메뉴 건너뛰기




Volumn 35, Issue 1, 2014, Pages 89-97

Yhhu3813 is a novel selective inhibitor of c-Met Kinase that inhibits c-met-dependent neoplastic phenotypes of human cancer cells

Author keywords

anticancer drug; c Met; human cancer; receptor tyrosine kinase; xenograft nude mouse model; Yhhu3813

Indexed keywords

[6 (6 FLUORO 1 H INDOL 1 YL) 2 [2 [[7 [3 (4 METHYLPIPERAZIN 1 YL)PROPOXY]QUINOLIN 4 YL]OXY]ETHYL]PYRIDAZIN 2(2H) ONE]; ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; EPHRIN RECEPTOR A2; EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR RECEPTOR 1; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; YHHU 3813;

EID: 84891800475     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2013.125     Document Type: Article
Times cited : (16)

References (28)
  • 4
    • 19544389146 scopus 로고    scopus 로고
    • C-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention
    • DOI 10.1016/j.canlet.2004.09.044, PII S0304383504007657
    • Christensen JG, Burrows J, Salgia R. c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention. Cancer Lett 2005; 225: 1-26. (Pubitemid 40732764)
    • (2005) Cancer Letters , vol.225 , Issue.1 , pp. 1-26
    • Christensen, J.G.1    Burrows, J.2    Salgia, R.3
  • 5
    • 66149135285 scopus 로고    scopus 로고
    • The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma
    • Seiwert TY, Jagadeeswaran R, Faoro L, Janamanchi V, Nallasura V, El Dinali M, et al. The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res 2009; 69: 3021-31.
    • (2009) Cancer Res , vol.69 , pp. 3021-3031
    • Seiwert, T.Y.1    Jagadeeswaran, R.2    Faoro, L.3    Janamanchi, V.4    Nallasura, V.5    El Dinali, M.6
  • 7
    • 55449116539 scopus 로고    scopus 로고
    • Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer
    • Okuda K, Sasaki H, Yukiue H, Yano M, Fujii Y. Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer. Cancer Sci 2008; 99: 2280-5.
    • (2008) Cancer Sci , vol.99 , pp. 2280-2285
    • Okuda, K.1    Sasaki, H.2    Yukiue, H.3    Yano, M.4    Fujii, Y.5
  • 8
    • 81255138189 scopus 로고    scopus 로고
    • A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3
    • Liu X, Wang Q, Yang G, Marando C, Koblish HK, Hall LM, et al. A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3. Clin Cancer Res 2011; 17: 7127-38.
    • (2011) Clin Cancer Res , vol.17 , pp. 7127-7138
    • Liu, X.1    Wang, Q.2    Yang, G.3    Marando, C.4    Koblish, H.K.5    Hall, L.M.6
  • 9
    • 33748981862 scopus 로고    scopus 로고
    • The significance of serum hepatocyte growth factor levels in planning follow-up of postoperative jaundice-free patients with biliary atresia
    • DOI 10.1016/j.jpedsurg.2006.05.058, PII S0022346806003964
    • Toiyama Y, Miki C, Inoue Y, Okugawa Y, Tanaka K, Kusunoki M. Serum hepatocyte growth factor as a prognostic marker for stage II or III colorectal cancer patients. Int J Cancer 2009; 125: 1657-62. (Pubitemid 44441370)
    • (2006) Journal of Pediatric Surgery , vol.41 , Issue.10 , pp. 1657-1662
    • Uchida, K.1    Inoue, M.2    Otake, K.3    Yoshiyama, S.4    Toiyama, Y.5    Hiro, J.6    Araki, T.7    Miki, C.8    Kusunoki, M.9
  • 10
    • 58149347700 scopus 로고    scopus 로고
    • Predictive value of plasma hepatocyte growth factor/scatter factor levels in patients with clinically localized prostate cancer
    • Gupta A, Karakiewicz PI, Roehrborn CG, Lotan Y, Zlotta AR, Shariat SF. Predictive value of plasma hepatocyte growth factor/scatter factor levels in patients with clinically localized prostate cancer. Clin Cancer Res 2008; 14: 7385-90.
    • (2008) Clin Cancer Res , vol.14 , pp. 7385-7390
    • Gupta, A.1    Karakiewicz, P.I.2    Roehrborn, C.G.3    Lotan, Y.4    Zlotta, A.R.5    Shariat, S.F.6
  • 11
    • 63849163410 scopus 로고    scopus 로고
    • Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients
    • Cappuzzo F, Marchetti A, Skokan M, Rossi E, Gajapathy S, Felicioni L, et al. Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients. J Clin Oncol 2009; 27: 1667-74.
    • (2009) J Clin Oncol , vol.27 , pp. 1667-1674
    • Cappuzzo, F.1    Marchetti, A.2    Skokan, M.3    Rossi, E.4    Gajapathy, S.5    Felicioni, L.6
  • 12
    • 33847326735 scopus 로고    scopus 로고
    • Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome
    • DOI 10.1016/j.canlet.2006.07.007, PII S0304383506004800
    • Kammula US, Kuntz EJ, Francone TD, Zeng Z, Shia J, Landmann RG, et al. Molecular co-expression of the c-Met oncogene and hepatocyte growth factor in primary colon cancer predicts tumor stage and clinical outcome. Cancer Lett 2007; 248: 219-28. (Pubitemid 46330555)
    • (2007) Cancer Letters , vol.248 , Issue.2 , pp. 219-228
    • Kammula, U.S.1    Kuntz, E.J.2    Francone, T.D.3    Zeng, Z.4    Shia, J.5    Landmann, R.G.6    Paty, P.B.7    Weiser, M.R.8
  • 13
    • 0036217866 scopus 로고    scopus 로고
    • Invasive growth: From development to metastasis
    • DOI 10.1172/JCI200215392
    • Comoglio PM, Trusolino L. Invasive growth: from development to metastasis. J Clin Invest 2002; 109: 857-62. (Pubitemid 34275105)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.7 , pp. 857-862
    • Comoglio, P.M.1    Trusolino, L.2
  • 14
    • 0036221263 scopus 로고    scopus 로고
    • Dysregulation of Met receptor tyrosine kinase activity in invasive tumors
    • DOI 10.1172/JCI200215418
    • Danilkovitch-Miagkova A,Zbar B. Dysregulation of Met receptor tyrosine kinase activity in invasive tumors. J Clin Invest 2002; 109: 863-7. (Pubitemid 34275106)
    • (2002) Journal of Clinical Investigation , vol.109 , Issue.7 , pp. 863-867
    • Danilkovitch-Miagkova, A.1    Zbar, B.2
  • 15
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: Principles and functions in development, organ regeneration and cancer
    • Trusolino L, Bertotti A, Comoglio PM. MET signalling: principles and functions in development, organ regeneration and cancer. N at R ev Mol Cell Biol 2010; 11: 834-48.
    • (2010) N at R Ev Mol Cell Biol , vol.11 , pp. 834-848
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 17
    • 0021285134 scopus 로고
    • Partial formation and characterization of hepatocyte growth factor from serum of hepatectomized rats
    • Nakamura T, Nawa K, Ichihara A. Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun 1984; 122: 1450-9. (Pubitemid 14073577)
    • (1984) Biochemical and Biophysical Research Communications , vol.122 , Issue.3 , pp. 1450-1459
    • Nakamura, T.1    Nawa, K.2    Ichihara, A.3
  • 18
    • 0025734655 scopus 로고
    • Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET
    • Naldini L, Vigna E, Narsimhan RP, Gaudino G, Zarnegar R, Michalopoulos GK, et al. Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene 1991; 6: 501-4. (Pubitemid 21924112)
    • (1991) Oncogene , vol.6 , Issue.4 , pp. 501-504
    • Naldini, L.1    Vigna, E.2    Narsimhan, R.P.3    Gaudino, G.4    Zarnegar, R.5    Michalopoulos, G.K.6    Comoglio, P.M.7
  • 19
    • 0023661693 scopus 로고
    • Scatter factor is a fibroblast-derived modulator of epithelial cell mobility
    • Stoker M, Gherardi E, Perryman M, Gray J. Scatter factor is a fibroblast-derived modulator of epithelial cell mobility. Nature 1987; 327: 239-42. (Pubitemid 17071053)
    • (1987) Nature , vol.326 , Issue.6119 , pp. 239-242
    • Stoker, M.1    Gherardi, E.2    Perryman, M.3    Gray, J.4
  • 21
    • 33746504571 scopus 로고    scopus 로고
    • Invasive growth: A MET-driven genetic programme for cancer and stem cells
    • DOI 10.1038/nrc1912, PII NRC1912
    • Boccaccio C, Comoglio PM. Invasive growth: a MET-driven genetic programme for cancer and stem cells. Nat Rev Cancer 2006; 6: 637-45. (Pubitemid 44140861)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.8 , pp. 637-645
    • Boccaccio, C.1    Comoglio, P.M.2
  • 23
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2: 442-54.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 24
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • DOI 10.1016/j.ceb.2005.08.001, PII S0955067405001043
    • Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005; 17: 548-58. (Pubitemid 41267170)
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.5 SPEC. ISSUE. , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 26
    • 84880923318 scopus 로고    scopus 로고
    • A phase 2 multicenter study of tivantinib (ARQ 197) monotherapy in patients with relapsed or refractory germ cell tumors
    • Feldman DR, Einhorn LH, Quinn DI, Loriot Y, Joffe JK, Vaughn DJ, et al. A phase 2 multicenter study of tivantinib (ARQ 197) monotherapy in patients with relapsed or refractory germ cell tumors. Invest New Drugs 2013; 31:1016-22.
    • (2013) Invest New Drugs , vol.31 , pp. 1016-1022
    • Feldman, D.R.1    Einhorn, L.H.2    Quinn, D.I.3    Loriot, Y.4    Joffe, J.K.5    Vaughn, D.J.6
  • 27
    • 84874787799 scopus 로고    scopus 로고
    • Cabozantinib in patients with advanced prostate cancer: Results of a phase II randomized discontinuation trial
    • Smith DC, Smith MR, Sweeney C, Elfiky AA, Logothetis C, Corn PG, et al. Cabozantinib in patients with advanced prostate cancer: results of a phase II randomized discontinuation trial. J Clin Oncol 2013; 31: 412-9.
    • (2013) J Clin Oncol , vol.31 , pp. 412-419
    • Smith, D.C.1    Smith, M.R.2    Sweeney, C.3    Elfiky, A.A.4    Logothetis, C.5    Corn, P.G.6
  • 28
    • 77956379695 scopus 로고    scopus 로고
    • Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapy
    • Wang MH, Padhye SS, Guin S, Ma Q, Zhou YQ. Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapy. Acta Pharmacol Sin 2010; 31: 1181-8.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 1181-1188
    • Wang, M.H.1    Padhye, S.S.2    Guin, S.3    Ma, Q.4    Zhou, Y.Q.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.