AAV-mediated liver-specific MPV17 expression restores mtdna levels and prevents diet-induced liver failure

Molecular Therapy

Volumn 22, Issue 1, 2014, Pages 10-17

  Bottani, Emanuela ^a   Giordano, Carla ^b   Civiletto, Gabriele ^a   Di Meo, Ivano ^a   Auricchio, Alberto ^c   Ciusani, Emilio ^a   Marchet, Silvia ^a   Lamperti, Costanza ^a   D'Amati, Giulia ^b   Viscomi, Carlo ^a   Zeviani, Massimo ^a,d  

^a DEPARTMENT OF NEUROSURGERY   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LIVER PROTECTIVE AGENT; MITOCHONDRIAL DNA; MPV17 PROTEIN; UNCLASSIFIED DRUG; VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG DNA BINDING; DRUG EFFECT; DRUG MECHANISM; GENE; GENE DOSAGE; GENE FUNCTION; GENE IDENTIFICATION; IN VIVO STUDY; KETOGENIC DIET; LIVER CIRRHOSIS; LIVER FAILURE; LIVER HISTOLOGY; LIVER PROTECTION; LIVER REGENERATION; MOLECULAR WEIGHT; MOUSE; MPV17 GENE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PROTEIN DETERMINATION; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; VIRUS IDENTIFICATION;

ADENO-ASSOCIATED VIRUS; ANIMALIA; MUS;

ANIMALS; CELL LINE; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; GENE EXPRESSION; GENETIC THERAPY; GENETIC VECTORS; GENOTYPE; HUMANS; KETOGENIC DIET; LIVER CIRRHOSIS; LIVER FAILURE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; MOLECULAR WEIGHT; PHENOTYPE; PROTEIN MULTIMERIZATION;

EID: 84891835674     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.230     Document Type: Article

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