Cell adhesion molecules and oral cancer

Critical Reviews in Oral Biology and Medicine

Volumn 12, Issue 6, 2001, Pages 479-498

  Thomas, G J ^a   Speight, P M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Cadherins; CD44; Cell adhesion molecules; Immunoglobulin superfamily; Integrins; Oral cancer; Selectins

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; CADHERIN; CD31 ANTIGEN; CELL ADHESION MOLECULE; DESMOCOLLIN; DESMOGLEIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HERMES ANTIGEN; IMMUNOGLOBULIN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; NERVE CELL ADHESION MOLECULE; SCLEROPROTEIN; UVOMORULIN; VASCULAR CELL ADHESION MOLECULE 1;

CANCER GROWTH; CELL ADHESION; CELL DIFFERENTIATION; CELL DIVISION; CELL MIGRATION; CELL MOTILITY; HUMAN; KERATINOCYTE; MOUTH CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; SQUAMOUS EPITHELIUM;

EID: 0035675621     PISSN: 10454411     EISSN: None     Source Type: Journal    
DOI: 10.1177/10454411010120060301     Document Type: Review

References (235)

1. Expression of β1, β3, β4 and β5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes
2. The αvβ6 integrin promotes proliferation of colon carcinoma cells through a unique region of the β6 cytoplasmic domain
3. Multiplicity of fibronectin-binding alpha v integrin receptors in colorectal cancer
4. Molecular and cellular properties of PECAM-1 (ENDOcam/cd31): A novel vascular cell adhesion molecule
5. Integrin distribution in malignant melanoma: Association of the β3 subunit with tumour progression
6. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion
7. Integrins and E-cadherin cooperate with IGF-1 to induce migration of epithelial colonic cells
8. Cancer treatment by targetted drug delivery to tumour vasculature in a mouse model
9. Participation in normal immune responses of a metastasis-inducing splice variant of CD44
10. Activation of p53 function in carcinoma cells by the alpha 6 beta 4 integrin
11. Comparison of integrin, cadherin and catenin expression in squamous cell carcinoma of the oral cavity
12. Cadherins and catenins: Role in signal transduction and tumour progression
13. Dissecting tumor cell invasion: Epithelial cells aquire invasive properties after the loss of uvomorulin-mediated cell adhesion
14. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β catenin complex in cells transformed with a temperature sensitive v-src gene
15. Carcinoembryonic antigen, a human tumor marker, functions as an intercellular adhesion molecule
16. Selectins
17. Endothelial leukocyte adhesion molecule 1: An inducible receptor for neutrophils related to complement regulatory proteins and lectins
18. Isolation and characterisation of human melanoma cell variants expressing high and low levels of CD44
19. Regulation of matrilysin expression in cells of squamous cell carcinoma by E-cadherin mediated cell-cell contact
20. CD44v3,8-10 is involved in cytoskeletal-mediated tumour cell migration and matrix metalloproteinase (MMP-9) association in breast cancer cells
21. Expression of the cell-cell adhesion molecule E-cadherin in squamous cell carcinoma of the head and neck
22. Expression of the β6 subunit in development, neoplasia and tissue repair suggests a role in epithelial remodelling
23. Integrin αvβ3 antagonists promote tumour regression by inducing apoptosis of angiogeneic blood vessels
24. Localisation of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3
25. Mechanisms of binding of cutaneous lymphocyte-associated antigen-positive and αeβ7-positive lymphocytes to oral and skin keratinocytes
26. Immunoglobulin superfamily: Structure, function and relationship to other receptor molecules
27. E-cadherin and alpha-, beta-, and gamma-catenin protein expression in relation to metastasis in human breast carcinoma
28. Re-expression of E-cadherin, α-catenin and β-catenin but not of γcatenin in metastatic tissue from breast cancer patients
29. Identification of αvβ3 as a heterotypic ligand for CD31/PECAM-1
30. Cellular and molecular mechanisms that direct leukocyte traffic
31. Leukocyte-endothelial recognition: Three (or more) steps to specificity and diversity
32. 1 in cell-cell and cell-substrate adhesion of human epidermal cells
33. Cloning and sequence analysis of desmosomal glycoprotein 2 and 3 (desmocollins): Cadherin-like desmosomal adhesion molecules with heterogenous cytoplasmic domains
34. Evaluation of CD44 prognostic value in neuroblastoma: Comparison with the other prognostic factors
35. Integrin expression in head and neck cancers
36. Junctional epithelium expresses the intercellular adhesion molecule ICAM-1
37. Identification and purification of a cell surface glycoprotein mediating intercellular adhesion in embryonic and adult tissue
38. Loss of invasiveness in squamous cell carcinoma cells overexpressing desmosomal cadherins
39. Alpha 3 beta 1 integrin is required for normal development of the epidermal basement membrane
40. E-cadherin expression in intestinal epithelium
41. E-cadherin expression in colorectal cancer
42. E-cadherin expression in normal, hyperplastic and malignant oral epithelium
43. Loss of α6 and β4 integrin subunits coincides with loss of basement membrane components in oral squamous cell carcinoma
44. Induction by IL-1 and interferon γ: Tissue distribution, biochemistry and function of a natural adherence molecule (ICAM-1)
45. Adhesion of T lymphocytes to epidermal keratinocytes is regulated by interferon-μ and is mediated by intercellular adhesion molecule 1 (ICAM-1)
46. Cell adhesion molecules: Implications for a molecular histology
47. Activation of integrin signaling pathways by cell interactions with extracellular matrix
48. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site
49. Mapping the homotypic binding sites in CD31 and the role of CD31 adhesion in the formation of inter-endothelial cell contacts
50. Involvement of integrin αv gene expression in human melanoma tumorigenicity
51. Expression of the CD34 gene in vascular endothelial cells
52. The prognostic value of quantitative angiogenesis in breast cancer and role of adhesion molecule expression in tumour endothelium
53. Stimulation of urokinase-type plasminogen activator expression by blockage of E-cadherin-dependent cell-cell adhesion
54. CD44 stimulation induces integrin-mediated adhesion of colon carcinoma cell lines to endothelial cells by upregulation of integrins and c-Met and activation of integrins
55. Cadherins in cutaneous biology
56. Desmosomes-differentiation, development, dynamics and disease
57. Altered expression of alpha 6 integrin subunit in oral squamous cell carcinoma and oral potentially malignant lesions
58. Inhibition of tumor cell migration by Arg-Gly-Asp containing synthetic peptides
59. Elevated levels of the α5β1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells
60. Expression of selectin ligands by cutaneous squamous cell carcinoma
61. CD44: A multitude of isoforms with diverse functions
62. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells
63. Expression of integrin α9 subunit and tenascin in oral leukoplakia, lichen planus and squamous cell carcinoma
64. Expression of αvβ6 integrin in oral leukoplakia
65. Immunohistochemical detection of desmosomes in oral squamous cell carcinomas: Correlation with differentiation, mode of invasion and metastatic potential
66. Unstable expression of E-cadherin adhesion molecules in metastatic ovarian tumor cells
67. Radiolabelled alpha v beta 3 integrin antagonists: A new class of tracers for tumour targetting
68. The transmembrane hyaluronate receptor (CD44): Multiple functions, multiple forms
69. Induction of adhesion molecule expression on blood vessels and keratinocytes in recurrent oral ulceration
70. Characterisation of a high affinity monoclonal antibody specific for CD44v6 as a candidate for immunotherapy for squamous cell carcinomas
71. Expression of CD44 splice variants in squamous epithelia and squamous cell carcinomas of the head and neck
72. CD44 splice variants: Metastases meets lymphocytes
73. Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation
74. Ultrastructural localisation of E-cadherin cell adhesion molecule on the cytoplasmic membrane of keratinocytes in vivo and in vitro
75. Expression of integrins in human gingiva
76. Expression of E-cadherin in oral cancer cell lines and its relationship to invasiveness in SCID mice in vivo
77. A platelet membrane protein expressed during platelet activation and secretion
78. The integrin alpha v beta 6 is critical for keratinocyte migration on both its known ligand, fibronectin and on vitronectin
79. CD44 is the major peanut lectin-binding glycoprotein of human epidermal keratinocytes and plays a role in intercellular adhesion
80. Altered expression of CD44 isoforms in squamous cell carcinomas and cell lines derived from them
81. Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92-and 72-kilodalton enzyme genes in HT-1080 cells
82. Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin
83. The molecular basis and specificity of integrin-ligand interactions
84. A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells
85. Integrins: Versatility, modulation and signaling in cell adhesion
86. Co-expression of cCD44 variant (v10/ex14) and CD44S in human mammary epithelial cells promotes tumorigenesis
87. Adhesion molecules in breast cancer: The phoenix in tumour metastasis?
88. Expression of N-cadherin by human squamous cell carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion
89. Lymphocyte recognition of high endothelium: Antibodies to distinct epitopes of an 85-95 kD glycoprotein antigen differentially inhibit lymphocyte binding to lymph node, mucosal or synovial endothelial cells
90. De novo expression of intercellular adhesion molecule 1 in melanoma correlates with increased risk of metastasis
91. Integrin expression in normal, hyperplastic, dysplastic and malignant oral epithelium
92. Restoration of αvβ5 integrin in neoplastic keratinocytes results in increased capacity for terminal differentiation and suppression of anchorage independent growth
93. Changes in the expression of αvβ6 integrins in oral squamous cell carcinoma
94. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression
95. Cadherin-mediated adhesion is required for normal growth regulation of human gingival epithelial cells
96. Selectins and their ligands: Current concepts and controversies
97. Selective gene delivery to head and neck cancer cells via an integrin targetted adenoviral vector
98. Soluble E-cadherin fragments increased in circulation of cancer patients
99. Integrins and GTPases in tumor cell growth, motility and invasion
100. Novel small molecule alpha v integrin antagonists: Comparative anti-cancer efficacy with known angiogenesis inhibitors
101. Neural cell adhesion molecule expression, neuroendocrine differentiation and prognosis in lung carcinoma
102. Cell adhesion mechanisms utilised for lymphohaemopoiesis
103. Expression of the cell-cell adhesion molecule E-cadherin in tongue carcinoma cell lines
104. Identification of desmoglein, a constitutive desmosomal glycoprotein, as a member of the cadherin family of cell adhesion molecules
105. Expression of α2, α6 and β1 chains in normal mucosa and in adenomas of the colon, colon carcinomas and their liver metastases
106. Effect of CD44v6 on survival in colorectal carcinoma
107. Integrin distribution in renal cell carcinomas of various grades of malignancy
108. Integrin receptors and their relationship to cellular proliferation and differentiation of oral squamous cell carcinoma
109. Are selectins involved in metastasis?
110. The core protein of epican, a heparan sulphate proteoglycan on keratinocytes is an alternative form of CD44
111. Expression of CD44 variant 6 and its metastatic potential in squamous cell carcinoma of the oral cavity
112. Expression of CD44 avriants in osteosarcoma
113. Anti integrin antibodies induce type IV collagenase expression in keratinocytes
114. Expression of integrins and basement membrane components by wound keratinoyctes
115. Keratinocyte integrins in wound healing and chronic inflammation of the human periodontium
116. Tumour cell adhesion to endothelial cells: Endothelial leukocyte adhesion molecule-1 as an inducible receptor for colon carcinoma cells
117. Hyaluronan binding function of CD44 is transiently activated on T cells during an in vivo immune response
118. Leukocyte-endothelial recognition: Evidence of a common molecular mechanism shared by neutrophils, lymphocytes and other leukocytes
119. Cadherin function is required to assemble desmosomes and stratify in response to calcium
120. Heterogenicity of ICAM-1 expression, and cytokine regulation of ICAM-1 expression in skin and oral keratinocytes
121. Circulating intercellular adhesion molecule 1 (ICAM-1), E-selectin and vascular cell adhesion molecule 1 (VCAM-1) in head and neck cancer
122. Down-regulation of E-cadherin in mouse skin carcinoma cells enhances a migratory and invasive phenotype linked to matrix metalloproteinase-9 gelatinase expression
123. Suppression of prostate cancer invasive potential and matrix metalloproteinase activity by E-cadherin transfection
124. Expression and modulation of CD44 isoforms in humans
125. Expression of blood group antigen-related carbohydrates by human gingival epithelia
126. Modulation by interferons of HLA antigen, high molecular weight melanoma-associated antigen, and intercellular adhesion molecule 1 expression by cultured melanoma cells with different metastatic potential
127. Recombinant E-selectin protein mediates tumour cell adhesion via sialyl-Lea and sialyl-Lex
128. Polarised expression of integrin receptors (α6β4, α2β1, α3β1 and αvβ5) and their relationship with the cytoskeleton and basement membrane matrix in cultured human keratinocytes
129. The role of integrin-mediated processes in the biology of metastasis
130. The role of integrin-mediated processes in the biology of metastasis
131. Significance of CD44 gene products for cancer diagnosis and disease evaluation
132. Altered expression of E-cadherin in gastric cancer tissues and carcinomatous fluid
133. Soluble E-cadherin: A novel cutaneous disease marker
134. E-cadherin expression in head and neck squamous cell carcinoma is associated with clinical outcome
135. E-cadherin expression in primary and metastatic gastric cancer: Downregulation correlates with cellular differentiation and glandular disintegration
136. GMP-140, a platelet alpha granule membrane protein, is also synthesised by vascular endothelial cells and is localised in Weibel-Palade bodies
137. Increased cell adhesiveness and decreased tumorigenicity induced in human colon carcinoma cells by transfection with E-cadherin cDNA
138. Relationship between E-cadherin expression and lymph node metastasis in human oesophageal cancer
139. Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
140. PECAM-1 is required for transendothelial migration of leukocytes
141. E-cadherin gene mutations in signet ring cell carcinoma of the stomach
142. CD44: Structure, function and association with the malignant process
143. Integrin adhesion receptors: Structure, function and implications for biomedicine
144. 1 integrin during terminal differentiation of human keratinocytes
145. Markedly diminished epidermal keratinocyte expression of intercellular adhesion molecule 1 (ICAM-1) in Sezary syndrome
146. The role of adhesion molecules, chemotactic factors and cytokines in inflammatory and neoplastic skin disease
147. N-cadherin promotes motility in human breast cancer cells regardless of E-cadherin expression
148. CD44H plays an important role in peritoneal dissemination of scirrhous gastric cancer cells
149. Integrin mediated signaling of gelatinase B secretion in colon carcinoma cells
150. Involvement of very late activation antigen 4 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor alpha enhancement of experimental metastasis
151. Expression of CD44 variant exons by normal oral epithelia
152. Expression of CD44 variant exons by primary and metastatic oral squamous carcinomas
153. Direct expression cloning of a vascular cell adhesion molecule 1, a cytokine induced endothelial protein that binds to lymphocytes
154. 1 integrin subunit in vitro
155. Expression of the E-selectin gene in human gingival epithelial tissue
156. Unaltered strong immunohistochemical expression of CD44-Dv6 and -v5 isoforms during development and progression of oral squamous cell carcinomas
157. Low expression of collagen receptors in moderate and poorly differentiated colorectal adenocarcinoma
158. Integrins and their accessory adhesion molecules in mammary carcinomas: Loss of polarisation in poorly differentiated tumours
159. Morphoregulatory activities of E-cadherin and beta1 integrins in colorectal tumour cells
160. Loss of membranous E-cadherin expression in pancreatic cancer: Correlation with lymph node metastasis, high grade and advanced stage
161. Vascular adhesion molecules in oral lichen planus
162. Sialyl-Lewis (x/a)-decorated selectin ligands in head and neck tumours
163. An inducible endothelial cell surface glycoprotein mediates melanoma adhesion
164. CD44 expression in dysplastic epithelium and squamous cell carcinoma of the oesophagus
165. Stabilisation of β-catenin by genetic defects in melanoma cell lines
166. Correlation of E- and P-cadherin expression with differentiation grade and mode of invasion in gingival carcinoma
167. Regulated expression of exon v6 containing isoforms of CD44 in man: Downregulation during malignant transformation of tumours of squamocellular origin
168. The involvement of selectins in cell adhesion, tumour progression and metastasis
169. Induction of the intercellular adhesion molecule (ICAM-1) on squamous cell carcinoma by interferon gamma
170. E-cadherin expression in squamous cell carcinomas of head and neck: Inverse correlation with tumor dedifferentiation and lymph node metastasis
171. E-cadherin as a functional marker of the differentiation and invasiveness of squamous cell carcinoma of the head and neck
172. Bidirectional signaling between the cytoskeleton and integrins
173. Increased tumorgenicity of fibronectin receptor deficient Chinese hamster ovary cell variants
174. Integrins as signal transducing receptors
175. The identification of a new alternative exon with highly restricted tissue expression in transcripts encoding the mouse Pgp-1 (CD44) homing receptor. Comparison of all 10 variable exons between mouse, human and rat
176. The 72kDa type IV collagenase is modulated via differential expression of alpha v beta 3 and alpha 5 beta I integrins during human melanoma cell invasion
177. Evaluation of the prognostic value of serum soluble CD44 in patients with breast cancer
178. Cadherin intercellular adhesion molecule in hepatocellular carcinomas: Loss of E-cadherin expression in an undifferentiated carcinoma
179. Expression of E- and P-cadherin in gastric carcinoma
180. Cadherin cell adhesion molecules in human epithelial tissue and carcinomas
181. Expression of integrins in squamous cell carcinoma of the oral cavity. Correlations with tumour invasion and metastasis
182. The immunoglobulin superfamily
183. Immunolocalisation of E-cadherin in human head and neck cancer
184. Adhesion receptors of the immune system
185. The cadherin superfamily
186. Optimal selectin-mediated rolling of leukocytes during inflammation in vivo requires intercellular adhesion molecule1 expression
187. Comparison of integrin expression and terminal differentiation capacity in cell lines derived from oral squamous cell carcinoma
188. Structural and functional diversity of cadherin superfamily - Are new members of cadherin superfamily involved in signal transduction pathway
189. Modulation of epidermal differentiation by epiligrin and integrin α3β1
190. Human epidermal keratinocyte expression of sialyl-Lewis X
191. Adhesion of human cancer cells to vascular endothelium mediated by carbohydrate antigen, sialyl Lewis A
192. The significance of CD44 in human pancreatic cancer. High expression of CD44 in human pancreatic adenocarcinoma
193. Involvement of CD44 in matrix metalloproteinase-2 regulation in human melanoma cells
194. Cadherins: A molecular family important in selective cell-cell adhesion
195. Cadherin cell adhesion receptors as a morphogenic regulator
196. Cadherins in cancer: Implications for invasion and metastasis
197. Decreased E-cadherin expression is associated with haematogenous recurrence and poor prognosis in patients with squamous cell carcinoma of the oesophagus
198. The CD44 adhesion molecule and metastasis
199. Expression of CD44R1 adhesion molecule in colon carcinomas and metastasis
200. Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes
201. Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin
202. E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro
203. The selectins and their ligands
204. Evidence against a major role for integrins in calcium dependent intercellular adhesion of epidermal keratinocytes
205. Alpha v beta 6 integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes
206. αvβ6 integrin promotes invasion and migration in squamous carcinoma cells
207. Alpha V beta 6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9
208. Integrins in oral cancer
209. Expression of the αvβ6 integrin in squamous carcinoma cells promotes multiple aspects of cell behaviour associated with malignancy
210. Focal loss of CD44 variant protein expression is related to recurrence in superficial bladder cancer
211. Adhesion properties, intermediate filaments and malignant behaviour of head and neck squamous cell carcinoma cells in vitro
212. Detection of circulating intercellular adhesion molecule 1 antigen in malignant disease
213. Reduced expression of the CD44 variant exons in oral squamous cell carcinoma and its relationship to metastasis
214. Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high grade prostatic cancer
215. Monoclonal antibody U36, a suitable candidate for clinical immunotherapy of squamous cell carcinoma, recognises a CD44 isoform
216. Selectin ligands
217. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
218. Expression of 7F7 antigen, a human adhesion molecule identical to intercellular adhesion molecule-1 (ICAM-1) in human carcinomas and their stromal fibroblasts
219. The role of cell adhesion molecules on oral cancer
220. VCAM-1 and ICAM-1 are expressed by Langerhans cells, macrophages and endothelial cells in oral lichen planus
221. The role of the LFA/ICAM-1 interaction in human leukocyte homing and adhesion
222. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
223. Adhesion of head and neck squamous cell carcinoma to endothelial cells. The missing links
224. Soluble 80 kD fragment of cell-CAM 120/80 disrupts cell-cell adhesion
225. E-cadherin transfection down-regulates the epidermal growth factor receptor and reverses the invasive phenotype of human papilloma virus-transfected keratinocytes
226. Expression of cadherins and catenins in oral epithelial dysplasia and squamous cell carcinoma
227. Altered antigen expression predicts outcome in squamous cell carcinoma of the head and neck
228. The relationship between E-cadherin expression, clinical stage and tumour differentiation in oral squamous cell carcinoma
229. Dualistic nature of adhesive protein function: Fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function
230. Integrin transmembrane signaling and cytoskeletal control
231. Localisation of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44 mediated tumour invasion
232. The α5β1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2
233. Growth and differentiation regulate CD44 expression on human keratinocytes
234. Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes