Effects of extracts of unripe black raspberry and red ginseng on cholesterol synthesis

Korean Journal of Food Science and Technology

Volumn 45, Issue 5, 2013, Pages 628-635

  Lee, Su Jung ^a   Lee, Min Jung ^a   Ko, Young Jong ^a   Choi, Hye Ran ^a   Jeong, Jong Tae ^a   Choi, Kyung Min ^b   Cha, Jeong Dan ^b   Hwang, Seung Mi ^b   Jung, Hoo Kil ^c   Park, Jong Hyuk ^c   Lee, Tae Bum ^a  

^a Gochang Black Raspberry Research Institute   (South Korea)

^b Institute of JinAn Red Ginseng   (South Korea)

^c Lmsil Research Institute of Cheese Science   (South Korea)

Author keywords

3 hydroxy 3 methylglutaryl CoA reductase; Black raspberry; High density lipoprotein; Low density lipoprotein; Red ginseng

Indexed keywords

EID: 84891810888     PISSN: 03676293     EISSN: None     Source Type: Journal    
DOI: 10.9721/KJFST.2013.45.5.628     Document Type: Article

References (34)

1. Lim S, Shin H, Song JH, Kwak SH, Kang SM, Won Yoon J, Choi SH, Cho SI, Park KS, Lee HK, Jang HC, Koh KK. Increasing prevalence of metabolic syndrome in Korea: the Korean National Health and Nutrition Examination Survey for 1998-2007. Diabetes Care 34: 1323-1328 (2011)
2. Zimmet P, Alberti G, Shaw J. A new IDF worldwide definition of the metabolic syndrome: the rationale and the results. Diabetes Voice 50: 31-33 (2005)
3. Gupta AK, Dahlof B, Sever PS, Poulter NR. Metabolic syndrome, independent of its components, is a risk factor for stroke and death but not for coronary heart disease among hypertensive patients in the ASCOTBPLA. Diabetes Care 33: 1647-1651 (2010)
4. Korea National Statistics Office. Death statistics in 2011. Korea National Statistical Office, Daejeon, Korea (2011)
5. Moon SJ. Nutritional problems of Korean. J. Nutr. Health 29: 371-380 (1996)
6. Yotsumoto H, Yanagita T, Yamamoto K, Ogawa Y, Cha JY, Mori Y. Inhibitory effect of Oren-Gedoku-to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells. Evidence from the cultured HepG2 cells and in vitro assay of ACAT. Planta Med. 63: 141-145 (1997) (Pubitemid 27196082)
7. Kim BK, Shin GG, Jeon BS, Cha JY. Cholesterol-lowering effect of mushrooms powder in hyperlipidemic rats. J. Korean Soc. Food Sci. Nutr. 30: 510-515 (2001) (Pubitemid 33332820)
8. Yang HM, Oh SM, Lim SS, Shin HK, Oh YS, Kim JK. Antiinflammatory activities of Rubus coreanus depend on the degree of fruit ripening. Phytother. Res. 22: 102-107 (2008)
9. Shibata S, Tanaka O, Ando T, Sado M, Tsushima S, Ohsawa T. Chemical studies on oriental plants drugs: Protopanaxadiol, a genuine saponin of ginseng saponin. Chem. Pharm. Bull. 14: 595-600 (1966)
10. Lee SH, Park JH, Cho NS, Yu HJ, You SK, Cho CW, Kim DC, Kim YH, Kim KH. Sensory evaluation and bioavailability of red ginseng extract (Rg1, Rb1) by complexation with -cyclodextrin. Korean J. Food Sci. Technol. 41: 106-110 (2009)
11. Joo CN, Koo JH. Biochemical study of some pharmacological effects of Panax ginseng C. A. Meyer. Korean Biochem. J. 13: 63-80 (1980)
12. Yoon SH, Joo CN. Study on the preventive effect of ginsenosides against hypercholesterolemia and its mechanism. Korean J. Ginseng Sci. 17: 1-12 (1993)
13. Kang BH, Koo JH, Joo CN. Effect of saponin fraction of Panax ginseng C. A. Meyer on blood serum lipoprotein distribution of cholesterol fed rabbits. Korean J. Ginseng Sci. 10: 114-121 (1986)
14. Xiu RJ. Microcirculation and traditional Chinese medicine. JAMA-J. Am. Med. Assoc. 260: 1755-1757 (1988)
15. Kim ID, Kang KS, Kwon RH, Yang JO, Lee JS, Ha BJ. The effect of Rubus coreanum Miquel against lipopolysaccharideinduced oxidative stress and lipid metabolism. J. Fd. Hyg. Safety 22: 213-217 (2007)
16. Sung JH, So NW, Jeon BH, Chang CC. Effect of white and red Panax ginseng extract on serum lipids level in high-fat-diet fed rats. J. Ginseng Res. 28: 33-38 (2004)
17. Park HJ, Lee JH, Ham HS, Cho HJ, Lim CR, Yoo YB, Park KH. Effects of intaking of red ginseng products on correlationship between obesity and blood lipids. Korean J. Biomed. Lab. Sci. 6: 253-260 (2000)
18. Kwon JW, Lee HK, Park HJ, Kwon TO, Choi HR, Song JY. Screening of biological activities to different ethanol extracts of Rubus coreanus Miq. Korean J. Medicinal Crop Sci. 19: 325-333 (2011)
19. Kim JM, Shin MS. Characteristics of Rubus coreanus Miq. fruits at different ripening stages. Korean J. Food Sci. Technol. 43: 341-347 (2011)
20. Park SH, Kim JL, Lee ES, Han SY, Gong JH, Kang MK, Kang YH. Dietary ellagic acid attenuates oxidized LDL uptake and stimulates cholesterol efflux in murine macrophages. J. Nutr. 141: 1931-1937 (2011)
21. Ngamukote S, Mäkynen K, Thilawech T, Adisakwattana S. Cholesterol-lowering activity of the major polyphenols in grape seed. Molecules 16: 5054-5061 (2011)
22. Kim EJ, Lee HI, Chung KY, Noh YH, Ro YT, Koo JH. The Ginsenoside- Rb2 lowers cholesterol and triacylglycerol levels in 3T3- L1 adipocytes cultured under high cholesterol or fatty acids conditions. BMB Rep. 42: 194-199 (2009)
23. Lee S, Lee MS, Kim CT, Kim IH, Kim Y. Ginsenoside Rg3 reduces lipid accumulation with AMP-activated protein kinase (AMPK) activation in HepG2 cells. Int. J. Mol. Sci. 13: 5729- 5739 (2012)
24. Brown MS, Goldstein JL. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89: 331-340 (1997) (Pubitemid 27220877)
25. Magaña MM, Koo SH, Towle HC, Osborne TF. Different sterol regulatory element-binding protein-1 isoforms utilize distinct coregulatory factors to activate the promoter for fatty acid synthase. J. Biol. Chem. 275: 4726-4733 (2000) (Pubitemid 30108861)
26. Yokoyama C, Wang X, Briggs MR, Admon A, Wu J, Hua X, Goldstein JL, Brown MS. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell 75: 187-197 (1993) (Pubitemid 23306032)
27. Horton JD, Shimomura I, Brown MS, Hammer RE, Goldstein JL, Shimano H. Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2. J. Clin. Invest. 101: 2331-2339 (1998) (Pubitemid 28270427)
28. Tsujita M, Wu CA, Abe-Dohmae S, Usui S, Okazaki M, Yokoyama S. On the hepatic mechanism of HDL assembly by the ABCA1/apoA-I pathway. J. Lipid Res. 46: 154-162 (2005) (Pubitemid 40066681)
29. Xia M, Hou M, Zhu H, Ma J, Tang Z, Wang Q, Li Y, Chi D, Yu X, Zhao T, Han P, Xia X, Ling W. Anthocyanins induce cholesterol efflux from mouse peritoneal macrophages: the role of the peroxisome proliferator-activated receptor {gamma}-liver X receptor {alpha}-ABCA1 pathway. J. Biol. Chem. 280: 36792-36801 (2005) (Pubitemid 41587759)
30. Brundert M, Heeren J, Bahar-Bayansar M, Ewert A, Moore KJ, Rinninger F. Selective uptake of HDL cholesteryl esters and cholesterol efflux from mouse peritoneal macrophages independent of SR-BI. J. Lipid Res. 47: 2408-2421 (2006) (Pubitemid 44936103)
31. Krause BR, Auerbach BJ. Reverse cholesterol transport and future pharmacological approaches to the treatment of atherosclerosis. Curr. Opin. Investig. D. 2: 375-381 (2001) (Pubitemid 32279782)
32. Yasuda A, Natsume M, Osakabe N, Kawahata K, Koga J. Cacao polyphenols influence the regulation of apolipoprotein in HepG2 and Caco2 cells. J. Agr. Food Chem. 59: 1470-1476 (2011)
33. Mullen E, Brown RM, Osborne TF, Shay NF. Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells. J. Nutr. 134: 2942-2947 (2004) (Pubitemid 39470066)
34. Pal S, Ho N, Santos C, Dubois P, Mamo J, Croft K, Allister E. Red wine polyphenolics increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells. J. Nutr. 133: 700-706 (2003) (Pubitemid 36268342)