SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 5, 2012, Pages 1969-1975

  Hieke, Martina ^a   Rödl, Carmen B ^a   Wisniewska, Joanna M ^a   La Buscató, Estel ^a   Stark, Holger ^a   Schubert Zsilavecz, Manfred ^a   Steinhilber, Dieter ^a   Hofmann, Bettina ^a   Proschak, Ewgenij ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

5 Lipoxygenase; Allergic diseases; Arachidonic acid cascade; Inflammation; One pot multicomponent reaction

Indexed keywords

IMIDAZO[1,2 A]PYRIDINE DERIVATIVE; LIPOXYGENASE INHIBITOR; N CYCLOHEXYL 6 METHYL 2 (4 MORPHOLINOPHENYL)IMIDAZO[1,2 A]PYRIDINE 3 AMINE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; HUMAN; HUMAN CELL; IC 50; ONE POT SYNTHESIS; STRUCTURE ACTIVITY RELATION; VIRTUAL SCREENING;

ANTI-INFLAMMATORY AGENTS; ARACHIDONATE 5-LIPOXYGENASE; HUMANS; LEUKOCYTES; LIPOXYGENASE INHIBITORS; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84857361838     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.038     Document Type: Article

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