Evidence of cell-mediated immune response and specific local mucosal immunoglobulin (Ig) a production against Lawsonia intracellularis in experimentally infected swine

Canadian Journal of Veterinary Research

Volumn 74, Issue 2, 2010, Pages 97-101

  Guedes, Roberto M C ^a   Gebhart, Connie J ^b  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G;

ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DESULFOVIBRIONACEAE INFECTION; ENTEROPATHY; HUMORAL IMMUNITY; INOCULATION; INTESTINE MUCOSA; LAWSONIA; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; SWINE;

ANIMALS; DESULFOVIBRIONACEAE INFECTIONS; ENTERITIS; HYPERSENSITIVITY, DELAYED; IMMUNITY, CELLULAR; IMMUNOGLOBULIN A, SECRETORY; INTESTINAL MUCOSA; LAWSONIA BACTERIA; SWINE; SWINE DISEASES;

ANIMALIA; LAWSONIA INTRACELLULARIS; SUIDAE;

EID: 77951428423     PISSN: 08309000     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Goldsby RA, Kindt TJ, Osborne BA. Kuby Immunology. 4th ed. New York, New York: WH. Freeman and Company, 2000: 380-410.
2. Zuckermann FA, Martin S, Husmann RJ, Brandt J. Use of interleukin-12 to enhance the cellular immune response of swine to an inactivated herpesvirus vaccine. Adv Vet Med 1999;41:447-461.
3. Guedes RMC, Gebhart CJ. Onset and duration of fecal shedding, cell-mediated and humoral immune responses in pigs after challenge with a pathogenic isolate or attenuated vaccine strain of Lawsonia intracellularis. Vet Microbiol 2003;91:135-145.
4. Segalés J, Fernández-Salguero JM, Fructuoso G, et al. Granulomatous enteritis and lymphadenitis in Iberian pigs naturally infected with Lawsonia intracellularis. Vet Pathol 2001;38:343-346.
5. Lamm ME, Nedrud JG, Kaetzel CS, Mazane MB. IgA and mucosal defense. APMIS 1995;103:241-246.
6. Smith DGE, Lawson GHK. Lawsonia intracellularis: Getting inside of the pathogenesis of proliferative enteropathy. Vet Microbiol 2001;82:331-345.
7. Guedes RMC, Gebhart CJ. Comparison of intestinal mucosa homogenate and pure culture of the homologous Lawsonia intracellularis isolate in reproducing proliferative enteropathy in swine. Vet Microbiol 2003;93:159-166.
8. Guedes RMC, Gebhart CJ, Winkelman NA, Mackie-Nuss RA, Marsterlleres TA, Deen J. Comparison of different methods for diagnosis of porcine proliferative enteropathy. Can J Vet Res 2002;66:99-107.
9. Guedes RMC, Gebhart CJ, Winkelman NL, Mackie-Nuss RA. A comparative study of an indirect fluorescent antibody test and an immunoperoxidase monolayer assay for the diagnosis of porcine proliferative enteropathy. J Vet Diag Invest 2002;14:420-423.
10. Jones GF, Ward GE, Murtaugh MP, Lin G, Gebhart CJ. Enhanced detection of the intracellular organism of swine proliferative enteritis, Ileal symbiont intracellularis, in feces by polymerase chain reaction. J Clin Microbiol 1993;31:2611-2615.
11. Filip C, Fletcher G, Wulff JL, Earhart CF. Solubilization of the cytoplasmic membrane of Escherichia coli by the ionic detergent sodium-lauryl sarcosinate. J Bacteriol 1973;115:717-722.
12. Barenkamp SJ, Munson RS, Granoff DM. Subtyping isolates of Haemophilus influenzae type b by outer-membrane protein profiles. J Infect Dis 1981;143:668-676.
13. Guedes RMC, Gebhart CJ, Deen J, Winkelman NL. Validation of an immunoperoxidase monolayer assay as a serologic test for porcine proliferative enteropathy. J Vet Diag Invest 2002;14:528-530.
14. Knittel J P, Jordan DM, Schwartz KJ, et al. Evaluation of antemortem polymerase chain reaction and serologic methods for detection of Lawsonia intracellularis exposed pigs. Am J Vet Res 1998;59:722-726.
15. Lawson GHK, Rowland AC, Roberts L, Fraser G, McCartney E. Proliferative haemorrhagic enteropathy. Res Vet Sci 1979;27:46-51.
16. McOrist S, MacIntyre N, Stokes CR, Lawson GHK. Immunocytological responses in porcine proliferative enteropathies. Infect Immun 1992;60:4184-4191.
17. Holyoake PK. Proliferative enteritis: Endemic in Australian piggeries? Aust Vet J 1993;70:167-169.
18. Smith DGE, Mitchell SC, Nash T, Rhind S. Gamma interferon influences intestinal epithelial hyperplasia caused by Lawsonia intracellularis infection in mice. Infect Immun 2000;68:6737-6743.