Toxicology study assessing efficacy and safety of repeated administration of lipid/DNA complexes to mouse lung

Gene Therapy

Volumn 21, Issue 1, 2014, Pages 89-95

  Alton, E W F W ^a,b   Boyd, A C ^a,c   Cheng, S H ^d   Davies, J C ^a,b   Davies, L A ^a,e   Dayan, A ^f   Gill, D R ^a,e   Griesenbach, U ^a,b   Higgins, T ^a,b   Hyde, S C ^a,e   Innes, J A ^a,g   McLachlan, G ^a,h   Porteous, D ^a,c   Pringle, I ^a,e   Scheule, R K ^d   Sumner Jones, S ^a,e  

^a UK CF Gene Therapy Consortium   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d SANOFI   (France)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f Toxicology Consult   (United Kingdom)

^g WESTERN GENERAL HOSPITAL   (United Kingdom)

^h UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

cationic lipid; cystic fibrosis; gene transfer; repeat administration; toxicology

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; GENE THERAPY AGENT; GL 67 A; MESSENGER RNA; PLASMID DNA; UNCLASSIFIED DRUG;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; GENE EXPRESSION; LUNG FIBROSIS; MALE; MOUSE; NEBULIZER; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; REPEATED DRUG DOSE;

MURINAE; MUS;

ADMINISTRATION, INHALATION; ANIMALS; COMBINED MODALITY THERAPY; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENETIC THERAPY; GENETIC VECTORS; HUMANS; LIPIDS; LUNG; MALE; MICE; MICE, INBRED BALB C; PLASMIDS; REPRODUCIBILITY OF RESULTS;

EID: 84891742682     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2013.61     Document Type: Article

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