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Volumn 14, Issue 3, 2014, Pages

Genotyping for severe drug hypersensitivity

Author keywords

Altered peptide repertoire; DILI; DRESS; Drug hypersensitivity; Genotyping; Human leukocyte antigen; Major histocompatibility complex; Pharmacogenetics; Pharmacogenomics; SCAR; Stevens Johnson syndrome; Toxic epidermal necrolysis; Translation

Indexed keywords

ABACAVIR; ALLOPURINOL; AMOXICILLIN PLUS CLAVULANIC ACID; CARBAMAZEPINE; FLUCLOXACILLIN; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA B15 ANTIGEN; HLA B57 ANTIGEN; NEVIRAPINE; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; HLA B ANTIGEN;

EID: 84891894586     PISSN: 15297322     EISSN: 15346315     Source Type: Journal    
DOI: 10.1007/s11882-013-0418-0     Document Type: Review
Times cited : (37)

References (110)
  • 1
    • 48249152146 scopus 로고    scopus 로고
    • Hospital admissions associated with adverse drug reactions: A systematic review of prospective observational studies
    • Kongkaew C, Noyce PR, Ashcroft DM. Hospital admissions associated with adverse drug reactions: a systematic review of prospective observational studies. Ann Pharmacother. 2008;42(7):1017-25.
    • (2008) Ann Pharmacother , vol.42 , Issue.7 , pp. 1017-1025
    • Kongkaew, C.1    Noyce, P.R.2    Ashcroft, D.M.3
  • 2
    • 84892368789 scopus 로고    scopus 로고
    • Comparative epidemiology of hospital-acquired adverse drug reactions in adults and children and their impact on cost and hospital stay - A systematic review
    • Khan LM. Comparative epidemiology of hospital-acquired adverse drug reactions in adults and children and their impact on cost and hospital stay - a systematic review. Eur J Clin Pharmacol. 2013.
    • (2013) Eur J Clin Pharmacol
    • Khan, L.M.1
  • 3
    • 0033636535 scopus 로고    scopus 로고
    • Clinical and economic impact of adverse drug reactions in hospitalized patients
    • Suh DC et al. Clinical and economic impact of adverse drug reactions in hospitalized patients. Ann Pharmacother. 2000;34(12):1373-9.
    • (2000) Ann Pharmacother , vol.34 , Issue.12 , pp. 1373-1379
    • Suh, D.C.1
  • 5
    • 84865516911 scopus 로고    scopus 로고
    • HLA and pharmacogenetics of drug hypersensitivity
    • Pavlos R, Mallal S, Phillips E. HLA and pharmacogenetics of drug hypersensitivity. Pharmacogenomics. 2012;13(11):1285-306.
    • (2012) Pharmacogenomics , vol.13 , Issue.11 , pp. 1285-1306
    • Pavlos, R.1    Mallal, S.2    Phillips, E.3
  • 9
    • 0142087834 scopus 로고    scopus 로고
    • Delayed drug hypersensitivity reactions
    • Pichler WJ. Delayed drug hypersensitivity reactions. Ann Intern Med. 2003;139(8):683-93.
    • (2003) Ann Intern Med , vol.139 , Issue.8 , pp. 683-693
    • Pichler, W.J.1
  • 10
    • 84855866524 scopus 로고    scopus 로고
    • Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex
    • Bharadwaj M et al. Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex. Annu Rev Pharmacol Toxicol. 2012;52:401-31.
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 401-431
    • Bharadwaj, M.1
  • 11
    • 84863721147 scopus 로고    scopus 로고
    • Abacavir induces loading of novel self-peptides into HLA-B*57: 01: An autoimmune model for HLA-associated drug hypersensitivity
    • Using abacavir-treated HLA-B*57: 01 B-cell lines, the authors demonstrated additional evidence that abacavir alters the quantity and quality of self-peptide loading into HLA-B*57:01
    • •• Norcross MA et al. Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity. AIDS. 2012;26(11):F21-9. Using abacavir-treated HLA-B*57: 01 B-cell lines, the authors demonstrated additional evidence that abacavir alters the quantity and quality of self-peptide loading into HLA-B*57:01.
    • (2012) AIDS , vol.26 , Issue.11
    • Norcross, M.A.1
  • 12
    • 84862776700 scopus 로고    scopus 로고
    • Direct interaction between HLA-B and carbamazepine activates Tcells in patients with Stevens-Johnson syndrome
    • This article demonstrates a direct interaction of HLA molecules with drugs and provides a potential mechanism for HLA-associated drug hypersensitivity reactions. Supportive of altered peptide repertoire model for carbamazepine.
    • •• Wei CY et al. Direct interaction between HLA-B and carbamazepine activates Tcells in patients with Stevens-Johnson syndrome. J Allergy Clin Immunol. 2012;129(6):1562-9 e5. This article demonstrates a direct interaction of HLA molecules with drugs and provides a potential mechanism for HLA-associated drug hypersensitivity reactions. Supportive of altered peptide repertoire model for carbamazepine.
    • (2012) J Allergy Clin Immunol , vol.129 , Issue.6
    • Wei, C.Y.1
  • 13
    • 84862979660 scopus 로고    scopus 로고
    • Immune self-reactivity triggered by drug-modified HLA-peptide repertoire
    • Study supporting the altered peptide repertoire model for abacavir hypersensitivity. Abacavir associates with HLA-B*57:01 non-covalently and alters the shape and chemistry of the antigen-binding cleft. This leads to an altered repertoire of endogenous peptides binding HLA-B*57:01. The crystal structure of abacavir-MHC-peptide was resolved using an endogenous peptide. Preliminary evidence to support the altered peptide repertoire model for was also presented
    • •• Illing PT et al. Immune self-reactivity triggered by drug-modified HLA-peptide repertoire. Nature. 2012;486(7404):554-8. Study supporting the altered peptide repertoire model for abacavir hypersensitivity. Abacavir associates with HLA-B*57:01 non-covalently and alters the shape and chemistry of the antigen-binding cleft. This leads to an altered repertoire of endogenous peptides binding HLA-B*57:01. The crystal structure of abacavir-MHC-peptide was resolved using an endogenous peptide. Preliminary evidence to support the altered peptide repertoire model for was also presented.
    • (2012) Nature , vol.486 , Issue.7404 , pp. 554-558
    • Illing, P.T.1
  • 14
    • 84862532297 scopus 로고    scopus 로고
    • Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire
    • Provided structural, biochemical and functional evidence for non-covalent interaction between abacavir and HLA-B*57:01 and the altered repertoire model for abacavir. A synthetic peptide was derived that binds to HLA-B*57:01 only in the presence of abacavir. The crystal structure of abacavir-MHC-peptide was resolved using this peptide
    • •• Ostrov DA et al. Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire. Proc Natl Acad Sci U S A. 2012;109(25):9959-64. Provided structural, biochemical and functional evidence for non-covalent interaction between abacavir and HLA-B*57:01 and the altered repertoire model for abacavir. A synthetic peptide was derived that binds to HLA-B*57:01 only in the presence of abacavir. The crystal structure of abacavir-MHC-peptide was resolved using this peptide.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.25 , pp. 9959-9964
    • Ostrov, D.A.1
  • 16
    • 0035064040 scopus 로고    scopus 로고
    • A near-fatal hypersensitivity reaction to abacavir: Case report and literature review
    • Shapiro M, Ward KM, Stern JJ. A near-fatal hypersensitivity reaction to abacavir: case report and literature review. AIDS Read. 2001;11(4):222-6. (Pubitemid 32332270)
    • (2001) AIDS Reader , vol.11 , Issue.4 , pp. 222-226
    • Shapiro, M.1    Ward, K.M.2    Stern, J.J.3
  • 23
    • 53549095195 scopus 로고    scopus 로고
    • The cost-effectiveness of HLA-B*5701 genetic screening to guide initial antiretroviral therapy for HIV
    • Schackman BR et al. The cost-effectiveness of HLA-B*5701 genetic screening to guide initial antiretroviral therapy for HIV. AIDS. 2008;22(15):2025-33.
    • (2008) AIDS , vol.22 , Issue.15 , pp. 2025-2033
    • Schackman, B.R.1
  • 24
    • 33745295856 scopus 로고    scopus 로고
    • Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study
    • DOI 10.1086/504874
    • Rauch A et al. Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study. Clin Infect Dis. 2006;43(1):99-102. (Pubitemid 43939082)
    • (2006) Clinical Infectious Diseases , vol.43 , Issue.1 , pp. 99-102
    • Rauch, A.1    Nolan, D.2    Martin, A.3    McKinnon, E.4    Almeida, C.5    Mallal, S.6
  • 25
    • 84873705190 scopus 로고    scopus 로고
    • Studies on abacavir-induced hypersensitivity reaction: A successful example of translation of pharmacogenetics to personalized medicine
    • Guo Y et al. Studies on abacavir-induced hypersensitivity reaction: a successful example of translation of pharmacogenetics to personalized medicine. Sci China Life Sci. 2013;56(2):119-24.
    • (2013) Sci China Life Sci , vol.56 , Issue.2 , pp. 119-124
    • Guo, Y.1
  • 27
    • 84864007928 scopus 로고    scopus 로고
    • Avidity determines T-cell reactivity in abacavir hypersensitivity
    • Paper providing evidence that abacavir interacts with HLA-B*57:01 in a non-covalent and metabolism-independent fashion. Additionally, this study provided evidence that abacavir-reactive T-cell clones are dependent on the drug concentration, TCR avidity and level of HLA-B*57:01 molecules expressed on APCs
    • •• Adam J et al. Avidity determines T-cell reactivity in abacavir hypersensitivity. Eur J Immunol. 2012;42(7):1706-16. Paper providing evidence that abacavir interacts with HLA-B*57:01 in a non-covalent and metabolism-independent fashion. Additionally, this study provided evidence that abacavir-reactive T-cell clones are dependent on the drug concentration, TCR avidity and level of HLA-B*57:01 molecules expressed on APCs.
    • (2012) Eur J Immunol , vol.42 , Issue.7 , pp. 1706-1716
    • Adam, J.1
  • 28
    • 84865513600 scopus 로고    scopus 로고
    • Anticonvulsant hypersensitivity syndrome: An update
    • Knowles SR, Dewhurst N, Shear N. Anticonvulsant hypersensitivity syndrome: an update. Expert Opin Drug Saf. 2012;11(5):767-78.
    • (2012) Expert Opin Drug Saf , vol.11 , Issue.5 , pp. 767-778
    • Knowles, S.R.1    Dewhurst, N.2    Shear, N.3
  • 29
    • 79953197983 scopus 로고    scopus 로고
    • HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans
    • First GWAS for carbamazepine in Europeans that identified an association with HLA-A*31:01 and individuals of northern European ancestry with various phenotypes of carbamazepine-induced hypersensitivity reactions. Although this study suggested an association between HLA-A*31:01 and carbamazepine SJS/TEN in European populations, not all follow-up studies have supported this
    • • McCormack M et al. HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med. 2011;364(12):1134-43. First GWAS for carbamazepine in Europeans that identified an association with HLA-A*31:01 and individuals of northern European ancestry with various phenotypes of carbamazepine-induced hypersensitivity reactions. Although this study suggested an association between HLA-A*31:01 and carbamazepine SJS/TEN in European populations, not all follow-up studies have supported this.
    • (2011) N Engl J Med , vol.364 , Issue.12 , pp. 1134-1143
    • McCormack, M.1
  • 30
    • 1842784823 scopus 로고    scopus 로고
    • Medical genetics: A marker for Stevens-Johnson syndrome
    • Chung WH et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature. 2004;428(6982):486.
    • (2004) Nature , vol.428 , Issue.6982 , pp. 486
    • Chung, W.H.1
  • 31
    • 84863414368 scopus 로고    scopus 로고
    • HLA-B*1502 strongly predicts carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Thai patients with neuropathic pain
    • Kulkantrakorn K et al. HLA-B*1502 strongly predicts carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Thai patients with neuropathic pain. Pain Pract. 2012;12(3):202-8.
    • (2012) Pain Pract , vol.12 , Issue.3 , pp. 202-208
    • Kulkantrakorn, K.1
  • 32
    • 70450205028 scopus 로고    scopus 로고
    • Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians
    • Mehta TY et al. Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians. Indian J Dermatol Venereol Leprol. 2009;75(6):579-82.
    • (2009) Indian J Dermatol Venereol Leprol , vol.75 , Issue.6 , pp. 579-582
    • Mehta, T.Y.1
  • 33
    • 80052991636 scopus 로고    scopus 로고
    • Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients
    • Then SM et al. Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients. Asian Pac J Allergy Immunol. 2011;29(3):290-3.
    • (2011) Asian Pac J Allergy Immunol , vol.29 , Issue.3 , pp. 290-293
    • Then, S.M.1
  • 34
    • 34248589506 scopus 로고    scopus 로고
    • Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese
    • DOI 10.1111/j.1528-1167.2007.01022.x
    • Man CB et al. Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. Epilepsia. 2007;48(5):1015-8. (Pubitemid 46763406)
    • (2007) Epilepsia , vol.48 , Issue.5 , pp. 1015-1018
    • Man, C.B.L.1    Kwan, P.2    Baum, L.3    Yu, E.4    Lau, K.M.5    Cheng, A.S.H.6    Ng, M.H.L.7
  • 35
    • 79958294767 scopus 로고    scopus 로고
    • Association between HLA-B*1502 allele and carbamazepine-induced severe cutaneous adverse reactions in Han people of southern China mainland
    • Wang Q et al. Association between HLA-B*1502 allele and carbamazepine-induced severe cutaneous adverse reactions in Han people of southern China mainland. Seizure. 2011;20(6):446-8.
    • (2011) Seizure , vol.20 , Issue.6 , pp. 446-448
    • Wang, Q.1
  • 36
    • 80054776089 scopus 로고    scopus 로고
    • Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients
    • Zhang Y et al. Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients. Eur J Clin Pharmacol. 2011;67(9):885-7.
    • (2011) Eur J Clin Pharmacol , vol.67 , Issue.9 , pp. 885-887
    • Zhang, Y.1
  • 37
    • 79953216429 scopus 로고    scopus 로고
    • Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan
    • Chen P et al. Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan. N Engl J Med. 2011;364(12):1126-33.
    • (2011) N Engl J Med , vol.364 , Issue.12 , pp. 1126-1133
    • Chen, P.1
  • 38
    • 82555166978 scopus 로고    scopus 로고
    • Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome
    • Important in vitro study that establishes the essential role of the TCR in the mechanism behind SJS/TEN and explains why some HLA-B*15:02 carriers are tolerant to carbamazepine
    • • Ko TM et al. Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome. J Allergy Clin Immunol. 2011;128(6):1266-76. Important in vitro study that establishes the essential role of the TCR in the mechanism behind SJS/TEN and explains why some HLA-B*15:02 carriers are tolerant to carbamazepine.
    • (2011) J Allergy Clin Immunol , vol.128 , Issue.6 , pp. 1266-1276
    • Ko, T.M.1
  • 39
    • 84865616231 scopus 로고    scopus 로고
    • Case of carbamazepine-induced hypersensitivity syndrome associated with human leukocyte antigen-A*3101
    • Mizumoto K et al. Case of carbamazepine-induced hypersensitivity syndrome associated with human leukocyte antigen-A*3101. J Dermatol. 2012;39(9):791-2.
    • (2012) J Dermatol , vol.39 , Issue.9 , pp. 791-792
    • Mizumoto, K.1
  • 40
    • 84862263590 scopus 로고    scopus 로고
    • HLA-A31 strongly associates with carbamazepine-induced adverse drug reactions but not with carbamazepine-induced lymphocyte proliferation in a Japanese population
    • Niihara H et al. HLA-A31 strongly associates with carbamazepine-induced adverse drug reactions but not with carbamazepine-induced lymphocyte proliferation in a Japanese population. J Dermatol. 2012;39(7):594-601.
    • (2012) J Dermatol , vol.39 , Issue.7 , pp. 594-601
    • Niihara, H.1
  • 41
    • 79551600984 scopus 로고    scopus 로고
    • Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population
    • GWAS that showed association with HLA-A*31:01 and carbamazepine-induced immunologically mediated adverse drug reactions in those of Japanese ancestry
    • • Ozeki T et al. Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population. Hum Mol Genet. 2011;20(5):1034-41. GWAS that showed association with HLA-A*31:01 and carbamazepine-induced immunologically mediated adverse drug reactions in those of Japanese ancestry.
    • (2011) Hum Mol Genet , vol.20 , Issue.5 , pp. 1034-1041
    • Ozeki, T.1
  • 42
    • 84869494804 scopus 로고    scopus 로고
    • HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: A systematic review
    • Yip VL et al. HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review. Clin Pharmacol Ther. 2012;92(6):757-65.
    • (2012) Clin Pharmacol Ther , vol.92 , Issue.6 , pp. 757-765
    • Yip, V.L.1
  • 43
    • 84879393725 scopus 로고    scopus 로고
    • HLA-A 31:01 and HLA-B 15:02 as genetic markers for carbamazepine hypersensitivity in children
    • Amstutz U et al. HLA-A 31:01 and HLA-B 15:02 as genetic markers for carbamazepine hypersensitivity in children. Clin Pharmacol Ther. 2013;94(1):142-9.
    • (2013) Clin Pharmacol Ther , vol.94 , Issue.1 , pp. 142-149
    • Amstutz, U.1
  • 44
    • 84885110998 scopus 로고    scopus 로고
    • Allopurinol Hypersensitivity: A Systematic Review of All Published Cases, 1950-2012
    • Ramasamy SN et al. Allopurinol Hypersensitivity: A Systematic Review of All Published Cases, 1950-2012. Drug Saf. 2013.
    • (2013) Drug Saf
    • Ramasamy, S.N.1
  • 46
    • 0018595189 scopus 로고
    • Severe hypersensitivity reactions to allopurinol
    • Lang Jr PG. Severe hypersensitivity reactions to allopurinol. South Med J. 1979;72(11):1361-8.
    • (1979) South Med J , vol.72 , Issue.11 , pp. 1361-1368
    • Lang Jr., P.G.1
  • 47
    • 34748917556 scopus 로고    scopus 로고
    • Allopurinol dosing in renal impairment: Walking the tightrope between adequate urate lowering and adverse events
    • Dalbeth N, Stamp L. Allopurinol dosing in renal impairment: walking the tightrope between adequate urate lowering and adverse events. Semin Dial. 2007;20(5):391-5.
    • (2007) Semin Dial , vol.20 , Issue.5 , pp. 391-395
    • Dalbeth, N.1    Stamp, L.2
  • 48
    • 0024323734 scopus 로고
    • HLA and allopurinol drug eruption
    • Chan SH, Tan T. HLA and allopurinol drug eruption. Dermatologica. 1989;179(1):32-3. (Pubitemid 19172335)
    • (1989) Dermatologica , vol.179 , Issue.1 , pp. 32-33
    • Chan, S.H.1    Tan, T.2
  • 49
    • 15244349566 scopus 로고    scopus 로고
    • HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol
    • Hung SI et al. HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A. 2005;102(11):4134-9.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.11 , pp. 4134-4139
    • Hung, S.I.1
  • 50
    • 34250888038 scopus 로고    scopus 로고
    • Stevens-Johnson syndrome, drug-induced hypersensitivity syndrome and toxic epidermal necrolysis caused by allopurinol in patients with a common HLA allele: What causes the diversity? [4]
    • DOI 10.1159/000102045
    • Dainichi T et al. Stevens-Johnson syndrome, drug-induced hypersensitivity syndrome and toxic epidermal necrolysis caused by allopurinol in patients with a common HLA allele: what causes the diversity? Dermatology. 2007;215(1):86-8. (Pubitemid 46976024)
    • (2007) Dermatology , vol.215 , Issue.1 , pp. 86-88
    • Dainichi, T.1    Uchi, H.2    Moroi, Y.3    Furue, M.4
  • 51
    • 61549115662 scopus 로고    scopus 로고
    • HLA-B locus in Japanese patients with antiepileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis
    • Kaniwa N et al. HLA-B locus in Japanese patients with antiepileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis. Pharmacogenomics. 2008;9(11):1617-22.
    • (2008) Pharmacogenomics , vol.9 , Issue.11 , pp. 1617-1622
    • Kaniwa, N.1
  • 52
    • 70249122727 scopus 로고    scopus 로고
    • Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population
    • Tassaneeyakul Wet al. Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population. Pharmacogenet Genomics. 2009;19(9):704-9.
    • (2009) Pharmacogenet Genomics , vol.19 , Issue.9 , pp. 704-709
    • Tassaneeyakul, W.1
  • 53
    • 80155198743 scopus 로고    scopus 로고
    • HLA-B58 can help the clinical decision on starting allopurinol in patients with chronic renal insufficiency
    • Jung JW et al. HLA-B58 can help the clinical decision on starting allopurinol in patients with chronic renal insufficiency. Nephrol Dial Transplant. 2011;26(11):3567-72.
    • (2011) Nephrol Dial Transplant , vol.26 , Issue.11 , pp. 3567-3572
    • Jung, J.W.1
  • 54
    • 79955464425 scopus 로고    scopus 로고
    • Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans
    • Kang HR et al. Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans. Pharmacogenet Genomics. 2011;21(5):303-7.
    • (2011) Pharmacogenet Genomics , vol.21 , Issue.5 , pp. 303-307
    • Kang, H.R.1
  • 55
    • 38149108354 scopus 로고    scopus 로고
    • A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs
    • Lonjou C et al. A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs. Pharmacogenet Genomics. 2008;18(2):99-107.
    • (2008) Pharmacogenet Genomics , vol.18 , Issue.2 , pp. 99-107
    • Lonjou, C.1
  • 56
    • 79960882627 scopus 로고    scopus 로고
    • Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe
    • Genin E et al. Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe. Orphanet J Rare Dis. 2011;6:52.
    • (2011) Orphanet J Rare Dis , vol.6 , pp. 52
    • Genin, E.1
  • 57
    • 84872905876 scopus 로고    scopus 로고
    • A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients
    • Tohkin M et al. A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Pharmacogenomics J. 2013;13(1):60-9.
    • (2013) Pharmacogenomics J , vol.13 , Issue.1 , pp. 60-69
    • Tohkin, M.1
  • 58
    • 80052596861 scopus 로고    scopus 로고
    • Association of HLA-B*5801 allele and allopurinol-induced Stevens Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta-analysis
    • Somkrua R et al. Association of HLA-B*5801 allele and allopurinol-induced Stevens Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis. BMC Med Genet. 2011;12:118.
    • (2011) BMC Med Genet , vol.12 , pp. 118
    • Somkrua, R.1
  • 59
    • 84867422494 scopus 로고    scopus 로고
    • The structural basis of HLA-associated drug hypersensitivity syndromes
    • Pompeu YA et al. The structural basis of HLA-associated drug hypersensitivity syndromes. Immunol Rev. 2012;250(1):158-66.
    • (2012) Immunol Rev , vol.250 , Issue.1 , pp. 158-166
    • Pompeu, Y.A.1
  • 60
    • 0032419597 scopus 로고    scopus 로고
    • Safety profile of nevirapine, a nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus infection
    • DOI 10.1016/S0149-2918(98)80105-7
    • Pollard RB, Robinson P, Dransfield K. Safety profile of nevirapine, a nonnucleoside reverse transcriptase inhibitor for the treatment of human immunodeficiency virus infection. Clin Ther. 1998;20(6):1071-92. (Pubitemid 29058411)
    • (1998) Clinical Therapeutics , vol.20 , Issue.6 , pp. 1071-1092
    • Pollard, R.B.1    Robinson, P.2    Dransfield, K.3
  • 61
    • 0033913743 scopus 로고    scopus 로고
    • Frequency of cutaneous reactions on rechallenge with nevirapine and delavirdine
    • Gangar M et al. Frequency of cutaneous reactions on rechallenge with nevirapine and delavirdine. Ann Pharmacother. 2000;34(7-8):839-42. (Pubitemid 30471262)
    • (2000) Annals of Pharmacotherapy , vol.34 , Issue.7-8 , pp. 839-842
    • Gangar, M.1    Arias, G.2    O'Brien, J.G.3    Kemper, C.A.4
  • 63
    • 85027929582 scopus 로고    scopus 로고
    • Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descent
    • Genetic study investigating different clinical presentations of nevirapine hypersensitivity and reporting several new associations with specific HLA alleles
    • •• Yuan J et al. Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descent. AIDS. 2011;25(10):1271-80. Genetic study investigating different clinical presentations of nevirapine hypersensitivity and reporting several new associations with specific HLA alleles.
    • (2011) AIDS , vol.25 , Issue.10 , pp. 1271-1280
    • Yuan, J.1
  • 64
    • 39849105346 scopus 로고    scopus 로고
    • HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz
    • DOI 10.1097/QAD.0b013e3282f37812, PII 0000203020080219000015
    • Vitezica ZG et al. HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz. AIDS. 2008;22(4):540-1. (Pubitemid 351317299)
    • (2008) AIDS , vol.22 , Issue.4 , pp. 540-541
    • Vitezica, Z.G.1    Milpied, B.2    Lonjou, C.3    Borot, N.4    Ledger, T.N.5    Lefebvre, A.6    Hovnanian, A.7
  • 65
    • 84872833727 scopus 로고    scopus 로고
    • Associations between HLA-DRB1*0102, HLA-B*5801, and hepatotoxicity during initiation of nevirapine-containing regimens in South Africa
    • A class II allele DRB1*01:02 which is homologous to DRB1*01:01 is related to nevirapine-associated hepatitis in South African Black populations
    • •• Phillips E et al. Associations between HLA-DRB1*0102, HLA-B*5801, and hepatotoxicity during initiation of nevirapine-containing regimens in South Africa. J Acquir Immune Defic Syndr. 2013;62(2):e55-7. A class II allele DRB1*01:02 which is homologous to DRB1*01:01 is related to nevirapine-associated hepatitis in South African Black populations.
    • (2013) J Acquir Immune Defic Syndr , vol.62 , Issue.2
    • Phillips, E.1
  • 68
    • 84858251915 scopus 로고    scopus 로고
    • HLA-dependent hypersensitivity reaction to nevirapine in Chinese Han HIV-infected patients
    • Gao S et al. HLA-dependent hypersensitivity reaction to nevirapine in Chinese Han HIV-infected patients. AIDS Res Hum Retroviruses. 2012;28(6):540-3.
    • (2012) AIDS Res Hum Retroviruses , vol.28 , Issue.6 , pp. 540-543
    • Gao, S.1
  • 69
    • 59549096348 scopus 로고    scopus 로고
    • HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients
    • Chantarangsu S et al. HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients. Pharmacogenet Genomics. 2009;19(2):139-46.
    • (2009) Pharmacogenet Genomics , vol.19 , Issue.2 , pp. 139-146
    • Chantarangsu, S.1
  • 70
    • 79961219567 scopus 로고    scopus 로고
    • Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash
    • Chantarangsu S et al. Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash. Clin Infect Dis. 2011;53(4):341-8.
    • (2011) Clin Infect Dis , vol.53 , Issue.4 , pp. 341-348
    • Chantarangsu, S.1
  • 71
    • 77954378516 scopus 로고    scopus 로고
    • HLA-Cw*04 allele associated with nevirapine-induced rash in HIV-infected Thai patients
    • Likanonsakul S et al. HLA-Cw*04 allele associated with nevirapine-induced rash in HIV-infected Thai patients. AIDS Res Ther. 2009;6:22.
    • (2009) AIDS Res Ther , vol.6 , pp. 22
    • Likanonsakul, S.1
  • 72
    • 84875979097 scopus 로고    scopus 로고
    • Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population
    • First study to associate HLA-C*04:01 with nevirapine-associated Stevens-Johnson Syndrome/Toxic epidermal necrolysis in a Black African population
    • •• Carr DF et al. Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population. Clin Infect Dis. 2013;56(9):1330-9. First study to associate HLA-C*04:01 with nevirapine-associated Stevens-Johnson Syndrome/Toxic epidermal necrolysis in a Black African population.
    • (2013) Clin Infect Dis , vol.56 , Issue.9 , pp. 1330-1339
    • Carr, D.F.1
  • 73
    • 84855908033 scopus 로고    scopus 로고
    • Genetic association studies in drug-induced liver injury
    • Daly AK, Day CP. Genetic association studies in drug-induced liver injury. Drug Metab Rev. 2012;44(1):116-26.
    • (2012) Drug Metab Rev , vol.44 , Issue.1 , pp. 116-126
    • Daly, A.K.1    Day, C.P.2
  • 75
    • 0033756344 scopus 로고    scopus 로고
    • Co-amoxiclav jaundice: Clinical and histological features and HLA class II association
    • O'Donohue J et al. Co-amoxiclav jaundice: clinical and histological features and HLA class II association. Gut. 2000;47(5):717-20.
    • (2000) Gut , vol.47 , Issue.5 , pp. 717-720
    • O'Donohue, J.1
  • 76
    • 78049469917 scopus 로고    scopus 로고
    • Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury
    • Donaldson PT et al. Human leucocyte antigen class II genotype in susceptibility and resistance to co-amoxiclav-induced liver injury. J Hepatol. 2010;53(6):1049-53.
    • (2010) J Hepatol , vol.53 , Issue.6 , pp. 1049-1053
    • Donaldson, P.T.1
  • 77
    • 79957523368 scopus 로고    scopus 로고
    • Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles
    • Lucena MI et al. Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles. Gastroenterology. 2011;141(1):338-47.
    • (2011) Gastroenterology , vol.141 , Issue.1 , pp. 338-347
    • Lucena, M.I.1
  • 79
    • 84879990042 scopus 로고    scopus 로고
    • HLA alleles influence the clinical signature of amoxicillin-clavulanate hepatotoxicity
    • Stephens C et al. HLA alleles influence the clinical signature of amoxicillin-clavulanate hepatotoxicity. PLoS One. 2013;8(7):e68111.
    • (2013) PLoS One , vol.8 , Issue.7
    • Stephens, C.1
  • 80
    • 0026635401 scopus 로고
    • Liver damage from flucloxacillin, cloxacillin and dicloxacillin
    • Olsson R et al. Liver damage from flucloxacillin, cloxacillin and dicloxacillin. J Hepatol. 1992;15(1-2):154-61.
    • (1992) J Hepatol , vol.15 , Issue.1-2 , pp. 154-161
    • Olsson, R.1
  • 81
    • 21744447422 scopus 로고    scopus 로고
    • Risk of cholestatic liver disease associated with flucloxacillin and flucloxacillin prescribing habits in the UK: Cohort study using data from the UK General Practice Research Database
    • DOI 10.1111/j.1365-2125.2005.02370.x
    • Russmann S et al. Risk of cholestatic liver disease associated with flucloxacillin and flucloxacillin prescribing habits in the UK: cohort study using data from the UK General Practice Research Database. Br J Clin Pharmacol. 2005;60(1):76-82. (Pubitemid 40942784)
    • (2005) British Journal of Clinical Pharmacology , vol.60 , Issue.1 , pp. 76-82
    • Russmann, S.1    Kaye, J.A.2    Jick, S.S.3    Jick, H.4
  • 82
    • 67649859295 scopus 로고    scopus 로고
    • HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin
    • Daly AK et al. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet. 2009;41(7):816-9.
    • (2009) Nat Genet , vol.41 , Issue.7 , pp. 816-819
    • Daly, A.K.1
  • 83
    • 84872315945 scopus 로고    scopus 로고
    • HLA-B*5701 and flucloxacillin associated drug-induced liver disease
    • Phillips EJ, Mallal SA. HLA-B*5701 and flucloxacillin associated drug-induced liver disease. AIDS. 2013;27(3):491-2.
    • (2013) AIDS , vol.27 , Issue.3 , pp. 491-492
    • Phillips, E.J.1    Mallal, S.A.2
  • 84
    • 55449105260 scopus 로고    scopus 로고
    • Carbamazepine, HLA-B*1502 and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations
    • Ferrell Jr PB, McLeod HL. Carbamazepine, HLA-B*1502 and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations. Pharmacogenomics. 2008;9(10):1543-6.
    • (2008) Pharmacogenomics , vol.9 , Issue.10 , pp. 1543-1546
    • Ferrell Jr., P.B.1    McLeod, H.L.2
  • 86
    • 44449113606 scopus 로고    scopus 로고
    • A review of drug patch testing and implications for HIV clinicians
    • DOI 10.1097/QAD.0b013e3282f7cb60, PII 0000203020080531000001
    • Shear NH et al. A review of drug patch testing and implications for HIV clinicians. AIDS. 2008;22(9):999-1007. (Pubitemid 351769738)
    • (2008) AIDS , vol.22 , Issue.9 , pp. 999-1007
    • Shear, N.H.1    Milpied, B.2    Bruynzeel, D.P.3    Phillips, E.J.4
  • 87
    • 0037045073 scopus 로고    scopus 로고
    • Utility of patch testing in patients with hypersensitivity syndromes associated with abacavir
    • DOI 10.1097/00002030-200211080-00017
    • Phillips EJ et al. Utility of patch testing in patients with hypersensitivity syndromes associated with abacavir. AIDS. 2002;16(16):2223-5. (Pubitemid 35387279)
    • (2002) AIDS , vol.16 , Issue.16 , pp. 2223-2225
    • Phillips, E.J.1    Sullivan, J.R.2    Knowles, S.R.3    Shear, N.H.4
  • 88
    • 0038182560 scopus 로고    scopus 로고
    • Patch testing with carbamazepine and its main metabolite carbamazepine epoxide in cutaneous adverse drug reactions to carbamazepine
    • DOI 10.1034/j.1600-0536.2003.00065.x
    • Lee AY, Choi J, Chey WY. Patch testing with carbamazepine and its main metabolite carbamazepine epoxide in cutaneous adverse drug reactions to carbamazepine. Contact Dermatitis. 2003;48(3):137-9. (Pubitemid 36683480)
    • (2003) Contact Dermatitis , vol.48 , Issue.3 , pp. 137-139
    • Lee, A.-Y.1    Choi, J.2    Chey, W.-Y.3
  • 89
    • 84869498690 scopus 로고    scopus 로고
    • Patch testing is an effective method for the diagnosis of carbamazepine-induced drug reaction, eosinophilia and systemic symptoms (DRESS) syndrome in an 8-year-old girl
    • Buyuktiryaki AB et al. Patch testing is an effective method for the diagnosis of carbamazepine-induced drug reaction, eosinophilia and systemic symptoms (DRESS) syndrome in an 8-year-old girl. Australas J Dermatol. 2012;53(4):274-7.
    • (2012) Australas J Dermatol , vol.53 , Issue.4 , pp. 274-277
    • Buyuktiryaki, A.B.1
  • 90
    • 84880134985 scopus 로고    scopus 로고
    • A patch testing and cross-sensitivity study of carbamazepine-induced severe cutaneous adverse drug reactions
    • Lin YT, et al. A patch testing and cross-sensitivity study of carbamazepine-induced severe cutaneous adverse drug reactions. J Eur Acad Dermatol Venereol. 2012.
    • (2012) J Eur Acad Dermatol Venereol
    • Lin, Y.T.1
  • 91
    • 80051841201 scopus 로고    scopus 로고
    • HLA-B*1502 screening and toxic effects of carbamazepine
    • author reply 673
    • Phillips EJ, Mallal SA. HLA-B*1502 screening and toxic effects of carbamazepine. N Engl J Med. 2011;365(7):672. author reply 673.
    • (2011) N Engl J Med , vol.365 , Issue.7 , pp. 672
    • Phillips, E.J.1    Mallal, S.A.2
  • 94
    • 33645950777 scopus 로고    scopus 로고
    • A sensitive and rapid alternative to HLA typing as a genetic screening test for abacavir hypersensitivity syndrome
    • Martin AM et al. A sensitive and rapid alternative to HLA typing as a genetic screening test for abacavir hypersensitivity syndrome. Pharmacogenet Genomics. 2006;16(5):353-7.
    • (2006) Pharmacogenet Genomics , vol.16 , Issue.5 , pp. 353-357
    • Martin, A.M.1
  • 95
    • 84866251205 scopus 로고    scopus 로고
    • Copy number variation and incomplete linkage disequilibrium interfere with the HCP5 genotyping assay for abacavir hypersensitivity
    • Melis R et al. Copy number variation and incomplete linkage disequilibrium interfere with the HCP5 genotyping assay for abacavir hypersensitivity. Genet Test Mol Biomarkers. 2012;16(9):1111-4.
    • (2012) Genet Test Mol Biomarkers , vol.16 , Issue.9 , pp. 1111-1114
    • Melis, R.1
  • 96
    • 84886265139 scopus 로고    scopus 로고
    • HLA-B*13:01 and the dapsone hypersensitivity syndrome
    • Zhang FR et al. HLA-B*13:01 and the dapsone hypersensitivity syndrome. N Engl J Med. 2013;369(17):1620-8.
    • (2013) N Engl J Med , vol.369 , Issue.17 , pp. 1620-1628
    • Zhang, F.R.1
  • 97
    • 84891651331 scopus 로고    scopus 로고
    • Fever, rash and systemic symptoms: Understanding the role of virus and HLA in cutaneous drug allergy
    • Pavlos R, Mallal S, Ostrov D, Pompeu Y, Phillips E. Fever, rash and systemic symptoms: understanding the role of virus and HLA in cutaneous drug allergy. J Allerg Clin Immunol In Practice. 2014;2(1):21-33.
    • (2014) J Allerg Clin Immunol in Practice , vol.2 , Issue.1 , pp. 21-33
    • Pavlos, R.1    Mallal, S.2    Ostrov, D.3    Pompeu, Y.4    Phillips, E.5
  • 98
    • 81055156142 scopus 로고    scopus 로고
    • Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans
    • Kim SH et al. Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans. Epilepsy Res. 2011;97(1-2):190-7.
    • (2011) Epilepsy Res , vol.97 , Issue.1-2 , pp. 190-197
    • Kim, S.H.1
  • 99
    • 78650007285 scopus 로고    scopus 로고
    • HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients
    • Kaniwa N et al. HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Epilepsia. 2010;51(12):2461-5.
    • (2010) Epilepsia , vol.51 , Issue.12 , pp. 2461-2465
    • Kaniwa, N.1
  • 100
    • 75649107833 scopus 로고    scopus 로고
    • HLA class I markers in Japanese patients with carbamazepine-induced cutaneous adverse reactions
    • Ikeda H et al. HLA class I markers in Japanese patients with carbamazepine-induced cutaneous adverse reactions. Epilepsia. 2010;51(2):297-300.
    • (2010) Epilepsia , vol.51 , Issue.2 , pp. 297-300
    • Ikeda, H.1
  • 101
    • 77949600882 scopus 로고    scopus 로고
    • Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese
    • Hung SI et al. Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. Pharmacogenomics. 2010;11(3):349-56.
    • (2010) Pharmacogenomics , vol.11 , Issue.3 , pp. 349-356
    • Hung, S.I.1
  • 102
    • 65249085648 scopus 로고    scopus 로고
    • Oxcarbazepine-induced Stevens-Johnson syndrome: A case report
    • Lin LC et al. Oxcarbazepine-induced Stevens-Johnson syndrome: a case report. Kaohsiung J Med Sci. 2009;25(2):82-6.
    • (2009) Kaohsiung J Med Sci , vol.25 , Issue.2 , pp. 82-86
    • Lin, L.C.1
  • 103
    • 84879797179 scopus 로고    scopus 로고
    • HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese
    • Cheung YK et al. HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese. Epilepsia. 2013;54(7):1307-14.
    • (2013) Epilepsia , vol.54 , Issue.7 , pp. 1307-1314
    • Cheung, Y.K.1
  • 104
    • 57449118501 scopus 로고    scopus 로고
    • Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population
    • Locharernkul C et al. Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. Epilepsia. 2008;49(12):2087-91.
    • (2008) Epilepsia , vol.49 , Issue.12 , pp. 2087-2091
    • Locharernkul, C.1
  • 105
    • 84893344987 scopus 로고    scopus 로고
    • Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects
    • Kaniwa N et al. Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects. Pharmacogenomics. 2013;14(15):1821-31.
    • (2013) Pharmacogenomics , vol.14 , Issue.15 , pp. 1821-1831
    • Kaniwa, N.1
  • 106
    • 77952937737 scopus 로고    scopus 로고
    • HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis
    • Kim SH et al. HLA-B*5901 is strongly associated with methazolamide-induced Stevens-Johnson syndrome/toxic epidermal necrolysis. Pharmacogenomics. 2010;11(6):879-84.
    • (2010) Pharmacogenomics , vol.11 , Issue.6 , pp. 879-884
    • Kim, S.H.1
  • 108
    • 77955082302 scopus 로고    scopus 로고
    • A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury
    • Singer JB et al. A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. Nat Genet. 2010;42(8):711-4.
    • (2010) Nat Genet , vol.42 , Issue.8 , pp. 711-714
    • Singer, J.B.1
  • 110
    • 79952173247 scopus 로고    scopus 로고
    • HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer
    • Spraggs CF et al. HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer. J Clin Oncol. 2011;29(6):667-73.
    • (2011) J Clin Oncol , vol.29 , Issue.6 , pp. 667-673
    • Spraggs, C.F.1


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