The fibroproliferative response in acute respiratory distress syndrome: Mechanisms and clinical significance

European Respiratory Journal

Volumn 43, Issue 1, 2014, Pages 276-285

  Burnham, Ellen L ^a   Janssen, William J ^a,b   Riches, David W H ^a,b   Moss, Marc ^a   Downey, Gregory P ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b DEPARTMENT OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN;

ADULT RESPIRATORY DISTRESS SYNDROME; ARTIFICIAL VENTILATION; BRONCHOSCOPY; COMORBIDITY; COMPUTER ASSISTED TOMOGRAPHY; DISEASE SEVERITY; EXTRACELLULAR MATRIX; FIBROBLAST; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HISTOPATHOLOGY; HUMAN; LUNG FUNCTION TEST; LUNG LAVAGE; MORTALITY; PREVALENCE; PRIORITY JOURNAL; PROGNOSIS; QUALITY OF LIFE; REVIEW; TIDAL VOLUME; TOTAL LUNG CAPACITY; UNITED STATES;

FIBROBLASTS; HUMANS; LUNG; PULMONARY FIBROSIS; QUALITY OF LIFE; RESPIRATORY DISTRESS SYNDROME, ADULT; SURVIVORS;

EID: 84891952550     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00196412     Document Type: Review

References (92)

1. Ashbaugh DG, Bigelow DB, Petty TL, et al. Acute respiratory distress in adults. Lancet 1967; 2: 319-323.
2. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Rice TW, Wheeler AP, et al. Initial trophic vs full enteral feeding in patients with acute lung injury: The EDEN randomized trial. JAMA 2012; 307: 795-803.
3. ARDS Definition Task Force, Ranieri VM, Rubenfeld GD, et al. Acute respiratory distress syndrome: The Berlin Definition. JAMA 2012; 307: 2526-2533.
4. Mercat A, Richard JC, Vielle B, et al. Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: A randomized controlled trial. JAMA 2008; 299: 646-655.
5. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000; 342: 1301-1308.
6. National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, Wiedemann HP, Wheeler AP, et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med 2006; 354: 2564-2575.
7. Bienvenu OJ, Colantuoni E, Mendez-Tellez PA, et al. Depressive symptoms and impaired physical function after acute lung injury: A 2-year longitudinal study. Am J Respir Crit Care Med 2012; 185: 517-524.
8. Herridge MS, Cheung AM, Tansey CM, et al. One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med 2003; 348: 683-693.
9. Herridge MS, Tansey CM, Matté A, et al. Functional disabilityy years after acute respiratory distress syndrome. N Engl J Med 2011; 364: 1293-1304.
10. Heyland DK, Groll D, Caeser M. Survivors of acute respiratory distress syndrome: Relationship between pulmonary dysfunction and long-term health-related quality of life. Crit Care Med 2005; 33: 1549-1556.
11. Masclans JR, Roca O, Munoz X, et al. Quality of life, pulmonary function, and tomographic scan abnormalities after ARDS. Chest 2011; 139: 1340-1346.
12. Orme J Jr, Romney JS, Hopkins RO, et al. Pulmonary function and health-related quality of life in survivors of acute respiratory distress syndrome. Am J Respir Crit Care Med 2003; 167: 690-694.
13. Wilcox ME, Patsios D, Murphy G, et al. Radiologic outcomes att years after severe ARDS. Chest 2013; 143: 920-926.
14. Jones PW, Forde Y. St George's Respiratory Questionnaire Manual. London, University of London, 2009. Available from: www.healthstatus.sgul.ac.uk/sgrq/ sgrq-downloads
15. McHorney CA, Ware JE Jr, Lu JF, et al. The MOS 36-item Short-Form Health Survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Med Care 1994; 32: 40-66.
16. Desai SR, Wells AU, Rubens MB, et al. Acute respiratory distress syndrome: CT abnormalities at long-term followup. Radiology 1999; 210: 29-35.
17. Nobauer-Huhmann IM, Eibenberger K, Schaefer-Prokop C, et al. Changes in lung parenchyma after acute respiratory distress syndrome (ARDS): Assessment with high-resolution computed tomography. Eur Radiol 2001; 11: 2436-2443.
18. Burnham EL, Hyzy RC, Paine R 3rd, et al. Chest CT features are associated with poorer quality of life in acute lung injury survivors. Crit Care Med 2013; 41: 445-456.
19. Paine R 3rd, Standiford TJ, Dechert RE, et al. A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury. Crit Care Med 2012; 40: 90-97.
20. Matthay MA, Ware LB, Zimmerman GA. The acute respiratory distress syndrome. J Clin Invest 2012; 122: 2731-2740.
21. Matthay MA, Zemans RL. The acute respiratory distress syndrome: Pathogenesis and treatment. Annu Rev Pathol 2011; 6: 147-163.
22. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000; 342: 1334-1349.
23. Zemans RL, Colgan SP, Downey GP. Transepithelial migration of neutrophils: Mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol 2009; 40: 519-535.
24. Davey A, McAuley DF, O'Kane CM. Matrix metalloproteinases in acute lung injury: Mediators of injury and drivers of repair. Eur Respir J 2011; 38: 959-970.
25. González-Ló pez A, Astudillo A, Garća-Prieto E, et al. Inflammation and matrix remodeling during repair of ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol 2011; 301: L500-L509.
26. Lee WL, Downey GP. Leukocyte elastase: Physiological functions and role in acute lung injury. Am J Respir Crit Care Med 2001; 164: 896-904.
27. Dos Santos CC. Advances in mechanisms of repair and remodelling in acute lung injury. Intensive Care Med 2008; 34: 619-630.
28. Madtes DK, Rubenfeld G, Klima LD, et al. Elevated transforming growth factor-A levels in bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med 1998; 158: 424-430.
29. Chesnutt AN, Kheradmand F, Folkesson HG, et al. Soluble transforming growth factor-A is present in the pulmonary edema fluid of patients with acute lung injury. Chest 1997; 111: 652-656.
30. Snyder LS, Hertz MI, Peterson MS, et al. Acute lung injury. Pathogenesis of intraalveolar fibrosis. J Clin Invest 1991; 88: 663-673.
31. Tager AM, LaCamera P, Shea BS, et al. The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nat Med 2008; 14: 45-54.
32. White KE, Ding Q, Moore BB, et al. Prostaglandin E2 mediates IL-1b-related fibroblast mitogenic effects in acute lung injury through differential utilization of prostanoid receptors. J Immunol 2008; 180: 637-646.
33. Chandel NS, Budinger GR, Mutlu GM, et al. Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways. Crit Care Med 2009; 37: 1678-1684.
34. Yi ES, Williams ST, Lee H, et al. Keratinocyte growth factor ameliorates radiation- and bleomycin-induced lung injury and mortality. Am J Pathol 1996; 149: 1963-1970.
35. Verghese GM, McCormick-Shannon K, Mason RJ, et al. Hepatocyte growth factor and keratinocyte growth factor in the pulmonary edema fluid of patients with acute lung injury. Biologic and clinical significance. Am J Respir Crit Care Med 1998; 158: 386-394.
36. Fahy RJ, Lichtenberger F, McKeegan CB, et al. The acute respiratory distress syndrome: A role for transforming growth factor-b1. Am J Respir Cell Mol Biol 2003; 28: 499-503.
37. Wynn TA. Integrating mechanisms of pulmonary fibrosis. J Exp Med 2011; 208: 1339-1350.
38. Rock JR, Barkauskas CE, Cronce MJ, et al. Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. Proc Natl Acad Sci USA 2011; 108: E1475-E1483.
39. Chapman HA. Epithelial-mesenchymal interactions in pulmonary fibrosis. Annu Rev Physiol 2011; 73: 413-435.
40. Schrimpf C, Duffield JS. Mechanisms of fibrosis: The role of the pericyte. Curr Opin Nephrol Hypertens 2011; 20: 297-305.
41. Phillips RJ, Burdick MD, Hong K, et al. Circulating fibrocytes traffic to the lungs in response to CXCL12 and mediate fibrosis. J Clin Invest 2004; 114: 438-446.
42. Pelosi P, Rocco PR. Effects of mechanical ventilation on the extracellular matrix. Intensive Care Med 2008; 34: 631-639.
43. Tremblay LN, Miatto D, Hamid Q, et al. Injurious ventilation induces widespread pulmonary epithelial expression of tumor necrosis factor-A and interleukin-6 messenger RNA. Crit Care Med 2002; 30: 1693-1700.
44. Tremblay LN, Slutsky AS. Ventilator-induced lung injury: From the bench to the bedside. Intensive Care Med 2006; 32: 24-33.
45. Bachofen M, Weibel ER. Structural alterations of lung parenchyma in the adult respiratory distress syndrome. Clin Chest Med 1982; 3: 35-56.
46. Tomashefski JF Jr. Pulmonary pathology of acute respiratory distress syndrome. Clin Chest Med 2000; 21: 435-466.
47. Rocco PR, Dos Santos C, Pelosi P. Lung parenchyma remodeling in acute respiratory distress syndrome. Minerva Anestesiol 2009; 75: 730-740.
48. Keane MP, Belperio JA, Moore TA, et al. Neutralization of the CXC chemokine, macrophage inflammatory protein-2, attenuates bleomycin-induced pulmonary fibrosis. J Immunol 1999; 162: 5511-5518.
49. Ou XM, Li WC, Liu DS, et al. VEGFR-2 antagonist SU5416 attenuates bleomycin-induced pulmonary fibrosis in mice. Int Immunopharmacol 2009; 9: 70-79.
50. Hamada N, Kuwano K, Yamada M, et al. Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice. J Immunol 2005; 175: 1224-1231.
51. Maitre B, Boussat S, Jean D, et al. Vascular endothelial growth factor synthesis in the acute phase of experimental and clinical lung injury. Eur Respir J 2001; 18: 100-106.
52. Thickett DR, Armstrong L, Millar AB. A role for vascular endothelial growth factor in acute and resolving lung injury. Am J Respir Crit Care Med 2002; 166: 1332-1337.
53. Abadie Y, Bregeon F, Papazian L, et al. Decreased VEGF concentration in lung tissue and vascular injury during ARDS. Eur Respir J 2005; 25: 139-146.
54. Parikh SM, Mammoto T, Schultz A, et al. Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med 2006; 3: E46.
55. Clark JG, Milberg JA, Steinberg KP, et al. Type III procollagen peptide in the adult respiratory distress syndrome. Association of increased peptide levels in bronchoalveolar lavage fluid with increased risk for death. Ann Intern Med 1995; 122: 17-23.
56. Farjanel J, Hartmann DJ, Guidet B, et al. Four markers of collagen metabolism as possible indicators of disease in the adult respiratory distress syndrome. Am Rev Respir Dis 1993; 147: 1091-1099.
57. Meduri GU, Tolley EA, Chinn A, et al. Procollagen types I and III aminoterminal propeptide levels during acute respiratory distress syndrome and in response to methylprednisolone treatment. Am J Respir Crit Care Med 1998; 158: 1432-1441.
58. Bulpa PA, Dive AM, Mertens L, et al. Combined bronchoalveolar lavage and transbronchial lung biopsy: Safety and yield in ventilated patients. Eur Respir J 2003; 21: 489-494.
59. Patel SR, Karmpaliotis D, Ayas NT, et al. The role of open-lung biopsy in ARDS. Chest 2004; 125: 197-202.
60. Papazian L, Doddoli C, Chetaille B, et al. A contributive result of open-lung biopsy improves survival in acute respiratory distress syndrome patients. Crit Care Med 2007; 35: 755-762.
61. Krein PM, Sabatini PJ, Tinmouth W, et al. Localization of insulin-like growth factor-I in lung tissues of patients with fibroproliferative acute respiratory distress syndrome. Am J Respir Crit Care Med 2003; 167: 83-90.
62. Marshall RP, Bellingan G, Webb S, et al. Fibroproliferation occurs early in the acute respiratory distress syndrome and impacts on outcome. Am J Respir Crit Care Med 2000; 162: 1783-1788.
63. Budinger GR, Chandel NS, Donnelly HK, et al. Active transforming growth factor-b1 activates the procollagen I promoter in patients with acute lung injury. Intensive Care Med 2005; 31: 121-128.
64. Synenki L, Chandel NS, Budinger GR, et al. Bronchoalveolar lavage fluid from patients with acute lung injury/acute respiratory distress syndrome induces myofibroblast differentiation. Crit Care Med 2007; 35: 842-848.
65. de Pablo R, Monserrat J, Reyes E, et al. Sepsis-induced acute respiratory distress syndrome with fatal outcome is associated to increased serum transforming growth factor b-1 levels. Eur J Intern Med 2012; 23: 358-362.
66. Quesnel C, Nardelli L, Piednoir P, et al. Alveolar fibroblasts in acute lung injury: Biological behaviour and clinical relevance. Eur Respir J 2010; 35: 1312-1321.
67. Quesnel C, Piednoir P, Gelly J, et al. Alveolar fibrocyte percentage is an independent predictor of poor outcome in patients with acute lung injury. Crit Care Med 2012; 40: 21-28.
68. Nakayama Y, Kon S, Kurotaki D, et al. Blockade of interaction of a9 integrin with its ligands hinders the formation of granulation in cutaneous wound healing. Lab Invest 2010; 90: 881-894.
69. Mineo G, Ciccarese F, Modolon C, et al. Post-ARDS pulmonary fibrosis in patients with H1N1 pneumonia: Role of follow-up CT. Radiol Med 2012; 117: 185-200.
70. Steinberg KP, Mitchell DR, Maunder RJ, et al. Safety of bronchoalveolar lavage in patients with adult respiratory distress syndrome. Am Rev Respir Dis 1993; 148: 556-561.
71. Moeller A, Gilpin SE, Ask K, et al. Circulating fibrocytes are an indicator of poor prognosis in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2009; 179: 588-594.
72. Vij R, Noth I. Peripheral blood biomarkers in idiopathic pulmonary fibrosis. Transl Res 2012; 159: 218-227.
73. Barnett N, Ware LB. Biomarkers in acute lung injury - marking forward progress. Crit Care Clin 2011; 27: 661-683.
74. Calfee CS, Ware LB, Glidden DV, et al. Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury. Crit Care Med 2011; 39: 711-717.
75. Barlo NP, van Moorsel CH, Ruven HJ, et al. Surfactant protein-D predicts survival in patients with idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis 2009; 26: 155-161.
76. Gattinoni L, Caironi P, Cressoni M, et al. Lung recruitment in patients with the acute respiratory distress syndrome. N Engl J Med 2006; 354: 1775-1786.
77. Ichikado K, Suga M, Muller NL, et al. Acute interstitial pneumonia: Comparison of high-resolution computed tomography findings between survivors and nonsurvivors. Am J Respir Crit Care Med 2002; 165: 1551-1556.
78. Ichikado K, Suga M, Muranaka H, et al. Prediction of prognosis for acute respiratory distress syndrome with thinsection CT: Validation in 44 cases. Radiology 2006; 238: 321-329.
79. Ichikado K, Muranaka H, Gushima Y, et al. Fibroproliferative changes on high-resolution CT in the acute respiratory distress syndrome predict mortality and ventilator dependency: A prospective observational cohort study. BMJ Open 2012; 2: E000545.
80. Chung JH, Kradin RL, Greene RE, et al. CT predictors of mortality in pathology confirmed ARDS. Eur Radiol 2011; 21: 730-737.
81. Grieser C, Goldmann A, Steffen IG, et al. Computed tomography findings from patients with ARDS due to Influenza A (H1N1) virus-associated pneumonia. Eur J Radiol 2012; 81: 389-394.
82. Meduri GU, Headley AS, Golden E, et al. Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: A randomized controlled trial. JAMA 1998; 280: 159-165.
83. Steinberg KP, Hudson LD, Goodman RB, et al. Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med 2006; 354: 1671-1684.
84. Meduri GU, Golden E, Freire AX, et al. Methylprednisolone infusion in early severe ARDS: Results of a randomized controlled trial. Chest 2007; 131: 954-963.
85. Beyer C, Distler JH. Tyrosine kinase signaling in fibrotic disorders: Translation of basic research to human disease. Biochim Biophys Acta 2013; 1832: 897-904.
86. Yamaguchi Y, Takihara T, Chambers RA, et al. A peptide derived from endostatin ameliorates organ fibrosis. Sci Transl Med 2012; 4: 136ra71.
87. Massagué J. TGFb signalling in context. Nat Rev Mol Cell Biol 2012; 13: 616-630.
88. Biernacka A, Dobaczewski M, Frangogiannis NG. TGF-b signaling in fibrosis. Growth Factors 2011; 29: 196-202.
89. Wrighton KH, Lin X, Feng XH. Phospho-control of TGF-b superfamily signaling. Cell Res 2009; 19: 8-20.
90. King TE Jr, Albera C, Bradford WZ, et al. Effect of interferon c-1b on survival in patients with idiopathic pulmonary fibrosis (INSPIRE): A multicentre, randomised, placebo-controlled trial. Lancet 2009; 374: 222-228.
91. Raghu G, Brown KK, Bradford WZ, et al. A placebo-controlled trial of interferon c-1b in patients with idiopathic pulmonary fibrosis. N Engl J Med 2004; 350: 125-133.
92. King TE Jr, Brown KK, Raghu G, et al. BUILD-3: A randomized, controlled trial of bosentan in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2011; 184: 92-99.