Obsessive-compulsive-like behaviors in house mice are attenuated by a probiotic (Lactobacillus rhamnosus GG)

Behavioural Pharmacology

Volumn 25, Issue 1, 2014, Pages 71-79

  Kantak, Pranish A ^a   Bobrow, Dylan N ^a   Nyby, John G ^a  

^a LEHIGH UNIVERSITY   (United States)

Author keywords

fluoxetine; Lactobacillus rhamnosus; locomotor activity; mice; OCD; open field; perseveration; probiotics; RU 24969; SRI

Indexed keywords

FLUOXETINE; PROBIOTIC AGENT;

AGGRESSION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; LACTOBACILLUS RHAMNOSUS; MALE; MOUSE; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; OPEN FIELD BEHAVIOR; STEREOTYPY;

ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; FLUOXETINE; FREEZE DRYING; INDOLES; LACTOBACILLUS; MALE; MICE; MICE, INBRED BALB C; MOTOR ACTIVITY; OBSESSIVE-COMPULSIVE DISORDER; PROBIOTICS; SEROTONIN RECEPTOR AGONISTS; SOCIAL BEHAVIOR; TIME FACTORS; VOCALIZATION, ANIMAL;

EID: 84891875653     PISSN: 09558810     EISSN: 14735849     Source Type: Journal    
DOI: 10.1097/FBP.0000000000000013     Document Type: Article

References (39)

1. Angoa-Perez M, Kane M, Briggs D, Sykes C, Shah M, Francescutti D, et al. (2012). Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity. J Neurochem 121:974-984.
2. Bercik P, Park A, Sinclair D, Khoshdel A, Lu J, Huang X, et al. (2011). The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gutbrain communication. Neurogastroenterol Motil 23:1132-1139.
3. Bravo J, Forsythe P, Chew M, Escaravage E, Savignac H, Dinan T, et al. (2011). Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA 108:16050-16055.
4. Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F, et al. (2013). The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry 18:666-673.
5. Clement Y, Le Guisquet AM, Venault P, Chapouthier G, Belzung C (2009). Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation. PLoS One 4:e7745.
6. Cryan JF, Dinan TG (2012). Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 13:701-712.
7. D'Cruz AM, Ragozzino ME, Mosconi MW, Shrestha S, Cook EH, Sweeney JA (2013). Reduced behavioral flexibility in autism spectrum disorders. Neuropsychology 27:152-160.
8. Deacon R (2006). Digging and marble burying in mice: simple methods for in vivo identification of biological impacts. Nat Protoc 1:122-124.
9. Desbonnet L, Garrett L, Clarke G, Kiely B, Cryan J, Dinan T (2010). Effects of the probiotic Bifidobacterium infantis in the maternal separation model of depression. Neuroscience 170:1179-1188.
10. Dulawa SC, Holick KA, Gundersen B, Hen R (2004). Effects of chronic fluoxetine in animal models of anxiety and depression. Neuropsychopharmacol 29:1321-1330. (Pubitemid 38780655)
11. Fagiolini A, Comandini A, Dell'Osso M, Kasper S (2012). Rediscovering trazodone for the treatment of major depressive disorder. CNS Drugs 26:1033-1049.
12. Gill HS, Rutherfurd KJ (2001). Viability and dose-response studies on the effects of the immunoenhancing lactic acid bacterium Lactobacillus rhamnosus in mice. Br J Nutr 86:285-289. (Pubitemid 32780635)
13. Goyal N, Rishi P, Shukla G (2013). Lactobacillus rhamnosus GG antagonizes Giardia intestinalis induced oxidative stress and intestinal disaccharidases: an experimental study. World J Microbiol Biotechnol 29:1049-1057.
14. Grenham S, Clarke G, Cryan J, Dinan T (2011). Brain-gut-microbe communication in health and disease. Front Physiol 2:94.
15. Guandalini S (2011). Probiotics for prevention and treatment of diarrhea. J Clin Gastroenterol 45(Suppl):S149-S153.
16. Hemarajata P, Versalovic J (2013). Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation. Therap Adv Gastroenterol 6:39-51.
17. Huang E, Reichardt L (2001). Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677-736. (Pubitemid 32695243)
18. Jones M,Wootton B, Vaccaro L, Menzies R (2012). The impact of climate change on obsessive compulsive checking concerns. Aust N Z J Psychiatry 46:265-270.
19. Karch S, Pogarell O (2011). Neurobiology of obsessive-compulsive disorder. Nervenarzt 82:299-307.
20. Kim SW, Park KY, Kim B, Kim E, Hyun CK (2013). Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhancement of adiponectin production. Biochem Biophys Res Commun 431:258-263.
21. Louis P (2012). Does the human gut microbiota contribute to the etiology of autism spectrum disorders? Dig Dis Sci 57:1987-1989.
22. Lyte M, Li W, Opitz N, Gaykema RP, Goehler LE (2006). Induction of anxiety-like behavior in mice during the initial stages of infection with the agent of murine colonic hyperplasia Citrobacter rodentium. Physiol Behav 89:350-357. (Pubitemid 44436313)
23. Messaoudi M, Violle N, Bisson J, Desor D, Javelot H, Rougeot C (2011). Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers. Gut Microbes 2:256-261.
24. Neufeld KM, Kang N, Bienenstock J, Foster JA (2011). Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterol Motil 23:255-264, e119.
25. Novotny S, Hollander E, Phillips A, Allen A, Wasserman S, Iyengar R (2004). Increased repetitive behaviours and prolactin responsivity to oral m-chlorophenylpiperazine in adults with autism spectrum disorders. Int J Neuropsychopharmacol 7:249-254. (Pubitemid 39166459)
26. Nyby J,Whitney G (1978). Ultrasonic communication by adult myomorph rodents. Neurosci Biobehav Rev 2:1-14.
27. Nyby J (2009). Ultrasonic calls: hormonal and pheromonal regulation. In: Brudzynski S, editor. Handbook of mammalian vocalization, an integrative neuroscience approach. Oxford: Academic Press. pp. 303-310.
28. Ruscio A, Stein D, Chiu W, Kessler R (2010). The epidemiology of obsessivecompulsive disorder in the National Comorbidity Survey Replication. Mol Psychiatry 15:53-63.
29. Saulnier DM, Ringel Y, Heyman MB, Foster JA, Bercik P, Shulman RJ, et al. (2013). The intestinal microbiome, probiotics and prebiotics in neurogastroenterology. Gut Microbes 4:17-27.
30. Shanahan N, Holick Pierz K, Masten V, Waeber C, Ansorge M, Gingrich J, et al. (2009). Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice. Biol Psychiatry 65: 401-408.
31. Shanahan N, Velez L, Masten V, Dulawa S (2011). Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice. Biol Psychiatry 70: 1039-1048.
32. Storch E, Merlo L (2006). Obsessive-compulsive disorder: strategies for using CBT and pharmacotherapy. J Fam Pract 55:329-333.
33. Sudo N, Chida Y, Aiba Y, Sonoda J, Oyama N, Yu X, et al. (2004). Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol 558:263-275. (Pubitemid 39077406)
34. Thomas A, Burant A, Bui N, Graham D, Yuva-Paylor LA, Paylor R (2009). Marble burying reflects a repetitive and perseverative behavior more than noveltyinduced anxiety. Psychopharmacology (Berl) 204:361-373.
35. Tillisch K, Labus J, Kilpatrick L, Jiang Z, Stains J, Ebrat B, et al. (2013). Consumption of fermented milk product with probiotic modulates brain activity. Gastroenterology 144:1394-1401, e4.
36. Vega Matuszcyk J, Larsson K, Eriksson E (1998). The selective serotonin reuptake inhibitor fluoxetine reduces sexual motivation in male rats. Pharmacol Biochem Behav 60:527-532. (Pubitemid 28282694)
37. Wei H, Xu Y, Cheng B, Xiong Y (2007). Synergistic effects of Lactobacillus rhamnosus ZDY114 and bovine colostrums on the immunological function of mouse in vivo and in vitro. Appl Microbiol Biotechnol 75: 427-434. (Pubitemid 46866525)
38. White N, Prasad M, Barfield R, Nyby J (1998). 40-and 70-kHz vocalizations of mice (Mus musculus) during copulation. Physiol Behav 63:467-473. (Pubitemid 28119176)
39. Zhang Z, Xiang Y, Li N,Wang B, Ai H,Wang X, et al. (2013). Protective effects of Lactobacillus rhamnosus GG against human rotavirus-induced diarrhoea in a neonatal mouse model. Pathog Dis 67:184-191.