Immunogenomics for identification of disease resistance genes in pigs: A review focusing on Gram-negative bacilli

Journal of Animal Science and Biotechnology

Volumn 3, Issue 1, 2012, Pages

  Zhao, Shuhong ^a,b   Zhu, Mengjin ^a   Chen, Hongbo ^b  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b WUHAN POLYTECHNIC UNIVERSITY   (China)

Author keywords

Disease resistance breeding; Gram negative bacteria; Immunogenomics; Pig

Indexed keywords

EID: 84891902226     PISSN: 16749782     EISSN: 20491891     Source Type: Journal    
DOI: 10.1186/2049-1891-3-34     Document Type: Review

References (94)

1. Fairbrother JM, Nadeau E, Gyles CL. Escherichia coli in postweaning diarrhea in pigs: an update on bacterial types, pathogenesis, and prevention strategies. Anim Health Res Rev 2005, 6:17-39. 10.1079/AHR2005105, 16164007.
2. Zhao SH, Kuhar D, Lunney JK, Dawson H, Guidry C, Uthe JJ, Bearson SM, Recknor J, Nettleton D, Tuggle CK. Gene expression profiling in Salmonella Choleraesuis-infected porcine lung using a long oligonucleotide microarray. Mamm Genome 2006, 17:777-789. 10.1007/s00335-005-0155-3, 16845603.
3. Uthe JJ, Qu L, Couture O, Bearson SM, OConnor AM, McKean JD, Torres YR, Dekkers JC, Nettleton D, Tuggle CK. Use of bioinformatic SNP predictions in differentially expressed genes to find SNPs associated with Salmonella colonization in swine. J Anim Breed Genet 2011, 128:354-365. 10.1111/j.1439-0388.2011.00935.x, 21906181.
4. Chen H, Li C, Fang M, Zhu M, Li X, Zhou R, Li K, Zhao S. Understanding Haemophilus parasuis infection in porcine spleen through a transcriptomics approach. BMC Genomics 2009, 10:64. 10.1186/1471-2164-10-64, 2660370, 19196461.
5. Archibald AL, Bolund L, Churcher C, Fredholm M, Groenen MA, Harlizius B, Lee KT, Milan D, Rogers J, Rothschild MF, et al. Pig genome sequence-analysis and publication strategy. BMC Genomics 2010, 11:438. 10.1186/1471-2164-11-438, 3017778, 20642822.
6. Lundeheim N. Genetic analysis of respiratory diseases in pigs. Acta Agriculturae Scandinavica 1979, 29:209-215.
7. Lundeheim N. Health disorders and growth performance at a swedish pigprogeny testing station. Acta Agriculturae Scandinavica 1988, 38:77-88.
8. Henryon MBP, Jensen J, Andersen S. Genetic variation for resistance to clinical and subclinical diseases exists in growing pigs. Anim Sci 2001, 73:375-387.
9. Bishop SC, Woolliams JA. On the genetic interpretation of disease data. PLoS One 2010, 5:e8940. 10.1371/journal.pone.0008940, 2812510, 20126627.
10. Edfors-Lilja I, Wattrang E, Marklund L, Moller M, Andersson-Eklund L, Andersson L, Fossum C. Mapping quantitative trait loci for immune capacity in the pig. J Immunol 1998, 161:829-835.
11. Mallard BA WB, Kennedy BW, Quinton M. Use of estimated breeding values in a selection index to breed Yorkshire pigs for high and low immune and innate resistance factors. Anim Biotechnol 1992, 3:257-280.
12. Clapperton M, Bishop SC, Glass EJ. Innate immune traits differ between Meishan and large white pigs. Vet Immunol Immunopathol 2005, 104:131-144. 10.1016/j.vetimm.2004.10.009, 15734534.
13. Juul-Madsen HR, Krogh-Meibom T, Henryon M, Palaniyar N, Heegaard PM, Purup S, Willis AC, Tornoe I, Ingvartsen KL, Hansen S, et al. Identification and characterization of porcine mannan-binding lectin A (pMBL-A), and determination of serum concentration heritability. Immunogenetics 2006, 58:129-137. 10.1007/s00251-006-0092-7, 16518621.
14. Flori L, Gao Y, Laloe D, Lemonnier G, Leplat JJ, Teillaud A, Cossalter AM, Laffitte J, Pinton P, de Vaureix C, et al. Immunity traits in pigs: substantial genetic variation and limited covariation. PLoS One 2011, 6:e22717. 10.1371/journal.pone.0022717, 3146468, 21829490.
15. Gibbons RA, Jones GW, Sellwood R. An attempt to identify the intestinal receptor for the K88 adhesin by means of a haemagglutination inhibition test using glycoproteins and fractions from sow colostrum. J Gen Microbiol 1975, 86:228-240.
16. Moon HW, Hoffman LJ, Cornick NA, Booher SL, Bosworth BT. Prevalences of some virulence genes among Escherichia coli isolates from swine presented to a diagnostic laboratory in Iowa. J Vet Diagn Invest 1999, 11:557-560. 10.1177/104063879901100617, 12968745.
17. Peng QL, Ren J, Yan XM, Huang X, Tang H, Wang YZ, Zhang B, Huang LS. The g.243A>G mutation in intron 17 of MUC4 is significantly associated with susceptibility/resistance to ETEC F4ab/ac infection in pigs. Anim Genet 2007, 38:397-400. 10.1111/j.1365-2052.2007.01608.x, 17559554.
18. Zhang B, Ren J, Yan X, Huang X, Ji H, Peng Q, Zhang Z, Huang L. Investigation of the porcine MUC13 gene: isolation, expression, polymorphisms and strong association with susceptibility to enterotoxigenic Escherichia coli F4ab/ac. Anim Genet 2008, 39:258-266. 10.1111/j.1365-2052.2008.01721.x, 18454803.
19. Zhu M, Zhao S. Candidate gene identification approach: progress and challenges. Int J Biol Sci 2007, 3:420-427. 2043166, 17998950.
20. Rothschild MF, Hu ZL, Jiang Z. Advances in QTL mapping in pigs. Int J Biol Sci 2007, 3:192-197. 1802014, 17384738.
21. Hu ZL, Fritz ER, Reecy JM. AnimalQTLdb: a livestock QTL database tool set for positional QTL information mining and beyond. Nucleic Acids Res 2007, 35:D604-609. 10.1093/nar/gkl946, 1781224, 17135205.
22. Hu ZL, Ramos AM, Humphray SJ, Rogers J, Reecy JM, Rothschild MF. Use of genome sequence information for meat quality trait QTL mining for causal genes and mutations on pig chromosome 17. Front Genet 2011, 2:43. 3268380, 22303339.
23. Hu ZL, Reecy JM. Animal QTLdb: beyond a repository. A public platform for QTL comparisons and integration with diverse types of structural genomic information. Mamm Genome 2007, 18:1-4. 10.1007/s00335-006-0105-8, 17245610.
24. Galina-Pantoja L, Siggens K, van Schriek MG, Heuven HC. Mapping markers linked to porcine salmonellosis susceptibility. Anim Genet 2009, 40:795-803. 10.1111/j.1365-2052.2009.01916.x, 19496771.
25. Yang B, Huang X, Yan X, Ren J, Yang S, Zou Z, Zeng W, Ou Y, Huang W, Huang L. Detection of quantitative trait loci for porcine susceptibility to enterotoxigenic Escherichia coli F41 in a White Duroc x Chinese Erhualian resource population. Animal 2009, 3:946-950. 10.1017/S1751731109004509, 22444814.
26. Wang X, Quinn PJ. Endotoxins: lipopolysaccharides of gram-negative bacteria. Subcell Biochem 2010, 53:3-25. 10.1007/978-90-481-9078-2_1, 20593260.
27. Hacker J, Blum-Oehler G, Muhldorfer I, Tschape H. Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution. Mol Microbiol 1997, 23:1089-1097. 10.1046/j.1365-2958.1997.3101672.x, 9106201.
28. Schmidt H, Hensel M. Pathogenicity islands in bacterial pathogenesis. Clin Microbiol Rev 2004, 17:14-56. 10.1128/CMR.17.1.14-56.2004, 321463, 14726454.
29. Lawson GH, Gebhart CJ. Proliferative enteropathy. J Comp Pathol 2000, 122:77-100. 10.1053/jcpa.1999.0347, 10684678.
30. Pedersen KS, Holyoake P, Stege H, Nielsen JP. Diagnostic performance of different fecal Lawsonia intracellularis-specific polymerase chain reaction assays as diagnostic tests for proliferative enteropathy in pigs: a review. J Vet Diagn Invest 2010, 22:487-494. 10.1177/104063871002200401, 20622217.
31. Macinnes JI, Rosendal S. Prevention and Control of Actinobacillus (Haemophilus) pleuropneumoniae Infection in Swine: A review. Can Vet J 1988, 29:572-574. 1680813, 17423079.
32. Chiers K, De Waele T, Pasmans F, Ducatelle R, Haesebrouck F. Virulence factors of Actinobacillus pleuropneumoniae involved in colonization, persistence and induction of lesions in its porcine host. Vet Res 2010, 41:65. 10.1051/vetres/2010037, 2899255, 20546697.
33. Oliveira S, Pijoan C. Haemophilus parasuis: new trends on diagnosis, epidemiology and control. Vet Microbiol 2004, 99:1-12. 10.1016/j.vetmic.2003.12.001, 15019107.
34. Wang Y, Couture OP, Qu L, Uthe JJ, Bearson SM, Kuhar D, Lunney JK, Nettleton D, Dekkers JC, Tuggle CK. Analysis of porcine transcriptional response to Salmonella enterica serovar Choleraesuis suggests novel targets of NFkappaB are activated in the mesenteric lymph node. BMC Genomics 2008, 9:437. 10.1186/1471-2164-9-437, 2570369, 18811943.
35. Hur J, Choi YY, Park JH, Jeon BW, Lee HS, Kim AR, Lee JH. Antimicrobial resistance, virulence-associated genes, and pulsed-field gel electrophoresis profiles of Salmonella enterica subsp. enterica serovar Typhimurium isolated from piglets with diarrhea in Korea. Can J Vet Res 2011, 75:49-56. 3003562, 21461195.
36. Nataro JP, Kaper JB. Diarrheagenic escherichia coli. Clin Microbiol Rev 1998, 11:142-201. 121379, 9457432.
37. Li Y, Qiu X, Li H, Zhang Q. Adhesive patterns of escherichia coli F4 in piglets of three breeds. J Genet Genomics 2007, 34:591-599. 10.1016/S1673-8527(07)60067-8, 17643944.
38. Wilcock BP. Experimental Klebsiella and Salmonella infection in neonatal swine. Can J Comp Med 1979, 43:200-206. 1319918, 387185.
39. SEPTICAEMIA APEGK. http://vla.defra.gov.uk/science/docs/sci_klebsiella.pdf, SEPTICAEMIA.
40. Slee KJ, Button C. Enteritis in sheep, goats and pigs due to Yersinia pseudotuberculosis infection. Aust Vet J 1990, 67:320-322. 10.1111/j.1751-0813.1990.tb07814.x, 2098020.
41. Harper PA, Hornitzky MA, Rayward DG. Enterocolitis in pigs associated with Yersinia pseudotuberculosis infection. Aust Vet J 1990, 67:418-419. 10.1111/j.1751-0813.1990.tb03039.x, 2085301.
42. Bottone EJ. Yersinia enterocolitica: the charisma continues. Clin Microbiol Rev 1997, 10:257-276. 172919, 9105754.
43. McOrist S, Gebhart CJ, Boid R, Barns SM. Characterization of Lawsonia intracellularis gen. nov., sp. nov., the obligately intracellular bacterium of porcine proliferative enteropathy. Int J Syst Bacteriol 1995, 45:820-825. 10.1099/00207713-45-4-820, 7547305.
44. Jacobson M, Hard Af Segerstad C, Gunnarsson A, Fellstrom C, De Verdier Klingenberg K, Wallgren P, Jensen-Waern M. Diarrhoea in the growing pig - a comparison of clinical, morphological and microbial findings between animals from good and poor performance herds. Res Vet Sci 2003, 74:163-169. 10.1016/S0034-5288(02)00187-X, 12589741.
45. Olubunmi PA, Taylor DJ. Production of enteritis in pigs by the oral inoculation of pure cultures of Campylobacter coli. Vet Rec 1982, 111:197-202. 10.1136/vr.111.10.197, 7135771.
46. Katsikogianni M, Missirlis YF. Concise review of mechanisms of bacterial adhesion to biomaterials and of techniques used in estimating bacteria-material interactions. Eur Cell Mater 2004, 8:37-57.
47. Heumann D, Roger T. Initial responses to endotoxins and Gram-negative bacteria. Clin Chim Acta 2002, 323:59-72. 10.1016/S0009-8981(02)00180-8, 12135807.
48. Uthe JJ, Royaee A, Lunney JK, Stabel TJ, Zhao SH, Tuggle CK, Bearson SM. Porcine differential gene expression in response to Salmonella enterica serovars Choleraesuis and Typhimurium. Mol Immunol 2007, 44:2900-2914. 10.1016/j.molimm.2007.01.016, 17337057.
49. Chen H, Lunney JK, Cheng L, Li X, Cao J, Zhu M, Zhao S. Porcine S100A8 and S100A9: molecular characterizations and crucial functions in response to Haemophilus parasuis infection. Dev Comp Immunol 2011, 35:490-500. 10.1016/j.dci.2010.11.017, 21185856.
50. Thorgersen EB, Pharo A, Haverson K, Axelsen AK, Gaustad P, Kotwal GJ, Sfyroera G, Mollnes TE. Inhibition of complement and CD14 attenuates the Escherichia coli-induced inflammatory response in porcine whole blood. Infect Immun 2009, 77:725-732. 10.1128/IAI.01305-08, 2632024, 19047409.
51. Pisano F, Kochut A, Uliczka F, Geyer R, Stolz T, Thiermann T, Rohde M, Dersch P. In vivo-induced InvA-like autotransporters Ifp and InvC of Yersinia pseudotuberculosis promote interactions with intestinal epithelial cells and contribute to virulence. Infect Immun 2012, 80:1050-1064. 10.1128/IAI.05715-11, 3294637, 22158741.
52. Blanco I, Galina-Pantoja L, Oliveira S, Pijoan C, Sanchez C, Canals A. Comparison between Haemophilus parasuis infection in colostrums-deprived and sow-reared piglets. Vet Microbiol 2004, 103:21-27. 10.1016/j.vetmic.2004.06.011, 15381262.
53. Pomorska-Mol M, Markowska-Daniel I, Rachubik J, Pejsak Z. Effect of maternal antibodies and pig age on the antibody response after vaccination against Glassers disease. Vet Res Commun 2011, 35:337-343. 10.1007/s11259-011-9478-6, 21584780.
54. Bosse JT, Johnson RP, Nemec M, Rosendal S. Protective local and systemic antibody responses of swine exposed to an aerosol of Actinobacillus pleuropneumoniae serotype 1. Infect Immun 1992, 60:479-484. 257652, 1730479.
55. Crawley AM, Mallard B, Wilkie BN. Genetic selection for high and low immune response in pigs: effects on immunoglobulin isotype expression. Vet Immunol Immunopathol 2005, 108:71-76. 10.1016/j.vetimm.2005.07.006, 16098603.
56. Guedes RM, Gebhart CJ. Evidence of cell-mediated immune response and specific local mucosal immunoglobulin (Ig) A production against Lawsonia intracellularis in experimentally infected swine. Can J Vet Res 2010, 74:97-101. 2851731, 20592838.
57. Jeyasingham MD, Butty P, King TP, Begbie R, Kelly D. Escherichia coli K88 receptor expression in intestine of disease-susceptible weaned pigs. Vet Microbiol 1999, 68:219-234. 10.1016/S0378-1135(99)00052-8, 10510041.
58. Opriessnig T, Fenaux M, Thomas P, Hoogland MJ, Rothschild MF, Meng XJ, Halbur PG. Evidence of breed-dependent differences in susceptibility to porcine circovirus type-2-associated disease and lesions. Vet Pathol 2006, 43:281-293. 10.1354/vp.43-3-281, 16672575.
59. Blanco I, Canals A, Evans G, Mellencamp MA, Cia C, Deeb N, Wang L, Galina-Pantoja L. Differences in susceptibility to Haemophilus parasuis infection in pigs. Can J Vet Res 2008, 72:228-235. 2327248, 18505185.
60. Lunney JK, Steibel JP, Reecy JM, Fritz E, Rothschild MF, Kerrigan M, Trible B, Rowland RR. Probing genetic control of swine responses to PRRSV infection: current progress of the PRRS host genetics consortium. BMC Proc 2011, 5(Suppl 4):S30. 10.1186/1753-6561-5-S4-S30, 3287866, 22373451.
61. Veldhuizen EJ, Koomen I, Ultee T, van Dijk A, Haagsman HP. Salmonella serovar specific upregulation of porcine defensins 1 and 2 in a jejunal epithelial cell line. Vet Microbiol 2009, 136:69-75. 10.1016/j.vetmic.2008.09.072, 19019577.
62. Wang Y, Qu L, Uthe JJ, Bearson SM, Kuhar D, Lunney JK, Couture OP, Nettleton D, Dekkers JC, Tuggle CK. Global transcriptional response of porcine mesenteric lymph nodes to Salmonella enterica serovar Typhimurium. Genomics 2007, 90:72-84. 10.1016/j.ygeno.2007.03.018, 17499962.
63. Vandenbroucke V, Croubels S, Verbrugghe E, Boyen F, De Backer P, Ducatelle R, Rychlik I, Haesebrouck F, Pasmans F. The mycotoxin deoxynivalenol promotes uptake of Salmonella Typhimurium in porcine macrophages, associated with ERK1/2 induced cytoskeleton reorganization. Vet Res 2009, 40:64. 10.1051/vetres/2009045, 19674540.
64. Collado-Romero M, Arce C, Ramirez-Boo M, Carvajal A, Garrido JJ. Quantitative analysis of the immune response upon Salmonella typhimurium infection along the porcine intestinal gut. Vet Res 2010, 41:23. 10.1051/vetres/2009072, 2820228, 19941811.
65. Meurens F, Berri M, Auray G, Melo S, Levast B, Virlogeux-Payant I, Chevaleyre C, Gerdts V, Salmon H. Early immune response following Salmonella enterica subspecies enterica serovar Typhimurium infection in porcine jejunal gut loops. Vet Res 2009, 40:5. 10.1051/vetres:2008043, 2695014, 18922229.
66. Ma G, Huang J, Sun N, Liu X, Zhu M, Wu Z, Zhao S. Molecular characterization of the porcine GBP1 and GBP2 genes. Mol Immunol 2008, 45:2797-2807. 10.1016/j.molimm.2008.02.007, 18346789.
67. Veldhuizen EJ, Hendriks HG, Hogenkamp A, van Dijk A, Gaastra W, Tooten PC, Haagsman HP. Differential regulation of porcine beta-defensins 1 and 2 upon Salmonella infection in the intestinal epithelial cell line IPI-2I. Vet Immunol Immunopathol 2006, 114:94-102. 10.1016/j.vetimm.2006.07.012, 16938353.
68. Veldhuizen EJ, Rijnders M, Claassen EA, van Dijk A, Haagsman HP. Porcine beta-defensin 2 displays broad antimicrobial activity against pathogenic intestinal bacteria. Mol Immunol 2008, 45:386-394. 10.1016/j.molimm.2007.06.001, 17658606.
69. Uthe JJ, Wang Y, Qu L, Nettleton D, Tuggle CK, Bearson SM. Correlating blood immune parameters and a CCT7 genetic variant with the shedding of Salmonella enterica serovar Typhimurium in swine. Vet Microbiol 2009, 135:384-388. 10.1016/j.vetmic.2008.09.074, 18996651.
70. Fu WX, Liu Y, Lu X, Niu XY, Ding XD, Liu JF, Zhang Q. A genome-wide association study identifies two novel promising candidate genes affecting escherichia coli F4ab/F4ac susceptibility in swine. PLoS ONE 2012, 7:e32127. 10.1371/journal.pone.0032127, 3311625, 22457712.
71. Erickson AK, Baker DR, Bosworth BT, Casey TA, Benfield DA, Francis DH. Characterization of porcine intestinal receptors for the K88ac fimbrial adhesin of Escherichia coli as mucin-type sialoglycoproteins. Infect Immun 1994, 62:5404-5410. 303281, 7960120.
72. Joller D, Jorgensen CB, Bertschinger HU, Python P, Edfors I, Cirera S, Archibald AL, Burgi E, Karlskov-Mortensen P, Andersson L, et al. Refined localization of the Escherichia coli F4ab/F4ac receptor locus on pig chromosome 13. Anim Genet 2009, 40:749-752. 10.1111/j.1365-2052.2009.01881.x, 19392815.
73. Bao WB, Ye L, Zi C, Su XM, Pan ZY, Zhu J, Zhu GQ, Huang XG, Wu SL. Study on the age-dependent tissue expression of FUT1 gene in porcine and its relationship to E. coli F18 receptor. Gene 2012, 497:336-339. 10.1016/j.gene.2012.01.035, 22305985.
74. Bao WB, Ye L, Pan ZY, Zhu J, Du ZD, Zhu GQ, Huang XG, Wu SL. The effect of mutation at M307 in FUT1 gene on susceptibility of Escherichia coli F18 and gene expression in Sutai piglets. Mol Biol Rep 2012, 39:3131-3136. 10.1007/s11033-011-1078-6, 21691705.
75. Python P, Jorg H, Neuenschwander S, Asai-Coakwell M, Hagger C, Burgi E, Bertschinger HU, Stranzinger G, Vogeli P. Inheritance of the F4ab, F4ac and F4ad E. coli receptors in swine and examination of four candidate genes for F4acR. J Anim Breed Genet 2005, 122(Suppl 1):5-14.
76. Ouyang J, Zeng W, Ren J, Yan X, Zhang Z, Yang M, Han P, Huang X, Ai H, Huang L. Association of B3GNT5 polymorphisms with susceptibility to ETEC F4ab/ac in the white Duroc x Erhualian intercross and 15 outbred pig breeds. Biochem Genet 2012, 50:19-33. 10.1007/s10528-011-9454-4, 21956797.
77. Ji H, Ren J, Yan X, Huang X, Zhang B, Zhang Z, Huang L. The porcine MUC20 gene: molecular characterization and its association with susceptibility to enterotoxigenic Escherichia coli F4ab/ac. Mol Biol Rep 2011, 38:1593-1601. 10.1007/s11033-010-0268-y, 20890662.
78. Wang Y, Ren J, Lan L, Yan X, Huang X, Peng Q, Tang H, Zhang B, Ji H, Huang L. Characterization of polymorphisms of transferrin receptor and their association with susceptibility to ETEC F4ab/ac in pigs. J Anim Breed Genet 2007, 124:225-229. 10.1111/j.1439-0388.2007.00664.x, 17651325.
79. Bao WB, Ye L, Pan ZY, Zhu J, Du ZD, Cai JJ, Huang XG, Zhu GQ, Wu SL. [cDNA microarray on differently expressed genes in duodenum in porcine sensitive or resistant to Escherichia coli F18]. Yi Chuan 2011, 33:60-66. 10.3724/SP.J.1005.2011.00060, 21377960.
80. Niewold TA, van der Meulen J, Kerstens HH, Smits MA, Hulst MM. Transcriptomics of enterotoxigenic Escherichia coli infection. Individual variation in intestinal gene expression correlates with intestinal function. Vet Microbiol 2010, 141:110-114. 10.1016/j.vetmic.2009.08.014, 19716242.
81. Bruun CS, Leifsson PS, Johansen LK, Jensen HE, Nielsen J, Fredholm M. Expression of matrix metalloproteinase-9 and -12 in porcine lung infections. J Comp Pathol 2012, 146:253-257. 10.1016/j.jcpa.2011.05.005, 21737093.
82. Skovgaard K, Mortensen S, Boye M, Hedegaard J, Heegaard PM. Hepatic gene expression changes in pigs experimentally infected with the lung pathogen Actinobacillus pleuropneumoniae as analysed with an innate immunity focused microarray. Innate Immun 2010, 16:343-353. 10.1177/1753425909342730, 19710094.
83. Danilowicz E, Martinez-Arias R, Dolf G, Singh M, Probst I, Tummler B, Holtig D, Waldmann KH, Gerlach GF, Stanke F, et al. Characterization of the porcine transferrin gene (TF) and its association with disease severity following an experimental Actinobacillus pleuropneumoniae infection. Anim Genet 2010, 41:424-427.
84. Moser RJ, Reverter A, Lehnert SA. Gene expression profiling of porcine peripheral blood leukocytes after infection with Actinobacillus pleuropneumoniae. Vet Immunol Immunopathol 2008, 121:260-274. 10.1016/j.vetimm.2007.10.007, 18054086.
85. Hedegaard J, Skovgaard K, Mortensen S, Sorensen P, Jensen TK, Hornshoj H, Bendixen C, Heegaard PM. Molecular characterisation of the early response in pigs to experimental infection with Actinobacillus pleuropneumoniae using cDNA microarrays. Acta Vet Scand 2007, 49:11. 10.1186/1751-0147-49-11, 1868913, 17466061.
86. Wang Y, Liu C, Fang Y, Liu X, Li W, Liu S, Liu Y, Charreyre C, Audonnet JC, Chen P, et al. Transcription analysis on response of porcine alveolar macrophages to Haemophilus parasuis. BMC Genomics 2012, 13:68. 10.1186/1471-2164-13-68, 3296652, 22330747.
87. Wang SJ, Liu WJ, Yang LG, Sargent CA, Liu HB, Wang C, Liu XD, Zhao SH, Affara NA, Liang AX, et al. Effects of FUT1 gene mutation on resistance to infectious disease. Mol Biol Rep 2012, 39:2805-2810. 10.1007/s11033-011-1039-0, 21695432.
88. Wilkinson JM, Sargent CA, Galina-Pantoja L, Tucker AW. Gene expression profiling in the lungs of pigs with different susceptibilities to Glasser's disease. BMC Genomics 2010, 11:455. 10.1186/1471-2164-11-455, 3017779, 20670446.
89. Liu XD, Chen HB, Tong Q, Li XY, Zhu MJ, Wu ZF, Zhou R, Zhao SH. Molecular characterization of caveolin-1 in pigs infected with Haemophilus parasuis. J Immunol 2011, 186:3031-3046. 10.4049/jimmunol.0902687, 21282513.
90. Jacobson M, Andersson M, Lindberg R, Fossum C, Jensen-Waern M. Microarray and cytokine analyses of field cases of pigs with diarrhoea. Vet Microbiol 2011, 153:307-314. 10.1016/j.vetmic.2011.06.003, 21741782.
91. Jacobsen M, Cirera S, Joller D, Esteso G, Kracht SS, Edfors I, Bendixen C, Archibald AL, Vogeli P, Neuenschwander S, et al. Characterisation of five candidate genes within the ETEC F4ab/ac candidate region in pigs. BMC Res Notes 2011, 4:225. 10.1186/1756-0500-4-225, 3160978, 21718470.
92. Yu J, Wu J, Zhang Y, Guo L, Cong X, Du Y, Li J, Sun W, Shi J, Peng J, et al. Concurrent highly pathogenic porcine reproductive and respiratory syndrome virus infection accelerates Haemophilus parasuis infection in conventional pigs. Vet Microbiol 2012, 158:316-321. 10.1016/j.vetmic.2012.03.001, 22460022.
93. Oh YS, Lee JB, McOrist S. Microarray analysis of differential expression of cell cycle and cell differentiation genes in cells infected with Lawsonia intracellularis. Vet J 2010, 184:340-345. 10.1016/j.tvjl.2009.03.018, 19362500.
94. Kanehisa M, Goto S, Sato Y, Furumichi M, Tanabe M. KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res 2012, 40:D109-114. 10.1093/nar/gkr988, 3245020, 22080510.