More than apples and oranges - Detecting cancer with a fruit fly's antenna

Scientific Reports

Volumn 4, Issue SREP03576, 2014, Pages

  Strauch, Martin ^a   Lüdke, Alja ^a   Münch, Daniel ^a   Laudes, Thomas ^a   Giovanni Galizia, C ^a,b   Martinelli, Eugenio ^b   Lavra, Luca ^c   Paolesse, Roberto ^b   Ulivieri, Alessandra ^b   Catini, Alexandro ^b   Capuano, Rosamaria ^b   Di Natale, Corrado ^b  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

VOLATILE ORGANIC COMPOUND;

ANIMAL; ANTENNA (ORGAN); ARTICLE; CHEMISTRY; DROSOPHILA MELANOGASTER; HUMAN; NEOPLASM; ODOR; OLFACTORY RECEPTOR; PHYSIOLOGY;

ANIMALS; ARTHROPOD ANTENNAE; DROSOPHILA MELANOGASTER; HUMANS; NEOPLASMS; ODORS; OLFACTORY RECEPTOR NEURONS; VOLATILE ORGANIC COMPOUNDS;

EID: 84891819098     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep03576     Document Type: Article

References (55)

1. Tennant, D. A., Durán, R. V. & Gottlieb, E. Targeting metabolic transformation for cancer therapy. Nat. Rev. Cancer 10, 267-277 (2010).
2. Ward, P. S. & Thompson, C. B. Metabolic reprogramming: A cancer hallmark even Warburg did not anticipate. Cancer Cell 21, 297-308 (2012).
3. Kneepkens, C. M., Lepage, G. & Roy, C. C. The potential of the hydrocarbon breath test as ameasure of lipid peroxidation. Free Radical Biol. Med. 17, 127-160 (1994). (Pubitemid 24217183)
4. Singer, S. J. & Nicolson, G. L. The fluid mosaic model of the structure of cell membranes. Science 175, 720-731 (1972).
5. Jerby, L. et al. Metabolic associations of reduced proliferation and oxidative stress in advanced breast cancer. Cancer Res. 72, 5712-5720 (2012).
6. Hoffman, S. A., Joo, W.-A., Echan, L. A. & Speicher, D. W. Higher dimensional (hi-d) separation strategies dramatically improve the potential for cancer biomarker detection in serum and plasma. J. Chromatogr. B 849, 43-52 (2007). (Pubitemid 46529317)
7. Solassol, J., Du-Thanh, A., Maudelonde, T. & Guillot, B. Serum proteomic profiling reveals potential biomarkers for cutaneous malignant melanoma. Int. J. Biol. Markers 26, 82-87 (2011).
8. Phillips, M. et al. Volatile organic compounds in breath as markers of lung cancer: a cross-sectional study. Lancet 353, 1930-1933 (1999). (Pubitemid 29255706)
9. Amann, A., Spanel, P. & Smith, D. Breath analysis: The approach towards clinical applications. Mini-Rev. Med. Chem. 7, 115-129 (2007). (Pubitemid 46592175)
10. Hakim, M. et al. Volatile organic compounds of lung cancer and possible biochemical pathways. Chem. Rev. 112, 5949-5966 (2012).
11. Barash, O., Peled, N., Hirsch, F. R. & Haick, H. Sniffing the unique "odor print" of non-small-cell lung cancer with gold nanoparticles. Small 5, 2618-2624 (2009).
12. Filipiak, W. et al. Release of volatile organic compounds (VOCs) from the lung cancer cell line CALU-1 in vitro. Cancer Cell Int. 8, 17 (2008).
13. Bartolazzi, A. et al. A sensor array and GC study about VOCs and cancer cells. Sens. Actuators, B 146, 483-488 (2010).
14. Di Natale, C. et al. Lung cancer identification by the analysis of breath by means of an array of non-selective gas sensors. Biosens. Bioelectron. 18, 1209-1218 (2003). (Pubitemid 36776581)
15. Peng, G. et al. Diagnosing lung cancer in exhaled breath using gold nanoparticles. Nat. Nanotechnol. 4, 669-673 (2009).
16. Kwak, J. et al. Volatile biomarkers from human melanoma cells. J. Chromatogr. B 931, 90-96 (2013).
17. Persaud, K. & Dodd, G. H. Analysis of discrimination mechanisms in the mammalian olfactory system using a model nose. Nature 299, 352-355 (1982). (Pubitemid 12012862)
18. Röck, F., Barsan, N. & Weimar, U. Electronic nose: Current status and future trends. Chem. Rev. 108, 705-725 (2008). (Pubitemid 351344454)
19. Berna, A. Z., Anderson, A. R. & Trowell, S. C. Bio-benchmarking of electronic nose sensors. PLoS ONE 4, e6406 (2009).
20. Williams, H. & Pembroke, A. Sniffer dogs in the melanom clinic? Lancet 333, 734 (1989).
21. Church, J. & Williams, H. Another sniffer dog for the clinic? Lancet 358, 930 (2001).
22. Lippi, G. & Cervellin, G. Canine olfactory detection of cancer versus laboratory testing: myth or opportunity? Clin. Chem. Lab. Med. 50, 435-439 (2012).
23. Boedeker, E., Friedel, G. & Walles, T. Sniffer dogs as part of a bimodal bionic research approach to develop a lung cancer screening. Interact. Cardiovasc. Thorac. Surg. 14, 511-515 (2012).
24. Pickel, D., Manucy, G. P., Walker, D. B., Hall, S. B. & Walker, J. C. Evidence for canine olfactory detection of melanoma. Appl. Anim. Behav. Sci. 89, 107-116 (2004). (Pubitemid 39301104)
25. Willis, C. M. Olfactory detection of human bladder cancer by dogs: proof of principle study. BMJ 329, 712-0 (2004).
26. Cornu, J.-N., Cancel-Tassin, G., Ondet, V., Girardet, C. & Cussenot, O. Olfactory detection of prostate cancer by dogs sniffing urine: A step forward in early diagnosis. Eur. Urol. 59, 197-201 (2011).
27. McCulloch, M. et al. Diagnostic accuracy of canine scent detection in early-and late-stage lung and breast cancers. Integr. Cancer. Ther. 5, 30-39 (2006). (Pubitemid 43260792)
28. Ehmann, R. et al. Canine scent detection in the diagnosis of lung cancer: revisiting a puzzling phenomenon. Eur. Respir. J. 39, 669-676 (2012).
29. Horvath, G., Järverud, G. a. K., Järverud, S. & Horvath, I. Human ovarian carcinomas detected by specific odor. Integr. Cancer. Ther. 7, 76-80 (2008). (Pubitemid 351806533)
30. Horvath, G., Andersson, H. & Paulsson, G. Characteristic odour in the blood reveals ovarian carcinoma. BMC Cancer 10, 643 (2010).
31. Sonoda, H. et al. Colorectal cancer screening with odour material by canine scent detection. Gut 60, 814-819 (2011).
32. Marshall, B., Warr, C. G. & de Bruyne, M. Detection of volatile indicators of illicit substances by the olfactory receptors of Drosophila melanogaster. Chem Senses 35, 613-625 (2010).
33. Hallem, E. A., Ho, M. G. & Carlson, J. R. The molecular basis of odor coding in the Drosophila antenna. Cell 117, 965-79 (2004). (Pubitemid 38798861)
34. Hallem, E. A. & Carlson, J. R. Coding of odors by a receptor repertoire. Cell 125, 143-60 (2006).
35. Galizia, C. G., Münch, D., Strauch, M., Nissler, A. & Ma, S. Integrating Heterogeneous Odor Response Data into a Common Response Model: A DoOR to the Complete Olfactome. Chem. Senses 35, 551-563 (2010).
36. Charpak, S., Mertz, J., Beaurepaire, E., Moreaux, L. & Delaney, K. Odor-evoked calcium signals in dendrites of rat mitral cells. PNAS 98, 1230-1234 (2001). (Pubitemid 32121215)
37. Tian, L. et al. Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators. Nat. Methods 6, 875-81 (2009).
38. Lucas, P. & Shimahara, T. Voltage-and calcium-activated currents in cultured olfactory receptor neurons of male mamestra brassicae (Lepidoptera). Chem. Senses 27, 599-610 (2002).
39. Grienberger, C. & Konnerth, A. Imaging calcium in neurons. Neuron 73, 862-885 (2012).
40. Wicher, D. et al. Drosophila odorant receptors are both ligand-gated and cyclicnucleotide-activated cation channels. Nature 452, 1007-11 (2008). (Pubitemid 351589619)
41. Sato, K., Pellegrino, M., Nakagawa, T. T., Vosshall, L. B. & Touhara, K. Insect olfactory receptors are heteromeric ligand-gated ion channels. Nature 452, 1002-6 (2008). (Pubitemid 351589615)
42. 2+ probe composed of a single green fluorescent protein. Nat. Biotechnol. 19, 137-41 (2001). (Pubitemid 32144441)
43. Couto, A., Alenius, M. & Dickson, B. J. Molecular, anatomical, and functional organization of the Drosophila olfactory system. Curr. Biol. 15, 1535-1547 (2005). (Pubitemid 41219592)
44. Pelz, D., Roeske, T., Syed, Z., Bruyne, M. d. & Galizia, C. G. The molecular receptive range of an olfactory receptor in vivo (Drosophila melanogaster Or22a). J. Neurobiol. 66, 1544-1563 (2006). (Pubitemid 46005367)
45. Angioy, A. M., Desogus, A., Barbarossa, I. T., Anderson, P. & Hansson, B. S. Extreme sensitivity in an olfactory system. Chem. Senses 28, 279-284 (2003). (Pubitemid 39144821)
46. Weissbecker, B., Holighaus, G. & Schütz, S. Gas chromatography with mass spectrometric and electroantennographic detection: analysis of wood odorants by direct coupling of insect olfaction andmass spectrometry. J. Chromatogr. A 1056, 209-216 (2004). (Pubitemid 39505126)
47. Park, K. C., Zhu, J., Harris, J., Ochieng, S. A. & Baker, T. C. Electroantennogram responses of a parasitic wasp, Microplitis croceipes, to host-related volatile and anthropogenic compounds. Physiol. Ent. 26, 69-77 (2001). (Pubitemid 32228559)
48. Schöning, M. J., Schroth, P. & Schütz, S. The use of insect chemoreceptors for the assembly of biosensors based on semiconductor field-effect transistors. Electroanalysis 12, 645-652 (2000).
49. Schütz, S. et al. An insect-based BioFET as a bioelectronic nose. Sens. Actuators, B 65, 291-295 (2000).
50. Park, K. C., Ochieng, S. A., Zhu, J. & Baker, T. C. Odor discrimination using insect electroantennogram responses from an insect antennal array. Chem. Senses 27, 343-352 (2002). (Pubitemid 34537541)
51. de Bruyne, M., Foster, K. & Carlson, J. R. Odor coding in the Drosophila antenna. Neuron 30, 537-552 (2001). (Pubitemid 32530595)
52. Giannini, G. et al. EGF-and cell-cycle-regulated STAG1/PMEPA1/ERG1.2 belongs to a conserved gene family and is overexpressed and amplified in breast and ovarian cancer. Mol. Carcinog. 38, 188-200 (2003). (Pubitemid 37523711)
53. Münch, D., Schmeichel, B., Silbering, A. F. & Galizia, C. G. Weaker ligands can dominate an odor blend due to syntopic interactions. Chem. Senses 38, 293-304 (2013).
54. Strauch, M., Rein, J., Lutz, C. & Galizia, C. G. Signal extraction from movies of honeybee brain activity by convex analysis: The ImageBee plugin for KNIME. BMC Bioinformatics 14:(Suppl 18):S4 (2013).
55. Strauch, M., Rein, J. & Galizia, C. G. Signal extraction from movies of honeybee brain activity by convex analysis. In Mandoiu, I., Pop, M., Rajasekaran, S. & Spouge, J. (eds.) Proceedings of ICCABS, Feb 23-25 2012, Las Vegas, USA, IEEE (2012).