Gabapentin attenuates morphine tolerance through interleukin-10

NeuroReport

Volumn 25, Issue 2, 2014, Pages 71-76

  Bao, Yu Hua ^a   Zhou, Quan Hong ^a   Chen, Rui ^a   Xu, Hao ^a   Zeng, Lulu ^a   Zhang, Xin ^a   Jiang, Wei ^a   Du, Dongping ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

gabapentin; interleukin 10; intrathecal administration; morphine tolerance; proinflammatory

Indexed keywords

CYTOKINE; GABAPENTIN; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; MORPHINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG DOSE; MALE; MORPHINE TOLERANCE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL CORD; UPREGULATION;

AMINES; ANALGESICS; ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES; CYCLOHEXANECARBOXYLIC ACIDS; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; GAMMA-AMINOBUTYRIC ACID; HYPERALGESIA; INJECTIONS, SPINAL; INTERLEUKIN-10; MALE; MORPHINE; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; TIME FACTORS;

EID: 84891878169     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0b013e328363fde8     Document Type: Article

References (20)

1. Shavit Y, Wolf G, Goshen I, Livshits D, Yirmiya R. Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance. Pain 2005; 115: 50-59
2. Raghavendra V, Tanga FY, DeLeo JA. Attenuation of morphine tolerance, withdrawal-induced hyperalgesia, and associated spinal inflammatory immune responses by propentofylline in rats. Neuropsychopharmacology 2004; 29:327-334
3. Wen Y-R, Tan P-H, Cheng J-K, Liu Y-C, Ji R-R. Microglia: A promising target for treating neuropathic and postoperative pain, and morphine tolerance. J Formos Med Assoc 2011; 110:487-494
4. Johnston IN, Milligan ED,Wieseler-Frank J, Frank MG, Zapata V, Stephen L, et al. A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine. J Neurosci 2004; 24:7353-7365
5. Tai YH, Tsai RY, Lin SL, Yeh CC, Wang JJ, Tao PL, et al. Amitriptyline suppresses neuroinflammation-dependent interleukin-10-p38 mitogenactivated protein kinase-heme oxygenase-1 signaling pathway in chronic morphine-infused rats. Anesthesiology 2009; 110:1379-1389
6. Sacerdote P. Effects of in vitro and in vivo opioids on the production of IL-12 and IL-10 by murine macrophages. Ann N Y Acad Sci 2003; 992:129-140
7. Limiroli E, Gaspani L, Panerai AE, Sacerdote P. Differential morphine tolerance development in the modulation of macrophage cytokine production in mice. J Leukoc Biol 2002; 72:43-48
8. Shimoyama M, Shimoyama N, Inturrisi CE, Elliott KJ. Gabapentin enhances the antinociceptive effects of spinal morphine in the rat tail-flick test. Pain 1997; 72:375-382
9. Smiley MM, Lu Y, Vera-Portocarrero LP, Zidan A, Westlund KN. Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model. Anesthesiology 2004; 101:759-765
10. Hansen C, Gilron I, Hong M. The effects of intrathecal gabapentin on spinal morphine tolerance in the rat tail-flick and paw pressure tests. Anesth Analg 2004; 99:1180-1184
11. Wei X, Wei W. Role of gabapentin in preventing fentanyl- and morphine-withdrawal-induced hyperalgesia in rats. J Anesth 2012; 26:236-241
12. Field MJ, Oles RJ, Lewis AS, McCleary S, Hughes J, Singh L. Gabapentin (neurontin) and S-(+)-3-isobutylgaba represent a novel class of selective antihyperalgesic agents. Br J Pharmacol 1997; 121:1513-1522
13. Tai YH, Wang CS. Amitriptyline suppresses neuroinflammation and upregulates glutamate transporters in morphine-tolerant rats. Pain 2006; 124:77-86
14. Tsai RY, Jang FL, Tai YH, Lin SL, Shen CH, Wong CS. Ultra-low-dose naloxone restores the antinociceptive effect of morphine and suppresses spinal neuroinflammation in PTX-treated rats. Neuropsychopharmacology 2008; 33:2772-2782
15. Sung CS,Wen ZH, Chang WK, Chan KH, Ho ST, Tsai SK, et al. Inhibition of p38 mitogen-activated protein kinase attenuates interleukin-1beta-induced thermal hyperalgesia and inducible nitric oxide synthase expression in the spinal cord. J Neurochem 2005; 94:742-752
16. Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989; 170:2081-2095
17. Watkins LR, Hutchinson MR, Ledeboer A, Wieseler-Frank J, Milligan ED, Maier SF. Norman cousins lecture. Glia as the ?bad guys?: implications for improving clinical pain control and the clinical utility of opioids. Brain Behav Immun 2007; 21:131-146
18. Milligan ED, Sloane EM, Langer SJ, Hughes TS, Jekich BM, Frank MG, et al. Repeated intrathecal injections of plasmid DNA encoding interleukin-10 produce prolonged reversal of neuropathic pain. Pain 2006; 126:294-308
19. Di Santo E, Sironi M, Pozzi P, Gnocchi P, Isetta AM, Delvaux A, et al. Interleukin-10 inhibits lipopolysaccharide-induced tumor necrosis factor and interleukin-1 beta production in the brain without affecting the activation of the hypothalamus-pituitary-adrenal axis. Neuroimmunomodulation 1995; 2:149-154
20. Raghavendra V, Rutkowski MD, DeLeo JA. The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats. J Neurosci 2002; 22:9980-9989