Inhibitory effects of Oren-gedoku-to and its components on cholesteryl ester synthesis in cultured human hepatocyte HepG2 cells: Evidence from the cultured HepG2 cells and in vitro assay of ACAT

Planta Medica

Volumn 63, Issue 2, 1997, Pages 141-145

  Yotsumoto, H ^a   Yanagita, T ^a   Yamamoto, K ^a   Ogawa, Y ^a   Cha, J Y ^a   Mori, Y ^a  

^a SAGA UNIVERSITY   (Japan)

Author keywords

14C oleic acid; ACAT; baicaleine; cholesteryl ester; Coptis japonica; Gardenia jasminoides; HepG2 cells; herbal medicine; Oren gedoku to; Phellodendron amurense; Scutellaria baicalensis

Indexed keywords

BAICALEIN; CELL PROTEIN; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; CHOLESTEROL ESTER; COPTIS JAPONICA EXTRACT; FLAVONOID; GARDENIA JASMINOIDES EXTRACT; KAMPO; OLEIC ACID; ORENGEDOKU TO; PHELLODENDRON AMURENSE EXTRACT; PLANT EXTRACT; RADIOISOTOPE; SCUTELLARIA BAICALENSIS EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CHINESE HERB; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HERB; HUMAN; HUMAN CELL; LIPOGENESIS; LIVER CELL CULTURE; TRADITIONAL MEDICINE;

COPTIS JAPONICA; GARDENIA ANGUSTA; JAPONICA; PHELLODENDRON AMURENSE; SCUTELLARIA BAICALENSIS;

EID: 0031002621     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-957631     Document Type: Article

References (28)

1. Miller, J. P. (1995) Curr. Opin. Lipidol. 6, D15-D19.
2. Dietschy, J. M., Turley, S. D., Spady, D. K. (1993) J. Lipid Res. 34, 1637-1659.
3. Yamamoto, M., Uemura, T., Nakama, S., Uemiya, M., Deguchi, H., Miki, S., Tsukada, S. (1986) WAKAN-YAKU 3, 240-341.
4. Haranaka, R., Hasegawa, R., Kosoto, H., Owada, S., Hirano, N., Hanawa, T., Iimura, F., Nakagawa, S. (1986) WAKAN-YAKU 3, 51-57.
5. Shirai, K., Saito, Y., Morisaki, S., Kamizaki, T., Shiki, Y., Motoyama, N., Yoshida, S. (1987) Ther. Res. 6, 221-227.
6. Yamamoto, K., Sakai, T., Yanagita, T., Saku, K. (1991) Prog. Med. 11, 432-438.
7. Yamamoto, K., Ogawa, Y., Yanagita, T., Morito, F., Fukushima, N., Ozaki, I., Mizuta, T., Setoguchi, Y., Sakai, T. (1995) J. Ethnopharmacol. 46, 49-54.
8. Balasubramaniam, S., Mitropoulos, K. A., Myant, N. B., Mancini, M., Postiglione, A. (1979) Clin. Sci. 56, 373-375.
9. Erickson, S. K., Cooper, A. D. (1980) Metabolism 29, 991-996.
10. Einarsson, K., Benthin, L., Ewerth, S., Hellers, G., Stahlberg, D., Angelin, B. (1989) J. Lipid Res. 30, 739-746.
11. Fungwe, T. V., Cagen, L., Wilcox, H. G., Heimberg, M. (1992) J. Lipid Res. 33, 179-191.
12. Drevon, C. A., Engehorn, S. C., Steinberg, D. (1980) J. Lipid Res. 21, 1065-1071.
13. Krause, B. R., Anderson, M., Bisgaier, C. L., Bocan, T., Bousley, S., DeHart, S., Essenburg, A., Hamelehle, K., Homan, R., Kieft, K., McNally, W., Stanfield, R., Newton, R. S. (1993) J. Lipid Res. 34, 279-297.
14. Krause, B. R., Pape, M. E., Kieft, K., Auerbach, B., Bisgaier, C. L., Homan, R., Newton, R. S. (1994) Arterioscler. Thromb. 14, 598-604.
15. Turley, S. D., Herndon, M. W., Dietschy, J. M. (1994) J. Lipid Res. 35, 328-339.
16. Yanagita, T., Sonda, K., Yamamoto, K., Yotsumoto, H., Nunez, J. H., Murakami, S. (1995) Curr. Ther. Res. 56, 787-795.
17. Wu, X., Sakata, N., Lui, E., Ginsberg, H. N. (1994) J. Biol. Chem. 269, 12375, 1994.
18. Burrier, R. E., Deren, S., McGregor, D. G., Hoos, L. M., Smith, A. A., Davis, Jr. H. R. (1994) Biochem. Pharmacol. 47, 1545-1551.
19. Dashti, N. (1992) J. Biol. Chem. 267, 7160-7169.
20. Yanagita, T., Yamamoto, K., Ishida, S., Sonda, K., Morito, F., Saku, K., Sakai, T. (1994) Clin. Ther. 16, 200-208.
21. Saeki, M. personal communication.
22. Helgerud, P., Peterson, B., Norm, K. R. (1982) J. Lipid Res. 23, 609-618.
23. Ross, A. C. Go, K. G., Heider, J. G., Rothblat, G. H. (1984) J. Biol. Chem. 259, 815-819.
24. Bligh, E. G., Dyer, W. J. (1959) Can. J. Biochem. Physiol. 37, 911-917.
25. Yanagita, T., Satoh, M., Enomoto, N., Sugano, M. (1987) Biochim. Biophys. Acta 919, 64-70.
26. Lowry, O. H., Rosenbrough, N. J., Farr, A. L., Ranll, R. J. (1951) J. Biol. Chem. 193, 265-275.
27. Steel, R. G. D., Torrie, J. H. (1980) Principles and procedures of statistics, A biomedical Approach, pp. 124-156, McGraw Hill Publishing Co., New York.
28. Roth, B. D., Blankley, C. J., Hoefel, M., Holmes, A., Roark, W. H., Trived, B. K., Essentburg, A. D., Kieft, K. A., Krause, B. R., Stanfield, R. L. (1992) J. Med. Chem. 35, 1609-1617.