Protein kinase LKB1 regulates polarized dendrite formation of adult hippocampal newborn neurons

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 1, 2014, Pages 469-474

  Huang, Wei ^a,b   She, Liang ^a,b   Chang, Xing Ya ^a   Yang, Rong Rong ^a   Wang, Liang ^a,b   Ji, Hong Bin ^c   Jiao, Jian Wei ^a,d   Poo, Mu Ming ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^d INSTITUTE OF ZOOLOGY   (China)

Author keywords

Adult neurogenesis; Golgi deployment; Neuronal polarization

Indexed keywords

MOLECULAR LAYER; PROTEIN KINASE LKB1; SHORT HAIRPIN RNA; STRUCTURAL PROTEIN;

ADULT; ANIMAL CELL; ARTICLE; CELL DISRUPTION; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITE; ENZYME PHOSPHORYLATION; GENE DELETION; GENE OVEREXPRESSION; GOLGI COMPLEX; GRANULE CELL; HIPPOCAMPUS; MOSSY FIBER; MOUSE; NEWBORN; NONHUMAN; POLARIZATION; PRIORITY JOURNAL; SENSORY NERVE CELL; WILD TYPE;

ADULT NEUROGENESIS; GOLGI DEPLOYMENT; NEURONAL POLARIZATION;

ANIMALS; ANIMALS, NEWBORN; AUTOANTIGENS; AXONS; CARRIER PROTEINS; CELL POLARITY; CELL PROLIFERATION; DENDRITES; DENTATE GYRUS; GENE EXPRESSION REGULATION; GOLGI APPARATUS; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; NEUROGENESIS; NEURONS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 84891958767     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1321454111     Document Type: Article

References (46)

1. Ming GL, Song H (2005) Adult neurogenesis in the mammalian central nervous system. Annu Rev Neurosci 28: 223-250.
2. Clelland CD, et al. (2009) A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 325(5937): 210-213.
3. Sahay A, et al. (2011) Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472(7344): 466-470.
4. Nakashiba T, et al. (2012) Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. Cell 149(1): 188-201.
5. Santarelli L, et al. (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301(5634): 805-809.
6. Snyder JS, Soumier A, Brewer M, Pickel J, Cameron HA (2011) Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 476(7361): 458-461.
7. Zhao C, Teng EM, Summers RG, Jr., Ming GL, Gage FH (2006) Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus. J Neurosci 26(1): 3-11.
8. Kemphues KJ, Priess JR, Morton DG, Cheng NS (1988) Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 52(3): 311-320.
9. Martin SG, St Johnston D (2003) A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature 421(6921): 379-384.
10. Ossipova O, Bardeesy N, DePinho RA, Green JB (2003) LKB1 (XEEK1) regulates Wnt signalling in vertebrate development. Nat Cell Biol 5(10): 889-894.
11. Baas AF, et al. (2004) Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 116(3): 457-466.
12. Barnes AP, et al. (2007) LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell 129(3): 549-563.
13. Shelly M, Cancedda L, Heilshorn S, Sumbre G, Poo MM (2007) LKB1/STRAD promotes axon initiation during neuronal polarization. Cell 129(3): 565-577.
14. Asada N, Sanada K, Fukada Y (2007) LKB1 regulates neuronal migration and neuronal differentiation in the developing neocortex through centrosomal positioning. J Neurosci 27(43): 11769-11775.
15. van Praag H, et al. (2002) Functional neurogenesis in the adult hippocampus. Nature 415(6875): 1030-1034.
16. Lagace DC, et al. (2007) Dynamic contribution of nestin-expressing stem cells to adult neurogenesis. J Neurosci 27(46): 12623-12629.
17. Ylikorkala A, et al. (2001) Vascular abnormalities and deregulation of VEGF in Lkb1- deficient mice. Science 293(5533): 1323-1326.
18. Bardeesy N, et al. (2002) Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419(6903): 162-167.
19. Shelly M, et al. (2010) Local and long-range reciprocal regulation of cAMP and cGMP in axon/dendrite formation. Science 327(5965): 547-552.
20. Polleux F, Morrow T, Ghosh A (2000) Semaphorin 3A is a chemoattractant for cortical apical dendrites. Nature 404(6778): 567-573.
21. Ables JL, et al. (2010) Notch1 is required for maintenance of the reservoir of adult hippocampal stem cells. J Neurosci 30(31): 10484-10492.
22. Baas AF, et al. (2003) Activation of the tumour suppressor kinase LKB1 by the STE20- like pseudokinase STRAD. EMBO J 22(12): 3062-3072.
23. Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM (2009) Structure of the LKB1- STRAD-MO25 complex reveals an allosteric mechanism of kinase activation. Science 326(5960): 1707-1711.
24. Ye B, et al. (2007) Growing dendrites and axons differ in their reliance on the secretory pathway. Cell 130(4): 717-729.
25. Ori-McKenney KM, Jan LY, Jan YN (2012) Golgi outposts shape dendrite morphology by functioning as sites of acentrosomal microtubule nucleation in neurons. Neuron 76(5): 921-930.
26. Horton AC, et al. (2005) Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis. Neuron 48(5): 757-771.
27. Barr FA, Puype M, Vandekerckhove J, Warren G (1997) GRASP65, a protein involved in the stacking of Golgi cisternae. Cell 91(2): 253-262.
28. Puthenveedu MA, Bachert C, Puri S, Lanni F, Linstedt AD (2006) GM130 and GRASP65- dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution. Nat Cell Biol 8(3): 238-248.
29. Matsuki T, et al. (2010) Reelin and stk25 have opposing roles in neuronal polarization and dendritic Golgi deployment. Cell 143(5): 826-836.
30. Ge S, et al. (2006) GABA regulates synaptic integration of newly generated neurons in the adult brain. Nature 439(7076): 589-593.
31. Horton AC, Ehlers MD (2004) Secretory trafficking in neuronal dendrites. Nat Cell Biol 6(7): 585-591.
32. Suzuki A, Ohno S (2006) The PAR-aPKC system: Lessons in polarity. J Cell Sci 119(Pt 6): 979-987.
33. Nakano A, Takashima S (2012) LKB1 and AMP-activated protein kinase: Regulators of cell polarity. Genes Cells 17(9): 737-747.
34. Tenlen JR, Molk JN, London N, Page BD, Priess JR (2008) MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation. Development 135(22): 3665-3675.
35. Griffin EE, Odde DJ, Seydoux G (2011) Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycle. Cell 146(6): 955-968.
36. Kishi M, Pan YA, Crump JG, Sanes JR (2005) Mammalian SAD kinases are required for neuronal polarization. Science 307(5711): 929-932.
37. Jenne DE, et al. (1998) Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nat Genet 18(1): 38-43.
38. Boudeau J, et al. (2003) MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J 22(19): 5102-5114.
39. Alessi DR, Sakamoto K, Bayascas JR (2006) LKB1-dependent signaling pathways. Annu Rev Biochem 75: 137-163.
40. ten Klooster JP, et al. (2009) Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex. Dev Cell 16(4): 551-562.
41. Preisinger C, et al. (2004) YSK1 is activated by the Golgi matrix protein GM130 and plays a role in cell migration through its substrate 14-3-3zeta. J Cell Biol 164(7): 1009-1020.
42. Drewes G, Ebneth A, Mandelkow EM (1998) MAPs, MARKs and microtubule dynamics. Trends Biochem Sci 23(8): 307-311.
43. Duan X, et al. (2007) Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain. Cell 130(6): 1146-1158.
44. Kim JY, et al. (2012) Interplay between DISC1 and GABA signaling regulates neurogenesis in mice and risk for schizophrenia. Cell 148(5): 1051-1064.
45. Courchet J, et al. (2013) Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture. Cell 153(7): 1510-1525.
46. Teichmann HM, Shen K (2011) UNC-6 and UNC-40 promote dendritic growth through PAR-4 in Caenorhabditis elegans neurons. Nat Neurosci 14(2): 165-172.