Pancreas transplantation restores epinephrine response and symptom recognition during hypoglycemia in patients with long-standing type I diabetes and autonomic neuropathy

Diabetes

Volumn 46, Issue 2, 1997, Pages 249-257

  Kendall, David M ^a,b   Rooney, Desmond P ^a   Smets, Yves F C ^a   Bolding, Lupe Salazar ^a   Robertson, R Paul ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; C PEPTIDE; GLUCAGON; GLUCOSE; HEMOGLOBIN A1C; NORADRENALIN;

ADULT; ARTICLE; AUTONOMIC NEUROPATHY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GLUCOSE CLAMP TECHNIQUE; HORMONE RESPONSE; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY TRANSPLANTATION; MALE; PANCREAS TRANSPLANTATION; PRIORITY JOURNAL; SYMPTOMATOLOGY;

EID: 0030904145     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.46.2.249     Document Type: Article

References (37)

1. Cryer P: Hypoglycemia: the limiting factor in the management of IDDM. Diabetes 43:1378-1389, 1994
2. Cryer P, Fisher J, Shamoon H: Hypoglycemia. Diabetes Care 17:734-755, 1994
3. Dagogo-Jack S, Craft S, Cryer P: Hypoglycemia-associated autonomie failure in insulin dependent diabetes mellitus. J Clin Invest 91:819-828, 1993
4. Hepburn D, Patrick A, Eadington D, Weing D, Frier B: Unawareness of hypoglycaemia in insulin-treated diabetic patients: prevalence and relationship to autonomie neuropathy. Diabet Med 7:711-717, 1990
5. Hirsch B, Shamoon H: Defective epinephrine and growth hormone responses in type I diabetes are stimulus specific. Diabetes 36:20-26, 1987
6. Mitrakou A, Fanelli C, Veneman T, Perriello G, Calderone S, Platanisiotis D, Rambiotti A, Raptis S, Brunetti P, Cryer P, Gerich J, Bolli G: Reversibility of unawareness of hypoglycemia in patients with insulinomas. N Engl J Med 329:834-839, 1993
7. Rattarasarn C, Dagogo-Jack S, Zachwieja J, Cryer P: Hypoglycemia-induced autonomie failure in IDDM is specific for stimulus of hypoglycemia and is not attributable to prior autonomie activation. Diabetes 43:809-818, 1994
8. Cryer P: Iatrogenic hypoglycemia as a cause of hypoglycemia-associated autonomic failure in IDDM. Diabetes 41:255-260, 1992
9. Veneman T, Mitrakou A, Mokan M, Cryer P, Gerich J: Induction of hypoglycemic unawareness by asymptomatic nocturnal hypoglycemia. Diabetes 42:1233-1237, 1993
10. White N, Skor D, Cryer P, Bier D, Levandoski L, Santiago J: Identification of type I diabetic patients at increased risk for hypoglycemia during intensive therapy. N Engl J Med 308:485-491, 1983
11. Hoeldtke R, Guenther B, Shuman C, Owen O: Reduced epinephrine secretion and hypoglycemia unawareness in diabetic neuropathy. Ann Int Med 96:459-462, 1982
12. Amiel S, Tamborlane W, Simonson D, Sherwin R: Defective glucose counterregulation after strict control of insulin-dependent diabetes mellitus. N Engl J Med 316:1376-1383, 1987
13. Amiel S, Sherwin R, Simonson D, Tamborlane W: Effect of intensive insulin therapy on glycemic thresholds for counterregulatory hormone release. Diabetes 37:901-907, 1988
14. The DCCT Research Group: Epidemiology of severe hypoglycemia in the Diabetes Control and Complications Trial. Am J Phys 260:E705-E712, 1991
15. Windom B, Simonson DC: Intermittent hypoglycemia impairs glucose counterregulation. Diabetes 41:1597-1602, 1992
16. Powell AM, Sherwin RS, Shulman GI: Impaired hormonal responses to hypoglycemia in spontaneously diabetic and recurrently hypoglycemic rats. J Clin Invest 92:2667-2674, 1993
17. Heller S, Cryer P: Reduced neuroendocrine and symptomatic responses to subsequent hypoglycemia after one episode of hypoglycemia in nondiabetic humans. Diabetes 40:223-226, 1991
18. Cranston I, Lomas J, Maran A, Macdonald I, Amiel S: Restoration of hypoglycaemia awareness in patients with long-duration insulin-dependent diabetes. Lancet 344:283-287, 1994
19. Fanelli C, Epifano L, Rambotti A, Pampanelli S, DiVincenzo A, Modarelli F, Lepore M, Annibale B, Ciofetta M, Bottini P, Porcellati F, Scionti L, Santeusanio F, Bruneth P, Bolli GB: Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM. Diabetes 42:1683-1689, 1993
20. Fanelli C, Pampanelli S, Epifano L, Rambotti AM, DiVincenzo A, Modarelli F, Ciofetta M, Lepore M, Annibale B, Torlone E, Perriello G, DeFeo P, Santeusanio F, Brunetti P, Bolli GB: Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycaemia, following institution of rational, intensive insulin therapy in IDDM. Diabetologia 37:1265-1276, 1994
21. Dagogo-Jack S, Rattarasarn C, Cryer PE: Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM. Diabetes 43:1426-1434, 1994
22. Davis M, Mellman M, Friedman S, Chang CJ, Shamoon H: Recovery of epinephrine response but not hypoglycemic symptom threshold after intensive therapy in type 1 diabetes. Am J Med 97:535-542, 1994
23. Robertson RP: Pancreas and islet transplantation for diabetes: cures or curiosities? N Engl J Med 327:1861-1866, 1992
24. Robertson RP, Kendall D, Teuscher A, Sutherland DER: Long term metabolic control with pancreatic transplantation. Transplant Proc 26:386-387, 1993
25. Landgraf R, Nusser J, Riepl R, Fiedler F, Illiner W-D, Abendroth D, Land W: Metabolic and hormonal studies of type I (insulin-dependent) diabetic patients after successful pancreas and kidney transplantation. Diabetologia 34 (Suppl. 1):S61-S67, 1991
26. Morel P, Goetz F, Moudry-Munns K, Frier E, Sutherland D: Long-term glucose control in patients with pancreatic transplants. Ann Int Med 115:694-699, 1991
27. Diem P, Redmon J, Abid M, Moran A, Sutherland DER, Halter J, Robertson R: Glucagon, catecholamine and pancreatic polypeptide secretion in type I diabetic recipients of pancreas allografts. J Clin Invest 86:2008-2013, 1990
28. Barrou Z, Seaquist E, Robertson R: Pancreas transplantation in diabetic humans normalizes hepatic glucose production during hypoglycemia. Diabetes 43:661-666, 1994
29. Harris V, Faloon G, Unger R: Glucagon. In Methods of Hormone Radioimmunoassay. Jaffe B, Behrman H, Eds. New York, Academic Press, 1979, p. 643-656
30. Evans M, Halter J, Porte D Jr: Comparison of double and single isotope enzymatic derivative methods of measurement of catecholamines in human plasma. Clin Chem 24:567-570, 1978
31. Battezzati A, Luzi L, Perseghin G, Bianchi E, Spotti D, Secchi A, Vergani S, Di Carlo V, Pozza G: Persistence of counter-regulatory abnormalities in insulin-dependent diabetes mellitus after pancreas transplantation. Eur J Clin Invest 24:751-758, 1994
32. Landgraf R, Nusser J, Riepl RL, Fiedler F, Illner WD, Abendroth D, Land W: Metabolic and hormonal studies of type 1 (insulin-dependent) diabetic patients after successful pancreas and kidney transplantation. Diabetolagia 34 (Suppl. 1):561-567, 1991
33. Bolinder J, Wahrenberg H, Persson A, Linde B, Tydén G, Groth C-G, Ostman J: Effect of pancreas transplantation on glucose counterregulation in insulin-dependent diabetic patients prone to severe hypoglycemia. J Int Med 230:527-533, 1992
34. Fanelli C, Lalli C, Pampanelli S, Lepore M, Bartocci L, Brunetti P, Bolli GB: Recovery of hypoglycemia unawareness in IDDM with autonomic neuropathy (Abstract). Diabetologia 39 (Suppl. 1):A58, 1996
35. Fanelli C, Pampanelli S, Calderone S, Lepore M, Annibale B, Compagnucci P, Brunetti P, Bolli GB: Effects of recent, short-term hyperglycemia on responses to hypoglycemia in humans: relevance to the pathogenesis of hypoglycemia unawareness and hyperglycemia-induced insulin resistance. Diabetes 44:513-519, 1995
36. Crum R, Fairchild R, Bronsther O, Dominic W, Ward D, Fernandez R, Braun MR: Neuroendocrinology of chronic renal failure and renal transplantation. Transplantation 52:818-823, 1991
37. Kaye D, Thompson J, Jennings G, Ester M: Cyelosporine therapy after cardiac transplantation causes hypertension and renal vasoconstriction without sympathetic activation. Circulation 88:1101-1109, 1993