Methylation of P16 in exhaled breath condensate for diagnosis of non-small cell lung cancer

Lung Cancer

Volumn 83, Issue 1, 2014, Pages 56-60

  Xiao, Ping ^a   Chen, Jian rong ^a   Zhou, Feng ^a   Lu, Chen xi ^a   Yang, Qichan ^a   Tao, Guo hua ^a   Tao, Yi jiang ^a   Chen, Jing liang ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

Biological markers; Diagnosis; DNA methylation; Exhaled breath condensate; Fluorescence; Gene P16; Non small cell lung cancer; Polymerase chain reaction

Indexed keywords

BIOLOGICAL MARKER; PROTEIN P16;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; BREATHING; CANCER DIAGNOSIS; CANCER SCREENING; CANCER TISSUE; CONTROLLED STUDY; EXHALED BREATH CONDENSATE; FEMALE; FLUORESCENCE; FLUORESCENT QUANTITATIVE METHYLATION SPECIFIC POLYMERASE CHAIN REACTION; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PLASMA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN METHYLATION;

BIOLOGICAL MARKERS; DIAGNOSIS; DNA METHYLATION; EXHALED BREATH CONDENSATE; FLUORESCENCE; GENE P16; NON-SMALL CELL LUNG CANCER; POLYMERASE CHAIN REACTION;

ADULT; AGED; BREATH TESTS; CARCINOMA, NON-SMALL-CELL LUNG; DNA; DNA METHYLATION; EXHALATION; FEASIBILITY STUDIES; FEMALE; FLUORESCENCE; GENES, P16; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; PATHOLOGY, MOLECULAR; PROMOTER REGIONS, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 84891740572     PISSN: 01695002     EISSN: 18728332     Source Type: Journal    
DOI: 10.1016/j.lungcan.2013.09.008     Document Type: Article

References (20)

1. Jemal A., Thomas A., Murray T., Thun M. Cancer statistics, 2002. CA Cancer J Clin 2002, 52:23-47.
2. Parkin D.M., Bray F.I., Devesa S.S. Cancer burden in the year 2000. The global picture. Eur J Cancer 2001, 37(Suppl. 8):S4-S66.
3. Belinsky S.A. Silencing of genes by promoter hypermethylation: key event in rodent and human lung cancer. Carcinogenesis 2005, 26:1481-1487.
4. Jones P.A., Baylin S.B. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002, 3:415-428.
5. Herman J.G., Baylin S.B. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003, 349:2042-2054.
6. Suzuki M., Sunaga N., Shames D.S., Toyooka S., Gazdar A.F., Minna J.D. RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells. Cancer Res 2004, 64:3137-3143.
7. Toyooka S., Toyooka K.O., Maruyama R., Virmani A.K., Girard L., Miyajima K., et al. DNA methylation profiles of lung tumors. Mol Cancer Ther 2001, 1:61-67.
8. Zochbauer-Muller S., Minna J.D., Gazdar A.F. Aberrant DNA methylation in lung cancer: biological and clinical implications. Oncologist 2002, 7:451-457.
9. Nuovo G.J., Plaia T.W., Belinsky S.A., Baylin S.B., Herman J.G. In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis. Proc Natl Acad Sci U S A 1999, 96:12754-12759.
10. Liu W.B., Liu J.Y., Ao L., Zhou Z.Y., Zhou Y.H., Cui Z.H., et al. Dynamic changes in DNA methylation during multistep rat lung carcinogenesis induced by 3-methylcholanthrene and diethylnitrosamine. Toxicol Lett 2009, 189:5-13.
11. Yoshino M., Suzuki M., Tian L., Moriya Y., Hoshino H., Okamoto T., et al. Promoter hypermethylation of the p16 and Wif-1 genes as an independent prognostic marker in stage IA non-small cell lung cancers. Int J Oncol 2009, 35:1201-1209.
12. Barnes P.J., Chowdhury B., Kharitonov S.A., Magnussen H., Page C.P., Postma D., et al. Pulmonary biomarkers in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006, 174:6-14.
13. Gessner C., Rechner B., Hammerschmidt S., Kuhn H., Hoheisel G., Sack U., et al. Angiogenic markers in breath condensate identify non-small cell lung cancer. Lung Cancer 2010, 68:177-184.
14. Gessner C., Kuhn H., Toepfer K., Hammerschmidt S., Schauer J., Wirtz H. Detection of p53 gene mutations in exhaled breath condensate of non-small cell lung cancer patients. Lung Cancer 2004, 43:215-222.
15. Carpagnano G.E., Foschino-Barbaro M.P., Mule G., Resta O., Tommasi S., Mangia A., et al. 3p microsatellite alterations in exhaled breath condensate from patients with non-small cell lung cancer. Am J Respir Crit Care Med 2005, 172:738-744.
16. Han W., Wang T., Reilly A.A., Keller S.M., Spivack S.D. Gene promoter methylation assayed in exhaled breath, with differences in smokers and lung cancer patients. Respir Res 2009, 10:86.
17. Chan H.P., Lewis C., Thomas P.S. Exhaled breath analysis: novel approach for early detection of lung cancer. Lung Cancer 2009, 63:164-168.
18. Poirier F., Bourin P., Bladier D., Joubert-Caron R., Caron M. Effect of 5-azacytidine and galectin-1 on growth and differentiation of the human b lymphoma cell line bl36. Cancer Cell Int 2001, 1:2.
19. Yang H., Liang H., Yan J.S., Tao R., Hao S.G., Ma L.Y. Down-regulation of hematopoiesis master regulator PU.1 via aberrant methylation in chronic myeloid leukemia. Int J Hematol 2012, 96:65-73.
20. Huang X., Narayanaswamy R., Fenn K., Szpakowski S., Sasaki C., Costa J., et al. Sequence-specific biosensors report drug-induced changes in epigenetic silencing in living cells. DNA Cell Biol 2012, 31(Suppl. 1):S2-S10.