Tumor necrosis factor α induces epithelial-mesenchymal transition and promotes metastasis via NF-κB signaling pathway-mediated TWIST expression in hypopharyngeal cancer

Oncology Reports

Volumn 31, Issue 1, 2014, Pages 321-327

  Yu, Liang ^a   Mu, Yakui ^a   Sa, Na ^a   Wang, Haibo ^a   Xu, Wei ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Epithelial mesenchymal transition; Hypopharyngeal cancer; NF B; Tumor micro environment; Tumor necrosis factor ; TWIST

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NERVE CELL ADHESION MOLECULE; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR TWIST; TUMOR NECROSIS FACTOR ALPHA; UVOMORULIN; VIMENTIN;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL ADHESION; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL NUCLEUS; CELL POLARITY; CELL STRAIN FADU; CELL STRUCTURE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOPHARYNX CANCER; IMMUNOFLUORESCENCE; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

CADHERINS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOPHARYNGEAL NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NITRILES; NUCLEAR PROTEINS; PROTEIN TRANSPORT; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SULFONES; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA; TWIST TRANSCRIPTION FACTOR; VIMENTIN;

EID: 84891932910     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2841     Document Type: Article

References (30)

1. Shacter E and Weitzman SA: Chronic inflammation and cancer. Oncology 16: 217-226, 229, 2002.
2. Balkwill F: Tumour necrosis factor and cancer. Nat Rev Cancer 9: 361-371, 2009.
3. Karin M and Greten FR: NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5: 749-759, 2005.
4. Luo JL, Kamata H and Karin M: IKK/NF-κB signaling: balancing life and death - a new approach to cancer therapy. J Clin Invest 115: 2625-2632, 2005.
5. Thiery JP: Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454, 2002.
6. Huber MA, Kraut N and Beug H: Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 17: 548-558, 2005.
7. Kang Y and Massagué J: Epithelial-mesenchymal transitions: twist in development and metastasis. Cell 118: 277-279, 2004.
8. Yu L, Lu S, Tian J, et al: TWIST expression in hypopharyngeal cancer and the mechanism of TWIST-induced promotion of metastasis. Oncol Rep 27: 416-422, 2012.
9. Yu L, Li HZ, Lu SM, et al: Down-regulation of TWIST decreases migration and invasion of laryngeal carcinoma Hep-2 cells by regulating the E-cadherin, N-cadherin expression. J Cancer Res Clin Oncol 137: 1487-1493, 2011.
10. Wang H, Wang HS, Zhou BH, et al: Epithelial-mesenchymal transition (EMT) induced by TNF-α requires AKT/GSK-3β-mediated stabilization of Snail in colorectal cancer. PLoS One 8: e56664, 2013.
11. Techasen A, Namwat N, Loilome W, et al: Tumor necrosis factor-α (TNF-α) stimulates the epithelial-mesenchymal transition regulator Snail in cholangiocarcinoma. Med Oncol 29: 3083-3091, 2012.
12. Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM and Zhou BP: Stabilization of Snail by NF-κB is required for inflammation- induced cell migration and invasion. Cancer Cell 15: 416-428, 2009.
13. Wu ST, Sun GH, Hsu CY, et al: Tumor necrosis factor-α induces epithelial-mesenchymal transition of renal cell carcinoma cells via a nuclear factor κB-independent mechanism. Exp Biol Med 236: 1022-1029, 2011.
14. Smith RB, Apostolakis LW, Karnell LH, et al: National Cancer Data Base report on osteosarcoma of the head and neck. Cancer 98: 1670-1680, 2003.
15. Lefebvre JL, Castelain B, De la Torre JC, Delobelle-Deroide A and Vankemmel B: Lymph node invasion in hypopharynx and lateral epilarynx carcinoma: a prognostic factor. Head Neck Surg 10: 14-18, 1987.
16. Eccles SA and Welch DR: Metastasis: recent discoveries and novel treatment strategies. Lancet 369: 1742-1757, 2007.
17. Yu L, Li HZ, Lu SM, et al: Alteration in TWIST expression: possible role in paclitaxel-induced apoptosis in human laryngeal carcinoma Hep-2 cell line. Croat Med J 50: 536-542, 2009.
18. Bates RC and Mercurio AM: Tumor necrosis factor-α stimulates the epithelial-to-mesenchymal transition of human colonic organoids. Mol Biol Cell 14: 1790-1800, 2003.
19. Takahashi E, Nagano O, Ishimoto T, et al: Tumor necrosis factor-α regulates transforming growth factor-β-dependent epithelial-mesenchymal transition by promoting hyaluronan- CD44-moesin interaction. J Biol Chem 285: 4060-4073, 2010.
20. Balkwill F: Tumor necrosis factor or tumor promoting factor? Cytokine Growth Factor Rev 13: 135-141, 2002.
21. Lee SO, Lou W, Hou M, de Miguel F, Gerber L and Gao AC: Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells. Clin Cancer Res 9: 370-376, 2003.
22. Yamauchi Y, Kohyama T, Takizawa H, et al: Tumor necrosis factor-α enhances both epithelial-mesenchymal transition and cell contraction induced in A549 human alveolar epithelial cells by transforming growth factor-β1. Exp Lung Res 36: 12-24, 2010.
23. Drake JM, Strohbehn G, Bair TB, Moreland JG and Henry MD: ZEB1 enhances transendothelial migration and represses the epithelial phenotype of prostate cancer cells. Mol Biol Cell 20: 2207-2217, 2009.
24. Yang J, Mani SA, Donaher JL, et al: Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117: 927-939, 2004.
25. Peinado H, Olmeda D and Cano A: Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7: 415-428, 2007.
26. Li CW, Xia W, Huo L, et al: Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1. Cancer Res 72: 1290-1300, 2012.
27. Chua HL, Bhat-Nakshatri P, Clare SE, Morimiya A, Badve S and Nakshatri H: NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2. Oncogene 26: 711-724, 2007.
28. Min C, Eddy SF, Sherr DH and Sonenshein GE: NF-κB and epithelial to mesenchymal transition of cancer. J Cell Biochem 104: 733-744, 2008.
29. Kaisho T, Takeda K, Tsujimura T, et al: IκB kinase α is essential for mature B cell development and function. J Exp Med 193: 417-426, 2001.
30. Storci G, Sansone P, Mari S, et al: TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype. J Cell Physiol 225: 682-691, 2010.