Evaluation of intramitochondrial ATP levels identifies G0/G1 switch gene 2 as a positive regulator of oxidative phosphorylation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 1, 2014, Pages 273-278

  Kioka, Hidetaka ^a   Kato, Hisakazu ^a   Fujikawa, Makoto ^b   Tsukamoto, Osamu ^a   Suzuki, Toshiharu ^c,d   Imamura, Hiromi ^e   Nakano, Atsushi ^a,f   Higo, Shuichiro ^a   Yamazaki, Satoru ^f   Matsuzaki, Takashi ^a   Takafuji, Kazuaki ^a   Asanuma, Hiroshi ^g   Asakura, Masanori ^f   Minamino, Tetsuo ^a   Shintani, Yasunori ^a   Yoshida, Masasuke ^d   Noji, Hiroyuki ^h   Kitakaze, Masafumi ^f   Komuro, Issei ^a,i   Asano, Yoshihiro ^a   Takashima, Seiji ^a   more..

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^d KYOTO SANGYO UNIVERSITY   (Japan)

^e KYOTO UNIVERSITY   (Japan)

^f NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^g KYOTO PREFECTURAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^h UNIVERSITY OF TOKYO   (Japan)

ⁱ UNIVERSITY OF TOKYO   (Japan)

Author keywords

Energy metabolism; Live cell imaging

Indexed keywords

ADENOSINE TRIPHOSPHATE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ANIMAL CELL; ARTICLE; CELL STRESS; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; GENE EXPRESSION; GENE SWITCHING; HYPOXIA; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM;

ENERGY METABOLISM; LIVE-CELL IMAGING;

ADENOSINE TRIPHOSPHATE; ANIMALS; BIOSENSING TECHNIQUES; CATTLE; CELL CYCLE PROTEINS; CELL SURVIVAL; G0 PHASE; G1 PHASE; GENES, SWITCH; HEK293 CELLS; HELA CELLS; HUMANS; MICE; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MYOCYTES, CARDIAC; OLIGOMYCINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHOSPHORYLATION; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; TIME FACTORS;

EID: 84891933726     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1318547111     Document Type: Article

References (36)

1. Kim JW, Tchernyshyov I, Semenza GL, Dang CV (2006) HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia. Cell Metab 3(3): 177-185.
2. Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC (2006) HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 3(3): 187-197.
3. Semenza GL (2012) Hypoxia-inducible factors in physiology and medicine. Cell 148(3): 399-408.
4. Semenza GL, et al. (1996) Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxiainducible factor 1. J Biol Chem 271(51): 32529-32537.
5. Chen YC, et al. (2012) Identification of a protein mediating respiratory supercomplex stability. Cell Metab 15(3): 348-360.
6. Fukuda R, et al. (2007) HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell 129(1): 111-122.
7. Strogolova V, Furness A, Robb-McGrath M, Garlich J, Stuart RA (2012) Rcf1 and Rcf2, members of the hypoxia-induced gene 1 protein family, are critical components of the mitochondrial cytochrome bc1-cytochrome c oxidase supercomplex. Mol Cell Biol 32(8): 1363-1373.
8. Saks V, et al. (2006) Cardiac system bioenergetics: Metabolic basis of the Frank-Starling law. J Physiol 571(Pt 2): 253-273.
9. Smolenski RT, Lachno DR, Ledingham SJ, Yacoub MH (1990) Determination of sixteen nucleotides, nucleosides and bases using high-performance liquid chromatography and its application to the study of purine metabolism in hearts for transplantation. J Chromatogr A 527(2): 414-420.
10. Shimura D, et al. (2013) Metabolomic profiling analysis reveals chamber-dependent metabolite patterns in the mouse heart. Am J Physiol Heart Circ Physiol 305(4):H494-H505.
11. Kemp GJ, Meyerspeer M, Moser E (2007) Absolute quantification of phosphorus metabolite concentrations in human muscle in vivo by 31P MRS: A quantitative review. NMR Biomed 20(6): 555-565.
12. Ford SR, et al. (1996) Use of firefly luciferase for ATP measurement: Other nucleotides enhance turnover. J Biolumin Chemilumin 11(3): 149-167.
13. Imamura H, et al. (2009) Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators. Proc Natl Acad Sci USA 106(37): 15651-15656.
14. Lopaschuk GD, Kelly DP (2008) Signalling in cardiac metabolism. Cardiovasc Res 79(2): 205-207.
15. Hattori F, et al. (2010) Nongenetic method for purifying stem cell-derived cardiomyocytes. Nat Methods 7(1): 61-66.
16. Forsythe JA, et al. (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16(9): 4604-4613.
17. Wolf A, et al. (2011) Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J Exp Med 208(2): 313-326.
18. Russell L, Forsdyke DR (1991) A human putative lymphocyte G0/G1 switch gene containing a CpG-rich island encodes a small basic protein with the potential to be phosphorylated. DNA Cell Biol 10(8): 581-591.
19. Zandbergen F, et al. (2005) The G0/G1 switch gene 2 is a novel PPAR target gene. Biochem J 392(Pt 2): 313-324.
20. Heckmann BL, Zhang X, Xie X, Liu J (2013) The G0/G1 switch gene 2 (G0S2): Regulating metabolism and beyond. Biochim Biophys Acta 1831(2): 276-281.
21. Dimroth P, von Ballmoos C, Meier T (2006) Catalytic and mechanical cycles in F-ATP synthases. Fourth in the Cycles Review Series. EMBO Rep 7(3): 276-282.
22. Senior AE (2007) ATP synthase: Motoring to the finish line. Cell 130(2): 220-221.
23. Walker JE (1998) ATP synthesis by rotary catalysis (Nobel Lecture). Angew Chem Int Ed 37: 5000-5011.
24. Yoshida M, Muneyuki E, Hisabori T (2001) ATP synthase-a marvellous rotary engine of the cell. Nat Rev Mol Cell Biol 2(9): 669-677.
25. Fujikawa M, YoshidaM(2010) A sensitive, simple assay of mitochondrial ATP synthesis of cultured mammalian cells suitable for high-throughput analysis. Biochem Biophys Res Commun 401(4): 538-543.
26. Adachi K, et al. (2007) Coupling of rotation and catalysis in F(1)-ATPase revealed by single-molecule imaging and manipulation. Cell 130(2): 309-321.
27. Itoh H, et al. (2004) Mechanically driven ATP synthesis by F1-ATPase. Nature 427(6973): 465-468.
28. Noji H, Yasuda R, Yoshida M, Kinosita K, Jr. (1997) Direct observation of the rotation of F1-ATPase. Nature 386(6622): 299-302.
29. Rondelez Y, et al. (2005) Highly coupled ATP synthesis by F1-ATPase single molecules. Nature 433(7027): 773-777.
30. Uchihashi T, Iino R, Ando T, Noji H (2011) High-speed atomic force microscopy reveals rotary catalysis of rotorless F-ATPase. Science 333(6043): 755-758.
31. Giorgio V, et al. (2009) Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex. J Biol Chem 284(49): 33982-33988.
32. Siderovski DP, Blum S, Forsdyke RE, Forsdyke DR (1990) A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes. DNA Cell Biol 9(8): 579-587.
33. Yamada T, Park CS, Burns A, Nakada D, Lacorazza HD (2012) The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells. PLoS ONE 7(5):e38280.
34. Welch C, et al. (2009) Identification of a protein, G0S2, that lacks Bcl-2 homology domains and interacts with and antagonizes Bcl-2. Cancer Res 69(17): 6782-6789.
35. Kobayashi S, et al. (2008) Expression profiling of PBMC-based diagnostic gene markers isolated from vasculitis patients. DNA Res 15(4): 253-265.
36. Yang X, et al. (2010) The G(0)/G(1) switch gene 2 regulates adipose lipolysis through association with adipose triglyceride lipase. Cell Metab 11(3): 194-205.