Syk/JNK/AP-1 signaling pathway mediates interleukin-6-promoted cell migration in oral squamous cell carcinoma

International Journal of Molecular Sciences

Volumn 15, Issue 1, 2014, Pages 545-559

  Chuang, Jing Yuan ^a   Huang, Yuan Li ^b   Yen, Wei Lin ^a   Chiang, I Ping ^c   Tsai, Ming Hsui ^c   Tang, Chih Hsin ^a,b,d  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

c Jun N terminal kinase (JNK); Intercellular adhesion molecule 1 (ICAM 1); Interleukin 6 (IL 6); Oral squamous cell carcinoma (OSCC); Syk

Indexed keywords

CURCUMIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSCRIPTION FACTOR AP 1; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; INTERLEUKIN 6 RECEPTOR; MONOCLONAL ANTIBODY; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TYRO3 PROTEIN, HUMAN;

ARTICLE; CELL MIGRATION; CELL VIABILITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MICROSCOPY; MOUTH SQUAMOUS CELL CARCINOMA; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WOUND HEALING; ANTAGONISTS AND INHIBITORS; CELL MOTION; CHEMISTRY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; METABOLISM; MOUTH TUMOR; PATHOLOGY; RNA INTERFERENCE; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE; UPREGULATION;

ANTHRACENES; ANTIBODIES, MONOCLONAL; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MOUTH NEOPLASMS; PHOSPHORYLATION; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, INTERLEUKIN-6; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; UP-REGULATION;

EID: 84891779747     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15010545     Document Type: Article

References (39)

1. Lyons, A.J., Jones, J. Cell adhesion molecules, the extracellular matrix and oral squamous carcinoma. Int. J. Oral Maxillofac. Surg. 2007, 36, 671-679.
2. Bau, D.-T., Lin, C.-C., Chiu, C.-F., Tsai, M.-H. Role of nonhomologous end-joining in oral cancer and personalized pharmacogenomics. BioMedicine 2012, 2, 41-47.
3. Greenberg, J.S., El Naggar, A.K., Mo, V., Roberts, D., Myers, J.N. Disparity in pathologic and clinical lymph node staging in oral tongue carcinoma. Cancer 2003, 98, 508-515.
4. Thomas, G.J., Speight, P.M. Cell adhesion molecules and oral cancer. Crit. Rev. Oral Biol. Med. 2001, 12, 479-498.
5. Rose-John, S., Scheller, J., Elson, G., Jones, S.A. Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: Role in inflammation and cancer. J. Leukoc. Biol. 2006, 80, 227-236.
6. Okamoto, M., Lee, C., Oyasu, R. Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro. Cancer Res. 1997, 57, 141-146.
7. Okamoto, M., Hattori, K., Oyasu, R. Interleukin-6 functions as an autocrine growth factor in human bladder carcinoma cell lines in vitro. Int. J. Cancer 1997, 72, 149-154.
8. Miki, S., Iwano, M., Miki, Y., Yamamoto, M., Tang, B., Yokokawa, K., Sonoda, T., Hirano, T., Kishimoto, T. Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas. FEBS Lett. 1989, 250, 607-610.
9. Chen, L., Mory, Y., Zilberstein, A., Revel, M. Growth inhibition of human breast carcinoma and leukemia/lymphoma cell lines by recombinant interferon-beta 2. Proc. Natl. Acad. Sci. USA 1988, 85, 8037-8041.
10. Okamoto, M., Lee, C., Oyasu, R. Autocrine effect of androgen on proliferation of an androgen responsive prostatic carcinoma cell line, LNCAP: Role of interleukin-6. Endocrinology 1997, 138, 5071-5074.
11. Eustace, D., Han, X., Gooding, R., Rowbottom, A., Riches, P., Heyderman, E. Interleukin-6 (IL-6) functions as an autocrine growth factor in cervical carcinomas in vitro. Gynecol. Oncol. 1993, 50, 15-19.
12. Lu, C., Kerbel, R.S. Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression. J. Cell Biol. 1993, 120, 1281-1288.
13. Lin, Y.M., Chang, Z.L., Liao, Y.Y., Chou, M.C., Tang, C.H. IL-6 promotes ICAM-1 expression and cell motility in human osteosarcoma. Cancer Lett. 2013, 328, 135-143.
14. Tang, C.H., Chen, C.F., Chen, W.M., Fong, Y.C. IL-6 increases MMP-13 expression and motility in human chondrosarcoma cells. J. Biol. Chem. 2011, 286, 11056-11066.
15. Gupta, G.P., Massague, J. Cancer metastasis: Building a framework. Cell 2006, 127, 679-695.
16. Tang, C.H. Molecular mechanisms of chondrosarcoma metastasis. BioMedicine 2012, 2, 92-98.
17. Desgrosellier, J.S., Cheresh, D.A. Integrins in cancer: Biological implications and therapeutic opportunities. Nat. Rev. Cancer 2010, 10, 9-22.
18. Makrilia, N., Kollias, A., Manolopoulos, L., Syrigos, K. Cell adhesion molecules: Role and clinical significance in cancer. Cancer Investig. 2009, 27, 1023-1037.
19. Lawson, C., Wolf, S. ICAM-1 signaling in endothelial cells. Pharmacol. Rep. 2009, 61, 22-32.
20. Zimmerman, T., Blanco, F.J. Inhibitors targeting the LFA-1/ICAM-1 cell-adhesion interaction: Design and mechanism of action. Curr. Pharm. Des. 2008, 14, 2128-2139.
21. Duperray, A., Languino, L.R., Plescia, J., McDowall, A., Hogg, N., Craig, A.G., Berendt, A.R., Altieri, D.C. Molecular identification of a novel fibrinogen binding site on the first domain of ICAM-1 regulating leukocyte-endothelium bridging. J. Biol. Chem. 1997, 272, 435-441.
22. Huang, W.C., Chan, S.T., Yang, T.L., Tzeng, C.C., Chen, C.C. Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: Molecular and functional study of novel alpha-methylene-gamma-butyrolactone derivatives. Carcinogenesis 2004, 25, 1925-1934.
23. Rosette, C., Roth, R.B., Oeth, P., Braun, A., Kammerer, S., Ekblom, J., Denissenko, M.F. Role of ICAM1 in invasion of human breast cancer cells. Carcinogenesis 2005, 26, 943-950.
24. Yang, S.F., Chen, M.K., Hsieh, Y.S., Chung, T.T., Hsieh, Y.H., Lin, C.W., Su, J.L., Tsai, M.H., Tang, C.H. Prostaglandin E2/EP1 signaling pathway enhances intercellular adhesion molecule 1 (ICAM-1) expression and cell motility in oral cancer cells. J. Biol. Chem. 2010, 285, 29808-29016.
25. Chuang, J.Y., Chang, A.C., Chiang, I.P., Tsai, M.H., Tang, C.H. Apoptosis signal-regulating kinase 1 is involved in WISP-1-promoted cell motility in human oral squamous cell carcinoma cells. PLoS One 2013, 8, e78022.
26. Lin, C.W., Chuang, C.Y., Tang, C.H., Chang, J.L., Lee, L.M., Lee, W.J., Chow, J.M., Yang, S.F., Chien, M.H. Combined effects of icam-1 single-nucleotide polymorphisms and environmental carcinogens on oral cancer susceptibility and clinicopathologic development. PLoS One 2013, 8, e72940.
27. Lo, C.W., Chen, M.W., Hsiao, M., Wang, S., Chen, C.A., Hsiao, S.M., Chang, J.S., Lai, T.C., Rose-John, S., Kuo, M.L., et al. IL-6 trans-signaling in formation and progression of malignant ascites in ovarian cancer. Cancer Res. 2011, 71, 424-434.
28. Liu, J.F., Hou, S.M., Tsai, C.H., Huang, C.Y., Hsu, C.J., Tang, C.H. CCN4 induces vascular cell adhesion molecule-1 expression in human synovial fibroblasts and promotes monocyte adhesion. Biochim. Biophys. Acta 2013, 1833, 966-975.
29. Chen, Z., Hagler, J., Palombella, V.J., Melandri, F., Scherer, D., Ballard, D., Maniatis, T. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev. 1995, 9, 1586-1597.
30. Van de Stolpe, A., van der Saag, P.T. Intercellular adhesion molecule-1. J. Mol. Med. 1996, 74, 13-33.
31. Chen, L.M., Kuo, C.H., Lai, T.Y., Lin, Y.M., Su, C.C., Hsu, H.H., Tsai, F.J., Tsai, C.H., Huang, C.Y., Tang, C.H. RANKL increases migration of human lung cancer cells through intercellular adhesion molecule-1 up-regulation. J. Cell Biochem. 2011, 112, 933-941.
32. Fong, Y.C., Lin, C.Y., Su, Y.C., Chen, W.C., Tsai, F.J., Tsai, C.H., Huang, C.Y., Tang, C.H. CCN6 enhances ICAM-1 expression and cell motility in human chondrosarcoma cells. J. Cell. Physiol. 2012, 227, 223-232.
33. Coussens, L.M., Werb, Z. Inflammation and cancer. Nature 2002, 420, 860-867.
34. Mantovani, A., Bottazzi, B., Colotta, F., Sozzani, S., Ruco, L. The origin and function of tumor-associated macrophages. Immunol. Today 1992, 13, 265-270.
35. Efremov, D.G., Laurenti, L. The Syk kinase as a therapeutic target in leukemia and lymphoma. Expert Opin. Investig. Drugs 2011, 20, 623-636.
36. Tsou, H.K., Chen, H.T., Hung, Y.H., Chang, C.H., Li, T.M., Fong, Y.C., Tang, C.H. HGF and c-Met interaction promotes migration in human chondrosarcoma cells. PLoS One 2013, 8, e53974.
37. Wu, M.H., Lo, J.F., Kuo, C.H., Lin, J.A., Lin, Y.M., Chen, L.M., Tsai, F.J., Tsai, C.H., Huang, C.Y., Tang, C.H. Endothelin-1 promotes MMP-13 production and migration in human chondrosarcoma cells through FAK/PI3K/Akt/mTOR pathways. J. Cell. Physiol. 2012, 227, 3016-3026.
38. Tang, C.H., Hsu, C.J., Fong, Y.C. The CCL5/CCR5 axis promotes interleukin-6 production in human synovial fibroblasts. Arthritis Rheum. 2010, 62, 3615-3624.
39. Huang, C.Y., Chen, S.Y., Tsai, H.C., Hsu, H.C., Tang, C.H. Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts. Arthritis Rheum. 2012, 64, 3344-3354.