MicroRNA-155 controls RB phosphorylation in normal and malignant B lymphocytes via the noncanonical TGF-β1/SMAD5 signaling module

Blood

Volumn 123, Issue 1, 2014, Pages 86-93

  Jiang, Daifeng ^a   Aguiar, Ricardo C T ^a,b,c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b University of Texas Health Science Center at San Antonio   (United States)

^c SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA 155; PROTEIN P15; PROTEIN P21; RETINOBLASTOMA PROTEIN; SMAD5 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; MICRORNA; MIRN155 MICRORNA, MOUSE; SMAD5 PROTEIN, MOUSE;

ARTICLE; B LYMPHOCYTE; G1 PHASE CELL CYCLE CHECKPOINT; GENETIC ANALYSIS; HUMAN; HUMAN CELL; LARGE CELL LYMPHOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ANIMAL; CELL CYCLE; CELL STRAIN HEK293; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MOUSE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPLEEN; T LYMPHOCYTE; TUMOR CELL LINE;

ANIMALS; B-LYMPHOCYTES; CELL CYCLE; CELL LINE, TUMOR; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; LYMPHOMA, LARGE B-CELL, DIFFUSE; MICE; MICE, KNOCKOUT; MICRORNAS; PHOSPHORYLATION; RETINOBLASTOMA PROTEIN; SIGNAL TRANSDUCTION; SMAD5 PROTEIN; SPLEEN; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84891803020     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-07-515254     Document Type: Article

References (27)

1. Lovat F, Valeri N, Croce CM MicroRNAs in the pathogenesis of cancer. Semin Oncol. 2011; 38(6): 724-733.
2. Selbach M, Schwanhäusser B, Thierfelder N., Fang Z, Khanin R, Rajewsky N. Widespread changes in protein synthesis induced by microRNAs. Nature. 2008; 455(7209): 58-63.
3. Massagué J, Seoane J, Wotton D. Smad transcription factors. Genes Dev. 2005; 19(23): 2783-2810. (Pubitemid 41739965)
4. Massagué J. TGFbeta in Cancer. Cell. 2008; 134(2): 215-230.
5. Dong M, Blobe GC Role of transforming growth factor-beta in hematologic malignancies. Blood. 2006; 107(12): 4589-4596. (Pubitemid 43882602)
6. Li MO, Wan YY, Sanjabi S, Robertson A.K., Flavell RA Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol. 2006; 24: 99-146.
7. Rai D, Kim SW, McKeller M.R., Dahia PL, Aguiar RC Targeting of SMAD5 links microRNA-155 to the TGF-beta pathway and lymphomagenesis. Proc Natl Acad Sci USA. 2010; 107(7): 3111-3116.
8. Monti S, Chapuy B, Takeyama K., et al Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma. Cancer Cell. 2012; 22(3): 359-372.
9. Jardin F, Jais JP, Molina T.J., et al Diffuse large B-cell lymphomas with CDKN2A deletion have a distinct gene expression signature and a poor prognosis under R-CHOP treatment: a GELA study. Blood. 2010; 116(7): 1092-1104.
10. Thai TH, Calado DP, Casola S, et al Regulation of the germinal center response by microRNA-155. Science. 2007; 316(5824): 604-608. (Pubitemid 46683147)
11. Kim SW, Rai D, McKeller M.R., Aguiar RC Rational combined targeting of phosphodiesterase 4B and SYK in DLBCL. Blood. 2009; 113(24): 6153-6160.
12. Kim SW, Ramasamy K, Bouamar H., Lin AP, Jiang D, Aguiar RC MicroRNAs miR-125a and miR-125b constitutively activate the NF-kB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20). Proc Natl Acad Sci USA. 2012; 109(20): 7865-7870.
13. Kim SW, Rai D, Aguiar RC Gene set enrichment analysis unveils the mechanism for the phosphodiesterase 4B control of glucocorticoid response in B-cell lymphoma. Clin Cancer Res. 2011; 17(21): 6723-6732.
14. Huse K, Bakkebø M, Wälchli S, et al. Role of Smad proteins in resistance to BMP-induced growth inhibition in B-cell lymphoma. PLoS ONE. 2012; 7(10):e46117.
15. Seoane J, Le HV, Shen L, Anderson S.A., Massagué J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell. 2004; 117(2): 211-223. (Pubitemid 38496241)
16. Seoane J, Pouponnot C, Staller P., Schader M, Eilers M, Massagué J. TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat Cell Biol. 2001; 3(4): 400-408. (Pubitemid 32288448)
17. Chau BN, Wang JY Coordinated regulation of life and death by RB. Nat Rev Cancer. 2003; 3(2): 130-138. (Pubitemid 37328880)
18. Chen HZ, Tsai SY, Leone G. Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer. 2009; 9(11): 785-797.
19. Starostina NG, Kipreos ET Multiple degradation pathways regulate versatile CIP/KIP CDK inhibitors. Trends Cell Biol. 2012; 22(1): 33-41.
20. Goumans MJ, Valdimarsdottir G, Itoh S., Rosendahl A, Sideras P, ten Dijke P. Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J. 2002; 21(7): 1743-1753. (Pubitemid 34614630)
21. Wrighton KH, Lin X, Yu P.B., Feng XH Transforming growth factor beta can stimulate Smad1 phosphorylation independently of bone morphogenic protein receptors. J Biol Chem. 2009; 284(15): 9755-9763.
22. Daly AC, Randall RA, Hill CS Transforming growth factor beta-induced Smad1/5 phosphorylation in epithelial cells is mediated by novel receptor complexes and is essential for anchorage-independent growth. Mol Cell Biol. 2008; 28(22): 6889-6902.
23. Grö nroos E, Kingston IJ, Ramachandran A, Randall RA, Vizán P, Hill CS. Transforming growth factor b inhibits bone morphogenetic protein-induced transcription through novel phosphorylated Smad1/5-Smad3 complexes. Mol Cell Biol. 2012; 32(14): 2904-2916.
24. Eis PS, Tam W, Sun L., et al Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci USA. 2005; 102(10): 3627-3632. (Pubitemid 40354662)
25. Jung I, Aguiar RC MicroRNA-155 expression and outcome in diffuse large B-cell lymphoma. Br J Haematol. 2009; 144(1): 138-140.
26. Rai D, Karanti S, Jung I., Dahia PL, Aguiar RC Coordinated expression of microRNA-155 and predicted target genes in diffuse large B-cell lymphoma. Cancer Genet Cytogenet. 2008; 181(1): 8-15. (Pubitemid 351192031)
27. Lawrie CH. MicroRNAs and lymphomagenesis: a functional review. Br J Haematol. 2013; 160(5): 571-581.