylation of a small panel of genes augments the diagnostic accuracy in fne-needle aspirate washings of breast lesions
    • Jeronimo C, Monteiro P, Henrique R et al.: Quantitative hypermethylation of a small panel of genes augments the diagnostic accuracy in fne-needle aspirate washings of breast lesions. Breast Cancer Res. Treat. 109(1), 27-34 (2008).
    • (2008) Breast Cancer Res. Treat. , vol.109 , Issue.1 , pp. 27-34
    • Jeronimo, C.1    Monteiro, P.2    Henrique, R.3
  • 210
    • 0035992386 scopus 로고    scopus 로고
    • Methylation microarray ana lysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifes candidate epigenetic markers
    • Wei SH, Chen CM, Strathdee G et al.: Methylation microarray ana lysis of late-stage ovarian carcinomas distinguishes progression-free survival in patients and identifes candidate epigenetic markers. Clin. Cancer Res. 8(7), 2246-2252 (2002).
    • (2002) Clin. Cancer Res. , vol.8 , Issue.7 , pp. 2246-2252
    • Wei, S.H.1    Chen, C.M.2    Strathdee, G.3
  • 211
    • 33645366728 scopus 로고    scopus 로고
    • Methylation of the insulin-like growth factor binding protein-3 gene and prognosis of epithelial ovarian cancer
    • Wiley A, Katsaros D, Fracchioli S, Yu H: Methylation of the insulin-like growth factor binding protein-3 gene and prognosis of epithelial ovarian cancer. Int. J. Gynecol. Cancer 16(1), 210-218 (2006).
    • (2006) Int. J. Gynecol. Cancer , vol.16 , Issue.1 , pp. 210-218
    • Wiley, A.1    Katsaros, D.2    Fracchioli, S.3    Yu, H.4
  • 212
    • 33745871210 scopus 로고    scopus 로고
    • Aberrant promoter methylation of multiple genes in malignant ovarian tumors and in ovarian tumors with low malignant potential
    • Wiley A, Katsaros D, Chen H et al.: Aberrant promoter methylation of multiple genes in malignant ovarian tumors and in ovarian tumors with low malignant potential. Cancer 107(2), 299-308 (2006).
    • (2006) Cancer , vol.107 , Issue.2 , pp. 299-308
    • Wiley, A.1    Katsaros, D.2    Chen, H.3
  • 213
    • 27144499187 scopus 로고    scopus 로고
    • Hypermethylation of 18s and 28s ribosomal DNAs predicts progression-free survival in patients with ovarian cancer
    • Chan MW, Wei SH, Wen P et al.: Hypermethylation of 18s and 28s ribosomal DNAs predicts progression-free survival in patients with ovarian cancer. Clin. Cancer Res. 11(20), 7376-7383 (2005).
    • (2005) Clin. Cancer Res. , vol.11 , Issue.20 , pp. 7376-7383
    • Chan, M.W.1    Wei, S.H.2    Wen, P.3
  • 214
    • 46049092192 scopus 로고    scopus 로고
    • Hoxa11 DNA methylation-a novel prognostic biomarker in ovarian cancer
    • Fiegl H, Windbichler G, Mueller-Holzner E et al.: Hoxa11 DNA methylation-a novel prognostic biomarker in ovarian cancer. Int. J. Cancer 123(3), 725-729 (2008).
    • (2008) Int. J. Cancer , vol.123 , Issue.3 , pp. 725-729
    • Fiegl, H.1    Windbichler, G.2    Mueller-Holzner, E.3
  • 215
    • 7044220689 scopus 로고    scopus 로고
    • Analysis of methylated genes in peritoneal fuids of ovarian cancer patients: A new prognostic tool
    • Muller HM, Millinger S, Fiegl H et al.: Analysis of methylated genes in peritoneal fuids of ovarian cancer patients: a new prognostic tool. Clin. Chem. 50(11), 2171-2173 (2004).
    • (2004) Clin. Chem. , vol.50 , Issue.11 , pp. 2171-2173
    • Muller, H.M.1    Millinger, S.2    Fiegl, H.3
  • 216
    • 47649111322 scopus 로고    scopus 로고
    • Line-1 hypomethylation level as a potential prognostic factor for epithelial ovarian cancer
    • Pattamadilok J, Huapai N, Rattanatanyong P et al.: Line-1 hypomethylation level as a potential prognostic factor for epithelial ovarian cancer. Int. J. Gynecol. Cancer 18(4), 711-717 (2008).
    • (2008) Int. J. Gynecol. Cancer , vol.18 , Issue.4 , pp. 711-717
    • Pattamadilok, J.1    Huapai, N.2    Rattanatanyong, P.3
  • 217
    • 0032587282 scopus 로고    scopus 로고
    • Methylation of p16INK4A in primary gynecologic malignancy
    • Wong YF, Chung TK, Cheung TH et al.: Methylation of p16INK4A in primary gynecologic malignancy. Cancer Lett. 136(2), 231-235 (1999).
    • (1999) Cancer Lett. , vol.136 , Issue.2 , pp. 231-235
    • Wong, Y.F.1    Chung, T.K.2    Cheung, T.H.3
  • 218
    • 33749133448 scopus 로고    scopus 로고
    • Methylation status of the fragile histidine triad and E-cadherin genes in plasma of cervical cancer patients
    • DOI 10.1111/j.1525-1438.2006.00669.x
    • Ren CC, Miao XH, Yang B, Zhao L, Sun R, Song WQ: Methylation status of the fragile histidine triad and e-cadherin genes in plasma of cervical cancer patients. Int. J. Gynecol. Cancer 16(5), 1862-1867 (2006). (Pubitemid 44470047)
    • (2006) International Journal of Gynecological Cancer , vol.16 , Issue.5 , pp. 1862-1867
    • Ren, C.C.1    Miao, X.H.2    Yang, B.3    Zhao, L.4    Sun, R.5    Song, W.Q.6
  • 219
    • 1242281346 scopus 로고    scopus 로고
    • Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: Its relationship to clinical outcome
    • Narayan G, Arias-Pulido H, Koul S et al.: Frequent promoter methylation of CDH1, DAPK, RARB, and HIC1 genes in carcinoma of cervix uteri: its relationship to clinical outcome. Mol. Cancer 2, 24 (2003).
    • (2003) Mol. Cancer , vol.2 , pp. 24
    • Narayan, G.1    Arias-Pulido, H.2    Koul, S.3
  • 220
    • 2942696404 scopus 로고    scopus 로고
    • Epigenetic and genetic alternation of PTEN in cervical neoplasm
    • Cheung TH, Lo K W, Yim SF et al.: Epigenetic and genetic alternation of PTEN in cervical neoplasm. Gynecol. Oncol. 93(3), 621-627 (2004).
    • (2004) Gynecol. Oncol. , vol.93 , Issue.3 , pp. 621-627
    • Cheung, T.H.1    Lo, K.W.2    Yim, S.F.3
  • 221
    • 46049102782 scopus 로고    scopus 로고
    • Expression of Smad2 and Smad4 in cervical cancer: Absent nuclear Smad4 expression correlates with poor survival
    • Kloth JN, Kenter GG, Spijker HS et al.: Expression of Smad2 and Smad4 in cervical cancer: absent nuclear Smad4 expression correlates with poor survival. Mod. Pathol. 21(7), 866-875 (2008).
    • (2008) Mod. Pathol. , vol.21 , Issue.7 , pp. 866-875
    • Kloth, J.N.1    Kenter, G.G.2    Spijker, H.S.3
  • 222
    • 38549099046 scopus 로고    scopus 로고
    • Aberrant promoter methylation can be useful as a marker of recurrent disease in patients with cervical intraepithelial neoplasia grade III
    • Terra AP, Murta EF, Maluf PJ, Caballero OL, Brait M, Adad SJ: Aberrant promoter methylation can be useful as a marker of recurrent disease in patients with cervical intraepithelial neoplasia grade III. Tumori 93(6), 572-579 (2007).
    • (2007) Tumori , vol.93 , Issue.6 , pp. 572-579
    • Terra, A.P.1    Murta, E.F.2    Maluf, P.J.3    Caballero, O.L.4    Brait, M.5    Adad, S.J.6
  • 223
    • 34250626334 scopus 로고    scopus 로고
    • Hypermethylation of the COX-2 gene is a potential prognostic marker for cervical cancer
    • Jo H, Kang S, Kim JW et al.: Hypermethylation of the COX-2 gene is a potential prognostic marker for cervical cancer. J. Obstet. Gynaecol. Res. 33(3), 236-241 (2007).
    • (2007) J. Obstet. Gynaecol. Res. , vol.33 , Issue.3 , pp. 236-241
    • Jo, H.1    Kang, S.2    Kim, J.W.3
  • 224
    • 1942508923 scopus 로고    scopus 로고
    • Methylation status and expression of human telomerase reverse transcriptase in ovarian and cervical cancer
    • Widschwendter A, Muller HM, Hubalek MM et al.: Methylation status and expression of human telomerase reverse transcriptase in ovarian and cervical cancer. Gynecol. Oncol. 93(2), 407-416 (2004).
    • (2004) Gynecol. Oncol. , vol.93 , Issue.2 , pp. 407-416
    • Widschwendter, A.1    Muller, H.M.2    Hubalek, M.M.3
  • 225
    • 2442699984 scopus 로고    scopus 로고
    • A DNA methylation pattern similar to normal tissue is associated with better prognosis in human cervical cancer
    • Muller HM, Widschwendter A, Fiegl H et al.: A DNA methylation pattern similar to normal tissue is associated with better prognosis in human cervical cancer. Cancer Lett. 209(2), 231-236 (2004).
    • (2004) Cancer Lett. , vol.209 , Issue.2 , pp. 231-236
    • Muller, H.M.1    Widschwendter, A.2    Fiegl, H.3
  • 226
    • 18544406053 scopus 로고    scopus 로고
    • DNA methylation in serum of breast cancer patients: An independent prognostic marker
    • Muller HM, Widschwendter A, Fiegl H et al.: DNA methylation in serum of breast cancer patients: an independent prognostic marker. Cancer Res. 63(22), 7641-7645 (2003).
    • (2003) Cancer Res. , vol.63 , Issue.22 , pp. 7641-7645
    • Muller, H.M.1    Widschwendter, A.2    Fiegl, H.3
  • 227
    • 65949086183 scopus 로고    scopus 로고
    • Global histone modifcations in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome
    • Elsheikh SE, Green AR, Rakha EA et al.: Global histone modifcations in breast cancer correlate with tumor phenotypes, prognostic factors, and patient outcome. Cancer Res. 69(9), 3802-3809 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.9 , pp. 3802-3809
    • Elsheikh, S.E.1    Green, A.R.2    Rakha, E.A.3
  • 229
    • 72449138778 scopus 로고    scopus 로고
    • Methylation of cystatin M promoter is associated with unfavorable prognosis in operable breast cancer
    • Kioulafa M, Balkouranidou I, Sotiropoulou G et al.: Methylation of cystatin M promoter is associated with unfavorable prognosis in operable breast cancer. Int. J. Cancer 25(12), 2887-2892 (2009).
    • (2009) Int. J. Cancer , vol.25 , Issue.12 , pp. 2887-2892
    • Kioulafa, M.1    Balkouranidou, I.2    Sotiropoulou, G.3
  • 230
    • 67349087533 scopus 로고    scopus 로고
    • Prognostic signifcance of RASSF1A promoter methylation in operable breast cancer
    • Kioulafa M, Kaklamanis L, Mavroudis D, Georgoulias V, Lianidou ES: Prognostic signifcance of RASSF1A promoter methylation in operable breast cancer. Clin. Biochem. 42(10-11), 970-975 (2009).
    • (2009) Clin. Biochem. , vol.42 , Issue.10-11 , pp. 970-975
    • Kioulafa, M.1    Kaklamanis, L.2    Mavroudis, D.3    Georgoulias, V.4    Lianidou, E.S.5
  • 231
    • 58849143465 scopus 로고    scopus 로고
    • DNA methylation markers predict outcome in node-positive, estrogen receptor-positive breast cancer with adjuvant anthracycline-based chemotherapy
    • Hartmann O, Spyratos F, Harbeck N et al.: DNA methylation markers predict outcome in node-positive, estrogen receptor-positive breast cancer with adjuvant anthracycline-based chemotherapy. Clin. Cancer Res. 15(1), 315-323 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.1 , pp. 315-323
    • Hartmann, O.1    Spyratos, F.2    Harbeck, N.3
  • 232
    • 51249109684 scopus 로고    scopus 로고
    • Multigene methylation in serum of sporadic Chinese female breast cancer patients as a prognostic biomarker
    • Jing F, Jun L, Yong Z et al.: Multigene methylation in serum of sporadic Chinese female breast cancer patients as a prognostic biomarker. Oncology 75(1-2), 60-66 (2008).
    • (2008) Oncology , vol.75 , Issue.1-2 , pp. 60-66
    • Jing, F.1    Jun, L.2    Yong, Z.3
  • 233
    • 47249164378 scopus 로고    scopus 로고
    • Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis
    • Veeck J, Geisler C, Noetzel E et al.: Epigenetic inactivation of the secreted frizzled-related protein-5 (SFRP5) gene in human breast cancer is associated with unfavorable prognosis. Carcinogenesis 29(5), 991-998 (2008).
    • (2008) Carcinogenesis , vol.29 , Issue.5 , pp. 991-998
    • Veeck, J.1    Geisler, C.2    Noetzel, E.3
  • 234
    • 51649095103 scopus 로고    scopus 로고
    • DNA hypermethylation of pitx2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients
    • Nimmrich I, Sieuwerts AM, Meijer-van Gelder ME et al.: DNA hypermethylation of pitx2 is a marker of poor prognosis in untreated lymph node-negative hormone receptor-positive breast cancer patients. Breast Cancer Res. Treat. 111(3), 429-437 (2008).
    • (2008) Breast Cancer Res. Treat. , vol.111 , Issue.3 , pp. 429-437
    • Nimmrich, I.1    Sieuwerts, A.M.2    Meijer-Van Gelder, M.E.3
  • 235
    • 34447262607 scopus 로고    scopus 로고
    • DNA-methylation of the homeodomain transcription factor pitx2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients-technical and clinical validation in a multi-centre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) pathobiology group
    • Maier S, Nimmrich I, Koenig T et al.: DNA-methylation of the homeodomain transcription factor pitx2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients-technical and clinical validation in a multi-centre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) pathobiology group. Eur. J. Cancer 43(11), 1679-1686 (2007).
    • (2007) Eur. J. Cancer , vol.43 , Issue.11 , pp. 1679-1686
    • Maier, S.1    Nimmrich, I.2    Koenig, T.3
  • 236
    • 46249090608 scopus 로고    scopus 로고
    • Promoter methylation-associated loss of id4 expression is a marker of tumour recurrence in human breast cancer
    • Noetzel E, Veeck J, Niederacher D et al.: Promoter methylation-associated loss of id4 expression is a marker of tumour recurrence in human breast cancer. BMC Cancer 8, 154 (2008).
    • (2008) BMC Cancer , vol.8 , pp. 154
    • Noetzel, E.1    Veeck, J.2    Niederacher, D.3
  • 238
    • 0017249671 scopus 로고
    • A Phase i study of 5-azacytidine (NSC-102816)
    • Shnider BI, Baig M, Colsky J: A Phase I study of 5-azacytidine (NSC-102816). J. Clin. Pharmacol. 16(4), 205-212 (1976).
    • (1976) J. Clin. Pharmacol. , vol.16 , Issue.4 , pp. 205-212
    • Shnider, B.I.1    Baig, M.2    Colsky, J.3
  • 239
    • 0344990164 scopus 로고    scopus 로고
    • Phase i trial of continuous infusion 5-aza-2́-deoxycytidine
    • Aparicio A, Eads CA, Leong LA et al.: Phase I trial of continuous infusion 5-aza-2́-deoxycytidine. Cancer Chemother. Pharmacol. 51(3), 231-239 (2003).
    • (2003) Cancer Chemother. Pharmacol. , vol.51 , Issue.3 , pp. 231-239
    • Aparicio, A.1    Eads, C.A.2    Leong, L.A.3
  • 240
    • 12444321545 scopus 로고    scopus 로고
    • Phase i clinical trial of histone deacetylase inhibitor: Suberoylanilide hydroxamic acid administered intravenously
    • Kelly WK, Richon VM, O'Connor O et al.: Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously. Clin. Cancer Res. 9(10 Pt 1), 3578-3588 (2003).
    • (2003) Clin. Cancer Res. , vol.9 , Issue.10 PART 1 , pp. 3578-3588
    • Kelly, W.K.1    Richon, V.M.2    O'Connor, O.3
  • 241
    • 21244464349 scopus 로고    scopus 로고
    • Phase i study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer
    • Kelly WK, O'Connor OA, Krug LM et al.: Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer. J. Clin. Oncol. 23(17), 3923-3931 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.17 , pp. 3923-3931
    • Kelly, W.K.1    O'Connor, O.A.2    Krug, L.M.3
  • 242
    • 43049088775 scopus 로고    scopus 로고
    • Phase i study of oral LBH589, a novel deacetylase (DAC) inhibitor in advanced solid tumors and non-hodgkin's lymphoma
    • Meeting abstract
    • Prince HM, George D, Patnaik A: Phase I study of oral LBH589, a novel deacetylase (DAC) inhibitor in advanced solid tumors and non-hodgkin's lymphoma. J. Clin. Oncol. 25(18S), 3500 (2007) (Meeting abstract).
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 , pp. 3500
    • Prince, H.M.1    George, D.2    Patnaik, A.3
  • 243
    • 51649091668 scopus 로고    scopus 로고
    • A Phase i and pharmacokinetic study of the oral histone deacetylase inhibitor, MS-275, in patients with refractory solid tumors and lymphomas
    • Gore L, Rothenberg ML, O'Bryant CL et al.: A Phase I and pharmacokinetic study of the oral histone deacetylase inhibitor, MS-275, in patients with refractory solid tumors and lymphomas. Clin. Cancer Res. 14(14), 4517-4525 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.14 , pp. 4517-4525
    • Gore, L.1    Rothenberg, M.L.2    O'Bryant, C.L.3
  • 244
    • 21244458052 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of ms-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphoma
    • Ryan QC, Headlee D, Acharya M et al.: Phase I and pharmacokinetic study of ms-275, a histone deacetylase inhibitor, in patients with advanced and refractory solid tumors or lymphoma. J. Clin. Oncol. 23(17), 3912-3922 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , Issue.17 , pp. 3912-3922
    • Ryan, Q.C.1    Headlee, D.2    Acharya, M.3
  • 245
    • 34848883438 scopus 로고    scopus 로고
    • Phase i trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies
    • Kummar S, Gutierrez M, Gardner ER et al.: Phase I trial of MS-275, a histone deacetylase inhibitor, administered weekly in refractory solid tumors and lymphoid malignancies. Clin. Cancer Res. 13(18 Pt 1), 5411-5417 (2007).
    • (2007) Clin. Cancer Res. , vol.13 , Issue.18 PART 1 , pp. 5411-5417
    • Kummar, S.1    Gutierrez, M.2    Gardner, E.R.3
  • 246
    • 18444364803 scopus 로고    scopus 로고
    • A microarray-based method for detecting loci
    • Hatada I, Kato A, Morita S et al.: A microarray-based method for detecting loci. J. Hum. Genet. 47(8), 448-451 (2002).
    • (2002) J. Hum. Genet. , vol.47 , Issue.8 , pp. 448-451
    • Hatada, I.1    Kato, A.2    Morita, S.3
  • 247
    • 0036962761 scopus 로고    scopus 로고
    • Evaluation of a potential epigenetic biomarker by quantitative methyl-single nucleotide polymorphism
    • Uhlmann K, Brinckmann A, Toliat MR et al.: Evaluation of a potential epigenetic biomarker by quantitative methyl-single nucleotide polymorphism. Electrophoresis 23(24), 4072-4079 (2002).
    • (2002) Electrophoresis , vol.23 , Issue.24 , pp. 4072-4079
    • Uhlmann, K.1    Brinckmann, A.2    Toliat, M.R.3
  • 248
    • 24044455869 scopus 로고    scopus 로고
    • Genome sequencing in microfabricated high-density picolitre reactors
    • Margulies M, Egholm M, Altman WE et al.: Genome sequencing in microfabricated high-density picolitre reactors. Nature 437(7057), 376-380 (2005)
    • (2005) Nature , vol.437 , Issue.7057 , pp. 376-380
    • Margulies, M.1    Egholm, M.2    Altman, W.E.3
  • 249
    • 57849109058 scopus 로고    scopus 로고
    • Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters
    • Core LJ, Waterfall JJ, Lis JT: Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters. Science 322(5909), 1845-1848 (2008).
    • (2008) Science , vol.322 , Issue.5909 , pp. 1845-1848
    • Core, L.J.1    Waterfall, J.J.2    Lis, J.T.3
  • 250
    • 57849123049 scopus 로고    scopus 로고
    • RNA exosome depletion reveals transcription upstream of active human promoters
    • Preker P, Nielsen J, Kammler S et al.: RNA exosome depletion reveals transcription upstream of active human promoters. Science 322(5909), 1851-1854 (2008).
    • (2008) Science , vol.322 , Issue.5909 , pp. 1851-1854
    • Preker, P.1    Nielsen, J.2    Kammler, S.3
  • 251
    • 0036303417 scopus 로고    scopus 로고
    • Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: Structure of the proteins and their interactions with 16 S RNA
    • Brodersen DE, Clemons WM Jr, Carter A P, Wimberly BT, Ramakrishnan V: Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA. J. Mol. Biol. 316(3), 725-768 (2002).
    • (2002) J. Mol. Biol. , vol.316 , Issue.3 , pp. 725-768
    • De, B.1    Carter, A.P.2    Wimberly, B.T.3    Ramakrishnan, V.4


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