S100A4 is upregulated via the binding of c-Myb in methylation-free laryngeal cancer cells

Oncology Reports

Volumn 31, Issue 1, 2014, Pages 442-449

  Liu, Jia ^a   Xu, Zhen Ming ^b   Qiu, Guang Bin ^c   Zheng, Zhi Hong ^a   Sun, Kai Lai ^a   Fu, Wei Neng ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b The 463 Hospital of Chinese PLA   (China)

^c No 202 Hospital of PLA   (China)

Author keywords

c Myb; DNA methylation; Laryngeal squamous cell carcinoma; S100A4

Indexed keywords

CALVASCULIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; PROTEIN C MYB; TRANSCRIPTION FACTOR AP 2; TRANSCRIPTION FACTOR MSX1;

AMINO ACID SEQUENCE; ARTICLE; C MYB GENE; CANCER CELL CULTURE; CELLULAR DISTRIBUTION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA METHYLATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE IDENTIFICATION; GENE LOCATION; GENE SEQUENCE; HUMAN; HUMAN CELL; LARYNX CANCER; LUCIFERASE ASSAY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; S100A4 GENE; TRANSCRIPTION REGULATION; UPREGULATION;

BASE SEQUENCE; BINDING SITES; CCAAT-ENHANCER-BINDING PROTEINS; CELL LINE, TUMOR; DNA METHYLATION; HUMANS; LARYNGEAL NEOPLASMS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MYB; RESPONSE ELEMENTS; S100 PROTEINS; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84891919595     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2013.2824     Document Type: Article

References (31)

1. Ragin CC, Modugno F and Gollin SM: The epidemiology and risk factors of head and neck cancer: a focus on human papillomavirus. J Dent Res 86: 104-114, 2007.
2. Li DW, Gao S, Shen B and Dong P: Effect of apoptotic and proliferative indices, P-glycoprotein and survivin expression on prognosis in laryngeal squamous cell carcinoma. Med Oncol 28 (Suppl 1): S333-S340, 2011.
3. Holgersson G, Ekman S, Reizenstein J, et al: Molecular profiling using tissue microarrays as a tool to identify predictive biomarkers in laryngeal cancer treated with radiotherapy. Cancer Genomics Proteomics 7: 1-7, 2010.
4. Zou J, Yang H, Chen F, et al: Prognostic significance of fascin-1 and E-cadherin expression in laryngeal squamous cell carcinoma. Eur J Cancer Prev 19: 11-17, 2010.
5. Waha A, Felsberg J, Hartmann W, et al: Frequent epigenetic inactivation of the chaperone SGNE1/7B2 in human gliomas. Int J Cancer 131: 612-622, 2012.
6. Robertson KD: DNA methylation and human disease. Nat Rev Genet 6: 597-610, 2005.
7. Wilson IM, Davies JJ, Weber M, et al: Epigenomics: mapping the methylome. Cell Cycle 5: 155-158, 2006.
8. mC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing. Proc Natl Acad Sci USA 98: 10404-10409, 2001.
9. Esteller M: Cancer epigenetics: DNA methylation and chromatin alterations in human cancer. Adv Exp Med Biol 532: 39-49, 2003.
10. Waraya M, Yamashita K, Katoh H, et al: Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesis. BMC Cancer 12: 397, 2012.
11. Abildgaard MO, Borre M, Mortensen MM, et al: Downregulation of zinc finger protein 132 in prostate cancer is associated with aberrant promoter hypermethylation and poor prognosis. Int J Cancer 130: 885-895, 2012.
12. Lleras RA, Adrien LR, Smith RV, et al: Hypermethylation of a cluster of Krüppel-type zinc finger protein genes on chromosome 19q13 in oropharyngeal squamous cell carcinoma. Am J Pathol 178: 1965-1974, 2011.
13. Rosty C, Ueki T, Argani P, et al: Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am J Pathol 160: 45-50, 2002.
14. Choi JY, James SR, Link PA, et al: Association between global DNA hypomethylation in leukocytes and risk of breast cancer. Carcinogenesis 30: 1889-1897, 2009.
15. Liu J, Guo Y, Fu S, Yang M, Sun KL and Fu WN: Hypomethylation-induced expression of S100A4 increases the invasiveness of laryngeal squamous cell carcinoma. Oncol Rep 23: 1101-1107, 2010.
16. Burke E and Barik S: Megaprimer PCR: application in mutagenesis and gene fusion. Methods Mol Biol 226: 525-532, 2003.
17. Xie R, Loose DS, Shipley GL, Xie S, Bassett RL Jr and Broaddus RR: Hypomethylation-induced expression of S100A4 in endometrial carcinoma. Mod Pathol 20: 1045-1054, 2007.
18. Sato N, Maitra A, Fukushima N, et al: Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma. Cancer Res 63: 4158-4166, 2003.
19. Nakamura N and Takenaga K: Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines. Clin Exp Metastasis 16: 471-479, 1998.
20. Horiuchi A, Hayashi T, Kikuchi N, et al: Hypoxia upregulates ovarian cancer invasiveness via the binding of HIF-1α to a hypoxia-induced, methylation-free hypoxia response element of S100A4 gene. Int J Cancer 131: 1755-1767, 2012.
21. Mucenski ML, McLain K, Kier AB, et al: A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65: 677-689, 1991.
22. Malaterre J, Carpinelli M, Ernst M, et al: c-Myb is required for progenitor cell homeostasis in colonic crypts. Proc Natl Acad Sci USA 104: 3829-3834, 2007.
23. Drabsch Y, Hugo H, Zhang R, et al: Mechanism of and requirement for estrogen-regulated MYB expression in estrogen-receptor-positive breast cancer cells. Proc Natl Acad Sci USA 104: 13762-13767, 2007.
24. Bender TP, Kremer CS, Kraus M, Buch T and Rajewsky K: Critical functions for c-Myb at three checkpoints during thymocyte development. Nat Immunol 5: 721-729, 2004.
25. Nakagoshi H, Kanei-Ishii C, Sawazaki T, Mizuguchi G and Ishii S: Transcriptional activation of the c-myc gene by the c-myb and B-myb gene products. Oncogene 7: 1233-1240, 1992.
26. Frampton J, Ramqvist T and Graf T: v-Myb of E26 leukemia virus up-regulates bcl-2 and suppresses apoptosis in myeloid cells. Genes Dev 10: 2720-2731, 1996.
27. Taylor D, Badiani P and Weston K: A dominant interfering Myb mutant causes apoptosis in T cells. Genes Dev 10: 2732-2744, 1996.
28. Kowenz-Leutz E, Herr P, Niss K and Leutz A: The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation. Cell 91: 185-195, 1997.
29. Wang Q, Williamson M, Bott S, et al: Hypomethylation of WNT5A, CRIP1 and S100P in prostate cancer. Oncogene 26: 6560-6565, 2007.
30. Campanero MR, Armstrong MI and Flemington EK: CpG methylation as a mechanism for the regulation of E2F activity. Proc Natl Acad Sci USA 97: 6481-6486, 2000.
31. Fang F, Flegler AJ, Du P, Lin S and Clevenger CV: Expression of cyclophilin B is associated with malignant progression and regulation of genes implicated in the pathogenesis of breast cancer. Am J Pathol 174: 297-308, 2009.