Anti-filarial activity of antibiotic therapy is due to extensive apoptosis after Wolbachia depletion from filarial nematodes

PLoS Pathogens

Volumn 7, Issue 11, 2011, Pages

  Landmann, Frederic ^a   Voronin, Denis ^b   Sullivan, William ^a   Taylor, Mark J ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; TETRACYCLINE; ANTIINFECTIVE AGENT; CASPASE 3; DOXYCYCLINE; HELMINTH PROTEIN;

ANTIBIOTIC THERAPY; ANTIMICROBIAL ACTIVITY; APOPTOSIS; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DEATH; EMBRYO (ANATOMY); EMBRYO CELL; EMBRYO DEVELOPMENT; FILARIA; HYPODERMA; INSTRUMENT STERILIZATION; LARVAL STAGE; MICROFILARIA (NEMATODE LARVA); NEMATODE; NONHUMAN; SOMATIC CELL; WOLBACHIA; WORM; ANIMAL; BIOSYNTHESIS; BRUGIA MALAYI; CYTOLOGY; DRUG EFFECT; FEMALE; FILARIASIS; GERBIL; HUMAN; LARVA; MALE; METABOLISM; MICROBIOLOGY; NICK END LABELING; PARASITOLOGY; PHYSIOLOGY; SYMBIOSIS;

NEMATODA; WOLBACHIA;

ANIMALS; ANTI-BACTERIAL AGENTS; APOPTOSIS; BRUGIA MALAYI; CASPASE 3; DOXYCYCLINE; FEMALE; FILARIASIS; GERBILLINAE; HELMINTH PROTEINS; HUMANS; IN SITU NICK-END LABELING; LARVA; MALE; SYMBIOSIS; TETRACYCLINE; WOLBACHIA;

EID: 81755187248     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002351     Document Type: Article

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