메뉴 건너뛰기




Volumn 63, Issue 1, 2014, Pages 37-43

Non-genomic events determining the sensitivity of hemopoietic malignancies to glucocorticoid-induced apoptosis

Author keywords

BIM; CITIM 2013; Glucocorticoids; Glycogen synthase kinase 3; Hemopoietic tumors; Mitochondria

Indexed keywords

BECLIN 1; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLYCOGEN SYNTHASE KINASE 3; PREDNISONE; STAUROSPORINE; WORTMANNIN;

EID: 84891880086     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-013-1477-8     Document Type: Review
Times cited : (20)

References (45)
  • 1
    • 0031049297 scopus 로고    scopus 로고
    • A negative regulatory region containing a glucocorticosteroid response element (nGRE) in the human interleukin-1β gene
    • Zhang G, Zhang L, Duff GW (1997) A negative regulatory region containing a glucocorticosteroid response element (nGRE) in the human interleukin-1beta gene. DNA Cell Biol 16(2):145-152 (Pubitemid 27104563)
    • (1997) DNA and Cell Biology , vol.16 , Issue.2 , pp. 145-152
    • Zhang, G.1    Zhang, L.2    Duff, G.W.3
  • 2
    • 4444289382 scopus 로고    scopus 로고
    • Negative glucocorticoid receptor response elements and their role in glucocorticoid action
    • DOI 10.2174/1381612043383601
    • Dostert A, Heinzel T (2004) Negative glucocorticoid receptor response elements and their role in glucocorticoid action. Curr Pharm Des 10(23):2807-2816 (Pubitemid 39162399)
    • (2004) Current Pharmaceutical Design , vol.10 , Issue.23 , pp. 2807-2816
    • Dostert, A.1    Heinzel, T.2
  • 3
    • 78649269460 scopus 로고    scopus 로고
    • Protein kinase networks regulating glucocorticoid-induced apoptosis of hematopoietic cancer cells: Fundamental aspects and practical considerations
    • 10.3109/10428194.2010.506570 1:CAS:528:DC%2BC3cXhsVektLrI 20849387 10.3109/10428194.2010.506570
    • Kfir-Erenfeld S, Sionov RV, Spokoini R, Cohen O, Yefenof E (2010) Protein kinase networks regulating glucocorticoid-induced apoptosis of hematopoietic cancer cells: fundamental aspects and practical considerations. Leuk Lymphoma 51(11):1968-2005. doi: 10.3109/10428194.2010.506570
    • (2010) Leuk Lymphoma , vol.51 , Issue.11 , pp. 1968-2005
    • Kfir-Erenfeld, S.1    Sionov, R.V.2    Spokoini, R.3    Cohen, O.4    Yefenof, E.5
  • 4
    • 56849101027 scopus 로고    scopus 로고
    • Mechanisms regulating the susceptibility of hematopoietic malignancies to glucocorticoid-induced apoptosis
    • 10.1016/S0065-230X(08)00406-5 1:CAS:528:DC%2BD1MXht1CrtL%2FN 19055945
    • Sionov RV, Spokoini R, Kfir-Erenfeld S, Cohen O, Yefenof E (2008) Mechanisms regulating the susceptibility of hematopoietic malignancies to glucocorticoid-induced apoptosis. Adv Cancer Res 101:127-248. doi: 10.1016/S0065-230X(08)00406-5
    • (2008) Adv Cancer Res , vol.101 , pp. 127-248
    • Sionov, R.V.1    Spokoini, R.2    Kfir-Erenfeld, S.3    Cohen, O.4    Yefenof, E.5
  • 5
    • 0030925683 scopus 로고    scopus 로고
    • Steroid receptor interactions with heat shock protein and immunophilin chaperones
    • DOI 10.1210/er.18.3.306
    • Pratt WB, Toft DO (1997) Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr Rev 18(3):306-360 (Pubitemid 27246880)
    • (1997) Endocrine Reviews , vol.18 , Issue.3 , pp. 306-360
    • Pratt, W.B.1    Toft, D.O.2
  • 6
    • 31344468014 scopus 로고    scopus 로고
    • Role of mitochondrial glucocorticoid receptor in glucocorticoid-induced apoptosis
    • DOI 10.1084/jem.20050433
    • Sionov RV, Cohen O, Kfir S, Zilberman Y, Yefenof E (2006) Role of mitochondrial glucocorticoid receptor in glucocorticoid-induced apoptosis. J Exp Med 203(1):189-201. doi: 10.1084/jem.20050433 (Pubitemid 43139657)
    • (2006) Journal of Experimental Medicine , vol.203 , Issue.1 , pp. 189-201
    • Sionov, R.V.1    Cohen, O.2    Kfir, S.3    Zilberman, Y.4    Yefenof, E.5
  • 7
    • 71049190866 scopus 로고    scopus 로고
    • Mitochondrial translocation of the glucocorticoid receptor in double-positive thymocytes correlates with their sensitivity to glucocorticoid-induced apoptosis
    • 10.1093/intimm/dxp093 1:CAS:528:DC%2BD1MXhtlCrsrrP 19737783 10.1093/intimm/dxp093
    • Talaber G, Boldizsar F, Bartis D, Palinkas L, Szabo M, Berta G, Setalo G Jr, Nemeth P, Berki T (2009) Mitochondrial translocation of the glucocorticoid receptor in double-positive thymocytes correlates with their sensitivity to glucocorticoid-induced apoptosis. Int Immunol 21(11):1269-1276. doi: 10.1093/intimm/dxp093
    • (2009) Int Immunol , vol.21 , Issue.11 , pp. 1269-1276
    • Talaber, G.1    Boldizsar, F.2    Bartis, D.3    Palinkas, L.4    Szabo, M.5    Berta, G.6    Setalo, Jr.G.7    Nemeth, P.8    Berki, T.9
  • 8
    • 38149111023 scopus 로고    scopus 로고
    • Staurosporine sensitizes T lymphoma cells to glucocorticoid-induced apoptosis: Role of Nur77 and Bcl-2
    • 1:CAS:528:DC%2BD1cXit1ShtLk%3D 18073527 10.4161/cc.6.24.5023
    • Kfir S, Sionov RV, Zafrir E, Zilberman Y, Yefenof E (2007) Staurosporine sensitizes T lymphoma cells to glucocorticoid-induced apoptosis: role of Nur77 and Bcl-2. Cell Cycle 6(24):3086-3096
    • (2007) Cell Cycle , vol.6 , Issue.24 , pp. 3086-3096
    • Kfir, S.1    Sionov, R.V.2    Zafrir, E.3    Zilberman, Y.4    Yefenof, E.5
  • 9
    • 77954823170 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis
    • 10.1210/me.2009-0466 1:CAS:528:DC%2BC3cXns1Smtb0%3D 20371704 10.1210/me.2009-0466
    • Spokoini R, Kfir-Erenfeld S, Yefenof E, Sionov RV (2010) Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis. Mol Endocrinol 24(6):1136-1150. doi: 10.1210/me.2009-0466
    • (2010) Mol Endocrinol , vol.24 , Issue.6 , pp. 1136-1150
    • Spokoini, R.1    Kfir-Erenfeld, S.2    Yefenof, E.3    Sionov, R.V.4
  • 10
    • 0037592259 scopus 로고    scopus 로고
    • Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis
    • DOI 10.1074/jbc.M301843200
    • Wang Z, Malone MH, He H, McColl KS, Distelhorst CW (2003) Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis. J Biol Chem 278(26):23861-23867. doi: 10.1074/jbc.M301843200 (Pubitemid 36830212)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.26 , pp. 23861-23867
    • Wang, Z.1    Malone, M.H.2    He, H.3    McColl, K.S.4    Distelhorst, C.W.5
  • 11
    • 2442682766 scopus 로고    scopus 로고
    • The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells
    • DOI 10.1074/jbc.M310643200
    • Zhang L, Insel PA (2004) The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells. J Biol Chem 279(20):20858-20865. doi: 10.1074/jbc.M310643200 (Pubitemid 38656482)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.20 , pp. 20858-20865
    • Zhang, L.1    Insel, P.A.2
  • 13
    • 0042477712 scopus 로고    scopus 로고
    • FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons
    • DOI 10.1083/jcb.200303026
    • Gilley J, Coffer PJ, Ham J (2003) FOXO transcription factors directly activate bim gene expression and promote apoptosis in sympathetic neurons. J Cell Biol 162(4):613-622. doi: 10.1083/jcb.200303026 (Pubitemid 37022939)
    • (2003) Journal of Cell Biology , vol.162 , Issue.4 , pp. 613-622
    • Gilley, J.1    Coffer, P.J.2    Ham, J.3
  • 15
    • 56049109272 scopus 로고    scopus 로고
    • Glucocorticoid-induced apoptosis requires FOXO3A activity
    • 10.1016/j.bbrc.2008.10.097 1:CAS:528:DC%2BD1cXhsVais7rL 18957280 10.1016/j.bbrc.2008.10.097
    • Ma J, Xie Y, Shi Y, Qin W, Zhao B, Jin Y (2008) Glucocorticoid-induced apoptosis requires FOXO3A activity. Biochem Biophys Res Commun 377(3):894-898. doi: 10.1016/j.bbrc.2008.10.097
    • (2008) Biochem Biophys Res Commun , vol.377 , Issue.3 , pp. 894-898
    • Ma, J.1    Xie, Y.2    Shi, Y.3    Qin, W.4    Zhao, B.5    Jin, Y.6
  • 16
    • 20444497875 scopus 로고    scopus 로고
    • FOXO-dependent expression of the proapoptotic protein Bim: Pivotal role for apoptosis signaling in endothelial progenitor cells
    • DOI 10.1096/fj.04-2727fje
    • Urbich C, Knau A, Fichtlscherer S, Walter DH, Bruhl T, Potente M, Hofmann WK, de Vos S, Zeiher AM, Dimmeler S (2005) FOXO-dependent expression of the proapoptotic protein Bim: pivotal role for apoptosis signaling in endothelial progenitor cells. FASEB J 19(8):974-976. doi: 10.1096/fj.04-2727fje (Pubitemid 40827722)
    • (2005) FASEB Journal , vol.19 , Issue.8 , pp. 974-976
    • Urbich, C.1    Knau, A.2    Fichtischerer, S.3    Walter, D.H.4    Bruhl, T.5    Potente, M.6    Hofmann, W.K.7    De Vos, S.8    Zeiher, A.M.9    Dimmeler, S.10
  • 17
    • 11244305855 scopus 로고    scopus 로고
    • Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA
    • DOI 10.1074/jbc.M411767200
    • Abrams MT, Robertson NM, Yoon K, Wickstrom E (2004) Inhibition of glucocorticoid-induced apoptosis by targeting the major splice variants of BIM mRNA with small interfering RNA and short hairpin RNA. J Biol Chem 279(53):55809-55817. doi: 10.1074/jbc.M411767200 (Pubitemid 40066588)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.53 , pp. 55809-55817
    • Abrams, M.T.1    Robertson, N.M.2    Yoon, K.3    Wickstrom, E.4
  • 18
    • 33746391136 scopus 로고    scopus 로고
    • P38-MAP kinase activation followed by BIM induction is essential for glucocorticoid-induced apoptosis in lymphoblastic leukemia cells
    • DOI 10.1016/j.febslet.2006.05.031, PII S0014579306006235
    • Lu J, Quearry B, Harada H (2006) p38-MAP kinase activation followed by BIM induction is essential for glucocorticoid-induced apoptosis in lymphoblastic leukemia cells. FEBS Lett 580(14):3539-3544. doi: 10.1016/j.febslet.2006.05.031 (Pubitemid 44208999)
    • (2006) FEBS Letters , vol.580 , Issue.14 , pp. 3539-3544
    • Lu, J.1    Quearry, B.2    Harada, H.3
  • 20
    • 0036097786 scopus 로고    scopus 로고
    • Keeping killers on a tight leash: Transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins
    • DOI 10.1038/sj/cdd/4400998
    • Puthalakath H, Strasser A (2002) Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins. Cell Death Differ 9(5):505-512. doi: 10.1038/sj/cdd/4400998 (Pubitemid 34521178)
    • (2002) Cell Death and Differentiation , vol.9 , Issue.5 , pp. 505-512
    • Puthalakath, H.1    Strasser, A.2
  • 21
    • 68249106060 scopus 로고    scopus 로고
    • BH3-only proteins in apoptosis and beyond: An overview
    • 10.1038/onc.2009.39 1:CAS:528:DC%2BD1MXpt1Wgs7o%3D 2928556 19641503 10.1038/onc.2009.39
    • Lomonosova E, Chinnadurai G (2008) BH3-only proteins in apoptosis and beyond: an overview. Oncogene 27(Suppl 1):S2-S19. doi: 10.1038/onc.2009.39
    • (2008) Oncogene , vol.27 , Issue.SUPPL. 1
    • Lomonosova, E.1    Chinnadurai, G.2
  • 22
    • 0036794390 scopus 로고    scopus 로고
    • Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis
    • DOI 10.1038/ni834
    • Rathmell JC, Lindsten T, Zong WX, Cinalli RM, Thompson CB (2002) Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol 3(10):932-939. doi: 10.1038/ni834 (Pubitemid 35154006)
    • (2002) Nature Immunology , vol.3 , Issue.10 , pp. 932-939
    • Rathmell, J.C.1    Lindsten, T.2    Zong, W.-X.3    Cinalli, R.M.4    Thompson, C.B.5
  • 23
    • 70350105769 scopus 로고    scopus 로고
    • MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM
    • 10.1038/leu.2009.80 1:CAS:528:DC%2BD1MXht1GgtLvO 2761998 19404317 10.1038/leu.2009.80
    • Rambal AA, Panaguiton ZL, Kramer L, Grant S, Harada H (2009) MEK inhibitors potentiate dexamethasone lethality in acute lymphoblastic leukemia cells through the pro-apoptotic molecule BIM. Leukemia 23(10):1744-1754. doi: 10.1038/leu.2009.80
    • (2009) Leukemia , vol.23 , Issue.10 , pp. 1744-1754
    • Rambal, A.A.1    Panaguiton, Z.L.2    Kramer, L.3    Grant, S.4    Harada, H.5
  • 26
    • 28544436922 scopus 로고    scopus 로고
    • Activation of glycogen synthase kinase 3β disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity
    • DOI 10.1158/0008-5472.CAN-05-1925
    • Pastorino JG, Hoek JB, Shulga N (2005) Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Cancer Res 65(22):10545-10554. doi: 10.1158/0008-5472.CAN-05-1925 (Pubitemid 41743749)
    • (2005) Cancer Research , vol.65 , Issue.22 , pp. 10545-10554
    • Pastorino, J.G.1    Hoek, J.B.2    Shulga, N.3
  • 27
    • 1642473186 scopus 로고    scopus 로고
    • The mitochondrial phase of the glucocorticoid-induced apoptotic response in thymocytes comprises sequential activation of adenine nucleotide transporter (ANT)-independent and ANT-dependent events
    • DOI 10.1002/eji.200324650
    • Sade H, Khandre NS, Mathew MK, Sarin A (2004) The mitochondrial phase of the glucocorticoid-induced apoptotic response in thymocytes comprises sequential activation of adenine nucleotide transporter (ANT)-independent and ANT-dependent events. Eur J Immunol 34(1):119-125. doi: 10.1002/eji.200324650 (Pubitemid 38111527)
    • (2004) European Journal of Immunology , vol.34 , Issue.1 , pp. 119-125
    • Sade, H.1    Khandre, N.S.2    Mathew, M.K.3    Sarin, A.4
  • 28
    • 0036510541 scopus 로고    scopus 로고
    • Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis
    • DOI 10.1074/jbc.M109950200
    • Pastorino JG, Shulga N, Hoek JB (2002) Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis. J Biol Chem 277(9):7610-7618. doi: 10.1074/jbc.M109950200 (Pubitemid 34953160)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.9 , pp. 7610-7618
    • Pastorino, J.G.1    Shulga, N.2    Hoek, J.B.3
  • 29
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • DOI 10.1038/378785a0
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378(6559):785-789. doi: 10.1038/378785a0 (Pubitemid 26004411)
    • (1995) Nature , vol.378 , Issue.6559 , pp. 785-789
    • Cross, D.A.E.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 30
    • 33748299477 scopus 로고    scopus 로고
    • The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways
    • DOI 10.1016/j.pneurobio.2006.07.006, PII S0301008206000797
    • Beurel E, Jope RS (2006) The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol 79(4):173-189. doi: 10.1016/j.pneurobio.2006.07.006 (Pubitemid 44331500)
    • (2006) Progress in Neurobiology , vol.79 , Issue.4 , pp. 173-189
    • Beurel, E.1    Jope, R.S.2
  • 31
    • 29144497967 scopus 로고    scopus 로고
    • Inhibition of PI3-kinase-Akt pathway enhances dexamethasone-induced apoptosis in a human follicular lymphoma cell line
    • DOI 10.1016/j.yexcr.2005.10.023, PII S0014482705005070
    • Nuutinen U, Postila V, Matto M, Eeva J, Ropponen A, Eray M, Riikonen P, Pelkonen J (2006) Inhibition of PI3-kinase-Akt pathway enhances dexamethasone-induced apoptosis in a human follicular lymphoma cell line. Exp Cell Res 312(3):322-330. doi: 10.1016/j.yexcr.2005.10.023 (Pubitemid 41814841)
    • (2006) Experimental Cell Research , vol.312 , Issue.3 , pp. 322-330
    • Nuutinen, U.1    Postila, V.2    Matto, M.3    Eeva, J.4    Ropponen, A.5    Eray, M.6    Riikonen, P.7    Pelkonen, J.8
  • 33
    • 0038406498 scopus 로고    scopus 로고
    • IL-7 inhibits dexamethasone-induced apoptosis via Akt/PKB in mature, peripheral T cells
    • DOI 10.1002/eji.200323782
    • Sade H, Sarin A (2003) IL-7 inhibits dexamethasone-induced apoptosis via Akt/PKB in mature, peripheral T cells. Eur J Immunol 33(4):913-919. doi: 10.1002/eji.200323782 (Pubitemid 36546679)
    • (2003) European Journal of Immunology , vol.33 , Issue.4 , pp. 913-919
    • Sade, H.1    Sarin, A.2
  • 36
    • 0027246214 scopus 로고
    • Induction of early response genes by cross-linking membrane Ig on B lymphocytes
    • Mittelstadt PR, DeFranco AL (1993) Induction of early response genes by cross-linking membrane Ig on B lymphocytes. J Immunol 150(11):4822-4832 (Pubitemid 23150349)
    • (1993) Journal of Immunology , vol.150 , Issue.11 , pp. 4822-4832
    • Mittelstadt, P.R.1    DeFranco, A.L.2
  • 37
    • 0027976193 scopus 로고
    • Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77
    • DOI 10.1038/367281a0
    • Liu ZG, Smith SW, McLaughlin KA, Schwartz LM, Osborne BA (1994) Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77. Nature 367(6460):281-284. doi: 10.1038/367281a0 (Pubitemid 24051145)
    • (1994) Nature , vol.367 , Issue.6460 , pp. 281-284
    • Liu, Z.-G.1    Smith, S.W.2    McLaughlin, K.A.3    Schwartz, L.M.4    Osborne, B.A.5
  • 38
    • 0028008513 scopus 로고
    • Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas
    • DOI 10.1038/367277a0
    • Woronicz JD, Calnan B, Ngo V, Winoto A (1994) Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas. Nature 367(6460):277-281. doi: 10.1038/367277a0 (Pubitemid 24051144)
    • (1994) Nature , vol.367 , Issue.6460 , pp. 277-281
    • Woronicz, J.D.1    Calnan, B.2    Ngo, V.3    Winoto, A.4
  • 39
    • 0036238332 scopus 로고    scopus 로고
    • Nuclear hormone receptors in T lymphocytes
    • DOI 10.1016/S0092-8674(02)00710-9
    • Winoto A, Littman DR (2002) Nuclear hormone receptors in T lymphocytes. Cell 109(Suppl):S57-S66 (Pubitemid 34457852)
    • (2002) Cell , vol.109 , Issue.2 SUPPL. 1
    • Winoto, A.1    Littman, D.R.2
  • 40
    • 1342306819 scopus 로고    scopus 로고
    • Conversion of Bcl-2 from Protector to Killer by Interaction with Nuclear Orphan Receptor Nur77/TR3
    • DOI 10.1016/S0092-8674(04)00162-X
    • Lin B, Kolluri SK, Lin F, Liu W, Han YH, Cao X, Dawson MI, Reed JC, Zhang XK (2004) Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3. Cell 116(4):527-540 (Pubitemid 38264430)
    • (2004) Cell , vol.116 , Issue.4 , pp. 527-540
    • Lin, B.1    Kolluri, S.K.2    Lin, F.3    Liu, W.4    Han, Y.-H.5    Cao, X.6    Dawson, M.I.7    Reed, J.C.8    Zhang, X.-K.9
  • 41
    • 33645566549 scopus 로고    scopus 로고
    • NR4A1, 2, 3 an orphan nuclear hormone receptor family involved in cell apoptosis and carcinogenesis
    • 1:CAS:528:DC%2BD28Xls1SrsL8%3D 16493583
    • Li QX, Ke N, Sundaram R, Wong-Staal F (2006) NR4A1, 2, 3 an orphan nuclear hormone receptor family involved in cell apoptosis and carcinogenesis. Histol Histopathol 21(5):533-540
    • (2006) Histol Histopathol , vol.21 , Issue.5 , pp. 533-540
    • Li, Q.X.1    Ke, N.2    Sundaram, R.3    Wong-Staal, F.4
  • 42
    • 10744221976 scopus 로고    scopus 로고
    • Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor
    • DOI 10.1093/emboj/cdg620
    • Rajpal A, Cho YA, Yelent B, Koza-Taylor PH, Li D, Chen E, Whang M, Kang C, Turi TG, Winoto A (2003) Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptor. EMBO J 22(24):6526-6536. doi: 10.1093/emboj/cdg620 (Pubitemid 38009600)
    • (2003) EMBO Journal , vol.22 , Issue.24 , pp. 6526-6536
    • Rajpal, A.1    Cho, Y.A.2    Yelent, B.3    Koza-Taylor, P.H.4    Li, D.5    Chen, E.6    Whang, M.7    Kang, C.8    Turi, T.G.9    Winoto, A.10
  • 43
    • 0035980060 scopus 로고    scopus 로고
    • Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis
    • 10.1074/jbc.M105431200 1:CAS:528:DC%2BD3MXmvFCmt74%3D 11438550 10.1074/jbc.M105431200
    • Masuyama N, Oishi K, Mori Y, Ueno T, Takahama Y, Gotoh Y (2001) Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis. J Biol Chem 276(35):32799-32805. doi: 10.1074/jbc.M105431200
    • (2001) J Biol Chem , vol.276 , Issue.35 , pp. 32799-32805
    • Masuyama, N.1    Oishi, K.2    Mori, Y.3    Ueno, T.4    Takahama, Y.5    Gotoh, Y.6
  • 44
    • 56049110835 scopus 로고    scopus 로고
    • Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria
    • 10.1093/carcin/bgn197 1:CAS:528:DC%2BD1cXhtlalsLfM 18713840 10.1093/carcin/bgn197
    • Chen HZ, Zhao BX, Zhao WX, Li L, Zhang B, Wu Q (2008) Akt phosphorylates the TR3 orphan receptor and blocks its targeting to the mitochondria. Carcinogenesis 29(11):2078-2088. doi: 10.1093/carcin/bgn197
    • (2008) Carcinogenesis , vol.29 , Issue.11 , pp. 2078-2088
    • Chen, H.Z.1    Zhao, B.X.2    Zhao, W.X.3    Li, L.4    Zhang, B.5    Wu, Q.6
  • 45
    • 33646868555 scopus 로고    scopus 로고
    • Glucocorticoid-induced apoptosis revisited: A novel role for glucocorticoid receptor translocation to the mitochondria
    • Sionov RV, Kfir S, Zafrir E, Cohen O, Zilberman Y, Yefenof E (2006) Glucocorticoid-induced apoptosis revisited: a novel role for glucocorticoid receptor translocation to the mitochondria. Cell Cycle 5(10):1017-1026 (Pubitemid 43778733)
    • (2006) Cell Cycle , vol.5 , Issue.10 , pp. 1017-1026
    • Sionov, R.V.1    Kfir, S.2    Zafrir, E.3    Cohen, O.4    Zilberman, Y.5    Yefenof, E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.