Analysis of inter-subunit contacts reveals the structural malleability of extracellular domains in platelet glycoprotein Ib-IX complex

Journal of Thrombosis and Haemostasis

Volumn 12, Issue 1, 2014, Pages 82-89

  Zhou, L ^a   Yang, W ^b   Li, R ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Bernard Soulier syndrome; Leucine rich repeat proteins; Platelet glycoprotein GPIb IX complex; Protein protein interaction domains; Von Willebrand factor receptors

Indexed keywords

GLYCOPROTEIN IB; PLATELET GLYCOPROTEIN IB 9 COMPLEX; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHO CELL; EXTRACELLULAR MATRIX; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ANALYSIS;

BERNARD-SOULIER SYNDROME; LEUCINE-RICH REPEAT PROTEINS; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PROTEIN-PROTEIN INTERACTION DOMAINS; VON WILLEBRAND FACTOR RECEPTORS;

ANIMALS; BLOOD PLATELETS; CHO CELLS; CRICETINAE; CRICETULUS; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX;

EID: 84891892845     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12437     Document Type: Article

References (28)

1. Berndt MC, Gregory C, Kabral A, Zola H, Fournier D, Castaldi PA. Purification and preliminary characterization of the glycoprotein Ib complex in the human platelet membrane. Eur J Biochem 1985; 151: 637-49.
2. Luo S-Z, Mo X, Afshar-Kharghan V, Srinivasan S, Lopez JA, Li R. Glycoprotein Ibα forms disulfide bonds with 2 glycoprotein Ibβ subunits in the resting platelet. Blood 2007; 109: 603-9.
3. Li R, Emsley J. The organizing principle of the platelet glycoprotein Ib-IX-V complex. J Thromb Haemost 2013; 11: 605-14.
4. Huizinga EG, Tsuji S, Romijn RA, Schiphorst ME, de Groot PG, Sixma JJ, Gros P. Structures of glycoprotein Ibα and its complex with von Willebrand factor A1 domain. Science 2002; 297: 1176-9.
5. Dumas JJ, Kumar R, Seehra J, Somers WS, Mosyak L. Crystal structure of the GpIbα-thrombin complex essential for platelet aggregation. Science 2003; 301: 222-6.
6. Celikel R, McClintock RA, Roberts JR, Mendolicchio GL, Ware J, Varughese KI, Ruggeri ZM. Modulation of α-thrombin function by distinct interactions with platelet glycoprotein Ibα. Science 2003; 301: 218-21.
7. Lopez JA, Leung B, Reynolds CC, Li CQ, Fox JEB. Efficient plasma membrane expression of a functional platelet glycoprotein Ib-IX complex requires the presence of its three subunits. J Biol Chem 1992; 267: 12851-9.
8. Luo S-Z, Mo X, López JA, Li R. Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib-IX complex. J Thromb Haemost 2007; 5: 2494-502.
9. Mo X, Lu N, Padilla A, López JA, Li R. The transmembrane domain of glycoprotein Ibβ is critical to efficient expression of glycoprotein Ib-IX complex in the plasma membrane. J Biol Chem 2006; 281: 23050-9.
10. Berndt MC, Andrews RK. Bernard-Soulier syndrome. Haematologica 2011; 96: 355-9.
11. Kato K, Martinez C, Russell S, Nurden P, Nurden A, Fiering S, Ware J. Genetic deletion of mouse platelet glycoprotein Ibβ produces a Bernard-Soulier phenotype with increased α-granule size. Blood 2004; 104: 2339-44.
12. Strassel C, Nonne C, Eckly A, David T, Leon C, Freund M, Cazenave JP, Gachet C, Lanza F. Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome. Arterioscler Thromb Vasc Biol 2007; 27: 241-7.
13. Bodnar RJ, Xi X, Li Z, Berndt MC, Du X. Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ibβ. J Biol Chem 2002; 277: 47080-7.
14. Ravanat C, Strassel C, Hechler B, Schuhler S, Chicanne G, Payrastre B, Gachet C, Lanza F. A central role of GPIb-IX in the procoagulant function of platelets that is independent of the 45-kDa GPIbα N-terminal extracellular domain. Blood 2010; 116: 1157-64.
15. Maurer E, Tang C, Schaff M, Bourdon C, Receveur N, Ravanat C, Eckly A, Hechler B, Gachet C, Lanza F, Mangin PH. Targeting platelet GPIbβ reduces platelet adhesion, GPIb signaling and thrombin generation and prevents arterial thrombosis. Arterioscler Thromb Vasc Biol 2013; 33: 1221-9.
16. Luo SZ, Li R. Specific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complex. J Mol Biol 2008; 382: 448-57.
17. Kenny D, Morateck PA, Gill JC, Montgomery RR. The critical interaction of glycoprotein (GP) Ibβ with GPIX - a genetic cause of Bernard-Soulier syndrome. Blood 1999; 93: 2968-75.
18. Mo X, Nguyen NX, McEwan PA, Zheng X, Lopez JA, Emsley J, Li R. Binding of platelet glycoprotein Ibβ through the convex surface of leucine-rich repeats domain of glycoprotein IX. J Thromb Haemost 2009; 7: 1533-40.
19. McEwan PA, Yang W, Carr KH, Mo X, Zheng X, Li R, Emsley J. Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera. Blood 2011; 118: 5292-301.
20. Lopez JA, Weisman S, Sanan DA, Sih T, Chambers M, Li CQ. Glycoprotein (GP) Ibβ is the critical subunit linking GP Ibα and GP IX in the GP Ib-IX complex. Analysis of partial complexes. J Biol Chem 1994; 269: 23716-21.
21. Mo X, Luo S-Z, López JA, Li R. Juxtamembrane basic residues in glycoprotein Ibβ cytoplasmic domain are required for assembly and surface expression of glycoprotein Ib-IX complex. FEBS Lett 2008; 582: 3270-4.
22. Dong JF, Gao S, Lopez JA. Synthesis, assembly, and intracellular transport of the platelet glycoprotein Ib-IX-V complex. J Biol Chem 1998; 273: 31449-54.
23. Mo X, Liu L, Lopez JA, Li R. Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex. J Thromb Haemost 2012; 10: 1875-86.
24. Staron M, Wu S, Hong F, Stojanovic A, Du X, Bona R, Liu B, Li Z. Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex. Blood 2011; 117: 7136-44.
25. Wei P, Liu X, Hu MH, Zuo LM, Kai M, Wang R, Luo SZ. The dimerization interface of the glycoprotein Ibbeta transmembrane domain corresponds to polar residues within a leucine zipper motif. Protein Sci 2011; 20: 1814-23.
26. Finch CN, Lyle VA, Cunningham D, Miller JL. Expression of human platelet glycoprotein Ibβ in insect cells. Thromb Res 1996; 81: 679-86.
27. Perrault C, Mangin P, Santer M, Baas MJ, Moog S, Cranmer SL, Pikovski I, Williamson D, Jackson SP, Cazenave JP, Lanza F. Role of the intracellular domains of GPIb in controlling the adhesive properties of the platelet GPIb/V/IX complex. Blood 2003; 101: 3477-84.
28. Dai K, Bodnar R, Berndt MC, Du X. A critical role for 14-3-3ζ protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications. Blood 2005; 106: 1975-81.