Modulating the vaginal microbiome: The need for a bridge between science and practice

Seminars in Reproductive Medicine

Volumn 32, Issue 1, 2014, Pages 28-34

  Reid, Gregor ^a,b  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

bladder; infection; microbiome; probiotics; vagina

Indexed keywords

CLINDAMYCIN; METRONIDAZOLE; PROBIOTIC AGENT; ANTIINFECTIVE AGENT;

ARTICLE; BACTERIAL INFECTION; FUNDING; HEALTH CARE POLICY; HUMAN; MEDICAL PRACTICE; MICROBIOME; PATIENT CARE; VAGINA FLORA; FEMALE; LACTOBACILLUS; MICROBIOLOGY; MICROFLORA; PHYSIOLOGY; PREGNANCY; VAGINA; VAGINOSIS, BACTERIAL;

ANTI-BACTERIAL AGENTS; FEMALE; HUMANS; LACTOBACILLUS; MICROBIOTA; PREGNANCY; PROBIOTICS; VAGINA; VAGINOSIS, BACTERIAL;

EID: 84891775464     PISSN: 15268004     EISSN: 15264564     Source Type: Journal    
DOI: 10.1055/s-0033-1361820     Document Type: Article

References (49)

1. Hobday A. J., Haury L., Dayton P. K. Function of the human hymen. Med Hypotheses: 1997; 49 2 171 173 (Pubitemid 27316536)
2. Al-Achi A. An introduction to botanical medicines: history, science, uses, and dangers. Westport, CT Praeger Publishers: 2008; 126
3. van Leeuwenhoek A. Microscopical observations concerning blood, milk, bone, the brain, spittle, and cuticula, etc. Phil Trans: 1674; 9 121 128
4. Reid G., Younes J. A., Van der Mei H. C., Gloor G. B., Knight R., Busscher H. J. Microbiota restoration: natural and supplemented recovery of human microbial communities. Nat Rev Microbiol: 2011; 9 1 27 38
5. Hummelen R., Fernandes A. D., Macklaim J. M., et al. Deep sequencing of the vaginal microbiota of women with HIV. PLoS ONE: 2010; 5 8 e12078
6. Zhou X., Westman R., Hickey R., et al. Vaginal microbiota of women with frequent vulvovaginal candidiasis. Infect Immun: 2009; 77 9 4130 4135
7. Siddiqui H., Nederbragt A. J., Lagesen K., Jeansson S. L., Jakobsen K. S. Assessing diversity of the female urine microbiota by high throughput sequencing of 16S rDNA amplicons. BMC Microbiol: 2011; 11 244
8. Ravel J., Gajer P., Abdo Z., et al. Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci U S A: 2011; 108 01 4680 4687
9. Brown J. M., Hess K. L., Brown S., Murphy C., Waldman A. L., Hezareh M. Intravaginal practices and risk of bacterial vaginosis and candidiasis infection among a cohort of women in the United States. Obstet Gynecol: 2013; 121 4 773 780
10. Ferris D. G., Nyirjesy P., Sobel J. D., Soper D., Pavletic A., Litaker M. S. Over-the-counter antifungal drug misuse associated with patient-diagnosed vulvovaginal candidiasis. Obstet Gynecol: 2002; 99 3 419 425 (Pubitemid 34188402)
11. Shipitsyna E., Roos A., Datcu R., et al. Composition of the vaginal microbiota in women of reproductive age - sensitive and specific molecular diagnosis of bacterial vaginosis is possible? PLoS ONE: 2013; 8 4 e60670
12. Gardner H. L., Dukes C. D. Haemophilus vaginalis vaginitis: a newly defined specific infection previously classified non-specific vaginitis. Am J Obstet Gynecol: 1955; 69 5 962 976
13. Holmes K. K., Spiegel C., Amsel A. R., Eschenbach D. A., Chen K. C., Totten P. Nonspecific vaginosis. Scand J Infect Dis Suppl: 1981; 26 110 114 (Pubitemid 11092286)
14. Greaves W. L., Chungafung J., Morris B., Haile A., Townsend J. L. Clindamycin versus metronidazole in the treatment of bacterial vaginosis. Obstet Gynecol: 1988; 72 5 799 802
15. Koren O., Knights D., Gonzalez A., et al. A guide to enterotypes across the human body: meta-analysis of microbial community structures in human microbiome datasets. PLoS Comput Biol: 2013; 9 1 e1002863
16. Fernandes A. D., Macklaim J. M., Linn T. G., Reid G., Gloor G. B. ANOVA-like differential expression (ALDEx) analysis for mixed population RNA-Seq. PLoS ONE: 2013; 8 7 e67019
17. Oduyebo O. O., Anorlu R. I., Ogunsola F. T. The effects of antimicrobial therapy on bacterial vaginosis in non-pregnant women. Cochrane Database Syst Rev: 2009; 3 CD006055
18. Sobel J., Peipert J. F., McGregor J. A., et al. Efficacy of clindamycin vaginal ovule (3-day treatment) vs. clindamycin vaginal cream (7-day treatment) in bacterial vaginosis. Infect Dis Obstet Gynecol: 2001; 9 1 9 15 (Pubitemid 32510019)
19. Ferris D. G., Litaker M. S., Woodward L., Mathis D., Hendrich J. Treatment of bacterial vaginosis: a comparison of oral metronidazole, metronidazole vaginal gel, and clindamycin vaginal cream. J Fam Pract: 1995; 41 5 443 449
20. Ugwumadu A. H., Hay P. Bacterial vaginosis: sequelae and management. Curr Opin Infect Dis: 1999; 12 1 53 59 (Pubitemid 29095135)
21. O'Dowd T. C., Parker S., Kelly A. Women's experiences of general practitioner management of their vaginal symptoms. Br J Gen Pract: 1996; 46 408 415 418 (Pubitemid 26245292)
22. Johnson S. R., Griffiths H., Humberstone F. J. Attitudes and experience of women to common vaginal infections. J Low Genit Tract Dis: 2010; 14 4 287 294
23. Payne S. C., Cromer P. R., Stanek M. K., Palmer A. A. Evidence of African-American women's frustrations with chronic recurrent bacterial vaginosis. J Am Acad Nurse Pract: 2010; 22 2 101 108
24. Reid G., Zorzitto M. L., Bruce A. W., Jewett M. AS, Chan R. CY, Costerton J. W. The pathogenesis of urinary tract infection in the elderly: the role of bacterial adherence to uroepithelial cells. Curr Microbiol: 1984; 11 2 67 72 (Pubitemid 15059608)
25. Kirjavainen P., Pautler S., Baroja M. L., et al. Aberrant vaginal microbiota and IL-12 skewed cytokine production by antigen-presenting cells are characteristic of women prone to urinary tract infections. Clin Vaccine Immunol: 2008; 16 1 29 36
26. Davis C. P., Cohen M. S., Anderson M. D., Gruber M. B., Warren M. M. Urothelial hyperplasia and neoplasia. II. Detection of nitrosamines and interferon in chronic urinary tract infections in rats. J Urol: 1985; 134 5 1002 1006 (Pubitemid 16219296)
27. Nordenstam G. R., Brandberg C. A., Odén A. S., Svanborg Edén C. M., Svanborg A. Bacteriuria and mortality in an elderly population. N Engl J Med: 1986; 314 18 1152 1156 (Pubitemid 16138662)
28. Williams D. H., Schaeffer A. J. Current concepts in urinary tract infections. Minerva Urol Nefrol: 2004; 56 1 15 31 (Pubitemid 38937537)
29. Wagenlehner F. M., Hoyme U., Kaase M., Fünfstück R., Naber K. G., Schmiemann G. Uncomplicated urinary tract infections. Dtsch Arztebl Int: 2011; 108 24 415 423
30. Raz R. Fosfomycin: an old - new antibiotic. Clin Microbiol Infect: 2012; 18 1 4 7
31. Madani Y., Mann B. Nitrofurantoin-induced lung disease and prophylaxis of urinary tract infections. Prim Care Respir J: 2012; 21 3 337 341
32. Ferry S. A., Holm S. E., Stenlund H., Lundholm R., Monsen T. J. Clinical and bacteriological outcome of different doses and duration of pivmecillinam compared with placebo therapy of uncomplicated lower urinary tract infection in women: the LUTIW project. Scand J Prim Health Care: 2007; 25 1 49 57
33. Kim T. K., Thomas S. M., Ho M., et al. Heterogeneity of vaginal microbial communities within individuals. J Clin Microbiol: 2009; 47 4 1181 1189
34. Hickey R. J., Zhou X., Pierson J. D., Ravel J., Forney L. J. Understanding vaginal microbiome complexity from an ecological perspective. Transl Res: 2012; 160 4 267 282
35. Menard J. P., Mazouni C., Fenollar F., Raoult D., Boubli L., Bretelle F. Diagnostic accuracy of quantitative real-time PCR assay versus clinical and Gram stain identification of bacterial vaginosis. Eur J Clin Microbiol Infect Dis: 2010; 29 12 1547 1552
36. Macklaim J. M., Cohen C. R., Donders G., et al. Exploring a road map to counter misconceptions about the cervicovaginal microbiome and disease. Reprod Sci: 2012; 19 11 1154 1162
37. Hall-Stoodley L., Stoodley P. Evolving concepts in biofilm infections. Cell Microbiol: 2009; 11 7 1034 1043
38. Conrad D., Haynes M., Salamon P., Rainey P. B., Youle M., Rohwer F. Cystic fibrosis therapy: a community ecology perspective. Am J Respir Cell Mol Biol: 2013; 48 2 150 156
39. Qin Z., Yang L., Qu D., Molin S., Tolker-Nielsen T. Pseudomonas aeruginosa extracellular products inhibit staphylococcal growth, and disrupt established biofilms produced by Staphylococcus epidermidis. Microbiology: 2009; 155 Pt 7 2148 2156
40. McMillan A., Dell M., Zellar M. P., et al. Disruption of urogenital biofilms by lactobacilli. Colloids Surf B Biointerfaces: 2011; 86 1 58 64
41. Absolom D. R. The role of bacterial hydrophobicity in infection: bacterial adhesion and phagocytic ingestion. Can J Microbiol: 1988; 34 3 287 298
42. Verstraelen H., Swidsinski A. The biofilm in bacterial vaginosis: implications for epidemiology, diagnosis and treatment. Curr Opin Infect Dis: 2013; 26 1 86 89
43. Macklaim J. M., Fernandes A. D., Reid G., Gloor G. B. Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis. Microbiome: 2013; 1 12
44. Nicholson J. K., Holmes E., Kinross J. M., Darzi A. W., Takats Z., Lindon J. C. Metabolic phenotyping in clinical and surgical environments. Nature: 2012; 491 7424 384 392
45. Luong M. L., Libman M., Dahhou M., et al. Vaginal douching, bacterial vaginosis, and spontaneous preterm birth. J Obstet Gynaecol Can: 2010; 32 4 313 320
46. Enos M., Burton J. P., Dols J., et al. Probiotics for the first 1000 days of life in the developing world. Benef. Microbes: 2013; 4 1 3 16
47. Reid G., Charbonneau D., Erb J., et al. Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women. FEMS Immunol Med Microbiol: 2003; 35 2 131 134 (Pubitemid 36298934)
48. Beerepoot M. A., ter Riet G., Nys S., et al. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Arch Intern Med: 2012; 172 9 704 712
49. Morelli L., Zonenenschain D., Del Piano M., Cognein P. Utilization of the intestinal tract as a delivery system for urogenital probiotics. J Clin Gastroenterol: 2004; 38 (6, Suppl): S107 S110