Restoration of self-awareness of hypoglycemia in adultswith long-standing type 1 diabetes: Hyperinsulinemic-hypoglycemic clamp substudy results from the HypoCOMPaSS trial

Diabetes Care

Volumn 36, Issue 12, 2013, Pages 4063-4070

  Leelarathna, Lalantha ^a   Little, Stuart A ^b   Walkinshaw, Emma ^c   Tan, Horng Kai ^d   Lubina Solomon, Alexandra ^c   Kumareswaran, Kavita ^a   Lane, Annette P ^b   Chadwick, Thomas ^b   Marshall, Sally M ^b   Speight, Jane ^e,f,g   Flanagan, Daniel ^d   Heller, Simon R ^c   Shaw, James A M ^b   Evans, Mark L ^a  

^a INSTITUTE OF METABOLIC SCIENCE   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d DERRIFORD HOSPITAL   (United Kingdom)

^e AHP Research   (United Kingdom)

^f THE AUSTRALIAN CENTRE FOR BEHAVIOURAL RESEARCH IN DIABETES   (Australia)

^g DEAKIN UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

METADRENALIN; ANTIDIABETIC AGENT; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN; INSULIN;

ADULT; AGED; ARTICLE; BLOOD GLUCOSE MONITORING; COGNITION; CONTROLLED STUDY; DRUG RESPONSE; FACTORIAL DESIGN; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; HUMAN; HYPERINSULINEMIA; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; PROSPECTIVE STUDY; RISK FACTOR; SELF CONCEPT; STROOP TEST; AWARENESS; BLOOD; CLINICAL TRIAL; DIABETES MELLITUS, TYPE 1; DOSE RESPONSE; FEMALE; INSULIN INFUSION; MALE; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; PSYCHOLOGY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ADULT; AWARENESS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUCOSE CLAMP TECHNIQUE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; HYPOGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN INFUSION SYSTEMS; MALE; MIDDLE AGED; TREATMENT OUTCOME;

EID: 84891877558     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc13-1004     Document Type: Article

References (38)

1. Cryer PE. Elimination of hypoglycemia from the lives of people affected by diabetes. Diabetes 2011;60:24-27
2. McCrimmon RJ, Sherwin RS. Hypoglycemia in type 1 diabetes. Diabetes 2010; 59:2333-2339
3. Amiel SA. Hypoglycemia: from the laboratory to the clinic. Diabetes Care 2009; 32:1364-1371
4. Secrest AM, Becker DJ, Kelsey SF, Laporte RE, Orchard TJ. Characterizing sudden death and dead-in-bed syndrome in Type 1 diabetes: analysis from two childhoodonset Type 1 diabetes registries. Diabet Med 2011;28:293-300
5. UK Hypoglycaemia Study Group. Risk of hypoglycaemia in types 1 and 2 diabetes: effects of treatment modalities and their duration. Diabetologia 2007;50:1140-1147
6. Gold AE, MacLeod KM, Frier BM. Frequency of severe hypoglycemia in patients with type I diabetes with impaired awareness of hypoglycemia. Diabetes Care 1994;17:697-703
7. Cryer PE. Iatrogenic hypoglycemia as a cause of hypoglycemia-associated autonomic failure in IDDM. A vicious cycle. Diabetes 1992;41:255-260
8. Heller SR, Cryer PE. Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after 1 episode of hypoglycemia in nondiabetic humans. Diabetes 1991;40:223-226
9. Davis MR, Shamoon H. Counterregulatory adaptation to recurrent hypoglycemia in normal humans. J Clin Endocrinol Metab 1991;73:995-1001
10. Widom B, Simonson DC. Intermittent hypoglycemia impairs glucose counterregulation. Diabetes 1992;41:1597-1602
11. Dagogo-Jack SE, Craft S, Cryer PE. Hypoglycemia-associated autonomic failure in insulin-dependent diabetes mellitus. Recent antecedent hypoglycemia reduces autonomic responses to, symptoms of, and defense against subsequent hypoglycemia. J Clin Invest 1993;91:819-828
12. Davis SN, Mann S, Briscoe VJ, Ertl AC, Tate DB. Effects of intensive therapy and antecedent hypoglycemia on counterregulatory responses to hypoglycemia in type 2 diabetes. Diabetes 2009;58:701-709
13. Mitrakou A, Fanelli C, Veneman T, et al. Reversibility of unawareness of hypoglycemia in patients with insulinomas. N Engl J Med 1993;329:834-839
14. Maran A, Taylor J, Macdonald IA, Amiel SA. Evidence for reversibility of defective counterregulation in a patient with insulinoma. Diabet Med 1992;9:765-768
15. Kendall DM, Rooney DP, Smets YF, Salazar Bolding L, Robertson RP. Pancreas transplantation restores epinephrine response and symptom recognition during hypoglycemia in patients with longstanding type I diabetes and autonomic neuropathy. Diabetes 1997;46:249-257
16. Paty BW, Lanz K, Kendall DM, Sutherland DE, Robertson RP. Restored hypoglycemic counterregulation is stable in successful pancreas transplant recipients for up to 19 years after transplantation. Transplantation 2001;72:1103-1107
17. Leitão CB, Tharavanij T, Cure P, et al. Restoration of hypoglycemia awareness after islet transplantation. Diabetes Care 2008;31:2113-2115
18. Fanelli CG, Epifano L, Rambotti AM, et al. Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM. Diabetes 1993;42:1683-1689
19. Cranston I, Lomas J, Maran A, Macdonald I, Amiel SA. Restoration of hypoglycaemia awareness in patients with long-duration insulin-dependent diabetes. Lancet 1994; 344:283-287
20. Fanelli C, Pampanelli S, Epifano L, et al. Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycaemia, following institution of rational, intensive insulin therapy in IDDM. Diabetologia 1994;37:1265-1276
21. Dagogo-Jack S, Rattarasarn C, Cryer PE. Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM. Diabetes 1994;43:1426-1434
22. Pickup JC, Sutton AJ. Severe hypoglycaemia and glycaemic control in Type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion. Diabet Med 2008;25:765-774
23. Doyle EA, Weinzimer SA, Steffen AT, Ahern JA, Vincent M, Tamborlane WV. A randomized, prospective trial comparing the efficacy of continuous subcutaneous insulin infusion with multiple daily injections using insulin glargine. Diabetes Care 2004;27:1554-1558
24. Hirsch IB, Bode BW, Garg S, et al.; Insulin Aspart CSII/MDI Comparison Study Group. Continuous subcutaneous insulin infusion (CSII) of insulin aspart versus multiple daily injection of insulin aspart/insulin glargine in type 1 diabetic patients previously treated with CSII. Diabetes Care 2005;28:533-538
25. Beck RW, Hirsch IB, Laffel L, et al.; Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group. The effect of continuous glucose monitoring in well-controlled type 1 diabetes. Diabetes Care 2009;32:1378-1383
26. Battelino T, Phillip M, Bratina N, Nimri R, Oskarsson P, Bolinder J. Effect of continuous glucosemonitoring on hypoglycemia in type 1 diabetes. Diabetes Care 2011;34:795-800
27. Ly TT, Hewitt J, Davey RJ, Lim EM, Davis EA, Jones TW. Improving epinephrine responses in hypoglycemia unawareness with real-time continuous glucose monitoring in adolescents with type 1 diabetes. Diabetes Care 2011;34:50-52
28. Little S, Chadwick T, Choudhary P, et al. Comparison of Optimised MDI versus Pumps with or without Sensors in Severe Hypoglycaemia (the Hypo COMPaSS trial). BMC Endocr Disord 2012;12:33
29. Workgroup on Hypoglycemia, American Diabetes Association. Defining and reporting hypoglycemia in diabetes: a report from the American Diabetes Association Workgroup on Hypoglycemia. Diabetes Care 2005;28:1245-1249
30. Maran A, Lomas J, Macdonald IA, Amiel SA. Lack of preservation of higher brain function during hypoglycaemia in patients with intensively-treated IDDM. Diabetologia 1995;38:1412-1418
31. Heller SR, Macdonald IA. The measurement of cognitive function during acute hypoglycaemia: experimental limitations and their effect on the study of hypoglycaemia unawareness. Diabet Med 1996;13:607-615
32. Lezak MD. Neuropsychological Assessment. Oxford, U.K., Oxford University Press, 1995
33. Bench CJ, Frith CD, Grasby PM, et al. Investigations of the functional anatomy of attention using the Stroop test. Neuropsychologia 1993;31:907-922
34. Deary IJ, Hepburn DA, MacLeod KM, Frier BM. Partitioning the symptoms of hypoglycaemia using multi-sample confirmatory factor analysis. Diabetologia 1993;36:771-777
35. Choudhary P, Lonnen K, Emery CJ, et al. Comparing hormonal and symptomatic responses to experimental hypoglycaemia in insulin-and sulphonylurea-treated Type 2 diabetes. Diabet Med 2009;26: 665-672
36. Bingham E, Hopkins D, Pernet A, Reid H, Macdonald IA, Amiel SA. The effects of KATP channel modulators on counterregulatory responses and cognitive function during acute controlled hypoglycaemia in healthy men: a pilot study. Diabet Med 2003;20:231-237
37. Fritsche A, Stefan N, Häring H, Gerich J, Stumvoll M. Avoidance of hypoglycemia restores hypoglycemia awareness by increasing beta-adrenergic sensitivity in type 1 diabetes. Ann Intern Med 2001; 134:729-736
38. Eisenhofer G, Rundquist B, Aneman A, et al. Regional release and removal of catecholamines and extraneuronal metabolism to metanephrines. J Clin Endocrinol Metab 1995;80:3009-3017