Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 1, 2014, Pages 261-266

  Okamoto, Toru ^a,b,c   Coultas, Leigh ^a,b   Metcalf, Donald ^a,b   Van Delft, Mark F ^a,b   Glaser, Stefan P ^a,b   Takiguchi, Megumi ^a,b   Strasser, Andreas ^a,b   Bouillet, Philippe ^a,b   Adams, Jerry M ^a,b   Huang, David C S ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Programmed cell death; Protein turnover

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CASPASE INHIBITOR; ETOPOSIDE; MYC PROTEIN; PROTEIN BCL 2; PROTEIN MCL 1;

ACUTE GRANULOCYTIC LEUKEMIA; ALLELE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL STRESS; CONTROLLED STUDY; DISEASE SEVERITY; DNA DAMAGE; GENE LOSS; HOMOZYGOTE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY POLYCYSTIC DISEASE; MALE; MALE INFERTILITY; MALE STERILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN METABOLISM; PROTEIN STABILITY; PROTEIN SYNTHESIS INHIBITION; TUMOR XENOGRAFT; ULTRAVIOLET IRRADIATION;

PROGRAMMED CELL DEATH; PROTEIN TURNOVER;

ALLELES; ANIMALS; APOPTOSIS; CELL DEATH; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; FIBROBLASTS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; INFERTILITY, MALE; LEUKEMIA, MYELOID, ACUTE; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; POLYCYSTIC KIDNEY DISEASES; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-MYC; SPERMATOGENESIS; TESTIS; TIME FACTORS; ULTRAVIOLET RAYS;

EID: 84891939629     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1321259110     Document Type: Article

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